当前位置： SCI文献检索 > JOURNAL OF VIRAL HEPATITIS期刊下所有文献 > Quantification of hepatitis C virus in patients treated with peginterferon-alfa 2a plus ribavirin treatment by COBAS TaqMan HCV test.

Quantification of hepatitis C virus in patients treated with peginterferon-alfa 2a plus ribavirin treatment by COBAS TaqMan HCV test.

Abstract：

:Extremely low levels of serum hepatitis C virus (HCV) RNA can be detected by COBAS TaqMan HCV test. To investigate whether the COBAS TaqMan HCV test is useful for measuring rapid virological response (RVR) and early virological response (EVR) to predict sustained virological response (SVR), we compared the virological response to PEG-IFN-alfa 2a plus RBV in 76 patients infected with HCV genotype 1 when undetectable HCV RNA by the COBAS TaqMan HCV test was used, with those when below 1.7 log IU/mL HCV RNA by COBAS TaqMan HCV test was used, which corresponded to the use of traditional methods. Among the 76 patients, 28 (36.8%) had SVR, 13 (17.1%) relapsed, 19 (25.0%) did not respond, and 16 (21.0%) discontinued the treatment due to side effects. The positive predictive values for SVR based on undetectable HCV RNA by COBAS TaqMan HCV test at 24 weeks after the end of treatment [10/10 (100%) at week 4, 21/23 (91.3%) at week 8 and 26/33 (78.7%) at week 12] were superior to those based on <1.7 log IU/mL HCV RNA [17/19 (89.4%) at week 4, 27/38 (71.0%) at week 8, and 27/43 (62.7%) at week 12]. The negative predictive values for SVR based on <1.7 log IU/mL HCV RNA by COBAS TaqMan HCV test [46/57 (80.7%) at week 4, 37/38 (97.3%) at week 8, and 32/33 (96.9%) at week 12] were superior to those based on undetectable HCV RNA [48/66 (72.7%) at week 4, 46/53 (86.7%) at week 8, and 41/43 (95.3%) at week 12]. The utilization of both undetectable RNA and <1.7 log IU/mL HCV RNA by COBAS TaqMan HCV test is useful and could predict SVR and non-SVR patients with greater accuracy.

journal_name

J Viral Hepat

journal_title

Journal of viral hepatitis

authors

Kanda T,Imazeki F,Yonemitsu Y,Mikami S,Takada N,Nishino T,Takashi M,Tsubota A,Kato K,Sugiura N,Tawada A,Wu S,Tanaka T,Nakamoto S,Mikata R,Tada M,Chiba T,Kurihara T,Arai M,Fujiwara K,Kanai F,Yokosuka O

doi

10.1111/j.1365-2893.2010.01409.x

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

e292-7

issue

7

eissn

1352-0504

issn

1365-2893

journal_volume

18

pub_type

杂志文章

相关文献

JOURNAL OF VIRAL HEPATITIS文献大全
  • Cross-sectional survey of the extent and indicators of hepatitis C virus infection in Houston Department of Health and Human Services' sexually transmitted disease clinics.

    abstract：:To evaluate the prevalence and indicators of hepatitis C virus (HCV) infection in Houston and determine the effectiveness of targeted HCV screening in sexually transmitted disease (STD) clinics. We performed a cross-sectional survey in low-risk and high-risk groups in Houston. This included a blinded survey of HCV con...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1046/j.1365-2893.2003.00410.x

    authors： D'Souza G,Arafat R,Hwang L,Cunningham C,Shah S,Reynolds K

    更新日期：2003-03-01 00:00:00

  • Adiponectin changes in HCV-Genotype 4: relation to liver histology and response to treatment.

    abstract：:Recently, attention has been focussed on adiponectin and its changes in different types of chronic liver disease. Its relation to hepatic fibrosis and insulin resistance in post-hepatitis liver disease is not clear. The aim of this study was to clarify the adiponectin changes in genotype 4 hepatitis C virus (HCV)-infe...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2009.01096.x

    authors： Derbala M,Rizk N,Al-Kaabi S,Amer A,Shebl F,Al Marri A,Aigha I,Alyaesi D,Mohamed H,Aman H,Basem N

    更新日期：2009-10-01 00:00:00

  • High levels of circulating N-terminal pro-brain natriuretic peptide in patients with hepatitis C.

