Diffusion tensor imaging in patients with focal epilepsy due to cortical dysplasia in the temporo-occipital region: electro-clinico-pathological correlations.

abstract：:Generalized seizures can induce both hypertension and hyperglycemia which may aggravate preexisting cerebral or medical conditions in patients. In vivo fluorescent imaging of regional cortical blood flow and brain intracellular pH (pHi) was performed in fasted New Zealand rabbits (n = 35) in which either mean arterial...

journal_title：Epilepsy research

authors： Tomlinson FH,Anderson RE,Meyer FB

更新日期：1993-02-01 00:00:00

abstract：:Posttraumatic epilepsy is a common consequence of traumatic brain injury in humans. Major predictors for the development of posttraumatic epilepsy include the severity of injury and occurrence of cortical contusions. The effect of the size or location of the cortical lesion on the risk of epileptogenesis, however, is ...

journal_title：Epilepsy research

authors： Kharatishvili I,Pitkänen A

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:To identify clinical risk factors for Dravet syndrome (DS) in a population of children with status epilepticus (SE). MATERIAL AND METHODS:Children aged between 1 month and 16 years with at least one episode of SE were referred from 6 pediatric neurology centers in Switzerland. SE was defined as a clinical seiz...

journal_title：Epilepsy research

authors： Le Gal F,Lebon S,Ramelli GP,Datta AN,Mercati D,Maier O,Combescure C,Rodriguez MI,Seeck M,Roulet E,Korff CM

更新日期：2014-05-01 00:00:00

abstract：:Levetiracetam is a novel antiepileptic drug with an unknown mechanism of action. To-date levetiracetam is not known to be associated with any clinically significant pharmacokinetic interaction. Similarly, levetiracetam has not been associated with any pharmacodynamic interactions. We present four patients with severe ...

journal_title：Epilepsy research

authors： Sisodiya SM,Sander JW,Patsalos PN

更新日期：2002-02-01 00:00:00

abstract：:Plasma total homocysteine (p-tHcy), serum folate (s-F), serum vitamin B-12 (s-B12) and plasma pyridoxal-5'-phosphate (p-PLP) were measured in epileptic children before and after a 20-week period of sodium valproate (group A, n=32) and carbamazepine (group B, n=20) monotherapy. P-tHcy significantly increased in both gr...

journal_title：Epilepsy research

authors： Attilakos A,Papakonstantinou E,Schulpis K,Voudris K,Katsarou E,Mastroyianni S,Garoufi A

更新日期：2006-10-01 00:00:00

abstract：:Absence seizures are thought to be linked to abnormal interplays between regions of a thalamocortical network. However, the complexity of this widespread network makes characterizing the functional interactions among various brain regions challenging. Using whole-brain functional connectivity and network analysis of m...

journal_title：Epilepsy research

authors： Youssofzadeh V,Agler W,Tenney JR,Kadis DS

更新日期：2018-09-01 00:00:00

abstract：:The prevailing understanding of generalized epilepsy is shaped by the traditional definition that "the responsible neuronal discharge takes place, if not throughout the entire grey matter, then at least in the greater part of it and simultaneously on both sides". This view is no longer tenable since concurrent finding...

journal_title：Epilepsy research

authors： Wolf P,Yacubian EM,Avanzini G,Sander T,Schmitz B,Wandschneider B,Koepp M

更新日期：2015-08-01 00:00:00

abstract：:Apolipoprotein E (ApoE) has been implicated as one of the susceptibility genes for temporal lobe epilepsy (TLE). Previous studies indicate that ApoE ɛ4 is associated with several disease-related traits including the increased risk of late posttraumatic seizures, earlier onset of TLE, refractory complex partial seizure...

journal_title：Epilepsy research

authors： Fu YH,Lv RJ,Jin LR,Lu Q,Shao XQ,He JS,Wu LW,Zhang LS,Hu HG

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:We sought to systematically review and perform a meta-analysis of the magnetic resonance spectroscopy (MRS) findings regarding juvenile myoclonic epilepsy (JME). METHODS:We searched for studies in the PubMed, Web of Science, and Embase electronic databases. Two authors collected articles and extracted data ind...

journal_title：Epilepsy research

authors： Zhang L,Li H,Hong P,Zou X

更新日期：2016-03-01 00:00:00

abstract：:Interpreting electrocorticography (ECoG) in the context of neuroimaging requires that multimodal information be integrated accurately. However, the implantation of ECoG electrodes can shift the brain impacting the spatial interpretation of electrode locations in the context of pre-implant imaging. We characterized the...

