Protein-sparing effect in skeletal muscle of growth hormone treatment in critically ill patients.

Abstract:

OBJECTIVE:To investigate the effect of growth hormone (GH) treatment on skeletal muscle protein catabolism in patients with multiple organ failure in the intensive care unit (ICU). SUMMARY BACKGROUND DATA:Skeletal muscle depletion affects the incidence of complications and the length of hospital stay. A protein-sparing effect of GH treatment in skeletal muscle of long-term ICU patients was hypothesized. METHODS:Twenty critically ill ICU patients were randomized to treatment with GH (0.3 U/kg/day) or as controls. Percutaneous muscle biopsy samples were taken before and after a 5-day treatment period starting on day 3 to 42 of the patient's ICU stay. Protein content, protein synthesis, water, nucleic acids, and free amino acids in muscle were analyzed. RESULTS:The protein content decreased by 8% +/- 11% in the control patients, with no significant change in the GH group. The fractional synthesis rate of muscle proteins increased in the GH group by 33% +/- 48%, and muscle free glutamine increased by 207% +/- 327% in the GH group. Total intramuscular water increased by 12% +/- 14% in the control group as a result of an increase in extracellular water of 67% +/- 86%; these increases were not seen in the GH group. In contrast, the intracellular water increased by 6% +/- 8% in the GH group. CONCLUSION:Treatment with GH for 5 days in patients with multiple organ failure stimulated muscle protein synthesis, increased muscle free glutamine, and increased intracellular muscle water.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Gamrin L,Essén P,Hultman E,McNurlan MA,Garlick PJ,Wernerman J

doi

10.1097/00000658-200004000-00018

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

577-86

issue

4

eissn

0003-4932

issn

1528-1140

journal_volume

231

pub_type

临床试验,杂志文章,随机对照试验
  • Early gastric cancer. 21-year experience.

    abstract::From 1963 through 1983, 327 patients underwent resection for gastric adenocarcinoma at Charity Hospital in New Orleans. Fifteen lesions (4.6%) were early gastric carcinoma (limited to the mucosa or submucosa regardless of nodal metastases). These lesions were in eight men and seven women (14 blacks and 1 white), with ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198608000-00001

    authors: Bringaze WL 3rd,Chappuis CW,Correa P,Cohn I Jr

    更新日期:1986-08-01 00:00:00

  • Studies in fetal wound healing. V. A prolonged presence of hyaluronic acid characterizes fetal wound fluid.

    abstract::Midgestation fetal wound healing is characterized by healing without fibrosis or scar formation. The mechanisms that underlie this remarkable process are mediated in part through a fetal wound extracellular matrix rich in hyaluronic acid. In this study a newly developed assay was used to determine the hyaluronic acid ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199104000-00003

    authors: Longaker MT,Chiu ES,Adzick NS,Stern M,Harrison MR,Stern R

    更新日期:1991-04-01 00:00:00

  • Variceal recurrence, rebleeding, and survival after endoscopic injection sclerotherapy in 287 alcoholic cirrhotic patients with bleeding esophageal varices.

    abstract:OBJECTIVE:This study tested the validity of the hypothesis that eradication of esophageal varices by repeated injection sclerotherapy would reduce recurrent variceal bleeding and death from bleeding varices in a high-risk cohort of alcoholic patients with cirrhosis. SUMMARY BACKGROUND DATA:Although banding of esophage...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000231704.45005.4e

    authors: Krige JE,Kotze UK,Bornman PC,Shaw JM,Klipin M

    更新日期:2006-11-01 00:00:00

  • The effect of complications on length of stay.

    abstract:OBJECTIVES:The authors determined the effect of complications on length of stay (LOS) in surgical patients. SETTING:From 1987 to 1990, in the Professional General Surgical Unit of Royal Victoria Hospital, a retrospective survey was conducted on 5128 consecutively admitted patients with 396 different diagnosis; 228 dif...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199412000-00006

    authors: McAleese P,Odling-Smee W

    更新日期:1994-12-01 00:00:00

  • Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the Quorum Sensing Signaling System.

    abstract:OBJECTIVE:We have previously demonstrated that P. aeruginosa can have profound effects on the intestinal epithelial barrier via one of its virulence factors, the PA-I lectin/adhesin. The aims of the present study were to further characterize the interaction of P. aeruginosa and the intestinal epithelium using both in v...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000094551.88143.f8

    authors: Wu L,Holbrook C,Zaborina O,Ploplys E,Rocha F,Pelham D,Chang E,Musch M,Alverdy J

    更新日期:2003-11-01 00:00:00

  • A multivariate analysis of preoperative risk factors in patients with common bile duct stones. Implications for treatment.