    abstract：:Many patients chronically infected by hepatitis C virus (HCV) experience symptoms like fatigue, dyspnea and reduced physical activity. However, in many patients, these symptoms are not proportional to the liver involvement and could resemble symptoms of chronic heart failure. To our knowledge, no study evaluated serum...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2009.01237.x

    authors： Antonelli A,Ferri C,Ferrari SM,Colaci M,Sebastiani M,Zignego AL,Ghiri E,Goglia F,Fallahi P

    更新日期：2010-12-01 00:00:00

  • Clinical importance of serum hepatitis B surface antigen levels in chronic hepatitis B.

    abstract：:Quantitative serology for hepatitis B surface antigen (HBsAg) is a new candidate marker for prediction of clinical outcome. The aim of this study was to investigate the clinical significance of quantifying HBsAg in patients with hepatitis B virus (HBV) infection. A total of 424 patients who tested positive for HBsAg a...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2011.01486.x

    authors： Togo S,Arai M,Tawada A,Chiba T,Kanda T,Fujiwara K,Imazeki F,Yokosuka O

    更新日期：2011-10-01 00:00:00

  • High prevalence of hantavirus infection in a group of Chinese patients with acute hepatitis of unknown aetiology.

    abstract：:In southwestern China, small but substantial numbers of patients with acute hepatitis were found without known hepatropic viral infections (hepatitis A, B, C, D or E, cytomegalovirus, Epstein-Barr virus) and were receiving no hepatotoxic drugs. Prevalence of antibodies, both neutralizing and specific immunoglobulin (I...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1046/j.1365-2893.1997.00140.x

    authors： Meng G,Lan Y,Nakagawa M,Maehara T,Mitani K,Tomiyama T,Che XG,Ohkubo A

    更新日期：1997-07-01 00:00:00

  • Noninvasive assessment of liver fibrosis via spleen stiffness measurement using acoustic radiation force impulse sonoelastography in patients with chronic hepatitis B or C.

    abstract：:Portal hypertension and splenomegaly are common in patients with cirrhosis. However, there is limited previous in vivo research on the correlation between spleen stiffness and stages of liver fibrosis. This study aimed to evaluate the diagnostic value of spleen stiffness measurement (SSM), using acoustic radiation for...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2012.01588.x

    authors： Chen SH,Li YF,Lai HC,Kao JT,Peng CY,Chuang PH,Su WP,Chiang IP

    更新日期：2012-09-01 00:00:00

  • Watchful waiting: role of disease progression on uncertainty and depressive symptoms in patients with chronic hepatitis C.

    abstract：BACKGROUND AND AIMS:New therapies for HCV are rapidly emerging and providers are advising select patients to defer treatment and elect 'watchful waiting'. During the watchful waiting period, patients have been shown to have high rates of illness uncertainty and depression. We sought to answer the question of whether re...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12207

    authors： Colagreco JP,Bailey DE,Fitzpatrick JJ,Musil CM,Afdhal NH,Lai M

    更新日期：2014-10-01 00:00:00

  • T-helper cells and liver fibrosis in hepatitis C virus-monoinfected patients.

    abstract：:Limited data suggest that low T-helper cell levels may be observed in hepatitis C virus (HCV) monoinfected patients with decompensated liver disease. We sought to determine the distribution and relationship of T-helper cells (CD4) to liver fibrosis in HCV-monoinfected patients before and during pegylated interferon (P...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2009.01173.x

    authors： Rashkin S,Rouster S,Goodman ZD,Sherman KE

    更新日期：2010-03-01 00:00:00

  • Dual effects of hepatitis C virus Core protein on the transcription of cyclin-dependent kinase inhibitor p21 gene.

    abstract：:Transcription of p21 was activated in hepatitis C virus (HCV) Core-expressing HepG2 cells where its upstream p53 was stabilized. However, this effect was not absolutely required for the activation of p21 by Core, as demonstrated in Hep3B cells. In addition, an opposite effect on the transcription of p21 was observed i...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1046/j.1365-2893.2003.00434.x

    authors： Kwun HJ,Jang KL

    更新日期：2003-07-01 00:00:00

  • Treatment of chronic hepatitis C virus infection in patients with cirrhosis.