journal_title：Epilepsy research

authors： Foldes ST,Munter BT,Appavu BL,Kerrigan JF,Adelson PD

更新日期：2020-11-01 00:00:00

abstract：:Felbamate (FBM; 2-phenyl-1,3-propanediol dicarbamate) is an approved antiepileptic drug shown to be effective in a variety of seizure disorders refractory to other treatments. However, its use has been restricted because of association with occurrence of rare cases of aplastic anemia and hepatic failure. Since it was ...

journal_title：Epilepsy research

authors： Husain Z,Pinto C,Sofia RD,Yunis EJ

更新日期：2002-01-01 00:00:00

abstract：:We studied the electrocorticogram (ECoG) before and immediately after transcortical selective amygdalo-hippocampectomy, prospectively in 13 consecutive patients and retrospectively in three others. ECoG was performed with surface and two depth electrodes inserted through T2 aimed at the amygdala and anterior hippocamp...

journal_title：Epilepsy research

authors： Cendes F,Dubeau F,Olivier A,Cukiert A,Andermann E,Quesney LF,Andermann F

更新日期：1993-12-01 00:00:00

abstract：:Twenty-one children (11 boys, 10 girls) suffering from visual seizures were studied. The visual seizures manifested as loss of vision, flickering light, blurring or figurative hallucinations. Ictal EEGs during visual seizures were recorded in 4 cases; the ictal discharges all originated in the occipital area. Visual s...

journal_title：Epilepsy research

authors： Aso K,Watanabe K,Negoro T,Takaesu E,Furune A,Takahashi I,Yamamoto N,Nomura K

更新日期：1987-07-01 00:00:00

abstract：:Single photon emission computed tomography (SPECT) has frequently been used to investigate cerebral brain perfusion (CBP) occurring ictally and inter-ictally in epileptic patients. Several studies have addressed the multimodal analysis of the modifications occurring in cerebral areas involved in seizure activity, by c...

journal_title：Epilepsy research

authors： Marrosu F,Puligheddu M,Giagheddu M,Cossu G,Piga M

更新日期：2000-06-01 00:00:00

abstract：:Assessing the functional reserve of key memory structures in the medial temporal lobes (MTL) of pre-surgical patients with intractable temporal lobe epilepsy (TLE) remains a challenge. Conventional functional MRI (fMRI) memory paradigms have yet to fully convince of their ability to confidently assess the risk of a po...

journal_title：Epilepsy research

authors： Bonnici HM,Sidhu M,Chadwick MJ,Duncan JS,Maguire EA

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:To characterize gabapentin pharmacokinetics in infants and children using a population approach and to identify important demographic and/or physiologic determinants of gabapentin disposition. METHODS:Gabapentin was administered in single doses of 10 mg/kg (N=48 healthy subjects, age 1 month-12 years) or in mu...

journal_title：Epilepsy research

authors： Ouellet D,Bockbrader HN,Wesche DL,Shapiro DY,Garofalo E

更新日期：2001-12-01 00:00:00

abstract：:The genetically epilepsy-prone rat (GEPR) has become an important model to study genetic predisposition to epilepsy involving not only the brainstem but also forebrain structures. Previous work in CA1 hippocampal cells showed a reduction in spike frequency adaptation and only subtle changes in slow afterhyperpolarizat...

journal_title：Epilepsy research

authors： Verma-Ahuja S,Evans MS,Pencek TL

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVE:To assess functional organization of the motor cortex in patients with Unverricht-Lundborg disease (EPM1A) using a combined neurophysiologic and imaging approach. METHODS:EPM1A patients underwent transcranial magnetic stimulation (TMS)-based cortical mapping of the motor hand area. Moreover, they performed n...

journal_title：Epilepsy research

authors： Rossi Sebastiano D,Visani E,Contarino VE,Panzica F,Duran D,D'Incerti L,Franceschetti S,Canafoglia L

更新日期：2020-02-01 00:00:00

abstract：:Prevention of epileptogenesis after brain insults, such as status epilepticus (SE), head trauma, or stroke, remains a challenge. Even if epilepsy cannot be prevented, it would be beneficial if the pathologic process could be modified to result in a less severe disease. We examined whether early discontinuation of SE r...

journal_title：Epilepsy research

authors： Pitkänen A,Kharatishvili I,Narkilahti S,Lukasiuk K,Nissinen J

更新日期：2005-01-01 00:00:00

abstract：:Freeze-lesion-induced focal cortical dysplasia in rats closely resembles human microgyria, a neuronal migration disorder associated with drug-resistant epilepsy. Alterations in expression of N-methyl-D-aspartate receptors (NMDARs) containing NR2B subunits have been suggested to play a role in the hyperexcitability see...

