Abstract:
:The benefits of prophylactic aspirin therapy to prevent cardiovascular and cerebrovascular disease in asymptomatic individuals remains unclear. The rationale for developing a multicentered, double-blind, placebo-controlled clinical trial to determine whether low-dose aspirin (100 mg daily) prevents cardiovascular and cerebrovascular morbidity and mortality in persons aged 70 years and over with no evidence of pre-existing cardiovascular or cerebrovascular disease is described. Sample size calculations have indicated that 15,000 subjects would be required over a 4-year follow-up period in order to demonstrate a 20% reduction in overall cardiovascular mortality at the 0.01 level with a power of 0.8. Such a large-scale community-based clinical trial has never been conducted in Australia in this age group. Therefore the PACE (prevention by low-dose aspirin of cardiovascular disease in the elderly) pilot study has been developed to test recruitment strategies and methods and ascertaining disease end-points.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Silagy CA,McNeil JJ,Bulpitt CJ,Donnan GA,Tonkin AM,Worsam Bdoi
10.1111/j.1532-5415.1991.tb02494.xsubject
Has Abstractpub_date
1991-05-01 00:00:00pages
484-91issue
5eissn
0002-8614issn
1532-5415journal_volume
39pub_type
临床试验,杂志文章,随机对照试验abstract::When medical schools change their curricula, this opens up opportunities for the development of new material and often eliminates previously designed courses. Emory University's School of Medicine revised its curriculum in 2007, combining clinical medicine and basic sciences in the first 18 months. As part of its firs...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2009.02363.x
更新日期:2009-08-01 00:00:00
abstract::The objectives of this study were to examine the prevalence of assistive technology (AT) use, type of assistance used for each activity of daily living (ADL) limitation, and correlates of AT use among Native Indian aged 55 and older. Data were collected as part of a cross-sectional study of disability with 505 members...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2010.03140.x
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVES:To determine whether the ability to walk 400 m could be predicted from self-reported walking habits and abilities in older adults and to develop an accurate self-report measure appropriate for observational trials of mobility when functional measures are impractical to collect. DESIGN:Cross-sectional. SETT...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2004.52571.x
更新日期:2004-12-01 00:00:00
abstract::The Wisconsin Drug Utilization Review Project used Medicaid claims data to examine the use of long-term, full doses histamine-2 receptor antagonists (H2RAs) among long-term care facility (LTCF) residents, ie, doses exceeding 800 mg per day of cimetidine or 150 mg per day of ranitidine for 12 weeks or more. Additional ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1988.tb04024.x
更新日期:1988-06-01 00:00:00
abstract:OBJECTIVES:To determine the relationship between blood pressure (BP) and all-cause mortality in subjects aged 80 and older with hypertension. DESIGN:Retrospective cohort study with 5 years of follow-up. SETTING:Ten Veterans AFFAIRS (VA) sites. PARTICIPANTS:Four thousand seventy-one ambulatory patients aged 80 and ol...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2007.01069.x
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:To examine the longitudinal associations between aging with preserved functionality, i.e. independent aging and survival, and lifestyle variables, dietary pattern and cardiovascular risk factors. DESIGN:Cohort study. SETTING:Uppsala Longitudinal Study of Adult Men, Sweden. PARTICIPANTS:Swedish men (n = 1,...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.14971
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To assess colonization and infection with methicillin-resistant Staphylococcus aureus (MRSA), high-level gentamicin-resistant enterococci (R-ENT) and gentamicin and/or ceftriaxone-resistant Gram-negative bacilli (R-GNB) and the factors that are associated with colonization and infection with these organisms. ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1994.tb06210.x
更新日期:1994-10-01 00:00:00
abstract:OBJECTIVE:To survey physicians to determine whether sociodemographic and practice-related variables are predictive of their attitudes toward suicide. DESIGN:Mailed questionnnaire survey. SETTING:Monroe County, New York. PARTICIPANTS:A 50 percent random sample of practicing primary care physicians. Of 186 potential r...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1995.tb05814.x
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVES:To compare relationships between the sleep-wake cycle and endogenous circadian rhythms in young and older adults and to examine correlates between evening naps and circadian rhythms in older adults. DESIGN:For 1 week of home recording, subjects wore wrist-activity monitors and kept daily sleep logs. After t...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1046/j.1532-5415.2003.51356.x
更新日期:2003-08-01 00:00:00
abstract::To improve delirium recognition and care, numerous serum biomarkers have been investigated as potential tools for risk stratification, diagnosis, monitoring, and prognostication of delirium. The literature was reviewed, and no evidence was found to support the clinical use of any delirium biomarker, although certain b...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
doi:10.1111/j.1532-5415.2011.03702.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVES:To compare the effectiveness of tai chi and low-level exercise in reducing falls in older adults; to determine whether mobility, balance, and lower limb strength improved and whether higher doses of tai chi resulted in greater effect. DESIGN:Randomized controlled trial. SETTING:Eleven sites throughout New ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1532-5415.2012.03928.x
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:We evaluated prospectively the use of acute hemodialysis among hospitalized patients to identify demographic and clinical predictors of and chart documentation concerning dialysis withheld and withdrawn. DESIGN:Prospective cohort study. SETTING:Five teaching hospitals. PATIENTS:Five hundred sixty-five seri...
