Clinical safety of lidocaine in patients with cocaine-associated myocardial infarction.

Abstract:

STUDY OBJECTIVE:To evaluate the safety of lidocaine in the setting of cocaine-induced myocardial infarction (MI). DESIGN:A retrospective, multicenter study. SETTING:Twenty-nine university, university-affiliated, or community hospitals during a 6-year period (total of 117 cumulative hospital-years). PARTICIPANTS:Patients with cocaine-associated MI who received lidocaine in the emergency department. RESULTS:Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited bradydysrhythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%). CONCLUSION:Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity.

journal_name

Ann Emerg Med

authors

Shih RD,Hollander JE,Burstein JL,Nelson LS,Hoffman RS,Quick AM

doi

10.1016/s0196-0644(95)70041-2

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

702-6

issue

6

eissn

0196-0644

issn

1097-6760

pii

S0196-0644(95)70041-2

journal_volume

26

pub_type

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