journal_title：Epilepsy research

authors： Bandyopadhyay S,Hablitz JJ

更新日期：2006-12-01 00:00:00

abstract：:This study was carried out to evaluate Synthetic Aperture Magnetometry-kurtosis (SAM(g(2))), a spatially filtered source localization technique in magnetoencephalography (MEG), for identification of epileptogenic areas of focal cortical dysplasia (FCD). Three children with FCD were investigated to localize the ictal o...

journal_title：Epilepsy research

authors： Ishii R,Canuet L,Ochi A,Xiang J,Imai K,Chan D,Iwase M,Takeda M,Snead OC 3rd,Otsubo H

更新日期：2008-10-01 00:00:00

abstract：:The distribution and kinetics of specific binding sites for gamma-hydroxybutyrate (GHB), a naturally occurring compound known to produce absence-like seizures, was studied in the brains of Wistar rats with spontaneous, bilaterally synchronous spike wave discharges (SWDs), a model of petit mal epilepsy, and non-epilept...

journal_title：Epilepsy research

authors： Snead OC 3rd,Hechler V,Vergnes M,Marescaux C,Maitre M

更新日期：1990-11-01 00:00:00

abstract：RATIONALE:Epilepsy is the most common serious neurological condition in the world, and an important cause of mortality and disability in developing countries. Because epidemiological and clinical characteristics of epilepsy vary by region, it is important to know the peculiarities of epilepsy in this area of the Americ...

journal_title：Epilepsy research

authors： Burneo JG,Tellez-Zenteno J,Wiebe S

更新日期：2005-08-01 00:00:00

abstract：:GABA transporters (GATs) are an essential element of the GABAergic system, which regulate excitability in the central nervous system and are thus used as targets for anticonvulsive therapy. However, in the immature nervous system the functions of the GABAergic system and the expression profile of GATs are distinct fro...

journal_title：Epilepsy research

authors： Sharopov S,Chen R,Sun H,Kolbaev SN,Kirischuk S,Luhmann HJ,Kilb W

更新日期：2014-02-01 00:00:00

abstract：:A randomised, double-blind, placebo-controlled crossover study of add-on remacemide hydrochloride was carried out in epilepsy patients being treated with phenytoin (PHT) monotherapy. Eleven patients were recruited, ten of whom completed the study. Plasma concentration profiles of PHT, remacemide, and its active desgly...

journal_title：Epilepsy research

authors： Leach JP,Girvan J,Jamieson V,Jones T,Richens A,Brodie MJ

更新日期：1997-01-01 00:00:00

abstract：:It has previously been suggested that abnormalities in cardiac repolarization (QTc lengthening and shortening) are more likely to accompany seizures with hypoxemia and may be involved in sudden unexpected death in epilepsy (SUDEP). Accordingly, we evaluated for associations between peri-ictal QTc changes and hypoxemia...

journal_title：Epilepsy research

authors： Moseley BD,Britton JW

更新日期：2014-07-01 00:00:00

abstract：:Treating a patient with antiepileptic drugs (AEDs) may give rise to unexpected life-threatening adverse events. Despite extensive experimental and clinical testing to ensure safety, most AEDs on the market have been associated with cases of severe cutaneous reactions, serious hematological disorders, or hepatic failur...

journal_title：Epilepsy research

authors： Arroyo S,de la Morena A

更新日期：2001-11-01 00:00:00

abstract：PURPOSE:Clobazam (CLB, 1,5-benzodiazepine, 1,5-BZP) has been reported to show unique antiepileptic action profile distinguishing from standard 1,4-BZPs. To further elucidate the action profile of CLB, its effects on the abnormal circling fits (ACFs) and generalized tonic-clonic convulsions (GTCs) in Ihara epileptic rat...

journal_title：Epilepsy research

authors： Miura Y,Amano S,Torii R,Ihara N

更新日期：2002-05-01 00:00:00

abstract：:The severe seizure genetically epilepsy-prone rat (GEPR-9) is characterized by a broad-based seizure predisposition and is increasingly recognized as a useful model of epilepsy. When sound stimulated, members of the GEPR-9 colony exhibit complete tonic extensor convulsions. Female GEPR-9s appear to experience a higher...

journal_title：Epilepsy research

authors： Mishra PK,Dailey JW,Reigel CE,Tomsic ML,Jobe PC

更新日期：1988-09-01 00:00:00

abstract：:Aminergic signalling in the CNS is terminated by clearance of neurotransmitters from the synapse via high affinity transporter molecules in the presynaptic membrane. Relatively recent sequence identification of these molecules has now permitted the initiation of studies of regulation of transporter function at the cel...

journal_title：Epilepsy research

authors： Figlewicz DP

更新日期：1999-12-01 00:00:00