Plasma lidocaine levels and PaO2 with endobronchial administration: dilution with normal saline or distilled water?

Abstract:

STUDY OBJECTIVE:To determine whether water or 0.9% saline should be used as diluent for endobronchial drug administration. PARTICIPANTS:Twelve adult patients. INTERVENTIONS:Patients were endobronchially administered 2 mg/kg lidocaine as marker substance in either 10 mL 0.9% saline or 10 mL distilled water during general anesthesia. MEASUREMENTS AND MAIN RESULTS:The differences in mean lidocaine plasma levels at five minutes (water vs saline, 2.35 vs 1.59 micrograms/mL) and ten minutes (water vs saline: 2.67 vs 1.88 micrograms/mL) were significant (P less than .05). With the initial mean PaO2 being almost (157 mm Hg; F1O2, 0.3) in the two groups, there was a mean drop of about 60 mm Hg in the saline-diluent group, but only about 40 mm Hg in the water-diluent group one minute after administration (P less than .05). CONCLUSION:The use of water resulted in better absorption of lidocaine and less impairment of the PaO2.

journal_name

Ann Emerg Med

authors

Hähnel JH,Lindner KH,Schürmann C,Prengel A,Ahnefeld FW

doi

10.1016/s0196-0644(05)82293-0

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

1314-7

issue

11

eissn

0196-0644

issn

1097-6760

pii

S0196-0644(05)82293-0

journal_volume

19

pub_type

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