Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis.

Abstract:

:The etiology and mechanisms by which severe trauma or sepsis induce hepatic failure are unknown. Previously we showed that Kupffer cells (KC), the fixed macrophages of the liver, induce a profound decrease in hepatocyte (HC) total-protein synthesis when exposed to endotoxin. Furthermore we demonstrated that endotoxin-activated KCs induce these changes in HC protein synthesis through the induction of a novel L-arginine-dependent biochemical pathway within the HC. In this pathway, the guanido nitrogen of L-arginine is converted to the highly reactive molecule nitric oxide (NO.). To identify the KC factors that act as signals for induction of HC NO. biosynthesis, recombinant cytokines were added to HC cultures and HC nitrogen oxide production and protein synthesis levels were determined. We found that no single cytokine, but rather a specific combination of tumor necrosis factor, interleukin-1, interferon-gamma, and endotoxin, were required for maximal induction of HC nitrogen oxide production. This specific combination of cytokines induced a 248.8 +/- 26.0 mumol/L (micromolar) increase in HC nitrogen oxide production and simultaneously inhibited HC total protein synthesis by 36.1% +/- 3.1%. These data demonstrate that multiple cytokines, produced by endotoxin-activated KC, induce the production of NO. within HC, which in turn leads to the inhibition of HC total-protein synthesis.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Curran RD,Billiar TR,Stuehr DJ,Ochoa JB,Harbrecht BG,Flint SG,Simmons RL

doi

10.1097/00000658-199010000-00009

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

462-9; discussion 470-1

issue

4

eissn

0003-4932

issn

1528-1140

journal_volume

212

pub_type

杂志文章
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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199509000-00008

    authors: Elshami AA,Kucharczuk JC,Sterman DH,Smythe WR,Hwang HC,Amin KM,Litzky LA,Albelda SM,Kaiser LR

    更新日期:1995-09-01 00:00:00

  • The walk-in anergic patient. How best to assess the risk of sepsis following elective surgery.

    abstract::This prospective study evaluated host resistance in a surgical population who walked into the hospital for elective surgery. Patients were stratified into Hospital Reactive (HR, n = 19) if they reacted to two or more of five recall skin test antigens and Walk-in Anergic (WA, n = 26) if they did not react to the antige...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198404000-00011

    authors: Christou NV,Rode H,Larsen D,Loose L,Broadhead M,Meakins JL

    更新日期:1984-04-01 00:00:00

  • Variation and Impact of Multiple Complications on Failure to Rescue After Inpatient Surgery.

    abstract:OBJECTIVE:To examine the extent to which multiple, sequential complications impacts variation in institutional postoperative mortality rates. BACKGROUND:Failure to rescue (FTR) has been proposed as an underlying factor in hospital variation in surgical mortality. However, little is currently known about hospital varia...

    journal_title:Annals of surgery

    pub_type: 杂志文章

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    authors: Massarweh NN,Anaya DA,Kougias P,Bakaeen FG,Awad SS,Berger DH

    更新日期:2017-07-01 00:00:00

  • Perioperative granulocyte colony-stimulating factor does not prevent severe infections in patients undergoing esophagectomy for esophageal cancer: a randomized placebo-controlled clinical trial.

    abstract:OBJECTIVE:Esophagectomy for esophageal cancer is associated with substantial postoperative morbidity as a result of infectious complications. In a prior phase II study, granulocyte colony-stimulating factor (G-CSF) was shown to improve leukocyte function and to reduce infection rates after esophagectomy. The aim of the...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/01.sla.0000129705.00210.24

    authors: Schaefer H,Engert A,Grass G,Mansmann G,Wassmer G,Hubel K,Loehlein D,Ulrich BC,Lippert H,Knoefel WT,Hoelscher AH

    更新日期:2004-07-01 00:00:00

  • Long-term survival after pancreatoduodenectomy for pancreatic adenocarcinoma: is cure possible?

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181613142

    authors: Schnelldorfer T,Ware AL,Sarr MG,Smyrk TC,Zhang L,Qin R,Gullerud RE,Donohue JH,Nagorney DM,Farnell MB

    更新日期:2008-03-01 00:00:00

  • Cytology adds value to imaging studies for risk assessment of malignancy in pancreatic mucinous cysts.

    abstract:OBJECTIVE:Evaluate the value of cytology relative to imaging features in risk assessment for malignancy as defined in the Sendai Guidelines. BACKGROUND:The Sendai Guidelines list symptoms, cyst size >30 mm, dilated main pancreatic duct (MPD) >6 mm, mural nodule (MN) and "positive" cytology as high risk stigmata for ma...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182383118

    authors: Genevay M,Mino-Kenudson M,Yaeger K,Konstantinidis IT,Ferrone CR,Thayer S,Castillo CF,Sahani D,Bounds B,Forcione D,Brugge WR,Pitman MB

    更新日期:2011-12-01 00:00:00

  • Evidence-based gallbladder cancer staging: changing cancer staging by analysis of data from the National Cancer Database.

    abstract:BACKGROUND:A recent revision of the American Joint Committee on Cancer (AJCC) staging for gallbladder cancer (6th Edition) involved some major changes. Most notably, T2N0M0 tumors were moved from stage II to stage IB; T3N1M0 disease was moved from stage III to stage IIB; and T4NxM0 (x = any) tumors were moved from stag...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000219737.81943.4e

    authors: Fong Y,Wagman L,Gonen M,Crawford J,Reed W,Swanson R,Pan C,Ritchey J,Stewart A,Choti M

    更新日期:2006-06-01 00:00:00

  • Gallstone pancreatitis: biliary tract pathology in relation to time of operation.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198109000-00008

    authors: Stone HH,Fabian TC,Dunlop WE

    更新日期:1981-09-01 00:00:00

  • Main pancreatic ductal anatomy can direct choice of modality for treating pancreatic pseudocysts (surgery versus percutaneous drainage).

