Abstract：
OBJECTIVE:Administration after spinal cord injury (SCI) of methylprednisolone (MP) for 24-48 h has been suggested to improve functional outcome. The safety of this approach has been questioned because of the known adverse effects of glucocorticoids on skeletal muscle and the immune system. The purpose of this study was to explicitly test adverse effects of regimen of MP administration on skeletal muscle. STUDY DESIGN:Male rats underwent spinal cord transection at T9-T10, followed by an intravenous injection of MP and subsequent infusion of MP for 24 h. RESULTS:MP significantly reduced the weight of the triceps, soleus, plantaris and gastrocnemius muscles, with the greatest effect being a 63% decrease in triceps weight (for example, muscle above the level of lesion) at 7 days; below the level of lesion, gastrocnemius weight was reduced by 33% by SCI alone, and by 45% by SCI and MP. Centralized nuclei were found in myofibers of the gastrocnemius and triceps from the MP-SCI group, but not other groups. MP increased expression in the triceps, soleus and plantaris of FOXO1, MAFbx, MuRF1 and REDD1 at 1 day, and, in plantaris, at 7 days. CONCLUSIONS:Thus, 1 day of MP at a dose comparable to those routinely employed in clinical practice immediately after SCI resulted in marked atrophy of functionally intact muscle above the level of lesion, and worsened atrophy of paralyzed muscle below the level of lesion, associated with elevations in expression of four genes involved in pathways associated with muscle atrophy.
journal_name
Spinal Cordjournal_title
Spinal cordauthors
Wu Y,Hou J,Collier L,Pan J,Hou L,Qin W,Bauman WA,Cardozo CPdoi
10.1038/sc.2011.28subject
Has Abstractpub_date
2011-08-01 00:00:00pages
867-73issue
8eissn
1362-4393issn
1476-5624pii
sc201128journal_volume
49pub_type
杂志文章相关文献
SPINAL CORD文献大全abstract：STUDY DESIGN:Case report. OBJECTIVE:To report a rare thoracic intervertebral disc herniation followed by acutely progressing paraplegia. SETTING:Spinal Injuries Center, Fukuoka, Japan. METHOD:A 37-year-old man presented with sudden severe backache and acutely progressing motor impairments of both lower extremities a...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101781
更新日期：2005-12-01 00:00:00
abstract：STUDY DESIGN:Cross-sectional comparison, control group. OBJECTIVES:To investigate the relationship between carotid arterial stiffness and circulating markers for cardiovascular disease (CVD) in spinal cord-injured (SCI) subjects compared with able-bodied (AB) individuals. SETTING:University Research Laboratory, Unive...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2011.56
更新日期：2011-09-01 00:00:00
abstract：STUDY DESIGN:Pictorial review. OBJECTIVES:To illustrate MRI signs of acute and subacute injury with emphasis on evidence-based links to clinical outcome and implications for treatment. METHODS:Description of important aspects of MRI techniques and illustration of critical MRI signs important in the assessment of spin...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sc.2011.107
更新日期：2012-01-01 00:00:00
abstract：STUDY DESIGN:A case report of cervical myelopathy caused by epidural beta (2)-microglobulin (beta2m) amyloid deposits in a 50-year-old woman with haemodialysis treatment. OBJECTIVE:Long-term haemodialysis in patients with end-stage renal disease leads to several complications based on beta2m deposits, which can affect...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101969
更新日期：2007-04-01 00:00:00
abstract：STUDY DESIGN:Register study. OBJECTIVES:To design and implement a validation process to check the completeness of the Hospital Discharge Register (HDR) held by the Swedish National Board of Health and Welfare. SETTING:Sweden. METHODS:An accurate traumatic spinal cord injury prevalence group (n=495) was acquired from...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2008.42
更新日期：2008-11-01 00:00:00
abstract：STUDY DESIGN:Retrospective chart review. OBJECTIVES:To establish the frequency and severity of autonomic dysreflexia (AD) during urodynamics among individuals with chronic spinal cord injury (SCI) and to investigate the possible effect of the number of years since SCI on the severity of AD. SETTING:SCI outpatient cli...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2016.110
更新日期：2017-03-01 00:00:00
