Alcohol consumption and breast cancer risk in Japanese women: the Miyagi Cohort study.


:Alcohol consumption is known to be a risk factor for breast cancer in Western countries, but few epidemiologic data have been available in Japan. This population-based prospective cohort study evaluated the associations of alcohol consumption with breast cancer risk in a Japanese population. A total of 19,227 women aged 40-64 years were followed from 1990 to 2003. During 246,703 person-years of follow-up, 241 breast cancer cases were identified. Hazard ratios (HRs) were estimated by the Cox proportional-hazard regression model. After adjustment for potential risk factors of breast cancer and nutritional factors, the HR and 95% confidence interval (CI) for current drinkers was 1.00 (0.74-1.34) compared with never drinkers. According to the amount of alcohol intake per day, a higher amount (≥15.0 g/day) had no significant relation to breast cancer risk (HR = 0.87, 95% CI: 0.40-1.91; P for trend = 0.85). Age upon starting to drink, and the frequency of drinking, were not associated with breast cancer risk. In analysis stratified according to exogenous female hormone use, a higher alcohol intake (≥15.0 g/day) was associated with an increased risk of breast cancer among hormone users (HR = 1.67, 95% CI: 0.17-16.73); however, this was not statistically significant. Stratification according to folate intake with energy adjustment (<219, ≥ 219 μg/day) found that breast cancer risk tended to increase with increasing alcohol consumption among women with a low intake of folate (P for trend = 0.09). Our findings suggest that alcohol consumption has no overall effect on breast cancer risk among Japanese women, whereas nutritional factors such as folate intake may modify the alcohol-breast cancer risk relationship.


Kawai M,Minami Y,Kakizaki M,Kakugawa Y,Nishino Y,Fukao A,Tsuji I,Ohuchi N




Has Abstract


2011-08-01 00:00:00












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    authors: Schüle J,Bergkvist L,Håkansson L,Gustafsson B,Håkansson A

    更新日期:2002-07-01 00:00:00

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    pub_type: 临床试验,杂志文章


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    更新日期:1991-12-01 00:00:00

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    authors: Gordon LG,Battistutta D,Scuffham P,Tweeddale M,Newman B

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    更新日期:2014-07-01 00:00:00

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    pub_type: 临床试验,杂志文章


    authors: Colozza M,Gori S,Mosconi AM,Anastasi P,Basurto C,Ludovini V,De Angelis V,Giansanti M,Tonato M

    更新日期:1996-01-01 00:00:00

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    更新日期:2003-08-01 00:00:00

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    更新日期:2007-05-01 00:00:00

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    authors: North WG,Gao G,Memoli VA,Pang RH,Lynch L

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    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:2000-06-01 00:00:00

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    更新日期:2011-01-01 00:00:00

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    authors: Thomassin-Naggara I,Lalonde L,David J,Darai E,Uzan S,Trop I

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    pub_type: 杂志文章,评审


    authors: Minisini AM,Pauletto G,Bergonzi P,Fasola G

    更新日期:2007-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Groen RS,Oosterhuis AW,Boers JE

    更新日期:2007-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Raychaudhuri M,Bronger H,Buchner T,Kiechle M,Weichert W,Avril S

    更新日期:2017-04-01 00:00:00

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    pub_type: 杂志文章


    authors: Groen EJ,Hudecek J,Mulder L,van Seijen M,Almekinders MM,Alexov S,Kovács A,Ryska A,Varga Z,Andreu Navarro FJ,Bianchi S,Vreuls W,Balslev E,Boot MV,Kulka J,Chmielik E,Barbé E,de Rooij MJ,Vos W,Farkas A,Leeuwis-Fedoro

    更新日期:2020-10-01 00:00:00

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    pub_type: 杂志文章,随机对照试验


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    更新日期:2013-04-01 00:00:00

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    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章,meta分析,评审


    authors: Aune D,Chan DS,Vieira AR,Rosenblatt DA,Vieira R,Greenwood DC,Norat T

    更新日期:2012-07-01 00:00:00