    abstract：:Chronic hepatitis C virus (HCV) infection eventually leads to cirrhosis in 20-30% of patients and to hepatocellular carcinoma (HCC) in 1-5% of patients. Rates of sustained virological response with standard interferon-alpha (IFN-alpha) are low in patients without cirrhosis (generally < 20%) and are even lower in those...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2893.2000.00229.x

    authors： Zeuzem S

    更新日期：2000-09-01 00:00:00

  • Consistent high prevalence of undiagnosed blood-borne virus infection in patients attending large urban emergency departments in England.

    abstract：:Understanding local viral hepatitis and HIV epidemiology is essential if WHO elimination targets are to be achieved. We demonstrate a consistently high prevalence of undiagnosed active infection in urban emergency department attendees in England, with variations in local risk groups crucial to informing targeted testi...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.13197

    authors： Hopkins MJ,Todd S,Beadsworth M,Anderson C,Mohamed Z,Muir D,Vivancos R,Brown AS,Ruf M,Chawla A

    更新日期：2020-01-01 00:00:00

  • Antiviral-resistant hepatitis B virus: can we prevent this monster from growing?

    abstract：:Despite the recent progress in antiviral therapy of chronic hepatitis B, clinical experience has shown that antiviral drug resistance is inevitable with the administration of nucleoside analog monotherapy. The long-term persistence of the viral genome in infected cells and the high rate of spontaneous mutation is the ...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2893.2007.00915.x

    authors： Zoulim F,Buti M,Lok AS

    更新日期：2007-11-01 00:00:00

  • The molecular basis of hepatitis B e antigen (HBeAg)-negative infections.

    abstract：:Hepatitis B e antigen (HBeAg)-negative infections are an unusual form of chronic hepatitis B virus (HBV) infection in which viral replication and liver damage persist despite antibodies against HBeAg. This form of HBV may be associated with fulminant hepatitis. The molecular basis for an HBeAg-minus phenotype has been...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2893.1997.00101.x

    authors： Miyakawa Y,Okamoto H,Mayumi M

    更新日期：1997-01-01 00:00:00

  • Role of nitric oxide synthase genes in hepatitis E virus infection.

    abstract：:Hepatitis E virus (HEV) is the most common cause of endemic and epidemic acute hepatitis. A correlation between iNOS, eNOS polymorphisms, levels and severity of disease has been reported, and here, we examined the role of iNOS and eNOS gene polymorphisms and their levels in HEV-related acute viral hepatitis and acute ...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12186

    authors： Hazam RK,Deka M,Kar P

    更新日期：2014-01-01 00:00:00

  • The epidemiology of hepatitis B virus infection in women of reproductive age in highly endemic areas in China.

    abstract：:We describe the epidemiology of hepatitis B virus (HBV) infection among women of reproductive age residing in areas of China that are highly endemic for chronic HBV, and provide evidence useful for decision-makers to guide strategies for preventing mother-to-child transmission of HBV, and assess the impact of perinata...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12757

    authors： Zheng H,Cui FQ,Wang FZ,Huang LF,Shao XP,Du JF,Li J,Zhou Y,Zheng HZ,Zhuo JT,Zeng XX,Zhang GM,Miao N,Sun XJ,Liang XF,Luo HM

    更新日期：2018-01-01 00:00:00

  • Drug use and phylogenetic clustering of hepatitis C virus infection among people who use drugs in Vancouver, Canada: A latent class analysis approach.

    abstract：:This study estimated latent classes (ie, unobserved subgroups in a population) of people who use drugs in Vancouver, Canada, and examined how these classes relate to phylogenetic clustering of hepatitis C virus (HCV) infection. HCV antibody-positive people who use drugs from two cohorts in Vancouver, Canada (1996-2012...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12758

    authors： Jacka B,Bray BC,Applegate TL,Marshall BDL,Lima VD,Hayashi K,DeBeck K,Raghwani J,Harrigan PR,Krajden M,Montaner JSG,Grebely J Senior

    更新日期：2018-01-01 00:00:00

  • Study on the function of circulating plasmacytoid dendritic cells in the immunoactive phase of patients with chronic genotype B and C HBV infection.

    abstract：:Hepatitis B virus (HBV) infection induces a wide range of chronic liver injury. The mechanism by which HBV evades the immune surveillance system remains obscure. Plasmacytoid dendritic cells (pDCs) seem to be the major endogenous interferon (IFN)-alpha producers and represent one of the most important cell types in th...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2006.00819.x

    authors： Wang K,Fan X,Fan Y,Wang B,Han L,Hou Y

    更新日期：2007-04-01 00:00:00

  • Characterization of hepatitis B virus surface antigen variability and impact on HBs antigen clearance under nucleos(t)ide analogue therapy.

