Abstract:
BACKGROUND:Deep brain stimulation (DBS) is an effective treatment for essential tremor (ET). Currently the ventrolateral thalamus is the target of choice, but the posterior subthalamic area (PSA), including the caudal zona incerta (cZi), has demonstrated promising results, and the subthalamic nucleus (STN) has been suggested as a third alternative. The objective of the current study was to evaluate the effect of STN DBS in ET and to compare this to cZi DBS. METHODS:Four patients with ET were implanted with two ipsilateral electrodes, one in the STN and one in the cZi. All contacts were evaluated concerning the acute effect on tremor, and the effect of chronic DBS in either target was analyzed. RESULTS:STN and cZi both proved to be potent targets for DBS in ET. DBS in the cZi was more efficient, since the same degree of tremor reduction could here be achieved at lower energy consumption. Three patients became tremor-free in the treated hand with either STN or cZi DBS, while the fourth had a minor residual tremor after stimulation in either target. CONCLUSION:In this limited material, STN DBS was demonstrated to be an efficient treatment for ET, even though cZi DBS was more efficient. The STN may be an alternative target in the treatment of ET, pending further investigations to decide on the relative merits of the different targets.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Blomstedt P,Sandvik U,Linder J,Fredricks A,Forsgren L,Hariz MIdoi
10.1007/s00701-011-1157-4subject
Has Abstractpub_date
2011-12-01 00:00:00pages
2329-35issue
12eissn
0001-6268issn
0942-0940journal_volume
153pub_type
临床试验,杂志文章abstract:BACKGROUND:Chronic subdural haematoma (cSDH) is a common disease in neurosurgical practise, especially in elderly patients. This is of growing importance as the number of elderly people in the population is increasing steadily. There are scarce data focussing especially on elderly patients with cSDH. This study intende...
journal_title:Acta neurochirurgica
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journal_title:Acta neurochirurgica
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pub_type: 杂志文章,多中心研究
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更新日期:2012-07-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/BF02188792
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pub_type: 杂志文章
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pub_type: 历史文章,杂志文章
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pub_type: 杂志文章
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更新日期:1977-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1979-01-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
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journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406198
更新日期:1983-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00