Abstract：
:Alcohol consumption is known to be a risk factor for breast cancer in Western countries, but few epidemiologic data have been available in Japan. This population-based prospective cohort study evaluated the associations of alcohol consumption with breast cancer risk in a Japanese population. A total of 19,227 women aged 40-64 years were followed from 1990 to 2003. During 246,703 person-years of follow-up, 241 breast cancer cases were identified. Hazard ratios (HRs) were estimated by the Cox proportional-hazard regression model. After adjustment for potential risk factors of breast cancer and nutritional factors, the HR and 95% confidence interval (CI) for current drinkers was 1.00 (0.74-1.34) compared with never drinkers. According to the amount of alcohol intake per day, a higher amount (≥15.0 g/day) had no significant relation to breast cancer risk (HR = 0.87, 95% CI: 0.40-1.91; P for trend = 0.85). Age upon starting to drink, and the frequency of drinking, were not associated with breast cancer risk. In analysis stratified according to exogenous female hormone use, a higher alcohol intake (≥15.0 g/day) was associated with an increased risk of breast cancer among hormone users (HR = 1.67, 95% CI: 0.17-16.73); however, this was not statistically significant. Stratification according to folate intake with energy adjustment (<219, ≥ 219 μg/day) found that breast cancer risk tended to increase with increasing alcohol consumption among women with a low intake of folate (P for trend = 0.09). Our findings suggest that alcohol consumption has no overall effect on breast cancer risk among Japanese women, whereas nutritional factors such as folate intake may modify the alcohol-breast cancer risk relationship.
journal_name
Breast Cancer Res Treatjournal_title
Breast cancer research and treatmentauthors
Kawai M,Minami Y,Kakizaki M,Kakugawa Y,Nishino Y,Fukao A,Tsuji I,Ohuchi Ndoi
10.1007/s10549-011-1381-xsubject
Has Abstractpub_date
2011-08-01 00:00:00pages
817-25issue
3eissn
0167-6806issn
1573-7217journal_volume
128pub_type
杂志文章abstract：PURPOSE:Nuclear factor E2-related factor 2 (NRF2) is a transcription factor that plays a major role in the regulation of intracellular antioxidant response. The effect of NRF2 overexpression in many malignancies is still unclear and recent meta-analysis correlated NRF2 overexpression with poor prognosis in a variety of...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章,meta分析
doi：10.1007/s10549-019-05494-4
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Breast cancer is a leading cause of death for women worldwide, with incidence increasing in lower-income countries. For patients with human epidermal growth factor receptor-2-positive (HER2+) breast cancer, widespread availability of several agents targeting the HER2 receptor has resulted in survival gains o...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章,评审
doi：10.1007/s10549-019-05303-y
更新日期：2019-09-01 00:00:00
abstract：:Germline mutations in BRCA1/2 confer a high risk of breast cancer (BC), but the magnitude of this risk varies according to various factors. Although controversial, there are data to support the hypothesis of allelic-risk heterogeneity. We assessed variation in BC risk according to the location of mutations recorded in...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-011-1655-3
更新日期：2011-12-01 00:00:00
abstract：:Identification of novel targets for the treatment of basal-like breast cancer is essential for improved outcomes in patients with this disease. This study investigates the association of MMP7 expression and MMP7 promoter methylation with subtype and outcome in breast cancer patient cohorts. Immunohistochemical analysi...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-014-2989-4
更新日期：2014-07-01 00:00:00
abstract：:The structure/activity relationships for inhibition of aromatase and cholesterol side-chain cleavage enzyme (CSCC) by aminoglutethimide and some of its analogues are reviewed. Although more effective against aromatase than CSCC, aminoglutethimide markedly inhibits both enzymes. Optimal competitive antagonism of aromat...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:The possible role of personality patterns and psychosocial factors in breast cancer has been studied extensively, through both human and animal experiments. The data are conflicting, and the conclusions controversial. This review will serve two purposes. First, we present evidence that behavioral patterns most commonl...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章,评审
doi：10.1023/a:1005964511134
更新日期：1997-11-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-012-2006-8
更新日期：2012-06-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10549-013-2822-5
更新日期：2014-02-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1023/a:1005732531318
更新日期：1997-06-01 00:00:00
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doi：10.1007/s10549-004-1000-1
更新日期：2005-01-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-008-9935-2
更新日期：2009-01-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10549-011-1776-8
更新日期：2012-01-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 临床试验,杂志文章
doi：10.1007/s10549-008-0187-y
更新日期：2009-07-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/BF01806353
更新日期：1990-05-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/BF01811240
更新日期：1988-12-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-012-2387-8
更新日期：2013-02-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章,多中心研究
doi：10.1007/s10549-017-4353-y
更新日期：2017-10-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1023/a:1006477109230
更新日期：2000-07-01 00:00:00
abstract：:IBEP-2, an established cell line recently derived from breast carcinoma, was characterized with regard to estrogen receptor (ER) expression, cell mitogenic response to estrogenic stimulation and sensitivity to antiestrogens. In addition, we examined ER modulation following binding of agonist and antagonists, and the E...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1023/B:BREA.0000032922.87541.31
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abstract：:The anti-estrogenic effect of tamoxifen is suggested to be mainly attributable to its metabolite (Z)-endoxifen, and a minimum therapeutic threshold for (Z)-endoxifen in serum has been proposed. The objective of this research was to establish the relationship between dried blood spot (DBS) and serum concentrations of t...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
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journal_title：Breast cancer research and treatment
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/BF01806232
更新日期：1983-01-01 00:00:00
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更新日期：2019-04-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-014-2844-7
更新日期：2014-02-01 00:00:00
abstract：:Old age is associated with comorbidity and decreased functioning which influences treatment decisions in elderly breast cancer patients. The purpose of this study was to identify risk factors for complications after breast cancer surgery in elderly patients, and to assess mortality in patients with postoperative compl...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-013-2462-9
更新日期：2013-04-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-020-06079-2
更新日期：2021-01-28 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-015-3618-6
更新日期：2015-11-01 00:00:00
abstract：PURPOSE:Although tamoxifen remains the frontline treatment for ERα-positive breast cancers, resistance to this drug limits its clinical efficacy. Most tamoxifen-resistant patients retain ERα expression which may support growth and progression of breast cancers. Therefore, we investigated epigenetic regulation of ERα th...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-019-05517-0
更新日期：2020-02-01 00:00:00
abstract：:The contribution of BRCA1 and BRCA2 to breast cancer incidence in Brazil has not yet been explored. In order to estimate the proportion of breast cancers due to BRCA1 and BRCA2 mutations in Brazil, we conducted a study of unselected breast cancer patients from Rio de Janeiro, Brazil. We enrolled 402 women with breast ...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-006-9378-6
更新日期：2007-07-01 00:00:00
