Abstract:
:Using the polymerase chain reaction and Southern blot analysis the expression was detected of a bcr-abl mRNA lacking abl exon a2. This was due to a corresponding unusual localization of the breakpoint in the c-abl gene and was seen in a patient with Philadelphia (Ph) chromosome positive chronic myelogeneous leukemia in chronic phase. This type of mRNA has been described only once before in two Ph-positive acute lymphoblastic leukemia patients, by Soekarman et al. (1). The abl exon a2 sequences, which are missing in the three reported patients, code for a part of the SH3 region of the abl protein, which is supposed to be involved in negative regulation of the kinase domain. The clinical significance of this finding is discussed.
journal_name
Leukemiajournal_title
Leukemiaauthors
van der Plas DC,Soekarman D,van Gent AM,Grosveld G,Hagemeijer Asubject
Has Abstractpub_date
1991-06-01 00:00:00pages
457-61issue
6eissn
0887-6924issn
1476-5551journal_volume
5pub_type
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