Phase II study of weekly paclitaxel by one-hour infusion for advanced gastric cancer.


PURPOSE:A phase clinical II trial was conducted to determine the antitumor activity and toxicity of weekly paclitaxel administered to patients with advanced gastric cancer. METHODS:Sixty-eight patients with advanced gastric cancer and performance status 0-2 were treated with 80 mg/m2 paclitaxel over 1 h following a short course of premedication with dexamethasone, diphenhydramine, and ranitidine administered 30 min prior to the delivery of the paclitaxel. In principle, the treatment was repeated weekly for three courses, followed by a 1-week rest. RESULTS:Objective responses were observed in 12 of 68 patients (17.6%; 95% confidence interval: 9.5%-28.8%). Two of fourteen (14.2%) patients with no prior chemotherapy and 10 of 54 (18.5%) patients previously treated for metastatic disease developed a partial response. The median therapeutic duration and the median survival time were 96 days and 222 days, respectively. In 212 (85.5%) of 248 total cycles, the original dose of 80 mg/m2 of paclitaxel was administered and was well tolerated. Fourteen of 68 patients (20.1%) experienced grade 3 or 4 neutropenia. Grade 1 or 2 peripheral neuropathy occurred in 10 patients (14.7%). CONCLUSION:Weekly paclitaxel therapy is an active and safe treatment for advanced gastric cancer.


Surg Today


Surgery today


Emi Y,Yamamoto M,Takahashi I,Orita H,Kakeji Y,Kohnoe S,Maehara Y




Has Abstract


2008-01-01 00:00:00












  • Efficacy of transumbilical laparoscopic-assisted appendectomy for appendicitis: a four-year experience at a single center.

    abstract:PURPOSE:To compare the surgical outcomes after transumbilical laparoscopic-assisted appendectomy (TULAA) and open appendectomy (OA) at a single institution. METHODS:We compared the surgical outcomes for 94 consecutive patients who underwent TULAA between April 2010 and March 2014 to those for 91 consecutive patients w...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Koizumi N,Kobayashi H,Nakase Y,Takagi T,Fukumoto K

    更新日期:2015-10-01 00:00:00

  • Successful surgical treatment for spontaneous retroperitoneal hematoma in polycythemia vera: report of a case.

    abstract::Bleeding is a common complication of such myeloproliferative disorders as polycythemia vera, and it usually occurs in either the skin or mucosa. We experienced a case of a massive retroperitoneal hematoma with no history of trauma in association with polycythemia vera. A 68-year-old man was referred to our hospital as...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Ishihara S,Yasuhara H,Ogawa S,Muto T

    更新日期:2000-01-01 00:00:00

  • The occurrence of a strangulated ileus due to a traumatic transmesenteric hernia: report of a case.

    abstract::We report herein the case of a 6-year-old boy in whom a strangulated ileus was caused by a traumatic transmesenteric hernia. The boy had fallen from his bicycle and suffered a severe blow to the abdomen. Abdominal pain and vomiting developed 10 h after the accident and he was admitted to our hospital. Abdominal ultras...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Kuga T,Taniguchi S,Inoue T,Zempo N,Esato K

    更新日期:2000-01-01 00:00:00

  • Laparoscopic surgery for splenic injuries in the era of non-operative management: current status and future perspectives.

    abstract::The spleen is one of the organs most commonly injured by blunt abdominal trauma. It plays an important role in immune response to infections, especially those sustained by encapsulated bacteria. Nonoperative management (NOM), comprising clinical and radiological observation with or without angioembolization, is the tr...

    journal_title:Surgery today

    pub_type: 杂志文章,评审


    authors: Romeo L,Bagolini F,Ferro S,Chiozza M,Marino S,Resta G,Anania G

    更新日期:2020-11-16 00:00:00

  • Chylothorax due to tuberculosis lymphadenopathy: report of a case.

