Abstract:
:Although allogeneic hematopoietic stem cell transplantation (HSCT) features severe physical and psychological strain, no previous study has prospectively investigated fatigue beyond 3 years after transplantation. We investigated the temporal course of fatigue over 5 years, compared patients with the general population (GP) and tested for treatment- and complication-related risk factors. Patients were assessed before conditioning (T0, N=239) and at 100-day (T1, N=150), 1-year (T2, N=102) and 5-year (T3, N=45) follow-up. We measured fatigue with the Multidimensional Fatigue Inventory-20. Patients were compared with the GP at T0 and at T3. Global fatigue increased from T0 to T1 (t=3.85, P<0.001), decreased from T1 to T2 (t=-2. 92, P=0.004) and then remained stable (t=0.45, P=0.656). No difference in global fatigue was found between T0 and T3 (t=0.68, P=0.497). Compared with the GP, patients showed higher global fatigue at T0 (t=-6.02, P<0.001) and T3 (t=-2.50, P=0.014). These differences reached meaningful effect sizes (d⩾0.5). Acute and chronic GvHD predicted global fatigue at T1 (γ=0.34, P=0.006) and T2 (γ=0.38, P=0.010), respectively. To conclude, fatigue among allogeneic HSCT patients improves with time, finally returning to pretransplantation levels. However, even after 5 years, the difference from the GP remains relevant. Patients with GvHD are at risk for increased fatigue.
journal_name
Bone Marrow Transplantjournal_title
Bone marrow transplantationauthors
Esser P,Kuba K,Mehnert A,Schwinn A,Schirmer L,Schulz-Kindermann F,Kruse M,Koch U,Zander AR,Kröger N,Schilling G,Götze H,Scherwath Adoi
10.1038/bmt.2016.344subject
Has Abstractpub_date
2017-05-01 00:00:00pages
753-758issue
5eissn
0268-3369issn
1476-5365pii
bmt2016344journal_volume
52pub_type
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journal_title:Bone marrow transplantation
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::This study evaluated delivery of involved field radiotherapy (IFRT) with transplantation for lymphomas timed to minimise toxicity. Patients transplanted for lymphoma had infradiaphragmatic disease irradiated pre-transplant and supradiaphragmatic disease post transplant. A total of 31 patients were studied, with a medi...
journal_title:Bone marrow transplantation
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Bone marrow transplantation
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journal_title:Bone marrow transplantation
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journal_title:Bone marrow transplantation
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journal_title:Bone marrow transplantation
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Bone marrow transplantation
pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:Bone marrow transplantation
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pub_type: 杂志文章
doi:10.1038/bmt.2016.343
更新日期:2017-05-01 00:00:00
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pub_type: 杂志文章
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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更新日期:2005-06-01 00:00:00
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更新日期:2000-03-01 00:00:00
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journal_title:Bone marrow transplantation
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