    abstract：:For hepatitis B virus (HBV)-related chronic infection under treatment by nucleos(t)ide analogues (NUCs), HBsAg clearance is the ultimate therapeutic goal but very infrequent. We investigated how HBV envelope protein variability could lead to differential HBsAg clearance on NUCs. For 12 HBV genotype D patients receivin...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12498

    authors： Velay A,Jeulin H,Eschlimann M,Malvé B,Goehringer F,Bensenane M,Frippiat JP,Abraham P,Ismail AM,Murray JM,Combet C,Zoulim F,Bronowicki JP,Schvoerer E

    更新日期：2016-05-01 00:00:00

  • BMI, male sex and IL28B genotype associated with persistently high hepatitis C virus RNA levels among chronically infected drug users up to 23 years following seroconversion.

    abstract：:The natural course of serum HCV RNA levels during chronic infection remains unclear. We investigated HCV RNA levels and factors associated with HCV RNA levels for the entire course from HCV seroconversion. We measured HCV RNA levels of 54 HCV seroconverters from the Amsterdam Cohort Studies among drug users at yearly ...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12303

    authors： Grady BP,Prins M,Rebers S,Molenkamp R,Geskus RB,Schinkel J

    更新日期：2015-03-01 00:00:00

  • Entecavir and tenofovir on renal function in patients with hepatitis B virus-related hepatocellular carcinoma.

    abstract：:The use of tenofovir disoproxil fumarate (TDF) is associated with a risk of renal dysfunction. We investigated whether TDF is associated with the deterioration of renal function in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) requiring frequent computed tomography (CT) evaluations and t...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.13313

    authors： Jeon MY,Lee JS,Lee HW,Kim BK,Park JY,Kim DY,Han KH,Ahn SH,Kim SU

    更新日期：2020-09-01 00:00:00

  • Telbivudine treatment is associated with high hepatitis B e antigen seroconversion and immune modulatory effects in chronic hepatitis B patients.

    abstract：:Chronic hepatitis B (CHB) is characterized by an impaired immune response to hepatitis B virus. Among the nucleos(t)ides used in CHB treatment, telbivudine is associated with the highest rates of hepatitis B e antigen (HBeAg) seroconversion rates, which are similar to those observed with pegylated interferon (PegIFN)....

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章,评审

    doi：10.1111/jvh.12059

    authors： Wang GQ,Ding YP,Dong YH

    更新日期：2013-04-01 00:00:00

  • Diabetes mellitus in chronic hepatitis B and C: prevalence and potential association with the extent of liver fibrosis.

    abstract：:Diabetes mellitus has been reported to have an increased prevalence and to be associated with more severe fibrosis in patients with chronic hepatitis C. We evaluated the prevalence of diabetes mellitus in patients with chronic hepatitis B or C as well as the possible association between presence of diabetes and extent...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2005.00677.x

    authors： Papatheodoridis GV,Chrysanthos N,Savvas S,Sevastianos V,Kafiri G,Petraki K,Manesis EK

    更新日期：2006-05-01 00:00:00

  • Migratory flow and hepatitis delta infection in Italy: A new challenge at the beginning of the third millennium.

    abstract：:In Italy, HDV infection endemicity has greatly decreased overtime. Migratory flow may change this scenario as migrants often come from high HDV endemicity areas. Here, we studied characteristics of HDV infection in Italy, particularly addressed to the birth area of subjects. Chronic HBsAg carriers consecutively referr...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.13310

    authors： Stroffolini T,Ciancio A,Furlan C,Vinci M,Fontana R,Russello M,Colloredo G,Morisco F,Coppola N,Babudieri S,Ferrigno L,Sagnelli C,Sagnelli E

    更新日期：2020-09-01 00:00:00

  • Trends of hepatitis A hospitalizations and costs associated with the hospitalization in Spain (2000-2005).

    abstract：:The objective of this study was to analyse data related to hospitalization, comorbidities, average stays and costs associated with the hospitalization cases of hepatitis A in Spain, during the period between 2000 and 2005. A retrospective, descriptive study of the epidemiological characteristics of hepatitis A patient...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2009.01075.x

    authors： Arteaga A,Carrasco-Garrido P,de Andres AL,de Miguel AG,Jiménez-García R

    更新日期：2009-04-01 00:00:00

  • Frequency and clinical outcomes of flares related to nucleos(t)ide analogue therapy in patients with chronic hepatitis B.

