Effects of tumor necrosis factor-alpha in vitro on steroidogenesis of healthy and atretic follicles of the rat: theca as a target.

abstract：:The cell of origin of human null cell pituitary adenomas is disputed. Although these tumors, by definition, do not produce any of the anterior pituitary hormones in vivo, they have been shown to express gonadotropin subunit genes, release gonadotropin hormones in vitro, and express the gonadotroph-associated transcrip...

journal_title：Endocrinology

authors： Kumar TR,Graham KE,Asa SL,Low MJ

更新日期：1998-07-01 00:00:00

abstract：:Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin driving GnRH release and neurokinin B (NKB) and dynorphin acting as start and stop signals, respectively. In this study, we tested this hypothesis...

journal_title：Endocrinology

authors： Goodman RL,Hileman SM,Nestor CC,Porter KL,Connors JM,Hardy SL,Millar RP,Cernea M,Coolen LM,Lehman MN

更新日期：2013-11-01 00:00:00

abstract：:A novel NADPH-dependent cytosolic 3,5,3'-triiodo-L-thyronine (T3)-binding protein (CTBP) was purified by sequential fractionation of rat liver cytosol on Q-Sepharose, phenyl-Sepharose, red-Sepharose, and polyacrylamide gel electrophoresis under nondenaturing conditions. The CTBP had a sedimentation coefficient of 5.1S...

journal_title：Endocrinology

authors： Kobayashi M,Hashizume K,Suzuki S,Ichikawa K,Takeda T

更新日期：1991-10-01 00:00:00

abstract：:Insulin resistance and smoking are significant risk factors for cardiac and cerebral vascular diseases. Because vascular smooth muscle cells play a key role in the development and progression of atherosclerosis, we investigated the effect of nicotine on insulin-induced mitogenic signaling in aortic vascular smooth mus...

journal_title：Endocrinology

authors： Wada T,Naito M,Kenmochi H,Tsuneki H,Sasaoka T

更新日期：2007-02-01 00:00:00

abstract：:In situ hybridization histochemistry was used to monitor the expression of 3beta-hydroxysteroid dehydrogenase, delta4-isomerase (3betaHSD) and cytochrome P450 11beta-hydroxylase (P45011beta) messenger RNA (mRNA) in adult rat adrenals after stimulation in vivo. In Exp 1, adrenals were collected from rats injected with ...

journal_title：Endocrinology

authors： Engeland WC,Levay-Young BK,Rogers LM,Fitzgerald D

更新日期：1997-06-01 00:00:00

abstract：:Hepatic synthesis of alpha 2u-globulin and its mRNA in the male rat is dependent on androgen, glucocorticoid, T4, insulin, and GH. Some of these hormones may act directly on the liver, while others may influence alpha 2u-globulin synthesis through indirect physiological changes. In the present study the specific role ...

journal_title：Endocrinology

authors： Murty CV,Rao KV,Roy AK

更新日期：1987-11-01 00:00:00

abstract：:In the present study the effects of stimulus deprivation on vasoactive intestinal peptide (VIP)- and alpha 1-adrenergically mediated amplification of VIP-stimulated cAMP and cGMP accumulation were examined. Dispersed pinealocytes were prepared from either Sprague-Dawley rats maintained for 2 weeks in a normal lighting...

journal_title：Endocrinology

authors： Chik CL,Ho AK

更新日期：1991-02-01 00:00:00

abstract：:Basal hypothalamic deafferentation abolished the nycthemeral rhythm of both plasma TSH and corticosterone. ...

journal_title：Endocrinology

authors： Fukuda H,Greer MA

更新日期：1975-09-01 00:00:00

abstract：:Three members of the progestin and adipoQ receptor (PAQR) family, PAQR-7, PAQR-8, and PAQR-5 [membrane progesterone (P4) receptor (PR) (mPR)α, mPRβ, and mPRγ], function as plasma mPRs coupled to G proteins in mammalian cells, but the characteristics of two other members, PAQR6 and PAQR9 (mPRδ and mPRε), remain unclear...

journal_title：Endocrinology

authors： Pang Y,Dong J,Thomas P

更新日期：2013-01-01 00:00:00

abstract：:Brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) are present in brain regions regulating LH secretion. Similarities in the molecular structure of these peptides suggest similar physiological function within the brain. This study examined the effects of centrally administered BNP and ANP on LH secre...

journal_title：Endocrinology

authors： Zhang J,Yuen BH,Currie WD,Leung PC

更新日期：1991-08-01 00:00:00

abstract：:A diurnal change of tuberoinfundibular dopaminergic (TIDA) neuronal activity exists in female rats, which is prerequisite for the estrogen-induced afternoon PRL surge. Because progesterone (P4) administered in the morning can advance and amplify the PRL surge, it is of interest to learn whether its action involves the...

