Long-term swimming exercise does not modulate the Akt-dependent endothelial nitric oxide synthase phosphorylation in healthy mice.

abstract：:Aspirin consumption has been reported to be able to reduce colorectal cancer risk in humans and in animal models of colon carcinogenesis. Although the mechanism involved in such an effect is not yet clear, both prostaglandin-dependent and -independent effects have been proposed. Using HT-29 Glc(-/+)cells, which origin...

journal_title：Canadian journal of physiology and pharmacology

authors： Eklou-Kalonji E,Andriamihaja M,Reinaud P,Mayeur C,Camous S,Robert V,Charpigny G,Blachier F

更新日期：2003-05-01 00:00:00

abstract：:The objective of this study was to investigate the protective effects of pomegranate (Punica granatum) juice (PGJ) on oxidative damages in liver tissue and erythrocytes of rats intoxicated by sodium fluoride (NaF). Rats were randomly divided into two groups: group I received standard diet and group II received orally ...

journal_title：Canadian journal of physiology and pharmacology

authors： Bouasla A,Bouasla I,Boumendjel A,Abdennour C,El Feki A,Messarah M

更新日期：2016-07-01 00:00:00

abstract：:The effects of 5-hydroxytryptamine (5-HT) on spinal motoneurons were examined in pentobarbital-anaesthetized cats and in nonanaesthetized decerebrate cats by intracellular recording and extracellular iontophoresis of 5-HT. 5-HT first induced a depolarization and then a long-lasting hyperpolarization (up to 60 min) wit...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang L

更新日期：1991-02-01 00:00:00

abstract：:Structural analysis of G-protein-coupled receptors has largely been limited to photoaffinity labeling and site-directed mutagenesis. This is primarily due to the difficulty in the production of antibodies against this class of receptors. We were therefore interested in tagging the amino-terminal side of the human angi...

journal_title：Canadian journal of physiology and pharmacology

authors： Roy SF,Laporte SA,Escher E,Leduc R,Guillemette G

更新日期：1997-06-01 00:00:00

abstract：:The purpose of this study was to examine the effects of norepinephrine infusion alone and during alkalosis on oxygen uptake in the dog gastrocnemius-plantaris muscle group under conditions of constant muscle blood flow. The animals were not cold acclimatized. Blood flow was pump controlled, alkalosis was produced by h...

journal_title：Canadian journal of physiology and pharmacology

authors： Chapler CK,Stainsby WN,Gladden LB

更新日期：1980-01-01 00:00:00

abstract：:Infusion of glucose alone or glucose with insulin in cats subjected to acute myocardial ischemia did not alter the hemodynamic response of the cats to coronary artery ligation. Furthermore, determination of myocardial creatine phosphokinase (CPK) (ATP:creatine N-phosphotransferase, EC 2.7.3.2) activities failed to rev...

journal_title：Canadian journal of physiology and pharmacology

authors： Spath JA,Ogletree ML,Lefer AM

更新日期：1976-08-01 00:00:00

abstract：:The direct effects of extrinsic nerve stimulation on coronary artery tone are unclear because of the complications arising from alterations in myocardial dynamics which themselves alter flow. An isolated and perfused nonbeating slab of beef ventricle was utilized in the present experiments to eliminate secondary compl...

journal_title：Canadian journal of physiology and pharmacology

authors： Kalsner S

更新日期：1979-03-01 00:00:00

abstract：:Both the kidney and colon secrete bicarbonate and transport water and electrolytes. The respective contributions of these two organs to acid-base and electrolyte balance in normal man has thus been studied in eight healthy male volunteers who underwent simultaneous renal clearance studies, and colonic perfusion with a...

journal_title：Canadian journal of physiology and pharmacology

authors： Crepeau R,Romeder JM,Devroede G,Plante GE

更新日期：1977-02-01 00:00:00

abstract：:Inactivation of endothelin B receptors (ETB), either through selective pharmacological antagonism or genetic mutation, increases the circulating concentration of endothelin-1 (ET-1), suggesting ETB plays an important role in clearance of this peptide. However, the cellular site of ETB-mediated clearance has not yet be...

journal_title：Canadian journal of physiology and pharmacology

authors： Kelland NF,Kuc RE,McLean DL,Azfer A,Bagnall AJ,Gray GA,Gulliver-Sloan FH,Maguire JJ,Davenport AP,Kotelevtsev YV,Webb DJ

更新日期：2010-06-01 00:00:00

abstract：:Oxidative stress plays a vital role in the pathogenesis of neurodegenerative diseases. Chikusetsu saponin V (CsV), the most abundant member of saponins from Panax japonicus (SPJ), has attracted increasing attention for its potential to treat neurodegenerative diseases. However, the mechanisms are unclear. Our study in...

