Potentiation of cytotoxic therapies by TNP-470 and minocycline in mice bearing EMT-6 mammary carcinoma.

abstract：:Introduction Trastuzumab is a highly effective therapy for the treatment of HER-2/neu positive breast cancer. To maximize benefit and minimize unnecessary toxicity, patient selection is essential. Currently HER-2/neu analysis is routinely performed only for primary invasive breast cancers, and trastuzumab therapy is r...

journal_title：Breast cancer research and treatment

authors： Lower EE,Glass E,Blau R,Harman S

更新日期：2009-01-01 00:00:00

abstract：:Although preoperative magnetic resonance imaging (MRI) can detect mammographically occult contralateral breast cancers (CBCs) among women with ductal carcinoma in situ (DCIS), the impact of MRI on the incidence of subsequent CBC events is unclear. We examined whether MRI use decreases CBC occurrences and detection of ...

journal_title：Breast cancer research and treatment

authors： Wang SY,Long JB,Killelea BK,Evans SB,Roberts KB,Silber A,Gross CP

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:In order to better define the breast cancer (BC) genetic risk factors in men, a germline investigation was carried out on 81 Male BC cases by screening the 24 genes involved in BC predisposition, genome stability maintenance and DNA repair mechanisms by next-generation sequencing. METHODS:Germline DNAs were te...

journal_title：Breast cancer research and treatment

authors： Scarpitta R,Zanna I,Aretini P,Gambino G,Scatena C,Mei B,Ghilli M,Rossetti E,Roncella M,Congregati C,Bonci F,Naccarato AG,Palli D,Caligo MA

更新日期：2019-12-01 00:00:00

abstract：:Psoriasin (S100A7) is a calcium-binding protein that has shown to be highly expressed in high-grade ductal carcinoma in situ (DCIS) and a subset of invasive breast cancers. However, its role in invasion and metastasis is not very well known. In this study, we have shown that S100A7 differentially regulates epidermal g...

journal_title：Breast cancer research and treatment

authors： Sneh A,Deol YS,Ganju A,Shilo K,Rosol TJ,Nasser MW,Ganju RK

更新日期：2013-04-01 00:00:00

abstract：:Screening of a breast cancer cDNA library from SKBR3 human breast cancer cells by SEREX (serological analysis of cDNA expression library) using a preselected serum from a breast cancer patient revealed 13 genes, two of which, INT-MI-1 and INT-MI-2, encode novel gene products, while the remaining 11 genes and their pro...

journal_title：Breast cancer research and treatment

authors： Forti S,Scanlan MJ,Invernizzi A,Castiglioni F,Pupa S,Agresti R,Fontanelli R,Morelli D,Old LJ,Pupa SM,Ménard S

更新日期：2002-06-01 00:00:00

abstract：UNLABELLED:Taxanes and anthracyclines improve the outcome of early breast cancer, although the benefit is limited to a small proportion of patients and are toxic. We prospectively looked for predictors of response to these drugs. EXPERIMENTAL DESIGN:Four cycles of doxorubicin (75 mg/m²) or docetaxel (100 mg/m²) were c...

journal_title：Breast cancer research and treatment

authors： Martin M,Romero A,Cheang MC,López García-Asenjo JA,García-Saenz JA,Oliva B,Román JM,He X,Casado A,de la Torre J,Furio V,Puente J,Caldés T,Vidart JA,Lopez-Tarruella S,Diaz-Rubio E,Perou CM

更新日期：2011-07-01 00:00:00

abstract：:Epidemiological studies on the association between SULT1A1 codon 213 polymorphism and breast cancer risk are inconclusive. In order to derive a more precise estimation of the association, a meta-analysis was conducted in this article. Sixteen studies including 9,881 cases and 13,564 controls were collected for SULT1A1...

journal_title：Breast cancer research and treatment

authors： Sun Y,Zang Z,Xu X,Zhang Z,Zhong L,Zan W,Zhao Y,Sun L

更新日期：2011-01-01 00:00:00

abstract：:The regulation of gene expression by steroid hormones plays an important role in the normal development and function of many organs, as well in the pathogenesis of endocrine-related cancers. Previous experiments have shown that many kallikrein genes are under steroid hormone regulation in breast cancer cell lines. We ...

journal_title：Breast cancer research and treatment

authors： Paliouras M,Diamandis EP

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:Among patients diagnosed with breast cancer (BC), women also living with HIV (WLWH) have worse survival than women without HIV. Chronic HIV infection may interfere with the effectiveness of BC treatment, contributing to this disparity. We attempted to determine the impact of HIV infection on response to neoadju...

journal_title：Breast cancer research and treatment

authors： Nietz S,O'Neil DS,Ayeni O,Chen WC,Joffe M,Jacobson JS,Neugut AI,Ruff P,Mapanga W,Buccimazza I,Singh U,Čačala S,Stopforth L,Phakathi B,Chirwa T,Cubasch H

更新日期：2020-12-01 00:00:00

abstract：:Few studies have assessed the agreement between subjects' self-report and medical records among patients with breast cancer (BC), and none has addressed this issue in low-income women with BC. We assessed the level of agreement between self-report and medical records data for key BC treatment and prognostic characteri...

