Rationale for a primary prevention study using low-dose aspirin to prevent coronary and cerebrovascular disease in the elderly.

Abstract:

:The benefits of prophylactic aspirin therapy to prevent cardiovascular and cerebrovascular disease in asymptomatic individuals remains unclear. The rationale for developing a multicentered, double-blind, placebo-controlled clinical trial to determine whether low-dose aspirin (100 mg daily) prevents cardiovascular and cerebrovascular morbidity and mortality in persons aged 70 years and over with no evidence of pre-existing cardiovascular or cerebrovascular disease is described. Sample size calculations have indicated that 15,000 subjects would be required over a 4-year follow-up period in order to demonstrate a 20% reduction in overall cardiovascular mortality at the 0.01 level with a power of 0.8. Such a large-scale community-based clinical trial has never been conducted in Australia in this age group. Therefore the PACE (prevention by low-dose aspirin of cardiovascular disease in the elderly) pilot study has been developed to test recruitment strategies and methods and ascertaining disease end-points.

journal_name

J Am Geriatr Soc

authors

Silagy CA,McNeil JJ,Bulpitt CJ,Donnan GA,Tonkin AM,Worsam B

doi

10.1111/j.1532-5415.1991.tb02494.x

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

484-91

issue

5

eissn

0002-8614

issn

1532-5415

journal_volume

39

pub_type

临床试验,杂志文章,随机对照试验
  • A multimodal aging and dying course for first-year medical students improves knowledge and attitudes.

    abstract::When medical schools change their curricula, this opens up opportunities for the development of new material and often eliminates previously designed courses. Emory University's School of Medicine revised its curriculum in 2007, combining clinical medicine and basic sciences in the first 18 months. As part of its firs...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2009.02363.x

    authors: Eskildsen MA,Flacker J

    更新日期:2009-08-01 00:00:00

  • Assistive technology use of older American Indians in a southeastern tribe: the native elder care study.

    abstract::The objectives of this study were to examine the prevalence of assistive technology (AT) use, type of assistance used for each activity of daily living (ADL) limitation, and correlates of AT use among Native Indian aged 55 and older. Data were collected as part of a cross-sectional study of disability with 505 members...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2010.03140.x

    authors: Goins RT,Spencer SM,Goli S,Rogers JC

    更新日期:2010-11-01 00:00:00

  • Use of self-report to predict ability to walk 400 meters in mobility-limited older adults.

    abstract:OBJECTIVES:To determine whether the ability to walk 400 m could be predicted from self-reported walking habits and abilities in older adults and to develop an accurate self-report measure appropriate for observational trials of mobility when functional measures are impractical to collect. DESIGN:Cross-sectional. SETT...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2004.52571.x

    authors: Sayers SP,Brach JS,Newman AB,Heeren TC,Guralnik JM,Fielding RA

    更新日期:2004-12-01 00:00:00

  • An examination of histamine-2 receptor antagonist use by Medicaid recipients in Wisconsin long-term care facilities.

    abstract::The Wisconsin Drug Utilization Review Project used Medicaid claims data to examine the use of long-term, full doses histamine-2 receptor antagonists (H2RAs) among long-term care facility (LTCF) residents, ie, doses exceeding 800 mg per day of cimetidine or 150 mg per day of ranitidine for 12 weeks or more. Additional ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1988.tb04024.x

    authors: Lipowski EE,Bauwens SF,Collins TM

    更新日期:1988-06-01 00:00:00

  • Blood pressure and survival in the oldest old.

    abstract:OBJECTIVES:To determine the relationship between blood pressure (BP) and all-cause mortality in subjects aged 80 and older with hypertension. DESIGN:Retrospective cohort study with 5 years of follow-up. SETTING:Ten Veterans AFFAIRS (VA) sites. PARTICIPANTS:Four thousand seventy-one ambulatory patients aged 80 and ol...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2007.01069.x

    authors: Oates DJ,Berlowitz DR,Glickman ME,Silliman RA,Borzecki AM

    更新日期:2007-03-01 00:00:00

  • Predictors of Independent Aging and Survival: A 16-Year Follow-Up Report in Octogenarian Men.

    abstract:OBJECTIVES:To examine the longitudinal associations between aging with preserved functionality, i.e. independent aging and survival, and lifestyle variables, dietary pattern and cardiovascular risk factors. DESIGN:Cohort study. SETTING:Uppsala Longitudinal Study of Adult Men, Sweden. PARTICIPANTS:Swedish men (n = 1,...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.14971

    authors: Franzon K,Byberg L,Sjögren P,Zethelius B,Cederholm T,Kilander L

    更新日期:2017-09-01 00:00:00

  • Colonization and infection with antibiotic-resistant bacteria in a long-term care facility.

