Microglia inhibition is a target of mild hypothermic treatment after the spinal cord injury.

Abstract:

STUDY DESIGN:A basic study using a spinal cord injury (SCI) model in rats. OBJECTIVES:The effect of mild hypothermic treatment on histological changes and motor function after a rat spinal cord compression injury was assessed. METHODS:Mild spinal cord compression was performed at the eleventh thoracic vertebral level by a 20 g weight for 20 min. Rats in the mild hypothermic model were kept at a body temperature of 33 degrees C and rats in the normothermic group were kept at 37 degrees C for 1 h from beginning of compression. Motor function was evaluated by measuring the frequency of standing. Microglia were stained by isolectin B4 and observed in the compressed portion of the spinal cord. The amount of tumor necrosis factor-alpha (TNF-alpha) in the compressed spinal cord was measured by the ELISA method. RESULTS:In the normothermic rats, microglia proliferated up to 72 h after the compression. Proliferation was substantially inhibited at 48 and 72 h after compression in the hypothermic rats. The motor function of the hypothermic rats improved at 48 and 72 h after the compression, whereas no improvement was seen in the normothermic rats. The amount of TNF-alpha in the compressed portion of the spinal cord was lower in hypothermic rats compared with normothermic rats throughout the experiment. CONCLUSIONS:These results suggest that hypothermic treatment is effective for the amelioration of delayed motor dysfunction via inhibition of microglial inflammatory responses.

journal_name

Spinal Cord

journal_title

Spinal cord

authors

Morino T,Ogata T,Takeba J,Yamamoto H

doi

10.1038/sj.sc.3102163

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

425-31

issue

6

eissn

1362-4393

issn

1476-5624

pii

3102163

journal_volume

46

pub_type

杂志文章
  • Sexual health outcome measures for individuals with a spinal cord injury: a systematic review.

    abstract:STUDY DESIGN:A systematic review of all sexual health outcome measures reporting psychometric properties for a spinal cord injury (SCI) population. OBJECTIVES:To evaluate the psychometric evidence for sexual health outcome measures used in a SCI population in order to (1) determine the clinical relevance of current to...

    journal_title:Spinal cord

    pub_type: 杂志文章,评审

    doi:10.1038/sj.sc.3102136

    authors: Abramson CE,McBride KE,Konnyu KJ,Elliott SL,SCIRE Research Team.

    更新日期:2008-05-01 00:00:00

  • Delayed post-traumatic syringohydromyelia after an uncomplicated fracture of the spine: case report and literature review.

    abstract::A patient who had had a traffic accident resulting with a compression fracture of the L1 vertebra but with no neurological deficits, developed urinary incontinence and weakness in his lower extremities 25 years after the spinal injury. An MRI scan of the spine revealed gliosis of the conus medullaris at the level of t...

    journal_title:Spinal cord

    pub_type: 杂志文章,评审

    doi:10.1038/sc.1996.55

    authors: Güler-Uysal F,Orkun S,Cila A,Ozgirgin N

    更新日期:1996-05-01 00:00:00

  • Expansive cervical laminoplasties--observations on comparative changes in spinous process lengths following longitudinal laminal divisions using autogenous bone or hydroxyapatite spacers.

    abstract::Expansive laminoplasty is devised to preserve the posterior structures, including the original length of the spinous process which anchors the nucheal muscles, in order to prevent the postoperative development of instability and cervical kyphosis due to structural loss and poor tone of the nucheal muscles, which can r...

    journal_title:Spinal cord

    pub_type: 临床试验,杂志文章

    doi:10.1038/sc.1996.132

    authors: Hoshi K,Kurokawa T,Nakamura K,Hoshino Y,Saita K,Miyoshi K

    更新日期:1996-12-01 00:00:00

  • The impact of spinal cord injury on sexual function: concerns of the general population.