journal_title：Breast cancer research and treatment

authors： Liu Y,Diamant AL,Thind A,Maly RC

更新日期：2010-02-01 00:00:00

abstract：:A study has been conducted to compare the nature and severity of post-operative sensory changes (sensory loss, paraesthesiae, and pain) among patients with breast cancer treated by either modified radical mastectomy or a conservative procedure (tumourectomy, axillary clearance, iridium implant, and external radiothera...

journal_title：Breast cancer research and treatment

authors： Karydas I,Fentiman IS,Habib F,Hayward JL

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:Germline mutations in BRCA1 and BRCA2 confer a significant increase in risk for cancer, and determining pathogenicity of a BRCA variant can guide the clinical management of the disease. About 1/3 of BRCA1 variants reported in the public databases have uncertain clinical significance due to lack of conclusive ev...

journal_title：Breast cancer research and treatment

authors： Yang C,Jairam S,Amoroso KA,Robson ME,Walsh MF,Zhang L

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:The results of studies comparing survival in familial and sporadic breast cancer (BC) are inconsistent. A higher incidence of contralateral breast cancer (CBC) has been reported in familial BC. Ascertainment bias may influence both the reported familial CBC and survival. DESIGN:We assessed CBC incidence, dista...

journal_title：Breast cancer research and treatment

authors： Tilanus-Linthorst MM,Bartels KC,Alves C,Bakri B,Crepin E,van den Ouweland A,Klijn JG,Meijers-Heijboer H,Brekelmans CT

更新日期：2006-01-01 00:00:00

abstract：:The objective of this review was to assess the effectiveness of tai chi for supportive breast cancer care. Eleven databases were searched from inception through December 2009. Controlled trials testing tai chi in patients with breast cancer that assessed clinical outcome measures were considered. The selection of stud...

journal_title：Breast cancer research and treatment

authors： Lee MS,Choi TY,Ernst E

更新日期：2010-04-01 00:00:00

abstract：:Compelling evidence about the differences in the biology and behavior of invasive breast cancer between African-American (AA) and White-American (WA) women motivate inquiry into comparing the clinicopathology of non-invasive breast cancer (ductal carcinoma in situ, DCIS). AA and WA women diagnosed with their first pri...

journal_title：Breast cancer research and treatment

authors： Stark A,Stapp R,Raghunathan A,Yan X,Kirchner HL,Griggs J,Newman L,Chitale D,Dick A

更新日期：2012-01-01 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (MSCs) are known to specifically migrate to and engraft at tumour sites. Understanding interactions between cancer cells and MSCs has become fundamental to determining whether MSC-tumour interactions should be harnessed for delivery of therapeutic agents or considered a targe...

journal_title：Breast cancer research and treatment

authors： Martin FT,Dwyer RM,Kelly J,Khan S,Murphy JM,Curran C,Miller N,Hennessy E,Dockery P,Barry FP,O'Brien T,Kerin MJ

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:TOP2A gene encodes topoisomerase II alpha, the direct molecular target of anthracyclines. This gene is frequently coamplified with HER2. The aims of this study were to analyse the pattern of TOP2A amplification and protein expression in relation to the molecular subgroups of breast cancers; and to define the...

journal_title：Breast cancer research and treatment

authors： Arriola E,Rodriguez-Pinilla SM,Lambros MB,Jones RL,James M,Savage K,Smith IE,Dowsett M,Reis-Filho JS

更新日期：2007-12-01 00:00:00

abstract：:The effect of estradiol (E2) on the [3H]-acetylation of nuclear histones was studied in the MCF-7 human mammary cancer cell line in culture. Cells (approximately 10(8) were incubated with 8 x 10(-6) M [3H]-acetate in the absence (control) or in the presence of estradiol (10(-5)-10(-8) M). After 20 min incubation, the ...

journal_title：Breast cancer research and treatment

authors： Pasqualini JR,Mercat P,Giambiagi N

更新日期：1989-10-01 00:00:00

abstract：:To evaluate differences in use of sentinel lymph node biopsy (SLNB) by age and race in Medicare recipients with early-stage breast cancer, we examined Surveillance, Epidemiology and End Results-Medicare linked data for women undergoing breast conserving surgery for stage I or II breast cancer, including axillary stagi...

journal_title：Breast cancer research and treatment

authors： Reeder-Hayes KE,Bainbridge J,Meyer AM,Amos KD,Weiner BJ,Godley PA,Carpenter WR

更新日期：2011-08-01 00:00:00

abstract：:Resveratrol is a natural polyphenolic compound and has been shown to exhibit cardio-protective as well as anti-neoplastic effects on various types of cancers. However, the exact mechanism of its anti-tumor effect is not clearly defined. Resveratrol has been shown to have strong hypolipidemic effect on normal adipocyte...

journal_title：Breast cancer research and treatment

authors： Pandey PR,Okuda H,Watabe M,Pai SK,Liu W,Kobayashi A,Xing F,Fukuda K,Hirota S,Sugai T,Wakabayashi G,Koeda K,Kashiwaba M,Suzuki K,Chiba T,Endo M,Fujioka T,Tanji S,Mo YY,Cao D,Wilber AC,Watabe K