    abstract:OBJECTIVE:To assess colonization and infection with methicillin-resistant Staphylococcus aureus (MRSA), high-level gentamicin-resistant enterococci (R-ENT) and gentamicin and/or ceftriaxone-resistant Gram-negative bacilli (R-GNB) and the factors that are associated with colonization and infection with these organisms. ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1994.tb06210.x

    authors: Terpenning MS,Bradley SF,Wan JY,Chenoweth CE,Jorgensen KA,Kauffman CA

    更新日期:1994-10-01 00:00:00

  • Attitudes toward self-determined death: a survey of primary care physicians.

    abstract:OBJECTIVE:To survey physicians to determine whether sociodemographic and practice-related variables are predictive of their attitudes toward suicide. DESIGN:Mailed questionnnaire survey. SETTING:Monroe County, New York. PARTICIPANTS:A 50 percent random sample of practicing primary care physicians. Of 186 potential r...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1995.tb05814.x

    authors: Duberstein PR,Conwell Y,Cox C,Podgorski CA,Glazer RS,Caine ED

    更新日期:1995-04-01 00:00:00

  • Age-related changes of circadian rhythms and sleep-wake cycles.

    abstract:OBJECTIVES:To compare relationships between the sleep-wake cycle and endogenous circadian rhythms in young and older adults and to examine correlates between evening naps and circadian rhythms in older adults. DESIGN:For 1 week of home recording, subjects wore wrist-activity monitors and kept daily sleep logs. After t...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1046/j.1532-5415.2003.51356.x

    authors: Yoon IY,Kripke DF,Elliott JA,Youngstedt SD,Rex KM,Hauger RL

    更新日期:2003-08-01 00:00:00

  • Biomarkers for delirium--a review.

    abstract::To improve delirium recognition and care, numerous serum biomarkers have been investigated as potential tools for risk stratification, diagnosis, monitoring, and prognostication of delirium. The literature was reviewed, and no evidence was found to support the clinical use of any delirium biomarker, although certain b...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审

    doi:10.1111/j.1532-5415.2011.03702.x

    authors: Khan BA,Zawahiri M,Campbell NL,Boustani MA

    更新日期:2011-11-01 00:00:00

  • Effectiveness of tai chi as a community-based falls prevention intervention: a randomized controlled trial.

    abstract:OBJECTIVES:To compare the effectiveness of tai chi and low-level exercise in reducing falls in older adults; to determine whether mobility, balance, and lower limb strength improved and whether higher doses of tai chi resulted in greater effect. DESIGN:Randomized controlled trial. SETTING:Eleven sites throughout New ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1532-5415.2012.03928.x

    authors: Taylor D,Hale L,Schluter P,Waters DL,Binns EE,McCracken H,McPherson K,Wolf SL

    更新日期:2012-05-01 00:00:00

  • Withholding versus withdrawing life-sustaining treatment: patient factors and documentation associated with dialysis decisions.

    abstract:OBJECTIVE:We evaluated prospectively the use of acute hemodialysis among hospitalized patients to identify demographic and clinical predictors of and chart documentation concerning dialysis withheld and withdrawn. DESIGN:Prospective cohort study. SETTING:Five teaching hospitals. PATIENTS:Five hundred sixty-five seri...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1532-5415.2000.tb03145.x

    authors: Wenger NS,Lynn J,Oye RK,Liu H,Teno JM,Phillips RS,Desbiens NA,Sehgal A,Kussin P,Taub H,Harrell F,Knaus W

    更新日期:2000-05-01 00:00:00

  • Methicillin-resistant Staphylococcus aureus in Minnesota nursing homes.

    abstract:OBJECTIVE:To assess the experience of Minnesota nursing homes with methicillin-resistant Staphylococcus aureus (MRSA) and the policies and procedures used for its control. DESIGN:A 12-question survey, with primarily categorical responses, was mailed to the Directors of Nursing of all Minnesota long-term-care facilitie...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1991.tb02877.x

    authors: Thurn JR,Belongia EA,Crossley K

    更新日期:1991-11-01 00:00:00

  • Longitudinal Analysis of Mortality for Older Adults Receiving or Waiting for Aging Network Services.

    abstract:OBJECTIVES:For older adults screened by an Area Agency on Aging (AAA) in the National Aging Network, we aimed to examine the 12-month mortality rate for wait-listed callers compared with those who received services within 12 months, and to assess whether the mortality rate differed according to how quickly they receive...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.16232

    authors: Gum AM,Green O,Schonfeld L,Conner K,Rigg KK,Wagoner F,Melling KA,Parkinson K