    abstract::While pulmonary tuberculosis is a very frequent infection, chylothorax is an unusual manifestation of tuberculous disease. A 71-year-old woman with chylothorax is herein presented. The ductus thoracicus was ligated and lymphadenomegaly, which was adjacent to diaphragm, was resected. Based on the findings of various te...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Karapolat S,Sanli A,Onen A

    更新日期:2008-01-01 00:00:00

  • The development of a pyogenic liver abscess following radical resection of cholangiocellular carcinoma with ligation of the right hepatic artery: report of a case.

    abstract::We present herein the case of a pyogenic liver abscess developing from hepatic ischemia caused by resection of the right hepatic artery when a left hemihepatectomy with caudate lobectomy and extrahepatic bile duct resection was performed for cholangiocellular carcinoma. Postoperative cholangiography revealed communica...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Tanaka K,Nishimura A,Hombo K,Furoi A,Ikoma A,Yamauchi T,Taira A

    更新日期:1994-01-01 00:00:00

  • Surgical treatment of giant liver hydatid cysts: comparison of cystojejunostomy and partial cystectomy.

    abstract:PURPOSE:The aim of this study was to compare partial cystectomy and internal drainage of the cyst cavity with cystojejunostomy for the surgical treatment of giant hepatic hydatid cysts. METHODS:Patients who underwent any type of surgical treatment between March 2009 and May 2013 for giant hepatic hydatid cysts were re...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Acar F,Sahin M,Alptekin H,Yılmaz H,Kafalı ME

    更新日期:2014-11-01 00:00:00

  • Lung cancer associated with Sweet's syndrome: report of a case.

    abstract::Lung cancer associated with Sweet's syndrome is extremely rare. There are only seven reports of such cases. As far as could be determined from a comprehensive search, there is no reported operative case of lung cancer with this syndrome in the world literature. A 75-year-old Japanese man was diagnosed as having Sweet'...

    journal_title:Surgery today

    pub_type: 杂志文章,评审


    authors: Arai H,Rino Y,Yamanaka S,Suganuma N,Yukawa N,Wada N,Hara S,Hirokado M,Oshiro H,Masuda M

    更新日期:2008-01-01 00:00:00

  • The relationship of a Helicobacter heilmannii infection to the mucosal changes in abattoir and laboratory pig stomach.

    abstract:PURPOSE:A pig ulcer model in which ulceration is reproducibly induced in the pars oesophagea (a tongue of the oesophageal squamous epithelium that extends into the pig stomach) by bile duct ligation (BDL) was used in this study to determine whether Helicobacter heilmannii (Hh) is a predisposing factor in the ulceration...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Mall AS,Suleman N,Taylor K,Kidd M,Tyler M,Lotz Z,Hickman R,Kahn D

    更新日期:2004-01-01 00:00:00

  • Robotic versus laparoscopic surgery for rectal cancer: an overview of systematic reviews with quality assessment of current evidence.

    abstract:PURPOSE:The clinical benefits of robotic surgery for patients with rectal cancer have been reported and many systematic reviews have been published. However, they have investigated a variety of outcomes and differ remarkably in quality. In this overview, we summarize the findings of these reviews and evaluate their qua...

    journal_title:Surgery today

    pub_type: 杂志文章,评审


    authors: Hoshino N,Sakamoto T,Hida K,Sakai Y

    更新日期:2019-07-01 00:00:00

  • Intrahepatic cholangiocarcinoma with lymph node metastasis successfully treated by immunotherapy with CD3-activated T cells and dendritic cells after surgery: report of a case.

    abstract::Intrahepatic cholangiocarcinoma (ICC) with lymph node (LN) metastasis is generally associated with a poor prognosis. However, we treated ICC with LN metastasis successfully by surgery and postoperative immunotherapy in a 59-year-old woman. The immunotherapy consisted of CD3-activated T cells and tumor lysate- or pepti...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Higuchi R,Yamamoto M,Hatori T,Shimizu K,Imai K,Takasaki K

