Linking transgene expression of engineered mesenchymal stem cells and angiopoietin-1-induced differentiation to target cancer angiogenesis.

Abstract:

OBJECTIVE:To specifically target tumor angiogenesis by linking transgene expression of engineered mesenchymal stem cells to angiopoietin-1-induced differentiation. BACKGROUND:Mesenchymal stem cells (MSCs) have been used to deliver therapeutic genes into solid tumors. These strategies rely on their homing mechanisms only to deliver the therapeutic agent. METHODS:We engineered murine MSC to express reporter genes or therapeutic genes under the selective control of the Tie2 promoter/enhancer. This approach uses the differentiative potential of MSCs induced by the tumor microenvironment to drive therapeutic gene expression only in the context of angiogenesis. RESULTS:When injected into the peripheral circulation of mice with either, orthotopic pancreatic or spontaneous breast cancer, the engineered MSCs were actively recruited to growing tumor vasculature and induced the selective expression of either reporter red florescent protein or suicide genes [herpes simplex virus-thymidine kinase (TK) gene] when the adoptively transferred MSC developed endothelial-like characteristics. The TK gene product in combination with the prodrug ganciclovir (GCV) produces a potent toxin, which affects replicative cells. The homing of engineered MSC with selective induction of TK in concert with GCV resulted in a toxic tumor-specific environment. The efficacy of this approach was demonstrated by significant reduction in primary tumor growth and prolongation of life in both tumor models. CONCLUSION:This "Trojan Horse" combined stem cell/gene therapy represents a novel treatment strategy for tailored therapy of solid tumors.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Conrad C,Hüsemann Y,Niess H,von Luettichau I,Huss R,Bauer C,Jauch KW,Klein CA,Bruns C,Nelson PJ

doi

10.1097/SLA.0b013e3181fcb5d8

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

566-71

issue

3

eissn

0003-4932

issn

1528-1140

journal_volume

253

pub_type

杂志文章
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    abstract:BACKGROUND AND AIMS:The lower esophageal sphincter (LES) in patients with gastroesophageal reflux disease often has a low resting pressure and a short abdominal length. The mechanism by which this occurs is unknown. We hypothesize that gastric distension causes progressive effacement of the abdominal portion of the LES...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181e3e411

    authors: Ayazi S,Tamhankar A,DeMeester SR,Zehetner J,Wu C,Lipham JC,Hagen JA,DeMeester TR

    更新日期:2010-07-01 00:00:00

  • Improvement in treatment results and long-term survival of patients with esophageal cancer: impact of chemoradiation and change in treatment strategy.

    abstract:OBJECTIVE:To identify prognostic factors and reasons for improved survival over time in patients with esophageal cancer. SUMMARY BACKGROUND DATA:Management strategies for esophageal cancer have evolved with time. The impact of chemoradiation in the overall treatment results has not been adequately studied. METHODS:Fr...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000086545.45918.ee

    authors: Law S,Kwong DL,Kwok KF,Wong KH,Chu KM,Sham JS,Wong J

    更新日期:2003-09-01 00:00:00

  • Preoperative systemic chemoimmunotherapy and sequential resection for unresectable hepatocellular carcinoma.

    abstract:OBJECTIVE:To examine the surgical and pathologic findings of 15 patients who had initially unresectable hepatocellular carcinoma (HCC) and received preoperative systemic chemoimmunotherapy and sequential resection. SUMMARY BACKGROUND DATA:More than 80% of patients with HCC present for treatment at an unresectable stag...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200102000-00013

    authors: Lau WY,Leung TW,Lai BS,Liew CT,Ho SK,Yu SC,Tang AM

    更新日期:2001-02-01 00:00:00

  • The Effect of Arterial Disease Level on Outcomes of Supervised Exercise Therapy for Intermittent Claudication: A Prospective Cohort Study.

    abstract:OBJECTIVE:To assess whether level of arterial obstruction determines the effectiveness of SET in patients with IC. BACKGROUND DATA:Guidelines advocate SET before invasive treatment for IC, but early revascularization remains widespread, especially in patients with aortoiliac disease. METHODS:Patients were recruited f...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004073

    authors: van den Houten MML,Jansen S,van der Laan L,Vriens PWHE,Willigendael EM,Koelemay MJW,Scheltinga MRM,Teijink JAW,ELECT Study Group.