    更新日期:2020-03-01 00:00:00

  • Family and Other Unpaid Caregivers and Older Adults with and without Dementia and Disability.

    abstract:OBJECTIVES:To estimate the number of caregivers providing assistance to community-dwelling older persons with and without dementia and with or without substantial disability; to describe the characteristics of caregivers and care recipients in these groups; to characterize the health-related tasks that caregivers provi...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.14910

    authors: Riffin C,Van Ness PH,Wolff JL,Fried T

    更新日期:2017-08-01 00:00:00

  • Age and Sex Distributions of Age-Related Biomarker Values in Healthy Older Adults from the Long Life Family Study.

    abstract:OBJECTIVES:To determine reference values for laboratory tests in individuals aged 85 and older. DESIGN:Cross-sectional cohort study. SETTING:International. PARTICIPANTS:Long Life Family Study (LLFS) participants (N~5,000, age: range 25-110, median 67, 45% male). MEASUREMENTS:Serum biomarkers were selected based on ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.14522

    authors: Sebastiani P,Thyagarajan B,Sun F,Honig LS,Schupf N,Cosentino S,Feitosa MF,Wojczynski M,Newman AB,Montano M,Perls TT

    更新日期:2016-11-01 00:00:00

  • Professional development in geriatrics for community-based generalist faculty.

    abstract::Generalist physicians provide most primary care for older people. Increasingly, undergraduate clinical education occurs in community sites. Hence, community-based generalist faculty members need continuing education in geriatrics to support clinical practice and teaching. The Geriatrics Scholars Program provided conti...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2007.01050.x

    authors: Willett RM,Boling PA,Meyers ME,Hoban JD,Lawson SR,Schlesinger JB

    更新日期:2007-02-01 00:00:00

  • The effect of transitioning to medicare part d drug coverage in seniors dually eligible for medicare and medicaid.

    abstract:OBJECTIVES:To evaluate medication use, out-of-pocket spending, and medication switching during the transition period for patients dually eligible for Medicaid and Medicare (dual eligibles). DESIGN:Time-trend analysis, using segmented linear regression. SETTING:Patient-level pharmacy dispensing data from January 2005 ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2008.02025.x

    authors: Shrank WH,Patrick AR,Pedan A,Polinski JM,Varasteh L,Levin R,Liu N,Schneeweiss S

    更新日期:2008-12-01 00:00:00

  • Patient-related predictors of rehabilitation use for community-dwelling older Americans.

    abstract:OBJECTIVE:To determine patient factors that predict use of physical or occupational therapy (PT/OT) services by elderly people. DESIGN:Time-series study of the relationship of PT/OT use to a variety of characteristics present at baseline. PARTICIPANTS:Eight-hundred nine community-dwelling men and women aged 65 and ol...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1992.tb02131.x

    authors: Mayer-Oakes SA,Hoenig H,Atchison KA,Lubben JE,De Jong F,Schweitzer SO

    更新日期:1992-04-01 00:00:00

  • Use of urinary collection devices in skilled nursing facilities in five states.

    abstract:OBJECTIVES:To assess use of urinary collection devices (external, intermittent, and indwelling catheters; pads or briefs) and examine predictors of indwelling catheters in skilled nursing facilities (SNFs). DESIGN:Retrospective cohort study. SETTING:SNFs in California, Florida, Michigan, New York, and Texas. PARTICI...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2008.01675.x

    authors: Rogers MA,Mody L,Kaufman SR,Fries BE,McMahon LF Jr,Saint S

    更新日期:2008-05-01 00:00:00

  • Perspectives of Patients in Identifying Their Values-Based Health Priorities.

    abstract:OBJECTIVES:Patient Health Priorities Identification (PHPI) is a values-based process in which trained facilitators assist older adults with multiple chronic conditions identify their health priorities. The purpose of this study was to evaluate patients' perceptions of PHPI. DESIGN:Qualitative study using thematic anal...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.15850

    authors: Feder SL,Kiwak E,Costello D,Dindo L,Hernandez-Bigos K,Vo L,Geda M,Blaum C,Tinetti ME,Naik AD

    更新日期:2019-07-01 00:00:00

  • Cerebral amyloid angiopathy in the elderly.

    abstract::In this study an attempt was made to determine the relationship between cerebral amyloid angiopathy (AA) and other cerebrovascular lesions in the aged. The brains of 128 autopsy patients over 60 years of age were examined by both light and electron microscopy. The frequency of cerebral AA increased with age and was 58...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1981.tb01757.x

    authors: Tomonaga M

    更新日期:1981-04-01 00:00:00

  • Pneumonia versus aspiration pneumonitis in nursing home residents: diagnosis and management.

