Abstract:
PURPOSE:Carnosol is a phenolic diterpene that has potent antioxidant and anti-inflammatory activities. The purpose of this study was to investigate the preconditioning effects of carnosol on lung injury induced by intestinal ischemia/reperfusion (II/R). METHODS:Rats were divided into control, II/R, and carnosol groups. The II/R model was established by clamping the superior mesenteric artery for 1 h and reperfusion at 2, 4, and 6 h after ischemia. The carnosol group received 3 mg/kg carnosol intraperitoneally 1 h before the operation. The rats were then euthanized, and blood and lung specimens were obtained for analysis. RESULTS:The II/R induced lung injury, characterized by histological changes and significant increasing of bronchoalveolar lavage fluid protein. The activity of lung tissue superoxide was weakened, the tissue myeloperoxidase activity and serum interleukin-6 level increased significantly in II/R groups. A strong positive expression of lung intercellular adhesion molecule-1 (ICAM-1) and nuclear factor kappa B (NF-kappaB) were observed. Pretreatment with carnosol markedly reduced lung injury by increasing the tissue superoxide activity and decreasing the myeloperoxidase activity and interleukin-6 level, which was parallel to the decreased expression of ICAM-1 and NF-kappaB. CONCLUSION:Carnosol was able to ablate lung injury induced by II/R, partly attributed to the inhibition of NF-kappaB activation.
journal_name
Surg Todayjournal_title
Surgery todayauthors
Tian XF,Yao JH,Zhang XS,Zheng SS,Guo XH,Wang LM,Wang ZZ,Liu KXdoi
10.1007/s00595-009-4170-ysubject
Has Abstractpub_date
2010-09-01 00:00:00pages
858-65issue
9eissn
0941-1291issn
1436-2813journal_volume
40pub_type
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