    abstract:STUDY DESIGN:Secure, web-based survey. OBJECTIVES:Obtain information from the spinal cord injured (SCI) population regarding sexual dysfunctions, with the aim of developing new basic science and clinical research and eventual therapies targeting these issues. SETTING:Worldwide web. METHODS:Individuals 18 years or ol...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sj.sc.3101977

    authors: Anderson KD,Borisoff JF,Johnson RD,Stiens SA,Elliott SL

    更新日期:2007-05-01 00:00:00

  • Spinal cord injury in a 14-year-old male secondary to cervical hyperflexion with exercise.

    abstract:STUDY DESIGN:Case report. OBJECTIVES:To present an interesting case of a 14-year-old male with acute paresis of upper extremities and progressive difficulty with lower extremities. The patient is a competitive wrestler and was performing his daily abdominal workout 'sit-ups' with hands interlocked behind his head. Dur...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sj.sc.3101806

    authors: Dickerman RD,Mittler MA,Warshaw C,Epstein JA

    更新日期:2006-03-01 00:00:00

  • Targeting inflammation to influence cognitive function following spinal cord injury: a randomized clinical trial.

    abstract:STUDY DESIGN:This study was a randomized, parallel-group, controlled clinical trial. OBJECTIVES:The purpose of this study was to examine the efficacy of targeting inflammation as a means of improving cognitive function in individuals with spinal cord injury. SETTING:Participants were recruited from the Niagara region...

    journal_title:Spinal cord

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/sc.2016.96

    authors: Allison DJ,Josse AR,Gabriel DA,Klentrou P,Ditor DS

    更新日期:2017-01-01 00:00:00

  • Endoscopic management of urethral trauma in male spinal cord injury patients.

    abstract::Spinal cord injury (SCI) patients with a neuropathic bladder are more prone to develop catheter-induced urethral trauma than occurs in the general population because many of the SCI patients are on indwelling urethral catheter drainage, or intermittent urethral catheterisation is performed either by them or by their c...

    journal_title:Spinal cord

    pub_type: 临床试验,杂志文章

    doi:10.1038/sc.1996.117

    authors: Vaidyanathan S,Krishnan KR,Soni BM

    更新日期:1996-11-01 00:00:00

  • Content comparison of the Spinal Cord Injury Model System Database to the ICF Generic Sets and Core Sets for spinal cord injury.

    abstract:STUDY DESIGN:Mapping of the National Spinal Cord Injury Model System (SCIMS) Database (NSCID) to the International Classification of Functioning, Disability and Health (ICF). OBJECTIVES:To link the content of the latest two versions of the NSCID to the ICF; more specifically (1) to compare the content of the current N...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/s41393-019-0326-9

    authors: Maritz R,Pongpipatpaiboon K,Melvin JL,Graves DE,Prodinger B

    更新日期:2019-12-01 00:00:00

  • Postural responses during falling with rapid reach-and-grasp balance reaction in patients with motor complete paraplegia.

    abstract:STUDY DESIGN:Cross-sectional study. OBJECTIVES:To investigate the kinematic, kinetic and electromyographic (EMG) aspects of postural control during falling with rapid reach-and-grasp balance reaction in thoracic cord-injured individuals wearing knee-ankle-foot orthoses (KAFOs). SETTING:Institutional Motion Analysis L...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sj.sc.3102100

    authors: Lin KH,Lu TW,Hsu PP,Yu SM,Liao WS

    更新日期:2008-03-01 00:00:00

  • Successful tracheostomy decannulation after complete or sensory incomplete cervical spinal cord injury.

    abstract:STUDY DESIGN:Retrospective study. OBJECTIVES:To report the successful tracheostomy decannulation/extubation in cervical spinal cord injury (C-SCI) patients. SETTING:Tertiary university hospital, pulmonary rehabilitation center. METHODS:Complete or sensory incomplete C-SCI patients who had received invasive acute pha...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sc.2016.194

    authors: Kim DH,Kang SW,Choi WA,Oh HJ

    更新日期:2017-06-01 00:00:00

  • Spinal injuries admitted to a specialist centre over a 5-year period: a study to evaluate delayed admission.