    更新日期:2006-01-01 00:00:00

  • Current status of robotic gastrectomy for gastric cancer.

    abstract::Although over 3000 da Vinci Surgical System (DVSS) devices have been installed worldwide, robotic surgery for gastric cancer has not yet become widely spread and is only available in several advanced institutions. This is because, at least in part, the advantages of robotic surgery for gastric cancer remain unclear. T...

    journal_title:Surgery today

    pub_type: 杂志文章,评审


    authors: Obama K,Sakai Y

    更新日期:2016-05-01 00:00:00

  • Postoperative outcome of insufficient surgery for small differentiated thyroid carcinoma.

    abstract::We performed conservative surgery for small differentiated thyroid carcinoma, but also inadvertently carried out minimal insufficient surgery, such as enucleation (Ex) or partial lobectomy (pLx) without regional node dissection for malignant thyroid nodules. In this study, the long-term postoperative outcome after suc...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Shingu K,Sugenoya A,Kobayashi S,Kasuga Y,Fujimori M,Asanuma K,Hama Y,Ito K,Maruyama M,Itoh N,Amano J

    更新日期:1997-01-01 00:00:00

  • Preoperative endoscopic tattooing using India ink to determine the resection margins during totally laparoscopic distal gastrectomy for gastric cancer.

    abstract:PURPOSE:This study was conducted to determine whether establishing the proximal resection line using India ink tattooing can ensure safe resection margins during totally laparoscopic distal gastrectomy. METHODS:This retrospective study included 81 patients who underwent totally laparoscopic distal gastrectomy for gast...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Yamazaki Y,Kanaji S,Takiguchi G,Urakawa N,Hasegawa H,Yamamoto M,Matsuda Y,Yamashita K,Matsuda T,Oshikiri T,Nakamura T,Suzuki S,Kakeji Y

    更新日期:2021-01-01 00:00:00

  • A rare point mutation in the Ras oncogene in hepatocellular carcinoma.

    abstract:PURPOSE:The Ras gene is one of the oncogenes most frequently detected in human cancers, and codes for three proteins (K-, N-, and H-Ras). The aim of this study was to examine the mutations in codons 12, 13 and 61 of the three Ras genes in cases of human hepatocellular carcinoma (HCC). METHODS:Paired samples of HCC and...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Taketomi A,Shirabe K,Muto J,Yoshiya S,Motomura T,Mano Y,Ikegami T,Yoshizumi T,Sugio K,Maehara Y

    更新日期:2013-03-01 00:00:00

  • Human skin xenograft rejection in CD45 exon-6 knockout mice: the implication of involvement of a direct pathway.

    abstract::The results of previous studies indicate that only CD4+ T cells generated via the indirect pathway play an essential role in causing discordant skin xenograft rejection. The present study was conducted in an attempt to clarify further the roles of effector T cells generated via direct pathways on discordant xenograft ...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Tomita Y,Uchida T,Zhang QW,Shimizu I,Iwai T,Yoshikawa M,Kishihara K,Nomoto K,Yasui H

    更新日期:2000-01-01 00:00:00

  • The importance of neural invasion (NI) as a prognostic factor in diffuse invasive gastric cancer.

    abstract::The relationship between histological factors, including neural invasion (NI), and survival rates in patients with Borrmann type IV diffuse invasive gastric cancer was examined to determine the significance of NI as a prognostic factor. NI was studied histochemically in 75 patients who underwent resection after 1982, ...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Tanaka A,Yoshikawa H,Okuno K,Koh K,Watatani M,Matsumura E,Yasutomi M

    更新日期:1997-01-01 00:00:00

  • The occurrence of an abdominal wall abscess 11 years after appendectomy: report of a case.

    abstract::Most complications after appendectomy occur within 10 days; however, we report herein the unusual case of a patient in whom a wound abscess was detected more than 10 years after an appendectomy. A 26-year-old woman presented to our hospital with nausea and vomiting, pain, and a mass in the right lower abdominal wall. ...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Matsuda K,Masaki T,Toyoshima O,Ono M,Muto T

