Comparison of outcomes and the use of multimodality therapy in young and elderly people undergoing surgical resection of pancreatic cancer.

Abstract:

OBJECTIVES:To compare outcomes and the use of multimodality therapy in young and elderly people with pancreatic cancer undergoing surgical resection. DESIGN:Retrospective, single-institution study. SETTING:National Cancer Institute/National Comprehensive Cancer Network cancer center. PARTICIPANTS:Two hundred three individuals who underwent pancreaticoduodenectomy for pancreatic adenocarcinoma at Duke University Medical Center comprised the study population. Participants were divided into three groups based on age (<65, n = 97; 65-74, n = 74; ≥75, N = 32). MEASUREMENTS:Perioperative outcomes, the use of multimodality therapy, and overall survival of the different age groups were compared. RESULTS:Similar rates of perioperative mortality and morbidity were observed in all age groups, but elderly adults were more likely to be discharged to a rehabilitation or skilled nursing facility. A similar proportion of participants received neoadjuvant therapy, but a smaller proportion of elderly participants received adjuvant therapy. Overall survival was similar between the age groups. Predictors of poorer overall survival included coronary artery disease, positive resection margin, and less-differentiated tumor histology. Treatment with neoadjuvant and adjuvant therapy were predictors of better overall survival. CONCLUSION:Carefully selected elderly individuals experience similar perioperative outcomes and overall survival to those of younger individuals after resection of pancreatic cancer. There appears to be a significant disparity in the use of adjuvant therapy between young and elderly individuals.

journal_name

J Am Geriatr Soc

authors

Barbas AS,Turley RS,Ceppa EP,Reddy SK,Blazer DG 3rd,Clary BM,Pappas TN,Tyler DS,White RR,Lagoo SA

doi

10.1111/j.1532-5415.2011.03785.x

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

344-50

issue

2

eissn

0002-8614

issn

1532-5415

journal_volume

60

pub_type

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