    abstract:STUDY DESIGN:Retrospective study of 432 patients admitted to our institution with a spinal injury over a 5-year period. OBJECTIVES:To present epidemiological data relating to this spinal population, reporting specifically on delayed admission and length of hospitalisation. SETTING:Royal National Orthopaedic Hospital,...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sj.sc.3101734

    authors: Amin A,Bernard J,Nadarajah R,Davies N,Gow F,Tucker S

    更新日期:2005-07-01 00:00:00

  • Perceived functional impairment and spirituality/religiosity as predictors of depression in a Sri Lankan spinal cord injury patient population.

    abstract:STUDY DESIGN:Cross-sectional, questionnaire-based study. OBJECTIVES:To test the hypothesis that self-perceived functional impairment and religiosity/spirituality (S/R) predict depression among traumatic spinal cord injury (SCI) patients in Sri Lanka. SETTING:Ragama Rheumatology and Rehabilitation Hospital, Ragama, Sr...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sc.2016.56

    authors: Xue S,Arya S,Embuldeniya A,Narammalage H,da Silva T,Williams S,Ravindran A

    更新日期:2016-12-01 00:00:00

  • Static respiratory pressures in patients with post-traumatic tetraplegia.

    abstract::The purpose of this study was to examine ventilatory muscle strength as represented by static respiratory pressures in 30 tetraplegic patients with a complete lesion between the fifth and the eighth cervical vertebrae. The Inspiratory/Expiratory Pressure Meter was used to obtain maximum static expiratory mouth pressur...

    journal_title:Spinal cord

    pub_type: 临床试验,杂志文章

    doi:10.1038/sj.sc.3100336

    authors: Gounden P

    更新日期:1997-01-01 00:00:00

  • Restless legs syndrome: an unusual cause for a perplexing syndrome.

    abstract::Restless legs syndrome (RLS) is a well-defined symptom complex, occurring either as idiopathic RLS or in association with many other disorders. Although no definite etiology is known for this condition, several pathophysiological mechanisms have been proposed. There is supportive evidence that RLS is a central nervous...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sj.sc.3100929

    authors: Glasauer FE,Egnatchick JE

    更新日期:1999-12-01 00:00:00

  • Symptomatic postoperative spinal epidural hematoma after spine tumor surgery: Incidence, clinical features, and risk factors.

    abstract:STUDY DESIGN:Case-control study. OBJECTIVES:The objective of this study was to provide some useful information concerning the incidence, clinical features, and risk factors for symptomatic postoperative spinal epidural hematoma (SPSEH) in an isolated cohort of patients undergoing spine tumor surgery. SETTING:Hospital...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/s41393-019-0281-5

    authors: Gao X,Li L,Cao J,Zhao Y,Liu Y,Yang J,Dong L,Wan W,Liu T,Xiao J

    更新日期:2019-08-01 00:00:00

  • Use of pulsed irrigation evacuation in the management of the neuropathic bowel.

    abstract::Management of the neuropathic bowel is one of the major issues in the treatment of patients with severe spinal cord injury (SCI). Pulsed irrigation evacuation (PIE) has been evaluated in several small studies for the clearing of fecal impactions in patients with a neuropathic bowel. We evaluated our experience with 39...

    journal_title:Spinal cord

    pub_type: 临床试验,杂志文章

    doi:10.1038/sj.sc.3100491

    authors: Puet TA,Jackson H,Amy S

    更新日期:1997-10-01 00:00:00

  • Preserving transfer independence among individuals with spinal cord injury.

    abstract:STUDY DESIGN:Literature review. OBJECTIVES:Upper extremity (UE) joint degeneration, particularly at the shoulder, detrimentally influences functional independence, quality of life, cardiovascular disease risk, and life expectancy of individuals following spinal cord injury (SCI). This review (1) describes UE use for t...