journal_title：Canadian journal of physiology and pharmacology

authors： Wan J,Deng L,Zhang C,Yuan Q,Liu J,Dun Y,Zhou Z,Zhao H,Liu C,Yuan D,Wang T

更新日期：2016-09-01 00:00:00

abstract：:Long-lasting ischemia can result in cell loss; however, repeated episodes of brief ischemia increase the resistance of the heart against deleterious effects of subsequent prolonged ischemic insult and promote cell survival. Traditionally, it is believed that the supply of blood to the ischemic heart is associated with...

journal_title：Canadian journal of physiology and pharmacology

authors： Adameova A,Hrdlicka J,Szobi A,Farkasova V,Kopaskova K,Murarikova M,Neckar J,Kolar F,Ravingerova T,Dhalla NS

更新日期：2017-10-01 00:00:00

abstract：:The effect of the administration route, dose, and sampling time on the total urinary excretion of four major benzo[a]pyrene (BaP) metabolites, 3-hydroxyBaP (3-OHBaP), 9-hydroxyBaP 9-hydroxyBaP (9-OHBaP), trans-4,5-dihydrodiolBaP (4,5-diolBaP), and trans-9,10-dihydrodiolBaP (9,10-diolBaP), was studied in male Sprague-D...

journal_title：Canadian journal of physiology and pharmacology

authors： Bouchard M,Viau C

更新日期：1997-03-01 00:00:00

abstract：:Changes in force and stiffness during contractions of mouse extensor digitorum longus and soleus muscles were measured over a range of extracellular pH from 6.4 to 7.4. Muscle stiffness was measured using small amplitude (less than 0.1% of muscle length), high frequency (1.5 kHz) oscillations in length. Twitch force w...

journal_title：Canadian journal of physiology and pharmacology

authors： Renaud JM,Stein RB,Gordon T

更新日期：1987-08-01 00:00:00

abstract：:This study was designed to investigate whether and how triiodothyronine (T3) affects renal function in an experimental model of chronic kidney disease. Twenty-four female rats were divided into the following groups: sham-operated control group (n = 8), 5/6 nephrectomized group (Nx, n = 8), and 5/6 nephrectomized group...

journal_title：Canadian journal of physiology and pharmacology

authors： El Agaty SM

更新日期：2018-06-01 00:00:00

abstract：:This paper provides a brief overview of the adaptive control of prehension. Several primary issues for research in the field are considered. One pertains to the stages of prehensile activity, with particular concern for the kinematic control of precontact phases, and the coordination of load and grip forces following ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lederman SJ

更新日期：1994-05-01 00:00:00

abstract：:The effects of a number of peptides which are found in the gastrointestinal tract have been ascertained on the direct current recorded dorsal and ventral root responses of the isolated hemisected toad spinal cord. Motilin, substance P, bombesin, neurotensin, and thyrotropin releasing hormone had potent depolarizing ac...

journal_title：Canadian journal of physiology and pharmacology

authors： Phillis JW,Kirkpatrick JR

更新日期：1979-08-01 00:00:00

abstract：:The aim of this study was to investigate the possible effects of captopril as a promoter in modulating the oxidant-antioxidant balance in rats with type 1 diabetes, and the influence of protein kinase C (PKC) pathways in the production of reactive oxygen species (ROS) induced by bradykinin in type 1 diabetic rats. Thi...

journal_title：Canadian journal of physiology and pharmacology

authors： Rodrigues de Araujo G,Granato de Faria K,Lima WG,Pádua Bda C,Rossoni JV Jr,Souza AA,Chianca-Júnior D,Silva ME,Pedrosa ML,Chaves MM,Costa DC

更新日期：2011-12-01 00:00:00

abstract：:Energy balance studies suggest that the overall efficiency of energy utilization does not increase during pregnancy in rodents, other than as a consequence of "hyperphagia". Diet-induced thermogenesis is not stimulated in response to the increased energy intake of the pregnant animal, the extra intake being retained a...

journal_title：Canadian journal of physiology and pharmacology

authors： Trayhurn P

更新日期：1989-04-01 00:00:00

abstract：:The shear-stress sensor function of vascular glycocalyx heparan sulphate and hyaluronic acid was investigated in vivo by assessing flow-mediated dilation before and after their removal. Heparinase III exposure (100 mU·mL-1 for 20 min;n = 6) did not significantly affect flow-mediated dilation of the iliac, from 0.42 ± ...

journal_title：Canadian journal of physiology and pharmacology

authors： Ruane-O'Hora T,O'Malley D,Buckley MM,Markos F

更新日期：2019-08-01 00:00:00

abstract：:This Symposium includes 15 presentations and an editorial review dealing with prorenin activation and function. It comes 20 years after prorenin was first reported in various contexts and attracted attention because of its connection with renin--angiotensin, its high concentration relative to renin in the blood, and i...