    更新日期:1999-01-01 00:00:00

  • Bracy procedure with ductal mucosal pancreaticogastrostomy and an internal stent for pancreatic complex deep injury: how to do it.

    abstract::Pancreatic complex deep injury extending to the main pancreatic duct (MPD), caused by strong external forces such as traffic accidents, is lethal without emergency surgery. However, the best surgical procedure for this serious injury has not been established. The Bracey procedure is a relatively simple reconstructive ...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Shimizu T,Kittaka H,Taniguchi K,Uchiyama K,Akimoto H

    更新日期:2018-09-01 00:00:00

  • Phase III trial comparing UFT + PSK to UFT + LV in stage IIB, III colorectal cancer (MCSGO-CCTG).

    abstract:PURPOSE:Oral adjuvant uracil and tegafur plus leucovorin (UFT/LV) is not inferior to standard weekly fluorouracil and folinate for stage II/III colon cancer. However, protein-bound polysaccharide K (PSK) has been evaluated as postoperative adjuvant therapy for colorectal cancer. This report is the first of MCSGO-CCTG, ...

    journal_title:Surgery today

    pub_type: 杂志文章,多中心研究


    authors: Miyake Y,Nishimura J,Kato T,Ikeda M,Tsujie M,Hata T,Takemasa I,Mizushima T,Yamamoto H,Sekimoto M,Nezu R,Doki Y,Mori M,Multi-center Clinical Study Group of Osaka, Colorectal Cancer Treatment Group (MCSGO).

    更新日期:2018-01-01 00:00:00

  • Hemodynamic and humoral effects of atrial natriuretic peptide on pulmonary circulation after cardiac surgery.

    abstract:PURPOSE:Human atrial natriuretic peptide (h-ANP) elicits biological effects such as natriuresis, diuresis, and vasodilation, and plays a role in regulating pulmonary circulation. We conducted this clinical study to define its role and elucidate its mechanisms. METHODS:Twelve consecutive adult patients scheduled to und...

    journal_title:Surgery today

    pub_type: 临床试验,杂志文章


    authors: Morimoto K,Taniguchi I,Miyasaka S,Ishiguro S,Ohgi S

    更新日期:2008-01-01 00:00:00

  • Surgical management of a graftenteric fistula: a modified method of in situ reconstruction.

    abstract::Between December 1989 and May 1998, we performed a modified method of in situ reconstruction on three of seven patients with graftenteric fistulas (GEFs) at the Kurume University Hospital. The modification involved performing an anastomosis of the infrarenal abdominal aorta and running a new prosthesis through the lef...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Akashi H,Tayama K,Tanaka A,Onitsuka S,Sakashita H,Aoyagi S

    更新日期:2001-01-01 00:00:00

  • Intrahepatic cholangiocarcinoma arising 28 years after excision of a type IV-A congenital choledochal cyst: report of a case.

    abstract::This report presents a rare case of intrahepatic cholangiocarcinoma (IHCC) arising 28 years after excision of a type IV-A congenital choledochal cyst. The patient underwent excision of a congenital choledochal cyst (Todani's type IV-A) at 12 years of age, with Roux-en-Y hepaticojejunostomy reconstruction. She received...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Kumamoto T,Tanaka K,Takeda K,Nojiri K,Mori R,Taniguchi K,Matsuyama R,Ueda M,Sugita M,Ichikawa Y,Nagashima Y,Endo I

    更新日期:2014-02-01 00:00:00

  • Long-term outcomes after an aggressive resection of adenosquamous carcinoma of the pancreas.

    abstract:PURPOSE:Adenosquamous carcinoma (ASC) of the pancreas is a rare malignancy, associated with a poor prognosis after surgical resection, with reported median survival times (MSTs) ranging from 4.4 to 13.1 months. We conducted this study to investigate the long-term outcomes of patients after the resection for ASC. METHO...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Ito T,Sugiura T,Okamura Y,Yamamoto Y,Ashida R,Ohgi K,Sasaki K,Uesaka K