    abstract::A multivariate analysis of 30 preoperative risk factors was undertaken in 248 patients who underwent surgery alone for common bile duct (CBD) stones and in 190 patients who had endoscopic sphincterotomy (ES), 77 of whom subsequently also had surgery. Independently significant risk factors in those undergoing surgery w...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198902000-00004

    authors: Neoptolemos JP,Shaw DE,Carr-Locke DL

    更新日期:1989-02-01 00:00:00

  • Pigment gallstones form as a composite of bacterial microcolonies and pigment solids.

    abstract::Although previous studies have suggested that bacteria may contribute to pigment gallstone formation, the current experiments provide evidence that bacteria have a central role in this process. The studies included scanning electron microscopy (SEM) of gallstones, measurements of bacterial adherence to gallstones in v...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198709000-00002

    authors: Stewart L,Smith AL,Pellegrini CA,Motson RW,Way LW

    更新日期:1987-09-01 00:00:00

  • A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A Phase II trial of safety, efficacy, and immune activation.

    abstract:PURPOSE:Surgical resection provides the only possibility of cure for pancreas cancer. A standard adjuvant approach has not been established. We tested the safety and efficacy of a granulocyte-macrophage colony-stimulating factor (GM-CSF)-based immunotherapy administered in patients with resected pancreatic adenocarcino...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181fd271c

    authors: Lutz E,Yeo CJ,Lillemoe KD,Biedrzycki B,Kobrin B,Herman J,Sugar E,Piantadosi S,Cameron JL,Solt S,Onners B,Tartakovsky I,Choi M,Sharma R,Illei PB,Hruban RH,Abrams RA,Le D,Jaffee E,Laheru D

    更新日期:2011-02-01 00:00:00

  • Specialty networking in pediatric surgery: a paradigm for the future of academic surgery.

    abstract:OBJECTIVE:To review retrospectively a 4-year experience with pediatric surgical networking at a major academic medical center in the Midwest. BACKGROUND:The growth of managed care in the United States during the past decade has had a major impact on the practice of medicine in general, but especially on academic medic...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199909000-00006

    authors: Coran AG,Blackman PM,Sikina C,Harmon CM,Lelli JL Jr,Geiger JD,Hirschl RB,Teitelbaum DH,Polley TZ Jr,Golladay ES,Austin E,Adelman SH

    更新日期:1999-09-01 00:00:00

  • Prognosis in acute organ-system failure.

    abstract::This prospective study describes the current prognosis of patients in acute Organ System Failure (OSF). Objective definitions were developed for five OSFs, and then 5677 ICU admissions from 13 hospitals were monitored. The number and duration of OSF were linked to outcome at hospital discharge for each of the 2719 ICU...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198512000-00004

    authors: Knaus WA,Draper EA,Wagner DP,Zimmerman JE

    更新日期:1985-12-01 00:00:00

  • System Factors Affecting Patient Safety in the OR: An Analysis of Safety Threats and Resiliency.

    abstract:OBJECTIVE:The objective of this study is to determine the characteristics and frequency of intraoperative safety threats and resilience supports using a human factors measurement tool. BACKGROUND:Human factors analysis can provide insight into how system elements contribute to intraoperative adverse events. Empiric ev...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003616

    authors: Adams-McGavin RC,Jung JJ,van Dalen ASHM,Grantcharov TP,Schijven MP

    更新日期:2019-10-04 00:00:00

  • Treatment of anal incontinence by an implantable prosthetic anal sphincter.

    abstract::Twelve patients with anal incontinence due to neurologic disease or failure of previous incontinence surgery underwent implantation of an artificial anal sphincter. The system used was a modification of the AMS 800 artificial urinary sphincter. In two patients, infection necessitated removal of the system, and in four...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199204000-00013

    authors: Christiansen J,Sparsø B

    更新日期:1992-04-01 00:00:00

  • A stapling instrument for end-to-end inverting anastomoses in the gastrointestinal tract.

    abstract::A stapling instrument is described for end-to-end inverting anastomoses applicable principally to low rectal anastomosis or esophagogastric or esophagojejunal anastomosis. The instrument creates an inverting anastomosis held by a double staggered row of stainless steel wire staples creating an anastomosis 21.2 mm inte...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197906000-00017

    authors: Ravitch MM,Steichen FM

    更新日期:1979-06-01 00:00:00

  • An evaluation of information transfer through the continuum of surgical care: a feasibility study.

    abstract:OBJECTIVE:To evaluate information transfer and communication (ITC) across the surgical care pathway with the use of Information Transfer and Communication Assessment Tool for Surgery (ITCAS). BACKGROUND:Communication failures are the leading cause of surgical errors and adverse events. It is vital to assess the ITC ac...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181e986df

    authors: Nagpal K,Vats A,Ahmed K,Vincent C,Moorthy K

    更新日期:2010-08-01 00:00:00

  • Liver transplantation for hereditary hemorrhagic telangiectasia: Report of the European liver transplant registry.

    abstract:BACKGROUND:Hereditary hemorrhagic telangiectasia (HHT) or Rendu-Osler-Weber disease is a rare disease characterized by the presence of arteriovenous malformations. Hepatic involvement can lead to life-threatening conditions. MATERIAL AND METHODS:Forty patients, reported to the European Liver Transplant Registry, were ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000247258.35406.a4

    authors: Lerut J,Orlando G,Adam R,Sabbà C,Pfitzmann R,Klempnauer J,Belghiti J,Pirenne J,Thevenot T,Hillert C,Brown CM,Gonze D,Karam V,Boillot O,European Liver Transplant Association.

