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Predictors of non-compliance in autologous hematopoietic SCT patients undergoing out-patient transplants.

Abstract：

:Non-compliance has received significant attention in medicine, yet few studies have examined its correlates in autologous hematopoietic SCT (AHSCT) patients. This study examined predictors of non-compliance in a sample of 151 AHSCT patients treated in an outpatient setting. Before AHSCT, participants completed a validated measure of mood and retrospective chart reviews were conducted to assess non-compliance during AHSCT, defined as refusal of oral hygiene, prescribed exercise programs, oral nutrition and/or prescribed medications. We found 121 patients (80%) were non-compliant with an aspect of the AHSCT regimen on 1 or more days; mean percentage of non-compliant days was 16.6 (s.d. 15.6). Men were more likely than women to be non-compliant (P<0.05); as were participants with an elevated depression score (P<0.05). Stepwise regression models identified significant predictors of non-compliance: gender, depression, global distress and nausea and vomiting severity (P-values all <0.01). Further analysis revealed that the interaction of the psychological variables with gender was a more robust predictor of non-compliance (P<0.001). For outpatient AHSCT, our findings suggest the need to broaden conceptualizations of risk factors for non-compliance and the importance of assessing patient barriers to compliance to ensure optimal treatment outcome.

journal_name

Bone Marrow Transplant

journal_title

Bone marrow transplantation

authors

Mumby PB,Hurley C,Samsi M,Thilges S,Parthasarathy M,Stiff PJ

doi

10.1038/bmt.2011.129

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

556-61

issue

4

eissn

0268-3369

issn

1476-5365

pii

bmt2011129

journal_volume

47

pub_type

临床试验,杂志文章

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