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Microarray analysis of differentially expressed genes in vaginal tissues in postmenopausal women. The role of stress urinary incontinence.

Abstract：

INTRODUCTION AND HYPOTHESIS:This study aimed to explore gene expression and their regulatory mechanisms in etiology of stress urinary incontinence (SUI). METHODS:Tissue samples were taken from the paraurethral vaginal wall from three pairs of postmenopausal, age/body mass index/parity-matched SUI, and continent women and subjected to microarray analysis using the Affymetrix GeneChip® Human Genome U133 Plus 2.0 oligonucleotide chip set. The significantly differentially expressed genes and their protein expression were confirmed by quantitative PCR and Western blot. RESULTS:Seventy-five differentially expressed genes were listed; 31 genes were upregulated in SUI group, while 44 were downregulated. Gene metabolic pathway analysis showed that solutable N-ethylmaleimide-sensitive factor attachment protein receptor signaling pathway and neurodegenerative disorder pathway were the most predominant. CONCLUSIONS:Apolipoprotein E, growth factor receptor-bound protein 2, Golgi SNAP receptor complex member 1, and glucosidase, beta, acid may play a neurodegenerative role in SUI development.

journal_name

Int Urogynecol J

journal_title

International urogynecology journal

authors

Tong J,Lang J,Zhu L

doi

10.1007/s00192-010-1222-1

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

1545-51

issue

12

eissn

0937-3462

issn

1433-3023

journal_volume

21

pub_type

杂志文章

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