    abstract:OBJECTIVES:To determine the frequency of aspiration pneumonitis in nursing home residents with an initial diagnosis of pneumonia and to compare the clinical characteristics, management, and outcome of aspiration pneumonitis with those of pneumonia. DESIGN:Retrospective chart review. SETTING:Hospital geriatric unit fo...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1034/j.1601-5215.2002.51004.x

    authors: Mylotte JM,Goodnough S,Naughton BJ

    更新日期:2003-01-01 00:00:00

  • Incidence of tooth loss and prosthodontic dental care: effect on chewing difficulty onset, a component of oral health-related quality of life.

    abstract:OBJECTIVES:To quantify incidence of tooth loss, prosthodontic dental restoration, and chewing difficulty onset and the effect of tooth loss and prosthodontic restoration on chewing difficulty onset. DESIGN:A prospective cohort study of oral health and related behaviors with in-person interviews and clinical examinatio...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2004.52253.x

    authors: Gilbert GH,Meng X,Duncan RP,Shelton BJ

    更新日期:2004-06-01 00:00:00

  • Diagnosis-related group-adjusted hospital costs are higher in older medical patients with lower functional status.

    abstract:OBJECTIVES:To determine whether hospital costs are higher in patients with lower functional status at admission, defined as dependence in one or more activities of daily living (ADLs), after adjustment for Medicare Diagnosis-Related Group (DRG) payments. DESIGN:Prospective study. SETTING:General medical service at a ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1046/j.1532-5415.2003.51556.x

    authors: Chuang KH,Covinsky KE,Sands LP,Fortinsky RH,Palmer RM,Landefeld CS

    更新日期:2003-12-01 00:00:00

  • Falls in the institutionalized elderly.

    abstract::The reports on 72 of 190 accidents occurring among 189 nursing home residents during a 3-month period were drawn at random and reviewed. The majority of the accidents were falls, either major or minor. Personal data on the residents included age, sex, mental status, number of diseases, and number of drugs administered...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1978.tb05391.x

    authors: Kalchthaler T,Bascon RA,Quintos V

    更新日期:1978-09-01 00:00:00

  • Relationship between higher estradiol levels and 9-year mortality in older women: the Invecchiare in Chianti study.

    abstract:OBJECTIVES:To investigate the relationship between total estradiol (E2) levels and 9-year mortality in older postmenopausal women not taking hormone replacement therapy (HRT). DESIGN:Population-based study of persons living in the Chianti geographic area (Tuscany, Italy). SETTING:Community. PARTICIPANTS:A representa...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2009.02464.x

    authors: Maggio M,Ceda GP,Lauretani F,Bandinelli S,Ruggiero C,Guralnik JM,Metter EJ,Ling SM,Paolisso G,Valenti G,Cappola AR,Ferrucci L

    更新日期:2009-10-01 00:00:00

  • Neurotransmitter deficits in Alzheimer's disease: criteria for significance.

    abstract::A series of histopathologic, morphologic, and pharmacologic criteria are proposed to establish the significance of neurochemical deficits in Alzheimer's disease. The underlying pathogenic biochemistry of a better understood neurotransmitter-deficiency syndrome, Parkinson's disease, validates these criteria. The major ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审

    doi:10.1111/j.1532-5415.1983.tb04877.x

    authors: Greenwald BS,Mohs RC,Davis KL

    更新日期:1983-05-01 00:00:00

  • Apolipoprotein E ε4 allele interacts with sex and cognitive status to influence all-cause and cause-specific mortality in U.S. older adults.

    abstract:OBJECTIVES:To confirm associations of apolipoprotein E (ApoE) ε4 carrier status, sex, and time-dependent cognitive status with mortality risk and to investigate these joint effects of these associations in a cohort of community-dwelling U.S. adults. DESIGN:Prospective cohort study. SETTING:The Baltimore Longitudinal ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.12156

    authors: Beydoun MA,Beydoun HA,Kaufman JS,An Y,Resnick SM,O'Brien R,Ferrucci L,Zonderman AB

    更新日期:2013-04-01 00:00:00

  • A higher dose of vitamin d reduces the risk of falls in nursing home residents: a randomized, multiple-dose study.

    abstract:OBJECTIVES:To determine the effect of four vitamin D supplement doses on falls risk in elderly nursing home residents. DESIGN:Secondary data analysis of a previously conducted randomized clinical trial. SETTING:Seven hundred twenty-five-bed long-term care facility. PARTICIPANTS:One hundred twenty-four nursing home r...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1532-5415.2007.01048.x

    authors: Broe KE,Chen TC,Weinberg J,Bischoff-Ferrari HA,Holick MF,Kiel DP

    更新日期:2007-02-01 00:00:00