Abstract:
PURPOSE:The aim of this study was to investigate the effects of untreated and treated hypertension on abdominal wall healing. METHODS:Thirty-two spontaneously hypertensive rats (SHR) were randomly allocated into two groups: H (n = 16), untreated and E (n = 16), treated with enalapril (40 mg/kg per day). Group C (n = 16) was a nonhypertensive control group. The animals of each group were submitted to a midline laparotomy and randomly divided, according to the day on which they were killed (7th or 14th postoperative day), into subgroups of 8 animals, as follows: H-7, H-14, E-7, E-14, C-7 and C-14. On the day of their deaths, two strips of the anterior abdominal wall were collected. One strip was submitted to breaking strength measurement and the other to hydroxyproline determination. RESULTS:No mortalities or complications were observed in the six subgroups. The breaking strength in E-7 subgroup was significantly lower than in C-7 (P < 0.05). The tissue hydroxyproline levels were similar in all six subgroups (P > 0.05). CONCLUSIONS:Untreated hypertension had no effect on the abdominal wall healing of rats. Hypertensive animals treated with enalapril showed a significant decrease in abdominal wound-breaking strength on the 7th postoperative day.
journal_name
Surg Todayjournal_title
Surgery todayauthors
Tostes JM,Watanabe AL,Watanabe LMdoi
10.1007/s00595-006-3368-5subject
Has Abstractpub_date
2007-01-01 00:00:00pages
215-9issue
3eissn
0941-1291issn
1436-2813journal_volume
37pub_type
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