Genetic determinants of platelet response to clopidogrel.

abstract：:The Tissue Factor/Factor VIIa (TF/FVIIa) complex is an attractive target for pharmacological interruption of thrombin generation and hence blood coagulation, as this complex is the initiation point of the extrinsic pathway of coagulation. TF is a cell membrane-associated protein that interacts with soluble FVIIa to ac...

journal_title：Journal of thrombosis and thrombolysis

authors： Szalony JA,Taite BB,Girard TJ,Nicholson NS,LaChance RM

更新日期：2002-10-01 00:00:00

abstract：:A 64-year-old man first developed ligneous conjunctivitis at the age of 58 years after right pulmonary resection because of suspected cancer; otherwise, he had been healthy. Since then, he began to suffer from various forms of chronic pseudomembranous mucositis. Laboratory tests demonstrated that he had 7.8 % of plasm...

journal_title：Journal of thrombosis and thrombolysis

authors： Osaki T,Souri M,Song YS,Izumi N,Law R,Ichinose A

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The 4G/5G plasminogen activator inhibitor-1 (PAI-1) promoter polymorphism has been associated with basal PAI-1 levels, with ischemic heart disease, and with adverse prognosis in critically ill patients. We hypothesized it might also influence the acute-phase levels of PAI-1 following coronary b...

journal_title：Journal of thrombosis and thrombolysis

authors： Burzotta F,Iacoviello L,Di Castelnuovo A,Zamparelli R,D'Orazio A,Amore C,Schiavello R,Donati MB,Maseri A,Possati G,Andreotti F

更新日期：2003-12-01 00:00:00

abstract：:The relationship between vascular-specific epicardial adipose tissue (vEAT) volume and myocardial ischemia measured by fractional flow reserve (FFR) was not well investigated. Patients with typical and atypical chest pain undergoing coronary computed tomographic angiography scan followed by invasive coronary angiograp...

journal_title：Journal of thrombosis and thrombolysis

authors： Shan D,Wang X,Dou G,Zhang W,Jing J,He B,Li Y,Chen Y,Yang J

更新日期：2020-10-17 00:00:00

abstract：BACKGROUND:Radiographic contrast agents inhibit fibrinolysis, although by poorly defined pathways. The purpose of this study was to define specific mechanisms by which contrast agents inhibit clot lysis. METHODS AND RESULTS:Diatrizoate (high osmolar ionic agent), ioxaglate (low osmolar ionic), and ioversol (nonionic) ...

journal_title：Journal of thrombosis and thrombolysis

authors： Farrehi PM,Zhu Y,Fay WP

更新日期：2001-12-01 00:00:00

abstract：:Associations of Raynaud's phenomenon (RP) with venous thromboembolism (VTE) are unclear. We investigated the occurrence of RP together with prothrombotic state markers and fibrin clot properties in VTE patients. In this prospective cohort study we enrolled 360 patients free of known autoimmune disease. D-dimer, von Wi...

journal_title：Journal of thrombosis and thrombolysis

authors： Żuk J,Snarska-Drygalska A,Malinowski KP,Papuga-Szela E,Natorska J,Undas A

更新日期：2019-02-01 00:00:00

abstract：:Arterial thrombosis is the leading causes of morbidity and mortality worldwide, whereas venous thrombosis is the most common preventable cause of hospital death. In either case, venous and arterial thrombosis should be considered autonomous entities, with only minor overlaps in terms of risk factors, predisposing cond...

journal_title：Journal of thrombosis and thrombolysis

authors： Lippi G,Favaloro EJ,Franchini M

更新日期：2012-10-01 00:00:00

abstract：:To investigate the prevalence of permanent atrial fibrillation (AF), its clinical associated conditions and treatment status in the elderly population in rural Greece. 720 people (46.1% males) older than 65 years (mean age: 72.5 +/- 5.7 years) living in four villages in rural Greece were screened with an electrocardio...

journal_title：Journal of thrombosis and thrombolysis

authors： Ninios I,Bogossian H,Zarse M,Lazaridou F,Dimitriadis K,Ninios V,Lemke B,Louridas G

更新日期：2010-07-01 00:00:00

abstract：:Making a definitive diagnosis of heparin-induced thrombocytopenia (HIT) can be problematic. A prompt platelet rise following treatment has been proposed as a "post-test" criterion for diagnosis. However, the platelet response following discontinuation of heparin and initiation of a recommended alternative anticoagulan...

journal_title：Journal of thrombosis and thrombolysis

authors： Pon TK,Mahajan A,Rosenberg A,Amin A,Shah D,Jenkins I,Gupta V,Hofmann H,Bejjani A,White R

更新日期：2018-05-01 00:00:00

abstract：:In this feasibility study, a novel catheter prototype for laser thrombolysis under the guidance of optical coherence tomography (OCT) was designed and evaluated in a preclinical model. Human arteries and veins were integrated into a physiological flow model and occluded with thrombi made from the Chandler Loop. There ...

journal_title：Journal of thrombosis and thrombolysis

authors： Berndt R,Rusch R,Hummitzsch L,Lutz M,Heß K,Huenges K,Panholzer B,Otte C,Haneya A,Lutter G,Schlaefer A,Cremer J,Groß J