journal_title：Endocrinology

authors： Yen SH,Pan JT

更新日期：1998-04-01 00:00:00

abstract：:Steady state levels of the mRNAs for alpha 1B, beta 1- and beta 2-adrenergic receptors (alpha 1BAR, beta 1AR, beta 2AR) were quantified by DNA excess solution hybridization assays in the heart, lungs, and liver of rats. Tissues for RNA extraction were obtained from euthyroid and thyroidectomized rats and from thyroide...

journal_title：Endocrinology

authors： Lazar-Wesley E,Hadcock JR,Malbon CC,Kunos G,Ishac EJ

更新日期：1991-08-01 00:00:00

abstract：:The PRL-stimulating effect of metoclopramide (2-methoxy-5-chloroprocainamide) was examined in normal and adrenalectomized male rats pretreated with DL-p-chlorophenylalanine methyl ester (PCPA), an inhibitor of serotonin biosynthesis. PCPA significantly reduced the hypothalamic content of serotonin, increased basal PRL...

journal_title：Endocrinology

authors： Fang VS,Shian LR

更新日期：1981-05-01 00:00:00

abstract：:It has previously only been possible to assess osteoclastic bone resorption in intact bone, where other cell types may modify or mediate osteoclastic responses to environmental agents. We have recently developed techniques which enable us to measure bone resorption by osteoclasts extracted from bone and have used thes...

journal_title：Endocrinology

authors： Chambers TJ,McSheehy PM,Thomson BM,Fuller K

更新日期：1985-01-01 00:00:00

abstract：:It is generally accepted that cholesterol affects dynamic membrane properties and the function of membrane bound proteins involved in secretion processes. In the present study we employed GH4C1 cells treated with human lipoprotein-deficient serum (h-LPDS), exogenous cholesterol and high density lipoprotein (HDL3) to i...

journal_title：Endocrinology

authors： Lasa M,Perez-Caballero FJ,Usera F,Chiloeches A,Montes A,Toro MJ

更新日期：1993-04-01 00:00:00

abstract：:The present study investigated whether activation of the hexosamine biosynthesis pathway might mediate at least in part the high glucose effect on angiotensinogen (ANG) gene expression and immortalized renal proximal tubular cell (IRPTC) hypertrophy. IRPTC were cultured in monolayer. ANG, renin, and beta-actin mRNA ex...

journal_title：Endocrinology

authors： Hsieh TJ,Fustier P,Zhang SL,Filep JG,Tang SS,Ingelfinger JR,Fantus IG,Hamet P,Chan JS

更新日期：2003-10-01 00:00:00

abstract：:The Jar choriocarcinoma cell line was used as an in vitro placental cell model to determine the effects of polypeptide growth factors on hCG beta secretion. Epidermal and fibroblast growth factor (FGF) treatment of serum-free cultures stimulated hCG beta secretion 2.5- and 4.0-fold over basal serum-free control levels...

journal_title：Endocrinology

authors： Oberbauer AM,Linkhart TA,Mohan S,Longo LD

更新日期：1988-12-01 00:00:00

abstract：:The beta-isoform of protein kinase C (PKC) has paradoxically been suggested to be important for both insulin action and insulin resistance as well as for contributing to the pathogenesis of diabetic complications. Presently, we evaluated the effects of knockout of the PKCbeta gene on overall glucose homeostasis and in...

journal_title：Endocrinology

authors： Standaert ML,Bandyopadhyay G,Galloway L,Soto J,Ono Y,Kikkawa U,Farese RV,Leitges M

更新日期：1999-10-01 00:00:00

abstract：:Experiments were performed in vitro to examine the possible role of calcium and calmodulin in GRF-induced somatostatin (SRIF) release from the median eminence. Adult male rats were used as tissue donors. The median eminences were first prestimulated in 0.4 ml Krebs Ringer bicarbonate glucose buffer (pH 7.4) containing...

journal_title：Endocrinology

authors： Aguila MC,McCann SM

更新日期：1988-07-01 00:00:00

abstract：:The effects of morphine on the release of dopamine from tuberoinfundibular neurons and the release of PRL from the anterior pituitary gland were studied in diestrous female rats. Morphine ions ejected iontophoretically in minute quantities into the arcuate nuclei (using one electrode per nucleus) were found to reduce ...

journal_title：Endocrinology

authors： Haskins JT,Gudelsky GA,Moss RL,Porter JC

更新日期：1981-03-01 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) plays an important role in development of the central nervous system and is neurotropic for a variety of neurons. In this study, we investigated whether bFGF is neurotropic for GT1 GnRH neuronal cell lines and if these cells express functional FGF receptors (FGFRs). The GT1 cell l...