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200206000-00001

    authors: Nealon WH,Walser E

    更新日期:2002-06-01 00:00:00

  • Laparoscopic resection for rectal cancers: lessons learned from 579 cases.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31818e418a

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    更新日期:2009-01-01 00:00:00

  • Derivation and Validation of a Generalizable Preoperative Frailty Index Using Population-based Health Administrative Data.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002769

    authors: McIsaac DI,Wong CA,Huang A,Moloo H,van Walraven C

    更新日期:2019-07-01 00:00:00

  • Chronic Opioid Usage in Surgical Patients in a Large Academic Center.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001780

    authors: Jiang X,Orton M,Feng R,Hossain E,Malhotra NR,Zager EL,Liu R

    更新日期:2017-04-01 00:00:00

  • Women Surgeons' Perspectives on System-level Strategies to Address Interpersonal Workplace Conflict.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004074

    authors: Lindquist KM,Vitous CA,Dossett LA,Jagsi R,Telem DA

    更新日期:2020-07-07 00:00:00

  • Ultrasound in renal transplantation.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197704000-00012

    authors: Petrek J,Tilney NL,Smith EH,Williams JS,Vineyard GC

    更新日期:1977-04-01 00:00:00

  • A kinetic study of leucine metabolism in severely burned patients. Comparison between a conventional and branched-chain amino acid-enriched nutritional therapy.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198804000-00009

    authors: Yu YM,Wagner DA,Walesreswski JC,Burke JF,Young VR

    更新日期:1988-04-01 00:00:00

  • Steroids in the treatment of clinical septic shock.

    abstract::A prospective (Part I) and a retrospective (Part II) study were used to determine the safety and efficacy of corticosteroids in the treatment of septic shock. In Part I, 172 consecutive patients in septic shock admitted over an 8-year period were treated with either steroid or saline: 43 received dexamethasone (DMP), ...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-197609000-00011

    authors: Schumer W

    更新日期:1976-09-01 00:00:00

  • Primary Open Versus Closed Implantation Strategy for Totally Implantable Venous Access Ports: The Multicentre Randomized Controlled PORTAS-3 Trial (DRKS 00004900).

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003705

    authors: Hüttner FJ,Bruckner T,Hackbusch M,Weitz J,Bork U,Kotschenreuther P,Heupel O,Kümmel S,Schlitt HJ,Mattulat M,Pintér L,Seiler CM,Gutt CN,Nottberg HS,Pohl A,Ghanem F,Meyer T,Imdahl A,Neudecker J,Müller VA,Gehrig T,R

    更新日期:2020-12-01 00:00:00

  • Hospital Length of Stay Reduction Over Time and Patient Readmission for Severe Adverse Events Following Surgery.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003206

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  • Adequacy of margins of resection in gastrectomy for cancer.

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    pub_type: 杂志文章

    doi:10.1097/00000658-198212001-00012

    authors: Bozzetti F,Bonfanti G,Bufalino R,Menotti V,Persano S,Andreola S,Doci R,Gennari L

    更新日期:1982-12-01 00:00:00

  • Do safety checklists improve teamwork and communication in the operating room? A systematic review.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0000000000000206

    authors: Russ S,Rout S,Sevdalis N,Moorthy K,Darzi A,Vincent C

    更新日期:2013-12-01 00:00:00

  • Barium granuloma of the rectum: an uncommon complication of barium enema.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197504000-00009

    authors: Lewis JW Jr,Kerstein MD,Koss N

    更新日期:1975-04-01 00:00:00

  • Parietal cell vagotomy as an emergency procedure for bleeding peptic ulcer.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198711000-00005

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    更新日期:1987-11-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

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  • The Impact of Clinical and Pathological Features on Intraductal Papillary Mucinous Neoplasm Recurrence After Surgical Resection: Long-Term Follow-Up Analysis.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

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    authors: Thiede A,Engemann R,Korner HH,Deltz E,Muller-Ruchholtz W

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    doi:10.1097/00000658-198002000-00018

    authors: McCann RL,Hagen PO,Fuchs JC

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198711000-00004

    authors: Roughneen PT,Drath DB,Kulkarni AD,Rowlands BJ

    更新日期:1987-11-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00000658-198206000-00015

    authors: Fuchs JC,Fagraeus L,Lumb PD

    更新日期:1982-06-01 00:00:00

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    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000000326

    authors: Tsai TC,Orav EJ,Joynt KE

    更新日期:2014-06-01 00:00:00