    更新日期:2019-10-01 00:00:00

  • Surgical removal of a denture with sharp clasps impacted in the cervicothoracic esophagus: report of three cases.

    abstract::We report three cases of successful surgical removal of a denture with sharp clasps impacted in the cervical esophagus. Patient 1 was a 57-year-old woman institutionalized for over 30 years for schizophrenia, patient 2 was a 62-year-old man hospitalized for brain paralysis, and patient 3 was a 64-year-old man sufferin...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Toshima T,Morita M,Sadanaga N,Yoshida R,Yoshinaga K,Saeki H,Kakeji Y,Maehara Y

    更新日期:2011-09-01 00:00:00

  • Emergent laparoscopic cholecystectomy for acute acalculous cholecystitis revisited.

    abstract:PURPOSE:To compare the safety of emergent laparoscopic cholecystectomy for acute acalculous cholecystitis (AAC) with surgery for acute calculous cholecystitis (ACC). METHODS:We retrospectively reviewed the perioperative records of 111 patients who underwent emergent laparoscopic cholecystectomy for acute cholecystitis...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Ueno D,Nakashima H,Higashida M,Yoshida K,Hino K,Irei I,Moriya T,Matsumoto H,Hirai T,Nakamura M

    更新日期:2016-03-01 00:00:00

  • Risk factors and measures of pulmonary complications after thoracoscopic esophagectomy for esophageal cancer.

    abstract:PURPOSE:Postoperative pulmonary complications (PCs) after thoracoscopic esophagectomy for esophageal cancer (EC) still occur too frequently. We conducted this study to identify the risk factors for PCs developing in EC patients who undergo thoracoscopic esophagectomy. METHODS:The subjects of this retrospective study w...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Ohi M,Toiyama Y,Omura Y,Ichikawa T,Yasuda H,Okugawa Y,Fujikawa H,Okita Y,Yoshiyama S,Hiro J,Araki T,Kusunoki M

    更新日期:2019-02-01 00:00:00

  • Successful perioperative management of patients with Parkinson's disease following gastrointestinal surgery: report of three cases.

    abstract::Parkinson's disease is a chronic progressive disease with symptoms of tremors, rigidity, and akinesia. Parkinson's disease is a major risk factor for postoperative complications and it is difficult to manage patients with Parkinson's disease after gastrointestinal surgery. This report presents the cases of three patie...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Fujii T,Nakabayashi T,Hashimoto S,Kuwano H

    更新日期:2009-01-01 00:00:00

  • Splenic arterial hemorrhage in pancreatitis: report of three cases.

    abstract::Gastrointestinal hemorrhage is a rare complication of pancreatitis and can involve any of the peripancreatic vessels. The three cases reported herein illustrate the involvement of the splenic artery in diverse forms of pancreatitis: chronic pancreatitis, a pancreatic pseudocyst, and necrotizing pancreatitis. Bleeding ...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Singh G,Lobo DR,Jindal A,Marwaha RK,Khanna SK

    更新日期:1994-01-01 00:00:00

  • Low metabolic activity in primary gastric adenocarcinoma is associated with resistance to chemoradiation and the presence of signet ring cells.

    abstract:PURPOSES:Preoperative chemoradiation is a potential treatment option for localized gastric adenocarcinoma (GAC). Currently, the response to chemoradiation cannot be predicted. We analyzed the pretreatment maximum standardized uptake value (SUVmax) and total lesion glycolysis (TLG) on positron emission tomography/comput...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Harada K,Patnana M,Wang X,Iwatsuki M,Murphy MAB,Zhao M,Das P,Minsky BD,Weston B,Lee JH,Bhutani MS,Estrella JS,Shanbhag N,Ikoma N,Badgwell BD,Ajani JA

    更新日期:2020-10-01 00:00:00