Use of the BCR probe to demonstrate extramedullary recurrence of CGL with a T cell lymphoid phenotype following bone marrow transplantation.

Abstract:

:A case of Philadelphia chromosome (Ph1) positive chronic granulocytic leukemia (CGL) is described in which the patient underwent successful treatment with supralethal chemoradiotherapy and allogeneic bone marrow transplantation (BMT) after transformation to blast crisis. Supraclavicular adenopathy developed 5 months after BMT and biopsy revealed a hematopoietic lymphoid neoplasm with an early T cell phenotype. A concurrent bone marrow was microscopically and cytogenetically normal. A metaphase chromosome preparation could not be obtained from nodal tissue. Lymph node DNA, however, was easily extracted and a rearrangement of BCR identical to that in the bone marrow prior to BMT was demonstrated indicating recurrent CGL rather than a de novo lymphoproliferative process. Appropriate therapy for lymphoid blast crisis resulted in a marked regression of measurable disease. The BCR probe may prove to be a useful tool for the diagnosis of CGL when standard cytogenetic techniques cannot be applied.

journal_name

Bone Marrow Transplant

authors

Giannone L,Whitlock JA,Kinney MC,Wolff SN,Dev VG

subject

Has Abstract

pub_date

1988-11-01 00:00:00

pages

631-5

issue

6

eissn

0268-3369

issn

1476-5365

journal_volume

3

pub_type

杂志文章
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    doi:

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    doi:

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    pub_type: 杂志文章

    doi:

    authors: Martino R,Brunet S,García A,Sureda A,Soler J,Martínez C,Domingo-Albós A,Baiget M

    更新日期:1995-12-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

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    更新日期:2010-12-01 00:00:00

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    journal_title:Bone marrow transplantation

    pub_type: 杂志文章

    doi:

    authors: Faucher C,le Corroller AG,Blaise D,Novakovitch G,Manonni P,Moatti JP,Maraninchi D

    更新日期:1994-12-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1038/bmt.2009.272

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    更新日期:2010-05-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1038/sj.bmt.1703328

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    更新日期:2002-01-01 00:00:00

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    doi:

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    pub_type: 杂志文章

    doi:

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    更新日期:1993-08-01 00:00:00

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    pub_type: 杂志文章

    doi:

    authors: Simpson DR,Browett PJ,Doak PB,Palmer SJ

    更新日期:1994-10-01 00:00:00

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    pub_type: 杂志文章

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    authors: Kinugawa N,Imashuku S,Hirota Y,Yamada K,Yamamoto A,Akazai A,Oda M,Miura N,Kakuta H,Sato T,Endo M,Takano T

    更新日期:1999-10-01 00:00:00

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    journal_title:Bone marrow transplantation

    pub_type: 杂志文章

    doi:10.1038/bmt.2009.104

    authors: Vossen JM,Donker AE,Heemskerk MB,Lie JL,van Weel-Sipman MH,Bredius RG,Bakker JD,Egeler RM,Oudshoorn M

    更新日期:2010-01-01 00:00:00

  • IL-21 is critical for GVHD in a mouse model.

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    pub_type: 杂志文章

    doi:10.1038/bmt.2009.223

    authors: Meguro A,Ozaki K,Oh I,Hatanaka K,Matsu H,Tatara R,Sato K,Leonard WJ,Ozawa K

    更新日期:2010-04-01 00:00:00

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    doi:

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    更新日期:2001-01-01 00:00:00

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    doi:

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    更新日期:1993-10-01 00:00:00

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    更新日期:2007-10-01 00:00:00

  • Multicentre European study comparing selection techniques for the isolation of CD34+ cells.

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    pub_type: 杂志文章,多中心研究

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    doi:

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    更新日期:1998-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1038/sj.bmt.1700730

    authors: Itälä M,Pelliniemi TT,Rajamäki A,Remes K

    更新日期:1997-04-01 00:00:00

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    更新日期:2006-03-01 00:00:00