Comparison of autologous peripheral blood stem cell dosing by ideal vs actual body weight.

Abstract:

:In this retrospective study, we evaluated the predictability of PBSC dose for hematopoietic engraftment comparing that calculated by ideal body weight (IBW) vs another calculated by actual body weight (ABW) for each patient. Sixty-three consecutive patients treated similarly using one transplant protocol were analyzed. While all patients had data available on CFU-GM and nucleated cells (NC), data on CD34+ enumeration was present only in 34 patients. We found that 49% of the patients were greater than 25% over their IBW. In addition, least-squares linear regression was used to assess the strength of the linear relationship between the inverse of cell dose/kg of ABW or IBW and time to AGC or platelet engraftment and showed no difference in r2 values for platelet engraftment, while using dose/kg of IBW greatly improved the ability of NC (r2 improved from 0.19 for ABW to 0.35 for IBW) and CFU-GM (r2 improved from 0.35 for ABW to 0.53 for IBW) to predict time to AGC engraftment, but did not change the CD34 r2. Hazard ratios were estimated using Cox proportional hazards regression and in all instances were found greater than 1.0 indicating that the probability of engraftment increased as cell dose/kg ABW or IBW increased. Finally, our data showed that 10 patients (16%) could have had one less apheresis procedure performed to obtain their set target stem cell dose calculated per kg IBW rather than ABW. In conclusion, PBSC dose per kg IBW is as good or better predictor of engraftment of AGC and may lead to cost savings in a certain subset of patients.

journal_name

Bone Marrow Transplant

authors

Waples JM,Moreb JS,Sugrue M,Belanger G,Kubilis P,Lynch JW,Gian V,Weeks F,Wingard J

doi

10.1038/sj.bmt.1701731

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

867-73

issue

9

eissn

0268-3369

issn

1476-5365

journal_volume

23

pub_type

杂志文章
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    authors: Abdelkefi A,Torjman L,Ben Romdhane N,Ladeb S,El Omri H,Ben Othman T,Elloumi M,Bellaj H,Lakhal A,Jeddi R,Aissaouï L,Saad A,Hsaïri M,Boukef K,Dellagi K,Ben Abdeladhim A

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    doi:10.1038/sj.bmt.1701255

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  • Survival time of cardiac allografts prolonged by isogeneic BMT in mice.

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    pub_type: 杂志文章

    doi:10.1038/bmt.2011.215

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    更新日期:2012-08-01 00:00:00

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    更新日期:2013-04-01 00:00:00

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    pub_type: 杂志文章

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    doi:

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    authors: Meehan KR,Wu J,Bengtson E,Hill J,Ely P,Szczepiorkowski Z,Kendall M,Ernstoff MS

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    journal_title:Bone marrow transplantation

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    authors: Wassmann B,Scheuring U,Thiede C,Pfeifer H,Bornhäuser M,Griesinger F,Hochhaus A,Schleyer E,Gschaidmeier H,Hoelzer D,Ottmann OG

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    doi:

    authors: Hebart H,Müller C,Löffler J,Jahn G,Einsele H

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  • Enhanced graft-versus-host disease in older recipient mice following allogeneic bone marrow transplantation.

    abstract::The incidence and severity of GVHD following bone marrow transplantation increases with recipient age. The role of recipient age on the development of GVHD was analyzed in a semi-allogeneic (C57BL/6-->(C57BL/6 x DBA/2)F1) murine GVHD system. Young adult (2 months) and old (12-14 months) recipient mice were lethally ir...

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  • Umbilical cord blood banking in The Netherlands.

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    doi:

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    pub_type: 临床试验,杂志文章,评审

    doi:

    authors: Gordon-Smith EC

    更新日期:1989-12-01 00:00:00

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    pub_type: 杂志文章

    doi:

    authors: Ben-Yehuda A,Ben-Yehuda-Salz D,Or R,Landau EH,Krausz MM

    更新日期:1989-01-01 00:00:00

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    doi:10.1038/bmt.2014.307

    authors: Hamidieh AA,Dehaghi MO,Paragomi P,Navaei S,Jalali A,Eslami GG,Behfar M,Ghavamzadeh A

    更新日期:2015-04-01 00:00:00

  • Low bone mineral density is associated with insulin resistance in bone marrow transplant subjects.

    abstract::Post-BMT subjects have an increased bone fracture risk. Additionally, several factors were associated with osteopenia and osteoporosis in these individuals. We aimed to identify other factors associated with osteopenia and osteoporosis in allogeneic post-BMT subjects. We conducted a cross-sectional study with 47 allog...

    journal_title:Bone marrow transplantation

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    doi:10.1038/bmt.2009.70

    authors: Faulhaber GA,Premaor MO,Moser Filho HL,Silla LM,Furlanetto TW

    更新日期:2009-06-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:10.1038/sj.bmt.1703950

    authors: Oyama Y,Traynor AE,Barr W,Burt RK

    更新日期:2003-08-01 00:00:00

  • Elevated lactate dehydrogenase is an adverse predictor of outcome in HLA-matched sibling bone marrow transplant for acute myelogenous leukemia.

    abstract::Prognostic factors for survival following allogeneic BMT for AML include age, disease status and cytogenetic risk classification. Lactate dehydrogenase (LDH) levels have not been studied as a potential risk factor. We reviewed our experience with BMT for AML and included LDH at the time of admission in an analysis of ...

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    pub_type: 杂志文章

    doi:10.1038/sj.bmt.1705811

    authors: Kalaycio M,Rybicki L,Pohlman B,Dean R,Sweetenham J,Andresen S,Sobecks R,Sekeres MA,Advani A,Brown S,Bolwell B

    更新日期:2007-10-01 00:00:00