Abstract:
OBJECTIVES:To compare outcomes and the use of multimodality therapy in young and elderly people with pancreatic cancer undergoing surgical resection. DESIGN:Retrospective, single-institution study. SETTING:National Cancer Institute/National Comprehensive Cancer Network cancer center. PARTICIPANTS:Two hundred three individuals who underwent pancreaticoduodenectomy for pancreatic adenocarcinoma at Duke University Medical Center comprised the study population. Participants were divided into three groups based on age (<65, n = 97; 65-74, n = 74; ≥75, N = 32). MEASUREMENTS:Perioperative outcomes, the use of multimodality therapy, and overall survival of the different age groups were compared. RESULTS:Similar rates of perioperative mortality and morbidity were observed in all age groups, but elderly adults were more likely to be discharged to a rehabilitation or skilled nursing facility. A similar proportion of participants received neoadjuvant therapy, but a smaller proportion of elderly participants received adjuvant therapy. Overall survival was similar between the age groups. Predictors of poorer overall survival included coronary artery disease, positive resection margin, and less-differentiated tumor histology. Treatment with neoadjuvant and adjuvant therapy were predictors of better overall survival. CONCLUSION:Carefully selected elderly individuals experience similar perioperative outcomes and overall survival to those of younger individuals after resection of pancreatic cancer. There appears to be a significant disparity in the use of adjuvant therapy between young and elderly individuals.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Barbas AS,Turley RS,Ceppa EP,Reddy SK,Blazer DG 3rd,Clary BM,Pappas TN,Tyler DS,White RR,Lagoo SAdoi
10.1111/j.1532-5415.2011.03785.xsubject
Has Abstractpub_date
2012-02-01 00:00:00pages
344-50issue
2eissn
0002-8614issn
1532-5415journal_volume
60pub_type
杂志文章abstract:OBJECTIVES:To compare nosologist coding of underlying cause of death according to the death certificate with adjudicated cause of death for subjects aged 65 and older in the Cardiovascular Health Study (CHS). DESIGN:Observational. SETTING:Four communities: Forsyth County, North Carolina (Wake Forest University); Sacr...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1532-5415.2008.02056.x
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:To examine relationships between race and psychotropic drug use (antidepressant, antianxiety, sedative/hypnotic agents) in informal caregivers with symptoms of depression who provide care for elderly relatives with progressive dementia. Whether racial differences in medication use relate to racial difference...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2005.53155.x
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVES:To determine whether providing physical therapy (PT) services in the emergency department (ED) improves outcomes for older adults who fall. DESIGN:We used Medicare claims data to examine differences in recurrent fall-related ED revisit rates of older adults who presented to the ED for a ground-level fall an...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.15469
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:There is a need to assess longitudinal trends in physical function and to understand the prevalence of physical function status in the older population using objectively measured physical function. Therefore, the primary purpose of this study was to examine longitudinal sex-specific physical function trends ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.16638
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:To examine current utilization patterns of cholinesterase inhibitor (ChEI) therapy for dementia to determine treatment duration, use in long-term care, how often patients receive these drugs until death, and frequency of switching between the available ChEIs. DESIGN:A population-based healthcare administrat...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1532-5415.2007.01377.x
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVES:To compare patient characteristics and family perceptions of patient function at one urban and one rural memory disorders clinic. DESIGN:Secondary, cross-sectional data analyses of an extant clinical database. SETTING/PARTICIPANTS:First time visits (n = 956) at two memory disorders clinics. MEASUREMENTS:P...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1046/j.1532-5415.2001.49127.x
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVES:To examine the relationship between frequent falls in older drivers and motor vehicle collision (MVC) involvement. DESIGN:Cross-sectional. SETTING:North central Alabama. PARTICIPANTS:Population-based sample of 2,000 licensed drivers aged 70 and older. MEASUREMENTS:Self-reported history of falling two or ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.12594
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:To determine whether older adults with the hepatitis C virus (HCV) achieve a sustained viral response (SVR) after treatment with direct-acting antiviral therapy. PARTICIPANTS:Individuals aged 80 and older with chronic HCV infection (N = 253; n = 213 with cirrhosis, n = 40 with advanced fibrosis). MEASUREME...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.15140
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:To identify risk factors for new-onset geriatric epilepsy that may trigger clinicians to consider a differential diagnosis of epilepsy at symptom onset. DESIGN:Retrospective cohort study. SETTING:National Veterans Affairs (VA) databases. PARTICIPANTS:Veterans aged 66 and older in fiscal year 2000 (FY00) w...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2008.02124.x
更新日期:2009-02-01 00:00:00
abstract::Cognitive impairment in old age is one of the most important topics in modern geriatrics. This article discusses the historical dimensions of this phenomenon. To this end, a number of primary sources ranging from antiquity to the modern era are evaluated. Although a physiology and pathology of old age were conceptuali...