    更新日期:2020-07-24 00:00:00

  • Small amount of low-residue diet with parenteral nutrition can prevent decreases in intestinal mucosal integrity.

    abstract:OBJECTIVE:To investigate the suitable combination ratio of low-residue diet (LRD) and parenteral nutrition (PN) for nutritional support of surgical patients. SUMMARY BACKGROUND DATA:Bacterial translocation (BT) is a severe complication of total parenteral nutrition (TPN). However, it is sometimes impossible to supply ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200001000-00016

    authors: Omura K,Hirano K,Kanehira E,Kaito K,Tamura M,Nishida S,Kawakami K,Watanabe Y

    更新日期:2000-01-01 00:00:00

  • Pouch Versus No Pouch Following Total Gastrectomy: Meta-analysis of Randomized and Non-randomized Studies.

    abstract:OBJECTIVE:The aim of the study was to assess the impact of pouch reconstruction on perioperative outcomes, postprandial symptoms, nutritional and anthropometric parameters, and overall quality of life after total gastrectomy for gastric malignancy. SUMMARY BACKGROUND DATA:The short-term perioperative risks and longer ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,meta分析

    doi:10.1097/SLA.0000000000003082

    authors: Syn NL,Wee I,Shabbir A,Kim G,So JB

    更新日期:2019-06-01 00:00:00

  • Proficiency of surgeons in inguinal hernia repair: effect of experience and age.

    abstract:OBJECTIVES:We examined the influence of surgeon age and other factors on proficiency in laparoscopic or open hernia repair. SUMMARY BACKGROUND DATA:In a multicenter, randomized trial comparing open and laparoscopic herniorrhaphies, conducted in Veterans Administration hospitals (CSP 456), we reported significant diffe...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/01.sla.0000179644.02187.ea

    authors: Neumayer LA,Gawande AA,Wang J,Giobbie-Hurder A,Itani KM,Fitzgibbons RJ Jr,Reda D,Jonasson O,CSP #456 Investigators.

    更新日期:2005-09-01 00:00:00

  • Prophylactic revascularization of the gut.

    abstract::Reconstitution of the mesenteric vascular circulation, in our experience, is advisable when advanced occlusive disease is noted on the preoperative arteriogram of patients selected for aortoiliofemoral, renal artery, or aortic aneurysm surgery. A lateral aortogram is mandatory, and the presence of an anastomotic meand...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197910000-00011

    authors: Connolly JE,Kwaan JH

    更新日期:1979-10-01 00:00:00

  • A small arterial substitute: expanded microporous polytetrafluoroethylene: patency versus porosity.

    abstract::Eighty-nine grafts of expanded microporous polytetrafluoroethylene (PTFE) with a diameter of 4 mm, were placed in the carotid and femoral arteries of dogs. The animals were sacrificed at varying intervals beginning three days after operation. Four animals remain alive with patent grafts 10 months post-operatively. Twe...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197508000-00010

    authors: Campbell CD,Goldfarb D,Roe R

    更新日期:1975-08-01 00:00:00

  • Sciatic and Femoral Nerve Resection During Extended Radical Surgery for Advanced Pelvic Tumours: Long-term Survival, Functional, and Quality-of-life Outcomes.

    abstract:OBJECTIVE:To report survival, functional, and quality-of-life (QoL) outcomes after extended radical resection for advanced pelvic tumors with en bloc sciatic or femoral nerve resection. BACKGROUND:Advanced pelvic tumors involving the sciatic or femoral nerve have traditionally been considered inoperable. Small studies...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003390

    authors: Brown KGM,Solomon MJ,Lau YC,Steffens D,Austin KKS,Lee PJ

    更新日期:2019-06-07 00:00:00

  • Endorectal ileoanal anastomosis with isoperistaltic ileal reservoir after colectomy and mucosal proctectomy.

    abstract::Forty-nine patients with chronic ulcerative colitis refractory to medical therapy and four with multiple polyposis have undergone total colectomy, mucosal protectomy, and endorectal ileal pull-through with ileoanal anastomosis at the UCLA Medical Center during the past 12 years (mean age, 19.4 years). Thirty-eight pat...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198402000-00003

    authors: Fonkalsrud EW

    更新日期:1984-02-01 00:00:00

  • Use of abdominal ultrasonography to assess pediatric splenic trauma. Potential pitfalls in the diagnosis.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the accuracy of abdominal ultrasonography (US) for screening and grading pediatric splenic injury. SUMMARY BACKGROUND DATA:The use of abdominal US has increased rapidly as a method of evaluating organ damage after blunt abdominal trauma. Despite US's increasing use, ...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000658-199704000-00010

    authors: Krupnick AS,Teitelbaum DH,Geiger JD,Strouse PJ,Cox CS,Blane CE,Polley TZ