journal_title:Journal of the American Geriatrics Society
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/j.1532-5415.2000.tb03145.x
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:To assess the experience of Minnesota nursing homes with methicillin-resistant Staphylococcus aureus (MRSA) and the policies and procedures used for its control. DESIGN:A 12-question survey, with primarily categorical responses, was mailed to the Directors of Nursing of all Minnesota long-term-care facilitie...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1991.tb02877.x
更新日期:1991-11-01 00:00:00
abstract:OBJECTIVES:For older adults screened by an Area Agency on Aging (AAA) in the National Aging Network, we aimed to examine the 12-month mortality rate for wait-listed callers compared with those who received services within 12 months, and to assess whether the mortality rate differed according to how quickly they receive...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.16232
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:To estimate the number of caregivers providing assistance to community-dwelling older persons with and without dementia and with or without substantial disability; to describe the characteristics of caregivers and care recipients in these groups; to characterize the health-related tasks that caregivers provi...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.14910
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:To determine reference values for laboratory tests in individuals aged 85 and older. DESIGN:Cross-sectional cohort study. SETTING:International. PARTICIPANTS:Long Life Family Study (LLFS) participants (N~5,000, age: range 25-110, median 67, 45% male). MEASUREMENTS:Serum biomarkers were selected based on ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.14522
更新日期:2016-11-01 00:00:00
abstract::Generalist physicians provide most primary care for older people. Increasingly, undergraduate clinical education occurs in community sites. Hence, community-based generalist faculty members need continuing education in geriatrics to support clinical practice and teaching. The Geriatrics Scholars Program provided conti...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2007.01050.x
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVES:To evaluate medication use, out-of-pocket spending, and medication switching during the transition period for patients dually eligible for Medicaid and Medicare (dual eligibles). DESIGN:Time-trend analysis, using segmented linear regression. SETTING:Patient-level pharmacy dispensing data from January 2005 ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2008.02025.x
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To determine patient factors that predict use of physical or occupational therapy (PT/OT) services by elderly people. DESIGN:Time-series study of the relationship of PT/OT use to a variety of characteristics present at baseline. PARTICIPANTS:Eight-hundred nine community-dwelling men and women aged 65 and ol...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1992.tb02131.x
更新日期:1992-04-01 00:00:00
abstract:OBJECTIVES:To assess use of urinary collection devices (external, intermittent, and indwelling catheters; pads or briefs) and examine predictors of indwelling catheters in skilled nursing facilities (SNFs). DESIGN:Retrospective cohort study. SETTING:SNFs in California, Florida, Michigan, New York, and Texas. PARTICI...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2008.01675.x
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVES:Patient Health Priorities Identification (PHPI) is a values-based process in which trained facilitators assist older adults with multiple chronic conditions identify their health priorities. The purpose of this study was to evaluate patients' perceptions of PHPI. DESIGN:Qualitative study using thematic anal...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.15850
更新日期:2019-07-01 00:00:00
abstract::In this study an attempt was made to determine the relationship between cerebral amyloid angiopathy (AA) and other cerebrovascular lesions in the aged. The brains of 128 autopsy patients over 60 years of age were examined by both light and electron microscopy. The frequency of cerebral AA increased with age and was 58...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1981.tb01757.x
更新日期:1981-04-01 00:00:00
abstract:OBJECTIVES:To determine the frequency of aspiration pneumonitis in nursing home residents with an initial diagnosis of pneumonia and to compare the clinical characteristics, management, and outcome of aspiration pneumonitis with those of pneumonia. DESIGN:Retrospective chart review. SETTING:Hospital geriatric unit fo...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1034/j.1601-5215.2002.51004.x
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:To quantify incidence of tooth loss, prosthodontic dental restoration, and chewing difficulty onset and the effect of tooth loss and prosthodontic restoration on chewing difficulty onset. DESIGN:A prospective cohort study of oral health and related behaviors with in-person interviews and clinical examinatio...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2004.52253.x
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVES:To determine whether hospital costs are higher in patients with lower functional status at admission, defined as dependence in one or more activities of daily living (ADLs), after adjustment for Medicare Diagnosis-Related Group (DRG) payments. DESIGN:Prospective study. SETTING:General medical service at a ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1046/j.1532-5415.2003.51556.x
更新日期:2003-12-01 00:00:00
abstract::The reports on 72 of 190 accidents occurring among 189 nursing home residents during a 3-month period were drawn at random and reviewed. The majority of the accidents were falls, either major or minor. Personal data on the residents included age, sex, mental status, number of diseases, and number of drugs administered...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1978.tb05391.x
更新日期:1978-09-01 00:00:00
abstract:OBJECTIVES:To investigate the relationship between total estradiol (E2) levels and 9-year mortality in older postmenopausal women not taking hormone replacement therapy (HRT). DESIGN:Population-based study of persons living in the Chianti geographic area (Tuscany, Italy). SETTING:Community. PARTICIPANTS:A representa...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2009.02464.x
更新日期:2009-10-01 00:00:00
abstract::A series of histopathologic, morphologic, and pharmacologic criteria are proposed to establish the significance of neurochemical deficits in Alzheimer's disease. The underlying pathogenic biochemistry of a better understood neurotransmitter-deficiency syndrome, Parkinson's disease, validates these criteria. The major ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
doi:10.1111/j.1532-5415.1983.tb04877.x
更新日期:1983-05-01 00:00:00
abstract:OBJECTIVES:To confirm associations of apolipoprotein E (ApoE) ε4 carrier status, sex, and time-dependent cognitive status with mortality risk and to investigate these joint effects of these associations in a cohort of community-dwelling U.S. adults. DESIGN:Prospective cohort study. SETTING:The Baltimore Longitudinal ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.12156
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVES:To determine the effect of four vitamin D supplement doses on falls risk in elderly nursing home residents. DESIGN:Secondary data analysis of a previously conducted randomized clinical trial. SETTING:Seven hundred twenty-five-bed long-term care facility. PARTICIPANTS:One hundred twenty-four nursing home r...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1532-5415.2007.01048.x
更新日期:2007-02-01 00:00:00