journal_title:Journal of the American Geriatrics Society
pub_type: 历史文章,杂志文章
doi:10.1111/j.1532-5415.2005.53558.x
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVES:To compare the ability of five measures of comorbidity to predict mortality and incident disability in basic activities of daily living (BADLs) in unselected older persons. DESIGN:An assessment of the data obtained from the Insufficienza Cardiaca negli Anziani Residenti a Dicomano (ICARe Dicomano) Study, a ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2005.00572.x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:To determine if alcohol use is a risk factor for fall injury events among community-dwelling older persons. DESIGN:Case-control study. SETTING:South Miami Beach, Florida. PARTICIPANTS:320 persons 65 or older who sought treatment at six area hospitals for injuries resulting from falls; 609 controls, matched...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1992.tb01955.x
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVES:To determine whether genetic variants in the ciliary neurotrophic factor (CNTF) gene are associated with muscle strength in older women. DESIGN:Cross-sectional analysis of baseline data from the Women's Health and Aging Studies I (1992) and II (1994), complementary population-based studies. SETTING:Twelve ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2006.00693.x
更新日期:2006-05-01 00:00:00
abstract::Eighty-seven community-dwelling nonagenarians provided with extensive medical and social services as needed were followed for two years. Fifty-one subjects were admitted to an acute care hospital at least once. Total durations of hospitalization for those who required it averaged 44 days per individual over the two ye...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1984.tb02038.x
更新日期:1984-05-01 00:00:00
abstract::Two concurrent studies of geriatric outpatients who received diagnoses of depression were conducted. In the first, patients were treated with one of two tricyclic antidepressants or with a placebo. In the second, patients were assigned to groups receiving either psychodynamic group therapy or cognitive-behavioral grou...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1982.tb01987.x
更新日期:1982-11-01 00:00:00
abstract::(-)Deprenyl (Selegiline, Jumex, Eldepryl, Movergan), a close structural relative to phenylethylamine (PEA), is a drug with a unique pharmacological spectrum. (1) It is a highly potent and selective, irreversible inhibitor of B-type monoamine oxidase (MAO), a predominantly glial enzyme in the brain. The activity of thi...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
doi:10.1111/j.1532-5415.1992.tb01860.x
更新日期:1992-08-01 00:00:00
abstract:OBJECTIVES:To examine the prevalence of mobility device use in community-dwelling older adults in the United States and to investigate the incidence of falls and worry about falling according to type and number of mobility devices used. DESIGN:Analysis of cross-sectional and longitudinal data from the 2011-12 National...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.13393
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To determine the validity of the Minimum Data Set (MDS). DESIGN:MDS domain scores were correlated with a variety of independently obtained measures of basic behavioral and mental health functions of 513 nursing home residents. SETTING:All participants were residents of the Philadelphia Geriatric Center. PA...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1998.tb03809.x
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVES:To determine the extent to which disease-related symptoms and impairments, which constitute measures of disease severity or targets of therapy, account for the associations between chronic diseases and universal health outcomes. DESIGN:Cross-sectional. SETTING:The Cardiovascular Health Study (CHS) and the ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2011.03576.x
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence of hypoalbuminemia and hypoprealbuminemia in hospitalized, elderly, skilled nursing facility residents and to correlate these findings with clinical outcomes. DESIGN:Prospective cohort study. SETTING:A 300-bed community hospital. PARTICIPANTS:Eighty-one hospitalized, skilled n...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1993.tb01893.x