journal_title：Canadian journal of physiology and pharmacology

authors： Osmond DH,Sealey JE,McKenzie JK

更新日期：1991-09-01 00:00:00

abstract：:Mechanisms leading to ifosfamide (IF)-induced renal damage have not been fully elucidated. Recent work suggests that localized renal tubular metabolism of IF and the production of the nephrotoxic chloroacetaldehyde may lead to nephrotoxicity. Presently no pharmacological method to reduce IF nephrotoxicity has been ide...

journal_title：Canadian journal of physiology and pharmacology

authors： Aleksa K,Halachmi N,Ito S,Koren G

更新日期：2005-06-01 00:00:00

abstract：:This study investigated the gastroprotective effects of N-acetylcysteine (NAC) against indomethacin-induced gastric ulcer in rats. Ulceration was induced by a single oral administration of indomethacin (30 mg/kg). 50 male albino rats were allocated into 5 equal groups: control group received normal saline orally, indo...

journal_title：Canadian journal of physiology and pharmacology

authors： Soliman NA,Zineldeen DH,Katary MA,Ali DA

更新日期：2017-04-01 00:00:00

abstract：:The vasculature of the mammalian renal medulla is complex, having neither discrete input nor output. There is also efficient countercurrent exchange between ascending and descending vasa recta in the vascular bundles. These considerations have hampered measurement of medullary blood flow since they impose pronounced c...

journal_title：Canadian journal of physiology and pharmacology

authors： Cupples WA

更新日期：1986-07-01 00:00:00

abstract：:The influence of variation in the extracellular concentrations of Na+, Mg2+, and Ca2+ in the depolarizing medium on isoproterenol-induced increases in cAMP levels and relaxation was studied in rat uterus. Isoproterenol (10(-8) M) failed to increase cAMP levels in the high-K+ medium containing no Na+. When 80 mM Na+ wa...

journal_title：Canadian journal of physiology and pharmacology

authors： Meisheri KD,McNeill JH

更新日期：1979-10-01 00:00:00

abstract：:Lesion to the posterior parietal cortex in monkeys and humans produces spatial deficits in movement and perception. In recording experiments from area 7a, a cortical subdivision in the posterior parietal cortex in monkeys, we have found neurons whose responses are a function of both the retinal location of visual stim...

journal_title：Canadian journal of physiology and pharmacology

authors： Andersen RA,Zipser D

更新日期：1988-04-01 00:00:00

abstract：:There is increasing evidence for a beneficial effect of ginseng on cardiac pathology. Here, we determined whether North American ginseng can modulate the deleterious effects of the β-adrenoceptor agonist isoproterenol on cardiac hypertrophy and function using in vitro and in vivo approaches. Isoproterenol was administ...

journal_title：Canadian journal of physiology and pharmacology

authors： Tang X,Gan XT,Rajapurohitam V,Huang CX,Xue J,Lui EM,Karmazyn M

更新日期：2016-12-01 00:00:00

abstract：:A striking feature of the mammalian respiratory rhythm generator is the abruptness of the transitions between the inspiratory (I) and expiratory (E) phases ("phase-switching"). Although reciprocal inhibitory actions between I and E neurons are important for maintaining the alternation of respiratory phases, phase-swit...

journal_title：Canadian journal of physiology and pharmacology

authors： Cohen MI

更新日期：1981-07-01 00:00:00

abstract：:Chronic potassium deficiency in one-kidney one-clip hypertensive dogs significantly reduces blood pressure and plasma potassium, with a simultaneous increase in plasma renin activity. Tissue potassium concentration was decreased and tissue sodium concentration was increased in striated muscle and adrenal glands, which...

journal_title：Canadian journal of physiology and pharmacology

authors： Garcia R,Constantopoulos G,Gutkowska J,Genest J

更新日期：1983-12-01 00:00:00

abstract：:Several studies suggest that heat stress affects placental functions including uteroplacental circulation, subsequently leading to pregnancy failure and birth weight reduction. To clarify the involvement of endothelin and placental prostaglandin (PG) systems in the uteroplacental circulation during heat stress, we exa...

journal_title：Canadian journal of physiology and pharmacology

authors： Nakamura H,Matsuzaki I,Hatta K,Ogino K

更新日期：2004-04-01 00:00:00

abstract：:Cyclic AMP formation from ATP was stimulated by unpurified and partially purified soluble hepatic guanylate cyclase in the presence of nitric oxide (NO) or compounds containing a nitroso moiety such as nitroprusside, N-methyl-N-nitro-N-nitrosoguanidine (MNNG), nitrosyl ferroheme, and S-nitrosothiols. Cyclic AMP format...

journal_title：Canadian journal of physiology and pharmacology

authors： McNamara DB,Kadowitz PJ,Hyman AL,Ignarro LJ

更新日期：1980-12-01 00:00:00