journal_title：Endocrinology

authors： Tsai PS,Werner S,Weiner RI

更新日期：1995-09-01 00:00:00

abstract：:The mechanism by which aluminum chloride stimulates de novo bone formation is unknown. To evaluate the role of bone remodeling and mature osteoblastic function in aluminum-induced neoosteogenesis, we compared the osteogenic effects of aluminum in normal beagles to those in animals with low turnover osteomalacia induce...

journal_title：Endocrinology

authors： Quarles LD,Drezner MK

更新日期：1992-07-01 00:00:00

abstract：:Thyroid hormone (T3) is required for postnatal skeletal growth. It exerts its effect by binding to nuclear receptors, TRs including TRα1 and TRβ1, which are present in most cell types. These cell types include chondrocytes and osteoblasts, the interactions of which are known to regulate endochondral bone formation. In...

journal_title：Endocrinology

authors： Desjardin C,Charles C,Benoist-Lasselin C,Riviere J,Gilles M,Chassande O,Morgenthaler C,Laloé D,Lecardonnel J,Flamant F,Legeai-Mallet L,Schibler L

更新日期：2014-08-01 00:00:00

abstract：:Somatostatin (SRIH) inhibits cell proliferation by interacting with five distinct SRIH receptor subtypes (SSTRs) activating several pathways in many tissues. We previously demonstrated that SRIH, by activating Src homology-2-containing protein, inhibits cell proliferation of the human medullary thyroid carcinoma cell ...

journal_title：Endocrinology

authors： Tagliati F,Zatelli MC,Bottoni A,Piccin D,Luchin A,Culler MD,Degli Uberti EC

更新日期：2006-07-01 00:00:00

abstract：:One physiological role for endogenous opioid peptides is to attenuate the release of oxytocin (OT) from the hypothalamo-neurohypophysial system during dehydration and hemorrhage when vasopressin maintains fluid balance and blood pressure. During lactation, OT, which stimulates milk ejection, is released without vasopr...

journal_title：Endocrinology

authors： Hartman RD,Rosella-Dampman LM,Summy-Long JY

更新日期：1987-08-01 00:00:00

abstract：:Nitric oxide is a ubiquitous estrogen-regulated signaling molecule that has been implicated in the regulation of bone maturation and remodeling. To better understand the role that bone-cell-secreted nitric oxide plays in ovariectomy-induced modifications of bone turnover, we examined the expression of endothelial NO s...

journal_title：Endocrinology

authors： Grassi F,Fan X,Rahnert J,Weitzmann MN,Pacifici R,Nanes MS,Rubin J

更新日期：2006-09-01 00:00:00

abstract：:To investigate the physiological role of GRF and somatostatin (SRIF) in GH secretion in adult male rats, we prepared in vitro models using the perifusion system of cultured rat anterior pituitary cells exposed to various combinations of human GRF-(1-44)NH2 (hGRF) and SRIF. We studied the following three models on GRF ...

journal_title：Endocrinology

authors： Sato M,Takahara J,Fujioka Y,Niimi M,Irino S

更新日期：1988-10-01 00:00:00

abstract：:Liver receptor homolog-1 (LRH-1) is an orphan nuclear receptor that belongs to the NR5A subgroup of nuclear receptors. LRH-1 induces key genes to regulate metabolic process, ovarian function, cancer cell proliferation, and steroidogenesis. In the breast, LRH-1 modulates and synergizes with endogenous estrogen signalin...

journal_title：Endocrinology

authors： Lazarus KA,Brown KA,Young MJ,Zhao Z,Coulson RS,Chand AL,Clyne CD

更新日期：2014-05-01 00:00:00

abstract：:Inflammatory mediators, such as cytokines and prostaglandins, play a fundamental role in estrogen-dependent breast cancer through their ability to up-regulate aromatase expression and subsequent local production of estrogens in the breast. To study the link between estrogens and inflammation further, we examined the r...

journal_title：Endocrinology

authors： Frasor J,Weaver AE,Pradhan M,Mehta K

更新日期：2008-12-01 00:00:00

abstract：:We have recently demonstrated that 17beta-estradiol (E2) opposes cytokine-dependent increase of inducible nitric oxide synthase (iNOS) activity in rat smooth muscle cells and proposed that this effect might be associated to an antiinflammatory activity of this hormone. In the present study, we examine the E2 effects o...

journal_title：Endocrinology

authors： Cuzzocrea S,Santagati S,Sautebin L,Mazzon E,Calabrò G,Serraino I,Caputi AP,Maggi A

更新日期：2000-04-01 00:00:00