Abstract:
INTRODUCTION AND HYPOTHESIS:Bladder pain syndrome (BPS) is a disease of unknown etiology defined as an unpleasant sensation related to the bladder, associated with lower urinary tract symptoms of more than 6 weeks' duration, in the absence of any identifiable causes. Despite its impact on quality of life (QoL) and socioeconomic burden, there are no objective methods for the diagnosis or assessment of therapeutic response. We systematically reviewed biomarkers associated with BPS to update the current knowledge on this issue. METHODS:A systematic review of the Cochrane Library, Embase, PubMed/MEDLINE, LILACS, SCOPUS, and ClinicalTrials.gov databases was conducted following the PRISMA statement. Original articles investigating biomarkers for the diagnosis or symptom assessment of patients with BPS were assessed; no language restrictions were applied. Animal or post-mortem studies were excluded. RESULTS:Of the 478 records retrieved, 11 articles were included. MIF, NGF, Etio-S, APF, and a combined methylhistamine/Il-6 model were increased in BPS urine samples versus controls. Also increased were glyceraldehyde in stool, in addition to the expression of some genes (ARID1A, ARF, CHAT, eNOS, GLI-1, iNOS, MCP-1, NGF, WNT-8A, WNT-10A), nerve density, IL-16, VCAM-1, and ICAM-1 in bladder tissue specimens. In contrast, some fecal bacteria, expression of other genes (CHT, HB-EGF, OCT-1, SMRT-1, WNT11) in the bladder urothelium, and urinary DNA methylation in CpG-sites, MCP-3, G5P1, and HB-EGF were decreased in BPS. As none of the biomarkers was studied more than once, a Forest plot could not be constructed. Only 4 articles reported the relation of biomarkers to symptom scores. CONCLUSIONS:Potential biomarkers for BPS in urine, stool, and bladder biopsy specimens are described. Further research is needed before their use in clinical practice.
journal_name
Int Urogynecol Jjournal_title
International urogynecology journalauthors
Magalhaes TF,Baracat EC,Doumouchtsis SK,Haddad JMdoi
10.1007/s00192-019-04075-9subject
Has Abstractpub_date
2019-11-01 00:00:00pages
1785-1794issue
11eissn
0937-3462issn
1433-3023pii
10.1007/s00192-019-04075-9journal_volume
30pub_type
杂志文章abstract::The number of women suffering from pelvic floor disorders (PFD) is likely to grow significantly in the coming years with a growing older population. There is an urgent need to investigate factors contributing to the development of PFD and develop preventative strategies. We have reviewed the literature and analyzed re...
journal_title:International urogynecology journal
pub_type: 杂志文章,评审
doi:10.1007/s00192-011-1530-0
更新日期:2012-02-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Double Incontinence (DI) is incontinence of urine and stool and is an extreme manifestation of pelvic floor dysfunction. The objective of this study was to estimate the prevalence and incidence of DI and the risk factors in elderly women in São Paulo, Brazil. METHODS:This was a prospective ...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-017-3365-9
更新日期:2018-02-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Vaginal bulging is considered the key symptom for genital organ prolapse. The aim was to investigate the age-related prevalence and frequency of symptomatic pelvic organ prolapse (sPOP) and other pelvic floor symptoms in nonpregnant nullipara aged 25-64 years. METHODS:This national postal a...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-018-3684-5
更新日期:2019-04-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Lower tract urinary symptoms are underestimated by women as well as health professionals. The objective of this study was to evaluate the behavior of adult women with urinary incontinence and overactive bladder symptoms in seeking medical treatment. METHODS:Two hundred ninety-two women betw...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-010-1352-5
更新日期:2011-07-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:The object of this review was to assess the efficacy and safety of urethral bulking agents (UBA), principally Macroplastique and Bulkamid, in the treatment of female stress urinary incontinence (SUI). METHODS:MEDLINE® and EMBASE® databases were systematically searched up to June 2016. Year ...