    journal_title:Spinal cord

    pub_type: 杂志文章,评审

    doi:10.1038/sj.sc.3101070

    authors: Nyland J,Quigley P,Huang C,Lloyd J,Harrow J,Nelson A

    更新日期:2000-11-01 00:00:00

  • Sympathetic influence on biomechanical skin properties after spinal cord injury.

    abstract:STUDY DESIGN:Case-control study. OBJECTIVES:To investigate changes of biomechanical skin properties and their relationship with paralysis following spinal cord injury (SCI). SETTING:South Korea. METHODS:A total of 48 male subjects with chronic SCI and 48 age-matched healthy controls were enrolled into this study. Th...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sc.2010.95

    authors: Park JW,Seo CH,Han SH,Lee YG

    更新日期:2011-02-01 00:00:00

  • Documentation of weight management practices for individuals with spinal cord injuries and disorders.

    abstract:STUDY DESIGN:This cross-sectional chart review study included 100 US Veterans with spinal cord injuries/disorders (SCI/D) who received care at a Veterans Affairs (VA) SCI facility during a 12-month period. Progress notes were examined to extract need for weight management (WM), patient-provider discussions about risk d...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sc.2016.59

    authors: Locatelli SM,LaVela SL

    更新日期:2016-12-01 00:00:00

  • Posterior spinal shortening for paraparesis following vertebral collapse due to osteoporosis.

    abstract:STUDY DESIGN:Retrospective case series. OBJECTIVES:To assess the efficacy of posterior spinal shortening for paraparetic patients following vertebral collapse owing to osteoporosis, especially on instrumentation loosening. SETTING:Department of orthopaedic surgery, Jichi Medical University Hospital and Omiya Medical ...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sj.sc.3102052

    authors: Saita K,Hoshino Y,Higashi T,Yamamuro K

    更新日期:2008-01-01 00:00:00

  • Sequential MR studies of cervical cord injury: correlation with neurological damage and clinical outcome.

    abstract:OBJECTIVE:To determine which images provide the most useful information and the best time to perform prognostic MRI. DESIGN:The severity of neurological complications was assessed using the ASIA impairment scale. MRI was first performed within 48 h of injury, and was subsequently performed after 2-3 weeks, 3 months, 6...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sj.sc.3100858

    authors: Shimada K,Tokioka T

    更新日期:1999-06-01 00:00:00

  • The role of plasma transglutaminase (F XIII) in wound healing of complicated pressure sores after spinal cord injury.

    abstract:STUDY DESIGN:A case report. OBJECTIVES:To demonstrate stimulating action of F XIII in wound healing of complicated pressure sores. SETTING:A Spinal Cord Injury Center in Germany. METHODS:Clinical exam, clinical and photographic wound control, biochemical serum monitoring. RESULTS:Recurrent pressure sores in plegic ...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sj.sc.3101092

    authors: Becker SW,Weidt F,Röhl K

    更新日期:2001-02-01 00:00:00

  • Use of a free jejunal graft for oesophageal reconstruction following perforation after cervical spine surgery: case report and review of the literature.

    abstract:STUDY DESIGN:: Single-subject (male, 16 years of age) case. OBJECTIVES:To demonstrate a suitable method for oesophageal repair after perforation as a complication of anterior spinal fusion in an individual with quadriplegia, and to review the literature on oesophageal perforation and repair. SETTING:University hospit...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sj.sc.3101439

    authors: Küntscher MV,Erdmann D,Boltze WH,Germann G

    更新日期:2003-10-01 00:00:00

  • Long-term morbidity and mortality after spinal cord injury: 50 years of follow-up.