更新日期：2011-11-01 00:00:00

abstract：:Gene-specific methylation alterations in breast cancer have been suggested to occur early in tumorigenesis and have the potential to be used for early detection and prevention. The continuous increase in worldwide breast cancer incidences emphasizes the urgent need for identification of methylation biomarkers for earl...

journal_title：Breast cancer research and treatment

authors： Li Z,Guo X,Wu Y,Li S,Yan J,Peng L,Xiao Z,Wang S,Deng Z,Dai L,Yi W,Xia K,Tang L,Wang J

更新日期：2015-02-01 00:00:00

abstract：:A model for a more precise prognosis of the risk of relapse is needed to avoid overtreatment of lymph node-negative breast cancer patients. A large derivation data set (n = 684) was generated by pooling three independent breast cancer expression microarray data sets. Two major prognostic factors, proliferation and imm...

journal_title：Breast cancer research and treatment

authors： Oh E,Choi YL,Park T,Lee S,Nam SJ,Shin YK

更新日期：2012-04-01 00:00:00

abstract：:Weight gain is a common problem amongst women receiving adjuvant chemotherapy for early breast cancer. We undertook a study to determine the causes of this weight gain. Prospective measurements of body mass and composition (skinfolds, bioelectrical impedance, total body potassium), energy balance (resting energy expen...

journal_title：Breast cancer research and treatment

authors： Harvie MN,Campbell IT,Baildam A,Howell A

更新日期：2004-02-01 00:00:00

abstract：:Macroautophagy (autophagy), a process for lysosomal degradation of organelles and long-lived proteins, has been linked to various pathologies including cancer and to the cellular response to anticancer therapies. In the human estrogen receptor positive MCF7 breast adenocarcinoma cell line, treatment with the endocrine...

journal_title：Breast cancer research and treatment

authors： Qadir MA,Kwok B,Dragowska WH,To KH,Le D,Bally MB,Gorski SM

更新日期：2008-12-01 00:00:00

abstract：:Whether or not breast cancer can be a feature of the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome has been debated. In order to clarify if defective mismatch repair (MMR) may indeed play a role in breast cancer, we used the Danish HNPCC register to identify all breast cancers that occurred in MMR gene mu...

journal_title：Breast cancer research and treatment

authors： Jensen UB,Sunde L,Timshel S,Halvarsson B,Nissen A,Bernstein I,Nilbert M

更新日期：2010-04-01 00:00:00

abstract：:The spectrum of germline mutations among Jewish non Ashkenazi high risk breast/ovarian cancer families includes a few predominant mutations in BRCA1 (185delAG and Tyr978X) and BRCA2 (8765delAG). A few additional recurring mutations [A1708E, 981delAT, C61G (BRCA1) R2336P, and IVS2 + 1G > A (BRCA2)] have been reported i...

journal_title：Breast cancer research and treatment

authors： Laitman Y,Simeonov M,Herskovitz L,Kushnir A,Shimon-Paluch S,Kaufman B,Zidan J,Friedman E

更新日期：2012-06-01 00:00:00

abstract：:Co-transfection studies indicate that HER2 (erbB-2) overexpression results in the phosphorylation and enhanced transcriptional activity of the androgen receptor (AR). This amplification of AR action is further enhanced by the expression of ARA70, a putative co-activator with a predilection for the AR. Because androgen...

journal_title：Breast cancer research and treatment

authors： Kollara A,Kahn HJ,Marks A,Brown TJ

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Epithelial-to-mesenchymal transition (EMT) has been implicated as an important step in the development of distant metastases. We therefore wished to study EMT status of primary breast carcinomas from patients who during follow-up developed distant metastases. METHODS:mRNA expression profiles of primary brea...

journal_title：Breast cancer research and treatment

authors： Savci-Heijink CD,Halfwerk H,Hooijer GKJ,Koster J,Horlings HM,Meijer SL,van de Vijver MJ

更新日期：2019-04-01 00:00:00

abstract：:Results from several randomised mammography screening trials have shown that it is possible to reduce mortality in breast cancer by mammographic screening at least for women above 50 years of age. The purpose of this article is to present data on mortality in breast cancer in study and control groups of the Stockholm ...

journal_title：Breast cancer research and treatment

authors： Frisell J,Lidbrink E,Hellström L,Rutqvist LE

更新日期：1997-09-01 00:00:00

abstract：:Electron paramagnetic resonance (EPR) imaging is an emerging modality that can detect and localize paramagnetic molecular probes (so-called spin probes) in vivo. We previously demonstrated that nitroxide spin probes can be encapsulated in liposomes at concentrations exceeding 100 mM, at which nitroxides exhibit a conc...

journal_title：Breast cancer research and treatment

authors： Burks SR,Macedo LF,Barth ED,Tkaczuk KH,Martin SS,Rosen GM,Halpern HJ,Brodie AM,Kao JP

更新日期：2010-11-01 00:00:00