The effects of high- and low-dose aspirin on thermoregulation during and after acute cold exposure.

Abstract:

OBJECTIVE:To explore the effect of aspirin on the thermoregulatory responses of men during exposure to 12°C air (acute cold exposure) for a period of 120 minutes and recovery in 25°C air (rewarming) for 120 minutes. METHODS:Seven male subjects (26.1 ± 2.4 yr) underwent pre-experimental testing to determine peak VO(2) and body composition. Participants underwent 3 trials in which they ingested the following for 1 week prior to each experimental trial: a capsule filled with cellulose (placebo), 81 mg · day(-1) of aspirin (low-dose aspirin), or 650 mg · day(-1) of aspirin (high-dose aspirin). Each trial consisted of a 30-minute baseline period, 120 minutes of exposure to 12°C air, and 120 minutes of recovery in 25°C air. Mean skin temperature and rectal temperature (T(re)) were measured, and heat production was calculated. RESULTS:During both acute cold exposure and rewarming, analysis of variance revealed a main effect for time (P < .05) with respect to T(re), mean skin temperature, and heat production. However, there were no significant differences between the treatments or treatment by time interactions. CONCLUSIONS:These data demonstrate that aspirin had no significant effect on the thermal and metabolic responses during acute cold exposure and rewarming.

journal_name

Wilderness Environ Med

authors

Murray LK,Otterstetter R,Muller MD,Glickman EL

doi

10.1016/j.wem.2011.06.007

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

321-5

issue

4

eissn

1080-6032

issn

1545-1534

pii

S1080-6032(11)00157-8

journal_volume

22

pub_type

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