journal_title:International urogynecology journal
pub_type: 杂志文章,评审
doi:10.1007/s00192-017-3278-7
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:There is a difference of opinion in the literature as to whether pelvic organ prolapse (POP) is a direct cause of female sexual dysfunction (FSD). Sexual function in women is negatively impacted by the presence of urinary symptoms. Thus, sexual dysfunction (SD) might be improved, unchanged, ...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-017-3500-7
更新日期:2018-06-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Several studies have indicated depression and anxiety to be associated with urinary incontinence (UI), however, the strength of the associations varies widely. The objective of this study was to determine these associations in a large survey. METHODS:In a cross-sectional population-based su...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-011-1564-3
更新日期:2012-03-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:The aim of the study was to determine whether a 6-week course of 5 mg of solifenacin succinate used to treat mixed incontinence, produces measurable changes in the appearance of the urethral sphincter. METHODS:Twenty-six women undergoing treatment for mixed incontinence were recruited from ...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-011-1410-7
更新日期:2011-08-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:A concern when using the retropubic tension-free vaginal tape (TVT) for stress urinary incontinence (SUI) is bladder perforation. This article describes a technique hypothesised to reduce the risk of intra-operative bladder perforation, termed the large space of Retzius infiltration (LSORI) ...
journal_title:International urogynecology journal
pub_type: 杂志文章,多中心研究
doi:10.1007/s00192-018-3730-3
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:Our aim was to identify drivers of and barriers to help-seeking behaviour of older women with pelvic floor dysfunction (PFD) living independently in Australia . METHODS:Women aged ≥55 years were recruited to this cross-sectional study during July and August 2016. Bladder, bowel, pelvic organ prolapse (POP) a...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-018-3618-2
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:This study aims to determine what women with overactive bladder (OAB) perceive as 'cure', assesses treatment acceptability and adverse events. It also determines impact on quality of life (QoL) and correlates it with expectations from therapy. METHODS:In 153 women with predominant OAB sympt...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-009-1049-9
更新日期:2010-04-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Urinary incontinence (UI) is common among the elderly, but the literature is sparse on the surgical treatment of UI among the elderly. This systematic review aims to assess the effectiveness of surgical interventions as treatment for urinary incontinence in the elderly population ≥65 years o...
journal_title:International urogynecology journal
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00192-014-2573-9
更新日期:2015-08-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:No previous studies have investigated the efficacy of mirabegron 50 mg as the first-line therapy in OAB patients. Hence, the primary objective of this study was to evaluate the efficacy of mirabegron in treatment-naive patients in comparison with those who had discontinued antimuscarinic the...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-016-3219-x
更新日期:2017-07-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:A process of added qualification of transvaginal mesh (TVM) placement is desirable. METHODS:Through a physician-led partnership of specialty societies, centers of excellence, and industry, a core curriculum encompassing mesh/graft biology, technical skills, and safety can be coupled with cu...
journal_title:International urogynecology journal
pub_type: 共识发展会议,杂志文章
doi:10.1007/s00192-012-1679-1
更新日期:2012-04-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Currently, there is no global outcome assessment index in prolapse research. Patient Global Impression of Improvement (PGI-I) has only been validated in incontinence. Our aim was to validate its use following prolapse surgery. METHODS:Women with prolapse were recruited from waiting lists an...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-009-1069-5
更新日期:2010-05-01 00:00:00
abstract::A pubic cartilaginous cyst is a rare condition and is considered a result of degenerative changes in the symphysis pubis, mainly described in elderly multiparous women. There are only a few reported cases in the literature, and patients presented most frequently with a painful vaginal/vulvar mass. This case report is ...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-014-2523-6
更新日期:2015-03-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:a terminology and standardized classification has yet to be developed for those complications arising directly from the insertion of synthetic (prostheses) and biological (grafts) materials in female pelvic floor surgery. METHODS:this report on the above terminology and classification combi...