abstract：:The author has taken care of patients with spinal cord injury for over 30 years. A major part of these years was spent doing tendon transfers on the patients with tetraplegia. Thirteen were not better, but not worse out of the 285 patients who had an operation. All of the patients have had a period of rehabilitation, ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3100475
更新日期：1998-05-01 00:00:00
abstract：:The demyelination process is an important factor contributing to long term sensory and motor impairments after spinal cord injury (SCI). Exposure of axonal K+ channels after demyelination may contribute to blockage of action potentials across the injury site. A K+ channel blocker, 4-aminopyridine (4-AP), has been effe...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3100502
更新日期：1998-01-01 00:00:00
abstract：STUDY DESIGN:Case report. OBJECTIVES:To report a penetrating gunshot injury at L1 with migration within the spinal canal to S2. SETTING:Istanbul, Turkey. METHODS:A 44-year-old man was admitted with an entrance gunshot wound on the left upper quadrant. An emergency exploratory laparotomy with left nephrectomy and tra...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101808
更新日期：2006-05-01 00:00:00
abstract：STUDY DESIGN:Patients with neurological walking impairment were rehabilitated with a new system, consisting of an apparatus to constantly relieve the body weight and a treadmill: The Walking Assistance and Rehabilitation Device (WARD). Patients were evaluated before and after rehabilitation with clinical scales and phy...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3100821
更新日期：1999-05-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to investigate the pharmacological effects of long-term oral tadalafil treatment on the corpus cavernosum function in rats subjected to experimental spinal cord transection (SCT). METHODS:Thirty young adult, male Sprague–Dawley rats were randomly divided into five groups (n¼ 6, eac...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2013.61
更新日期：2013-09-01 00:00:00
abstract：STUDY DESIGN:Longitudinal panel design over 10 years. OBJECTIVES:To describe the health outcomes for people with spinal cord injury and identify how indicators of health change over time. SETTING:Queensland, Australia. METHODS:A structured interview consisting of measures of perceived health, medical service utiliza...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3102159
更新日期：2008-05-01 00:00:00
abstract：STUDY DESIGN:A pilot study measuring the levels of serum-soluble CD95 ligand (CD95L) in eight spinal cord-injured patients. OBJECTIVES:To determine the soluble concentration of CD95L in spinal cord injury (SCI) patients after trauma. METHODS:We collected blood samples from eight patients with acute traumatic SCI. Sol...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2012.139
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVE:To compare self-reported health, independence, and depression in two samples of people with spinal cord injury (SCI), one which receives regular, comprehensive outpatient health care follow-up and one that does not. DESIGN:Exploratory study of self-reported secondary conditions in 235 individuals with SCI wh...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3100957
更新日期：2000-02-01 00:00:00
abstract：STUDY DESIGN:Although abnormal cutaneous reflex (CR) activity has been identified during gait after incomplete spinal cord injury (SCI), this activity has not been directly compared in subjects with and without the spasticity syndrome. OBJECTIVES:Characterisation of CR activity during controlled rest and 'ramp and hol...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2016.9
更新日期：2016-09-01 00:00:00
abstract：STUDY DESIGN:Psychometrics study. OBJECTIVES:The aim of this study is to investigate the validity, reliability and sensitivity to change of neurogenic bowel dysfunction (NBD) score. SETTING:Dokuz Eylül University Faculty of Medicine, Turkey. METHODS:The study included 42 patients with spinal cord injury (SCI). The r...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2017.82
更新日期：2017-12-01 00:00:00
abstract：STUDY DESIGN:Prospective multi-center cohort study. OBJECTIVES:To compare the neurological and functional recovery between tetraplegic Brown-Séquard-plus syndrome (BSPS) and incomplete tetraplegia (non-BSPS). SETTING:European Multicenter Study of Human Spinal Cord Injury (EM-SCI). METHODS:BSPS was defined as a traum...
