Changes in platelet count as a predictive tool in sickle cell acute vaso-occlusive crises: a pediatric study.

Abstract:

OBJECTIVE:Studies have shown that platelets play an important role in the pathophysiology of vaso-occlusive crises (VOC) in sickle cell disease. This study investigates whether changes in platelet indices from baseline can be predictive of complications during acute pain crisis. METHODS:Data were obtained from pediatric sickle cell patients in the well-clinic setting and compared with data gathered during VOC (n = 67). Primary outcome was complicated (admission, acute chest syndrome, transfusion, etc) versus uncomplicated (discharge from emergency department without subsequent return) course. RESULTS:Patients with uncomplicated courses had larger platelet declines (53.7) than those with complicated courses (14.8, P = .005). CONCLUSIONS:The study suggests that patients with uncomplicated VOC are more likely to experience a larger decline in platelets. The predictive value is limited by the need to have preexisting steady-state data and relatively small decline. Ongoing studies are needed to identify useful laboratory data to help predict severity of VOC.

journal_name

Clin Pediatr (Phila)

journal_title

Clinical pediatrics

authors

Shanley LA,Ebeling M,Titus MO

doi

10.1177/0009922811399347

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

657-61

issue

7

eissn

0009-9228

issn

1938-2707

pii

0009922811399347

journal_volume

50

pub_type

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