更新日期：2017-04-01 00:00:00

abstract：:Intravenous (IV) thrombolysis is the treatment in ischemic stroke, but only the minority of patients receive this medication. The primary objective of this study was to explore the reasons associated with the decision not to offer IV thrombolysis to stroke patients admitted to the Stroke Unit (SU). We conducted a retr...

journal_title：Journal of thrombosis and thrombolysis

authors： Cappellari M,Bosco M,Forlivesi S,Tomelleri G,Micheletti N,Carletti M,Bovi P

更新日期：2016-11-01 00:00:00

abstract：AIMS:Cancer patients have an increased risk for thromboembolism (TE). Factor V 1691 G-A(Leiden) (FVL) and prothrombin (PT) G20210A mutation are common inherited risk factor for TE. The aim of the study is to evaluate the prevalence of FVL and PT G20210A polymorphism in cancer patients with and without TE as compared to...

journal_title：Journal of thrombosis and thrombolysis

authors： Eroglu A,Ulu A,Cam R,Kurtman C,Akar N

更新日期：2007-02-01 00:00:00

abstract：:Objective: To define the changing incidence, risk, and therapy of acute myocardial infarction (A311). Data sources: Review of contemporary AMI data from the University of Alberta Hospitals, six other sites of the Clinical Quality Improvement Network (CQIN), and other Canadian and international centers. Data synthesis:...

journal_title：Journal of thrombosis and thrombolysis

authors： Montague T,Montague P,Barnes M,Taylor L,Wowk L,Fassbender K,Ackman M,Martin S,Armstrong PW,Teo K

更新日期：1996-01-01 00:00:00

abstract：:The recent development and approval of novel oral anticoagulants represents a significant success in the intelligent design of target-specific therapeutics. However, while these agents obviate many of the shortcomings of their predecessor (warfarin), they present novel challenges in pharmacologic management as well. E...

journal_title：Journal of thrombosis and thrombolysis

authors： Steinberg BA,Becker RC

更新日期：2014-01-01 00:00:00

abstract：:The objective was to compare the pharmacodynamic (PD) and pharmacokinetic (PK) effects of ticagrelor with clopidogrel among subjects of Hispanic ethnicity, as the PD and PK effects of antiplatelet agents among Hispanics are not specifically known. This was a randomised, open-label, crossover PD/PK study of 40 Hispanic...

journal_title：Journal of thrombosis and thrombolysis

authors： Price MJ,Clavijo L,Angiolillo DJ,Carlson G,Caplan R,Teng R,Maya J

更新日期：2015-01-01 00:00:00

abstract：:The direct oral anticoagulant dabigatran does not require therapeutic drug monitoring, however emergency measurements are gaining importance. Current assays feature good performance at intermediate and high dabigatran concentrations but show limited accuracy at low concentrations. This area requires more attention as ...

journal_title：Journal of thrombosis and thrombolysis

authors： Härtig F,Poli S,Ebner M,Birschmann I,Kuhn J,Ziemann U,Häring HU,Lehmann R,Peter A,Hörber S

更新日期：2020-04-01 00:00:00

abstract：:Point-of-care whole blood coagulation tests are critical in the management of patients who undergo percutaneous coronary intervention. The Hemochron and HemoTec devices have been traditionally used to measure the activated clotting time (ACT) in the cardiac catheterization laboratory. The heparin management test (HMT)...

journal_title：Journal of thrombosis and thrombolysis

authors： Tsimikas S,Beyer R,Hassankhani A

更新日期：2001-05-01 00:00:00

abstract：:Background: There is compelling evidence that coronary atherosclerosis represents a chronic active process characterized by inflammation, impaired fibrinolysis, intermittent plaque rupture, and luminal thrombosis. Identifying readily measurable plasma markers of procoagulant activity may have an important role in both...

journal_title：Journal of thrombosis and thrombolysis

authors： Rho R,Tracy RP,Bovill EG,Ball SP,Becker RC

更新日期：1995-01-01 00:00:00

abstract：:Data comparing the patient characteristics, management and outcomes for dabigatran versus warfarin major bleeding in the practice setting are limited. We performed a retrospective single health system study of atrial fibrillation patients with dabigatran or warfarin major bleeding from October 2010 through September 2...

journal_title：Journal of thrombosis and thrombolysis

authors： Smythe MA,Forman MJ,Bertran EA,Hoffman JL,Priziola JL,Koerber JM

更新日期：2015-10-01 00:00:00

abstract：:Little is known about the impact of thrombolytic agents on in-hospital outcomes in the Middle East. The objective of this study was to evaluate the impact of thrombolytic agents on in-hospital outcomes in ST-segment elevation myocardial infarction (STEMI) patients in six Middle Eastern countries. Gulf Registry of Acut...

journal_title：Journal of thrombosis and thrombolysis

authors： Al-Zakwani I,Ali A,Zubaid M,Panduranga P,Sulaiman K,Abusham A,Almahmeed W,Al-Motarreb A,Al Suwaidi J,Amin H