    更新日期:1997-04-01 00:00:00

  • Combination of SELDI-TOF-MS and data mining provides early-stage response prediction for rectal tumors undergoing multimodal neoadjuvant therapy.

    abstract:OBJECTIVE:We investigated whether proteomic analysis of the low molecular weight region of the serum proteome could predict histologic response of locally advanced rectal cancer to neoadjuvant radiochemotherapy (RCT). SUMMARY BACKGROUND DATA:Proteomic analysis of serum is emerging as a powerful new modality in cancer,...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000245577.68151.bd

    authors: Smith FM,Gallagher WM,Fox E,Stephens RB,Rexhepaj E,Petricoin EF 3rd,Liotta L,Kennedy MJ,Reynolds JV

    更新日期:2007-02-01 00:00:00

  • The potential of organizations of fee-for-service physicians for achieving significant decreases in hospitalization.

    abstract::Because hospitalization is a key factor in controlling health care costs and because fee-for-service remains the predominant mode of physician payment, a study was undertaken of the hospitalization experiences of open panel fee-for-service health maintenance organizations (IPA-HMOs) and Foundations for Medical Care (F...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197709000-00017

    authors: Edgahl RH,Taft CH,Friedland J,Linde K

    更新日期:1977-09-01 00:00:00

  • Early diagnosis of intestinal ischemia using urinary and plasma fatty acid binding proteins.

    abstract:OBJECTIVE:This study aims at improving diagnosis of intestinal ischemia, by measuring plasma and urinary fatty acid binding protein (FABP) levels. METHODS:Fifty consecutive patients suspected of intestinal ischemia were included and blood and urine were sampled at time of suspicion. Plasma and urinary concentrations o...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318207a767

    authors: Thuijls G,van Wijck K,Grootjans J,Derikx JP,van Bijnen AA,Heineman E,Dejong CH,Buurman WA,Poeze M

    更新日期:2011-02-01 00:00:00

  • The effect of mesh removal and selective neurectomy on persistent postherniotomy pain.

    abstract:UNLABELLED:SUMMARY BACKGROUND DATA AND OBJECTIVE: Persistent pain affects everyday activities in 5% to 8% of patients after groin hernia repair. Because previous reports on the effect of neurectomy and/or mesh removal suffer from methodological problems we performed a detailed prospective trial of the effect of neurect...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/SLA.0b013e31818eec49

    authors: Aasvang EK,Kehlet H

    更新日期:2009-02-01 00:00:00

  • Liver Resection and Transplantation for Patients With Hepatocellular Carcinoma Beyond Milan Criteria.

    abstract:OBJECTIVES:To assess survival after liver resection and transplantation in patients with hepatocellular carcinoma (HCC) beyond Milan criteria. BACKGROUND:The role of liver resection and transplantation remains controversial for patients with HCC beyond Milan criteria. Resection of advanced tumors and transplantation u...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001866

    authors: Zaydfudim VM,Vachharajani N,Klintmalm GB,Jarnagin WR,Hemming AW,Doyle MB,Cavaness KM,Chapman WC,Nagorney DM

    更新日期:2016-10-01 00:00:00

  • Long-term complications of laparotomy in Hodgkin's disease.

    abstract:OBJECTIVE:The authors determined the incidence of complications in 133 patients who had undergone staging laparotomy with splenectomy before treatment for Hodgkin's disease (stages I-IV). METHODS AND MATERIALS:Medical records were reviewed, and the patients or their relatives were interviewed. Median follow-up after l...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-199406000-00004

    authors: Jockovich M,Mendenhall NP,Sombeck MD,Talbert JL,Copeland EM 3rd,Bland KI

    更新日期:1994-06-01 00:00:00

  • Hereditary spherocytosis. Recent experience and current concepts of pathophysiology.

    abstract::Hereditary spherocytosis is a clinically heterogeneous, genetically determined red blood cell membrane disorder resulting in hemolytic anemia. A deficiency of spectrin, the largest and most abundant structural protein of the erythrocyte membrane skeleton, results in the formation of spherocytes which lack the strength...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198601000-00007

    authors: Croom RD 3rd,McMillan CW,Orringer EP,Sheldon GF

    更新日期:1986-01-01 00:00:00

  • Intermittent Pneumatic Compression in Addition to Standard Prophylaxis of Postoperative Venous Thromboembolism in Extremely High-risk Patients (IPC SUPER): A Randomized Controlled Trial.