journal_title：Spinal cord
pub_type： 杂志文章,多中心研究
doi：10.1038/sc.2009.189
更新日期：2010-08-01 00:00:00
abstract：STUDY DESIGN:Case report and review of the literature. OBJECTIVE:To report an unusual case of a spinal intradural extramedullary cavernous angioma (CA), located at the cauda equina, and to compare it with the previously published 22 surgically treated cases in the literature. SETTING:Ankara, Turkey. METHOD:A 67-year...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sj.sc.3101990
更新日期：2007-09-01 00:00:00
abstract：STUDY DESIGN:Mapping of the National Spinal Cord Injury Model System (SCIMS) Database (NSCID) to the International Classification of Functioning, Disability and Health (ICF). OBJECTIVES:To link the content of the latest two versions of the NSCID to the ICF; more specifically (1) to compare the content of the current N...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-019-0326-9
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVES:Noxious stimuli activate small to medium-sized dorsal root ganglion (DRG) neurons. Intense noxious stimuli result in the release of substance P (SP) from the central terminals of these neurons. It binds to the neurokinin type 1 receptor (NK1r) and sensitises the dorsal horn neurons. SP is also released from ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2015.206
更新日期：2016-03-01 00:00:00
abstract：:One hundred and twenty persons with new onset traumatic tetraplegia consecutively admitted to our rehabilitation service were screened for consideration for use of an upper extremity neuroprosthesis. Strict inclusion criteria allowed only for participation of patients with ASIA impairment scale A, B or C injuries at t...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章
doi：10.1038/sj.sc.3100460
更新日期：1997-09-01 00:00:00
abstract：STUDY DESIGN:A case report of purely epidural cavernous haemangioma with MRI appearance and pathological features. OBJECTIVE:To present a rare case of extradural mass with differential diagnosis. SETTING:Delhi, India. METHOD:A 55-year-old man presented with progressive weakness and diminished sensation in both lower...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sj.sc.3101248
更新日期：2002-04-01 00:00:00
abstract：STUDY DESIGN:A cross-sectional study. OBJECTIVE:To clarify the existing controversy with regard to whether paraplegic patients suffer a loss of bone mass in the upper limbs. SETTING:Madrid, Spain. METHODS:We evaluated bone mass by phalangeal ultrasonography in 35 male patients with paraplegia (mean age 49+/-12 years...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101256
更新日期：2002-02-01 00:00:00
abstract：STUDY DESIGN:A basic study using a spinal cord injury (SCI) model in rats. OBJECTIVES:The effect of mild hypothermic treatment on histological changes and motor function after a rat spinal cord compression injury was assessed. METHODS:Mild spinal cord compression was performed at the eleventh thoracic vertebral level...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3102163
更新日期：2008-06-01 00:00:00
abstract：STUDY DESIGN:The paper describes a technique for complete vertebrectomy and spinal cord decompression, followed by a formal anterior column reconstruction, using endoscopic instruments. This procedure is indicated for patients with radioresistant metastasis of the thoracic spine, particularly those involving the upper ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101194
更新日期：2001-09-01 00:00:00
abstract：STUDY DESIGN:Retrospective case-control study. OBJECTIVES:The intent of this study was to investigate the relationships between vertebral degenerative changes resulting in spinal canal stenosis, spinal cord lesions and the development of spinal cord decompression sickness (DCS) in scuba divers. SETTING:Referral hyper...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2013.121
更新日期：2014-03-01 00:00:00
abstract：:Previous studies have estimated that between 25% and 45% of people with spinal cord injury report severe levels of chronic pain. Few studies have examined this longitudinally. This study examines the primary pain sites, intensity and variability of perceived pain in 76 patients, 6 weeks post injury and 45 patients fro...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章
doi：10.1038/sj.sc.3100569
更新日期：1997-12-01 00:00:00
abstract：STUDY DESIGN:Randomised double-blind factorial-design placebo-controlled trial. OBJECTIVE:Urinary tract infections (UTIs) are common in people with spinal cord injury (SCI). UTIs are increasingly difficult to treat due to emergence of multi-resistant organisms. Probiotics are efficacious in preventing UTIs in post-men...
journal_title：Spinal cord
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/s41393-019-0251-y
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:To determine the long-term mortality rate and the types of morbidity among all people with spinal cord injuries (SCI) that occurred during the 1948 Israel War of Independence. METHOD:Chart review and telephone interviews for collecting demographic data, injury characteristics, marital status, physical activi...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101043
更新日期：2000-09-01 00:00:00
abstract：STUDY DESIGN:Review. OBJECTIVES:To explore the concept of quality of life (QOL), critique the practice and problems of assessing QOL following spinal cord injury (SCI) and to review the findings of studies into QOL for people with SCI both below and above the level of C4. METHODS:Relevant articles were identified fro...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sj.sc.3101636
更新日期：2004-09-01 00:00:00