    abstract:OBJECTIVE:To determine the long-term mortality rate and the types of morbidity among all people with spinal cord injuries (SCI) that occurred during the 1948 Israel War of Independence. METHOD:Chart review and telephone interviews for collecting demographic data, injury characteristics, marital status, physical activi...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sj.sc.3101043

    authors: Zeilig G,Dolev M,Weingarden H,Blumen N,Shemesh Y,Ohry A

    更新日期:2000-09-01 00:00:00

  • Mobility of the spine after spinal surgery in acute spinal cord injury.

    abstract:STUDY DESIGN:Retrospective study of mobility of the spine. OBJECTIVES:To study the relation between mobility of the spine, operation and length of surgical stabilisation. SETTING:The National Spinal Injuries Centre, Stoke Mandeville Hospital, Aylesbury, UK. METHOD:Questionnaires were sent to 99 consecutive acute tra...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sj.sc.3101528

    authors: Wang D,Bergström E,Clarke M,Henderson N,Gardner B

    更新日期:2003-11-01 00:00:00

  • How do patients with chronic spinal injury in Pakistan manage their bowels? A cross-sectional survey of 50 patients.

    abstract:STUDY DESIGN:A cross-sectional survey. OBJECTIVES:To document bowel care practices of chronic spinal cord injury (SCI) patients in Pakistan. SETTINGS:Outpatient Department, Armed Forces Institute of Rehabilitation Medicine, Rawalpindi, Pakistan. METHODS:A total of 50 adult patients (18-65 years) with SCI of duration...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sc.2010.46

    authors: Yasmeen R,Rathore FA,Ashraf K,Butt AW

    更新日期:2010-12-01 00:00:00

  • Guillian-Barré syndrome in high tetraplegia following acute respiratory illness.

    abstract:STUDY DESIGN:A case report of a Guillain-Barré syndrome (GBS) variant presenting in a patient with a high cervical spinal cord injury (SCI). OBJECTIVES:To illustrate a clinical presentation of GBS in an individual with chronic SCI. SETTING:Vancouver General Hospital, Vancouver, BC, Canada. METHODS/RESULTS:A 31-year-...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sc.2010.84

    authors: Grant C,Briscoe N,Mezei M,Krassioukov A

    更新日期:2011-03-01 00:00:00

  • Risk factors for mortality after spinal cord injury in the USA.

    abstract:STUDY DESIGN:Cohort study. OBJECTIVES:First, to examine three sets of risk and protective factors for mortality after spinal cord injury (SCI), with an emphasis on health and secondary conditions. Second, to extend earlier work with several methodologic enhancements and addition of new predictors. SETTING:Twenty hosp...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sc.2013.2

    authors: Cao Y,Krause JS,DiPiro N

    更新日期:2013-05-01 00:00:00

  • Cervical spinal cord injury due to fall while carrying heavy load on head: a problem in Bangladesh.

    abstract:STUDY DESIGN:Observational study. SETTING:Centre for the Rehabilitation of the Paralysed (CRP), Dhaka, Bangladesh. METHODS:This observational study was conducted on 84 patients of Cervical spinal cord injury (CSCI) due to fall while carrying heavy load on head. They were admitted at the CRP, Dhaka, Bangladesh between...

    journal_title:Spinal cord

    pub_type: 杂志文章

    doi:10.1038/sc.2011.153

    authors: Hoque MF,Hasan Z,Razzak AT,Helal SU

    更新日期:2012-04-01 00:00:00

  • Reliability of non-invasive cardiac output measurement in individuals with tetraplegia.

    abstract:STUDY DESIGN:The study is conducted on the basis of comparative-repeated measures. OBJECTIVES:The objective of this study is to assess the reliability of non-invasive cardiac output (CO) measurements in individuals with tetraplegia (TP) at rest and during exercise using Innocor, and to test the hypothesis that CO meas...

    journal_title:Spinal cord

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/sc.2010.173

    authors: Hostettler S,Brechbühl J,Leuthold L,Mueller G,Illi SK,Spengler CM

    更新日期:2011-05-01 00:00:00