    abstract:OBJECTIVE:To assess the efficacy of adjunctive IPC to standard prophylaxis of postoperative VTE in patients at extremely high-risk. SUMMARY OF BACKGROUND DATA:The standard prophylaxis for postoperative VTE is insufficient in extremely high-risk patients. It is unclear whether an adjunctive use of IPC would result in a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004556

    authors: Lobastov K,Sautina E,Alencheva E,Bargandzhiya A,Schastlivtsev I,Barinov V,Laberko L,Rodoman G,Boyarintsev V

    更新日期:2020-11-12 00:00:00

  • Management Considerations for the Surgical Treatment of Colorectal Cancer During the Global Covid-19 Pandemic.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004029

    authors: O'Leary MP,Choong KC,Thornblade LW,Fakih MG,Fong Y,Kaiser AM

    更新日期:2020-08-01 00:00:00

  • Remission of type 2 diabetes after Roux-en-Y gastric bypass or sleeve gastrectomy is associated with a distinct glycemic profile.

    abstract:BACKGROUND:Roux-en-Y gastric bypass (RYGBP) and sleeve gastrectomy (SG) have been associated with a high remission rate of type 2 diabetes mellitus (T2DM). However, whether such remission is associated with full restoration of postprandial glucose profile and/or the potentially nonrestored glycemic profile is associate...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000586

    authors: Jiménez A,Ceriello A,Casamitjana R,Flores L,Viaplana-Masclans J,Vidal J

    更新日期:2015-02-01 00:00:00

  • Carcinoembryonic antigen (CEA) as a prognostic and monitoring test in clinically complete resection of colorectal carcinoma.

    abstract::The prognostic and postoperative monitoring capabilities of the CEA assay were compared to pathological staging of the operative specimens, clinical followup including endoscopy, radiology and scanning techniques, as well as DNCB skin testing and laboratory enzyme determinations (alkaline phosphatase and transaminase)...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197601000-00002

    authors: Herrera MA,Chu TM,Holyoke ED

    更新日期:1976-01-01 00:00:00

  • Differences in healing of skin wounds caused by burn and freeze injuries.

    abstract::Circular, full-thickness dermal burn- and freeze-produced wounds were produced in rats to compare the difference in healing between the two types of thermal injuries. Contraction did not occur in wounds (n = 30) caused by freezing, while burn wounds (n = 30) contracted to less than one-third of original size by 21 day...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198002000-00019

    authors: Li AK,Ehrlich HP,Trelstad RL,Koroly MJ,Schattenkerk ME,Malt RA

    更新日期:1980-02-01 00:00:00

  • Derivation and Validation of a Generalizable Preoperative Frailty Index Using Population-based Health Administrative Data.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002769

    authors: McIsaac DI,Wong CA,Huang A,Moloo H,van Walraven C

    更新日期:2019-07-01 00:00:00

  • Preoperative optimization of cardiovascular hemodynamics improves outcome in peripheral vascular surgery. A prospective, randomized clinical trial.

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-199109000-00011

    authors: Berlauk JF,Abrams JH,Gilmour IJ,O'Connor SR,Knighton DR,Cerra FB

    更新日期:1991-09-01 00:00:00

  • Clinical behavior and prognostic factors of periampullary adenocarcinoma.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199511000-00005

    authors: Chan C,Herrera MF,de la Garza L,Quintanilla-Martinez L,Vargas-Vorackova F,Richaud-Patín Y,Llorente L,Uscanga L,Robles-Diaz G,Leon E

    更新日期:1995-11-01 00:00:00

  • Axillary lymph node status, but not tumor size, predicts locoregional recurrence and overall survival after mastectomy for breast cancer.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.SLA.0000065289.06765.71

    authors: Beenken SW,Urist MM,Zhang Y,Desmond R,Krontiras H,Medina H,Bland KI

    更新日期:2003-05-01 00:00:00

  • Vocal cord paralysis and reoperative parathyroidectomy. A prospective study.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198603000-00011

    authors: Patow CA,Norton JA,Brennan MF

    更新日期:1986-03-01 00:00:00

  • Predictive index for long-term survival after retransplantation of the liver in adult recipients: analysis of a 26-year experience in a single center.

    abstract:OBJECTIVE:To develop a prognostic scoring system for risk stratification of patients with hepatic graft failure (GF) undergoing retransplants of the liver (ReLT) and improve patient selection. SUMMARY OF BACKGROUND DATA:Retransplantation of the liver remains controversial because of inferior outcomes compared with the...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31822c5878

    authors: Hong JC,Kaldas FM,Kositamongkol P,Petrowsky H,Farmer DG,Markovic D,Hiatt JR,Busuttil RW

    更新日期:2011-09-01 00:00:00