    更新日期:2006-12-01 00:00:00

  • Evaluation of splenic injury by computed tomography and its impact on treatment.

    abstract::We reviewed 37 consecutive, hemodynamically stable patients (16 adults, 21 children) who had splenic injuries diagnosed by computed tomography (CT) scan to compare the CT evaluation with operative assessment of injury and eventual treatment. Computed tomographic scans and operative findings were graded by a splenic in...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199005000-00009

    authors: Malangoni MA,Cué JI,Fallat ME,Willing SJ,Richardson JD

    更新日期:1990-05-01 00:00:00

  • Opioid Use After Discharge in Postoperative Patients: A Systematic Review.

    abstract:BACKGROUND:Over the past 2 decades, there has been an increase in opioid use and subsequently, opioid deaths. The amount of opioid prescribed to surgical patients has also increased. The aim of this systematic review was to determine postdischarge opioid consumption in surgical patients compared with the amount of opio...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002591

    authors: Feinberg AE,Chesney TR,Srikandarajah S,Acuna SA,McLeod RS,Best Practice in Surgery Group.

    更新日期:2018-06-01 00:00:00

  • The Clinical Utility of Molecular Testing in the Management of Thyroid Follicular Neoplasms (Bethesda IV Nodules).

    abstract:OBJECTIVE:FN present a management quandary as they are often benign but may also be aggressive TC. Consensus recommendations have historically advised thyroidectomy for definitive diagnosis. Although MT have robust benefit in hypothetical cost analyses, under current management guidelines a real-time study of their cli...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004130

    authors: Carty SE,Ohori NP,Hilko DA,McCoy KL,French EK,Manroa P,Morariu E,Sridharan S,Seethala RR,Yip L

    更新日期:2020-10-01 00:00:00

  • The role of splenectomy in multimodality treatment of thrombotic thrombocytopenic purpura.

    abstract::Current treatment modalities for thrombotic thrombocytopenic purpura (TTP) include plasmapheresis (PP), splenectomy, steroids, dextran, other antiplatelet agents, and vinca alkaloids. Prior to the development of PP and use of multimodality treatment for TTP, mortality rates exceeded 50%. This report reviews 11 patient...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198509000-00007

    authors: Schneider PA,Rayner AA,Linker CA,Schuman MA,Liu ET,Hohn DC

    更新日期:1985-09-01 00:00:00

  • Increased CD4+ CD25+ T regulatory cell activity in trauma patients depresses protective Th1 immunity.

    abstract:OBJECTIVES:We recently reported increased CD4 CD25 T regulatory (Treg) activity after burn injury in mice. This study sought to determine if Tregs mediate the reduction in TH1-type immunity after serious injury in man and if Treg function is altered by injury. METHODS:Peripheral blood was withdrawn from 19 consenting ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000239031.06906.1f

    authors: MacConmara MP,Maung AA,Fujimi S,McKenna AM,Delisle A,Lapchak PH,Rogers S,Lederer JA,Mannick JA

    更新日期:2006-10-01 00:00:00

  • Prevention of biliary lesions that may occur during radiofrequency ablation of the liver: study on the pig.

    abstract:OBJECTIVE:To prevent bile duct injury by using a cold 5% glucose isotonic solution cooling in the bile ducts when radiofrequency (RF) is performed in a porcine model. SUMMARY BACKGROUND DATA:Complications that may arise during liver RF ablation include biliary stenosis and abscesses. METHODS:The RITA 1500 generator w...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000193831.39362.07

    authors: Marchal F,Elias D,Rauch P,Zarnegar R,Leroux A,Stines J,Verhaeghe JL,Guillemin F,Carteaux JP,Villemot JP

    更新日期:2006-01-01 00:00:00

  • Academic Advancement in Global Surgery: Appointment, Promotion, and Tenure: Recommendations From the American Surgical Association Working Group on Global Surgery.

    abstract::: There is growing interest in global surgery among US academic surgical departments. As academic global surgery is a relatively new field, departments may have minimal experience in evaluation of faculty contributions and how they integrate into the existing academic paradigm for promotion and tenure. The American Su...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003480

    authors: Wren SM,Balch CM,Doherty GM,Finlayson SR,Kauffman GL,Kibbe MR,Haider AH,Minter RM,Mock C,Muguti GI,Numann PJ,Olutoye OO,Roy N,Weigel RJ

