Abstract：
:The CEM-ON malignant T cell line and long-term cultured normal T cells can be induced to release CSF-1 in their culture supernatants. Chemical inducers (PMA + A23187) and, more interestingly, cytokines (tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha)), as well as physiological (antigen + IL-2) or specific (anti-CD3 + IL-2 or PMA) stimuli, lead to rapid transient colony-stimulating factor-1 (CSF-1) gene expression and production of biologically active CSF-1. These data suggest that CSF-1 may play a role in the early phases of immune response.
journal_name
Leukemiajournal_title
Leukemiaauthors
Praloran V,Gascan H,Papin S,Chevalier S,Trossaërt M,Boursier MCsubject
Has Abstractpub_date
1990-06-01 00:00:00pages
411-4issue
6eissn
0887-6924issn
1476-5551journal_volume
4pub_type
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