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of diabetes and examine its association with food intake, anthropometric and metabolic variables, and other coronary risk factors in urban and rural older Mexican populations. DESIGN:A cross-sectional study. SETTING:Three Mexican communities (urban areas of medium and low income ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1998.tb06005.x
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVES:To describe the prevalence of self reported sleep disturbances in older men and women and to describe their relationships with health status and cardiovascular disease (CVD). DESIGN:Cross-sectional study of sleep disturbance, CVD, general health, psychosocial factors, physical function, and use of psychotro...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1997.tb00970.x
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Patient activation encompasses the knowledge, skills, and confidence that equip adults to participate actively in their healthcare. Patients with hearing loss may be less able to participate due to poor aural communication. We examined whether difficulty hearing is associated with lower patient ac...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.15833
更新日期:2019-07-01 00:00:00
abstract::The benefits of prophylactic aspirin therapy to prevent cardiovascular and cerebrovascular disease in asymptomatic individuals remains unclear. The rationale for developing a multicentered, double-blind, placebo-controlled clinical trial to determine whether low-dose aspirin (100 mg daily) prevents cardiovascular and ...
journal_title:Journal of the American Geriatrics Society
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1532-5415.1991.tb02494.x
更新日期:1991-05-01 00:00:00
abstract:OBJECTIVE:To assess how dietary change affects gain in strength and muscle mass during heavy resistance training of elderly men. DESIGN:Randomized controlled trial. INTERVENTION:During 12 weeks of resistance training of knee extensors and flexors, a daily supplement of 560 +/- 16 kcal/day (17% energy from protein, 43...
journal_title:Journal of the American Geriatrics Society
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1532-5415.1992.tb01937.x
更新日期:1992-02-01 00:00:00
abstract:OBJECTIVES:To describe and provide baseline data from The National Pressure Ulcer Long-Term Care Study (NPULS). DESIGN:Retrospective cohort study of detailed resident characteristics, treatments, and outcomes using convenience sampling. SETTING:One hundred nine long-term care facilities throughout the United States. ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1046/j.1532-5415.2002.50510.x
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVES:To describe the prevalence of and characteristics associated with major and minor depression in older medical inpatients and to compare associated characteristics by sex and history of depression. DESIGN:Cross-sectional study of two patient samples, with and without a screening diagnosis of major or minor d...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2005.53404.x
更新日期:2005-08-01 00:00:00
abstract::Although the field of frailty research has expanded rapidly, it is still a nascent concept within the clinical specialties. Frailty, conceptualized as greater vulnerability to stressors because of significant depletion of physiological reserves, predicts poorer outcomes in several medical specialties, including cardio...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.14902
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Delirium in the intensive care units (ICUs) is prevalent, with both delirium duration and delirium severity associated with adverse outcomes. We designed a pragmatic trial to test the efficacy of a pharmacological management of delirium (PMD) bundle in improving delirium/coma-free days and reducing...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/jgs.15781
更新日期:2019-05-01 00:00:00
abstract::The Physician Orders for Life-Sustaining Treatment (POLST) form is a palliative care tool that contains standardized, actionable medical orders. It is designed to ensure that patient treatment preferences are elicited, communicated, and honored throughout the healthcare system. A systematic review of the literature wa...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
doi:10.1111/jgs.13248
更新日期:2015-02-01 00:00:00