更新日期：2012-04-01 00:00:00

abstract：:Coronary artery fistulae (CAF) are rare congenital or acquired in which a connection forms between one of the coronary arteries and a heart chamber or with other vessels. This paper describes three cases of CAF along with their initial presentation, imaging findings and management. The first case is a rare form of CAF...

journal_title：Journal of thrombosis and thrombolysis

authors： Ali M,Kassem KM,Osei K,Effat M

更新日期：2019-08-01 00:00:00

abstract：:Fondaparinux (FPX), a selective inhibitor of factor Xa, is widely used for the prophylaxis of venous thromboembolism (VTE) after total joint arthroplasty. However, the association between plasma FPX concentration and adverse events and the occurrence of VTE has not been clarified thus far. We aimed to prospectively ev...

journal_title：Journal of thrombosis and thrombolysis

authors： Yukizawa Y,Inaba Y,Watanabe S,Yajima S,Kobayashi N,Ishida T,Iwamoto N,Hyonmin C,Nakamura M,Saito T

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:There are several new strategies proposed to improve the outcome of patients with ST-elevation myocardial infarction (STEMI). One approach is the resurgent use of facilitated percutaneous coronary interventions (PCI). Until recently, deciding whether immediate PCI after combined treatment (facilitated PCI) i...

journal_title：Journal of thrombosis and thrombolysis

authors： Di Pasquale P,Cannizzaro S,Parrinello G,Giambanco F,Vitale G,Fasullo S,Scalzo S,Ganci F,La Manna N,Sarullo F,La Rocca G,Paterna S

更新日期：2006-04-01 00:00:00

abstract：INTRODUCTION:Recent investigations show that activated factor VII, the primary enzyme in the extrinsic pathway of blood coagulation, exerts additional extra-coagulant functions, such as apoptosis and angiogenesis. On the basis of these recent acquisitions, the present study was aimed to evaluate activated factor VII in...

journal_title：Journal of thrombosis and thrombolysis

authors： Volpe A,Salvagno GL,Lippi G,Caramaschi P,Montagnana M,Canestrini S,Carletto A,Bambara LM,Biasi D,Guidi GC

更新日期：2006-10-01 00:00:00

abstract：:Deep vein thrombosis (DVT) in hemiplegic patients mainly affects hemiplegic limbs, DVT can also occur only in healthy limbs, and some hemiplegic patients have DVT in both limbs. Characteristics and risk factors of DVT in hemiplegic, healthy, and bilateral limbs are unknown. To describe the proportion, risk factors, ex...

journal_title：Journal of thrombosis and thrombolysis

authors： Liang F,Chao M,Li JB,Ye XM

更新日期：2020-08-27 00:00:00

abstract：INTRODUCTION:While the CURE trial demonstrated the benefits of clopidogrel in acute coronary syndromes, patients receiving glycoprotein IIb/IIIa antagonists were excluded. Given the frequent coadministration of these two medications, we sought to examine their interaction and their combined effect on platelet inhibitio...

journal_title：Journal of thrombosis and thrombolysis

authors： Talreja D,Lubbe D,Orford JL,Lennon R,DiBattiste PM,Berger PB

更新日期：2004-08-01 00:00:00

abstract：:Patients with acute leukemia frequently develop catheter-related thrombosis (CRT) despite concurrent thrombocytopenia. The incidence, treatment and outcomes of this complication are poorly documented. We undertook this study to determine the incidence of CRT in patients with acute leukemia and assess the safety and ef...

journal_title：Journal of thrombosis and thrombolysis

authors： Htun KT,Ma MJY,Lee AYY

更新日期：2018-10-01 00:00:00

abstract：:The outbreak of 2019 novel coronavirus disease (COVID-19) began since early December 2019, and has been declared as a public health emergency by the World Health Organization. Due to the hypercoagulable state, blood stasis and endothelial injury, severe patients with COVID-19 are at high risk for thrombosis. We report...

journal_title：Journal of thrombosis and thrombolysis

authors： Zhou B,She J,Wang Y,Ma X

更新日期：2020-07-01 00:00:00

abstract：:Throughout the world, herbal medicines are consumed by most of the patients without considering their adverse effects. Many herbal medicines/plant extracts have been reported to interact with the natural blood clotting system. In continuation to this effort, thirty medicinal plant extracts were allowed to interact wit...

journal_title：Journal of thrombosis and thrombolysis

authors： Adhyapak MS,Kachole MS

更新日期：2016-05-01 00:00:00

abstract：:The optimal antithrombotic therapy for patients undergoing TAVI with concomitant indication for oral anticoagulation remains unclear. In this high-risk population group, there is a paucity of data with regards to the use of DOACs. In the present study we compared long-term clinical outcomes of TAVI patients requiring ...

journal_title：Journal of thrombosis and thrombolysis

authors： Kalogeras K,Jabbour RJ,Ruparelia N,Watson S,Kabir T,Naganuma T,Vavuranakis M,Nakamura S,Malik IS,Mikhail G,Dalby M,Panoulas V

更新日期：2020-07-01 00:00:00