    更新日期:2020-02-01 00:00:00

  • Prophylactic and preventive antibiotic therapy: timing, duration and economics.

    abstract::Previous studies have demonstrated that administered antibiotics must be active against major anticipated pathogens and must have reached sufficient concentrations in the tissue or body fluid at risk by the time of bacterial challenge if prophylactic therapy is to be maximally effective in reducing the infection rate ...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-197906000-00004

    authors: Stone HH,Haney BB,Kolb LD,Geheber CE,Hooper CA

    更新日期:1979-06-01 00:00:00

  • Hepatic resection but not radiofrequency ablation results in tumor growth and increased growth factor expression.

    abstract:OBJECTIVE:The purpose of this study was to examine the effects of radiofrequency ablation (RFA) on tumor growth and growth factor expression in a murine model. BACKGROUND:Surgical excision remains the only potentially curative therapy for hepatic malignancies. Tumor growth in the remaining liver may be accelerated aft...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000261319.51744.59

    authors: Meredith K,Haemmerich D,Qi C,Mahvi D

    更新日期:2007-05-01 00:00:00

  • Experience with mycophenolate mofetil (RS61443) in renal transplantation at a single center.

    abstract:OBJECTIVE:Mycophenolate mofetil (MM) is a new immunosuppressive agent that reversibly inhibits guanine nucleotide synthesis and DNA replication. Its activity is highly selective for T and B lymphocytes. Two open-label multicenter trials of MM in renal transplantation have been performed. This report summarizes the resu...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00000658-199305010-00007

    authors: Deierhoi MH,Kauffman RS,Hudson SL,Barber WH,Curtis JJ,Julian BA,Gaston RS,Laskow DA,Diethelm AG

    更新日期:1993-05-01 00:00:00

  • Noncirrhotic portal vein thrombosis. Physiology before and after shunts.

    abstract::Controversy exists concerning the proper therapy for bleeding gastroesophageal varices secondary to noncirrhotic portal vein thrombosis. Disparity of opinion exists regarding the significance of hepatic portal blood flow and the consequences of total portal-systemic shunts in this condition. One patient is presented w...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198009000-00009

    authors: Warren WD,Millikan WJ Jr,Smith RB 3rd,Rypins EB,Henderson JM,Salam AA,Hersh T,Galambos JT,Faraj BA

    更新日期:1980-09-01 00:00:00

  • Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multicenter, prospective, randomized study. Lymphadenectomy Study Group.

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00000658-199810000-00007

    authors: Pedrazzoli S,DiCarlo V,Dionigi R,Mosca F,Pederzoli P,Pasquali C,Klöppel G,Dhaene K,Michelassi F

    更新日期:1998-10-01 00:00:00

  • Surgical management of bleeding chronic peptic ulcer. A 10-year prospective study.

    abstract::Analysis of experience with chronic bleeding peptic ulcer in 504 patients, admitted from 1960 to 1971, shows a hospital mortality of 12%. This retrospective review suggested that early endoscopic diagnosis, adequate resuscitation and a policy of early selective surgery was necessary if mortality was to be reduced. Wit...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198401000-00008

    authors: Hunt PS

    更新日期:1984-01-01 00:00:00

  • Enhancement of gene therapy specificity for diffuse colon carcinoma liver metastases with recombinant herpes simplex virus.

    abstract:OBJECTIVE:The authors determined whether a recombinant herpes simplex virus (HSV) vector could destroy human colon carcinoma cells in vitro and whether the vector would selectively replicate in colon carcinoma liver metastases but not surrounding hepatocytes in vivo. BACKGROUND:The HSV vector hrR3 is defective in the ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199609000-00008

    authors: Carroll NM,Chiocca EA,Takahashi K,Tanabe KK

    更新日期:1996-09-01 00:00:00

  • The HYSLAR trial: a prospective randomized controlled trial of the use of a restrictive fluid regimen with 3% hypertonic saline versus lactated Ringers in patients undergoing pancreaticoduodenectomy.

    abstract:OBJECTIVE:This study was designed to determine whether the volume and type of fluid administered for pancreaticoduodenectomy impacts postoperative outcomes. BACKGROUND:Three percent hypertonic saline (HYS) has been suggested as a means of reducing the volume of fluid required to sustain tissue perfusion in the periope...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000000872

    authors: Lavu H,Sell NM,Carter TI,Winter JM,Maguire DP,Gratch DM,Berman RA,Feil MG,Grunwald Z,Leiby BE,Pequignot EC,Rosato EL,Yeo CJ

    更新日期:2014-09-01 00:00:00