journal_title:International urogynecology journal
pub_type: 共识发展会议,杂志文章
doi:10.1007/s00192-010-1324-9
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:The effect of incontinence pessaries for urine incontinence (UI) has previously been described in studies from high-income countries, where they have been documented to reduce urinary leakage significantly. However, there is a profound literature gap in these data in low- and middle-income c...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-019-03980-3
更新日期:2020-06-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:The objective of this video is to demonstrate a variety of available techniques that can be used in the management of acute presacral bleeding. METHODS:In this video, we demonstrate different methods for the management of presacral bleeding utilizing a fresh frozen cadaver. RESULTS:Presacr...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-019-03995-w
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Objective outcome measures of the extent of laceration at delivery are needed. In this study we evaluated and describe here a method for learning perineal ultrasound measurement of the anovaginal distance (AVD). The learning period needed for examiners proficient in vaginal ultrasound examin...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-017-3392-6
更新日期:2018-05-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Little data are available on the outcome of tension-free obturator tape (TVT-O) procedures in obese and overweight women. We hypothesized that the subjective and objective outcomes of TVT-O in women with a higher body mass index (BMI) would differ from those with a lower BMI. METHODS:We ret...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-010-1311-1
更新日期:2011-03-01 00:00:00
abstract::A 56-year-old female smoker presented after long diagnostic delay with high-grade transitional cell carcinoma in situ within a urethral diverticulum. This is the third report of this type in the literature. Preoperative investigations, including urine cytology and magnetic resonance imaging (MRI), were not helpful. ...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-012-1789-9
更新日期:2012-12-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:The aim of this study was to determine the predictive value of urodynamics to reproduce clinical findings of urinary frequency (UF), urge urinary incontinence (UUI), and/or stress urinary incontinence (SUI). METHODS:We retrospectively reviewed the data of patients diagnosed with UF, UUI, an...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-010-1180-7
更新日期:2010-10-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:The incidence of vesico-vaginal fistulas after hysterectomies for benign indications in developed countries is less than one percent. The objective of this video is to demonstrate an easy-to-follow, step-by-step approach to repairing a small, uncomplicated vesico-vaginal fistula transvaginal...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-017-3471-8
更新日期:2018-05-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Mediolateral episiotomy is one of the most frequent surgical interventions performed in obstetrics. There is conflicting evidence as to whether mediolateral episiotomy reduces the risk of obstetric anal sphincter injuries (OASI). Recent studies suggest that functional asymmetry of pelvic flo...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-018-3560-3
更新日期:2018-10-01 00:00:00
abstract:INTRODUCTION:High levels of androgens increase muscle mass. Due to the characteristics of hyperandrogenism in polycystic ovary syndrome (PCOS), it is plausible that women with PCOS may have increased pelvic floor muscle (PFM) thickness and neuromuscular activity levels compared with controls. The aim of this study was ...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-015-2865-8
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:In recent years uterine preservation surgery for pelvic organ prolapse has become more popular. Traditional operations such as vaginal hysterectomy do not address the underlying pathophysiology of poor connective tissue support, which may result in a higher incidence of recurrent prolapse. METHODS:This vi...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-013-2129-4
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:We sought to examine the change in utilization of the midurethral sling (MUS) for the treatment of stress urinary incontinence (SUI) after the 2011 US FDA communication regarding transvaginal mesh. METHODS:This is a retrospective cohort study evaluating surgical utilization of MUS at a mana...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-020-04597-7
更新日期:2020-11-18 00:00:00
abstract:OBJECTIVES:Nocturia is the number of times urine is passed during main sleep. This definition tells us that it is a need to void; it does not tell us what triggers it. The aim of this study is to report bladder sensations that wake up women with nocturia (N). Descriptions of sensations in relation to various overactive...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-020-04257-w
更新日期:2020-05-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Our aim was to evaluate the outcome of open colposuspension for women with urodynamic stress incontinence who had previously undergone a failed midurethral tape. METHODS:A retrospective study of 13 women who had undergone open colposuspension after a failed midurethral tape was conducted. ...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-012-1720-4
更新日期:2012-08-01 00:00:00