    abstract：:Flares in chronic hepatitis B are often detrimental but sometimes lead to sustained immune control and disease remission. The aim of this study was to estimate the frequency of hepatitis flares which occur during and/or after cessation of nucleos(t)ide analogue (NA) therapy, and to assess their outcomes. In a single c...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2011.01448.x

    authors： Zhang NP,Reijnders JG,Perquin M,Hansen BE,Janssen HL

    更新日期：2011-07-01 00:00:00

  • Assessment of factors associated with pre-diabetes in HCV infection including direct and dynamic measurements of insulin action.

    abstract：:Although hepatitis C (HCV) is associated with diabetes, few studies have examined pre-diabetes in this population. We aimed to evaluate factors associated with pre-diabetes in HCV-infected patients, including direct measurement of insulin action. Ninety-seven non-cirrhotic, non-diabetic and HCV-infected patients under...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2011.01568.x

    authors： Mukhtar NA,Ayala C,Maher JJ,Khalili M

    更新日期：2012-07-01 00:00:00

  • Altered balance between collagen formation and degradation after successful direct-acting antiviral therapy of chronic hepatitis C.

    abstract：:The effect of direct-acting antiviral (DAA) therapy on extracellular matrix (ECM) turnover, a prominent feature of chronic hepatitis C (CHC), is unknown. ECM protein degradation and formation generate fragments reflecting the tissue turnover balance when quantified in the blood. PRO-C3 and PRO-C4 reflect type III and ...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.13416

    authors： Laursen TL,Villesen IF,Leeming DJ,Karsdal MA,Sølund C,Tarp B,Kristensen LH,Holmboe CH,Leutscher P,Laursen AL,Gudmann NS,Grønbaek H

    更新日期：2021-02-01 00:00:00

  • Hepatitis C virus persistence after sustained virological response to antiviral therapy in patients with or without past exposure to hepatitis B virus.

    abstract：:Hepatitis C virus (HCV) and hepatitis B virus (HBV) frequently coinfect and persist long after clinical resolution. We assessed the incidence of low-level (occult) HCV infection (OCI) after sustained virological response (SVR) to standard anti-HCV therapy in individuals with or without past exposure to HBV to recogniz...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2011.01442.x

    authors： Pham TN,Coffin CS,Churchill ND,Urbanski SJ,Lee SS,Michalak TI

    更新日期：2012-02-01 00:00:00

  • Sequential therapy with adefovir dipivoxil and pegylated interferon alfa-2a for HBeAg-negative patients.

    abstract：:To assess the impact of sequential therapy with adefovir dipivoxil (ADV) and pegylated interferon alfa-2a (PEG-IFN) on virological (serum HBV-DNA) and serological (serum HBsAg) response in 20 consecutive HBeAg-negative patients. Patients received ADV for 20 weeks, then ADV and PEG-IFN for 4 weeks and lastly PEG-IFN fo...

    journal_title：Journal of viral hepatitis

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2893.2010.01332.x

    authors： Moucari R,Boyer N,Ripault MP,Castelnau C,Mackiewicz V,Dauvergne A,Valla D,Vidaud M,Chanoine MH,Marcellin P

    更新日期：2011-08-01 00:00:00

  • Long-term clearance of hepatitis C virus following interferon α-2b or peginterferon α-2b, alone or in combination with ribavirin.

    abstract：:Sustained virologic response (SVR) is the standard measure for evaluating response to therapy in patients with chronic hepatitis C (CHC). The aim of this study was to prospectively assess the durability of SVR in the pivotal studies of peginterferon (PEG-IFN) α-2b or IFN α-2b. We conducted two phase 3b long-term follo...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1111/jvh.12074

    authors： Manns MP,Pockros PJ,Norkrans G,Smith CI,Morgan TR,Häussinger D,Shiffman ML,Hadziyannis SJ,Schmidt WN,Jacobson IM,Bárcena R,Schiff ER,Shaikh OS,Bacon B,Marcellin P,Deng W,Esteban-Mur R,Poynard T,Pedicone LD,Brass CA

    更新日期：2013-08-01 00:00:00