Abstract：
PURPOSE:To evaluate the effect of genipin, a natural crosslinker, on porcine corneas. SETTING:Department of Ophthalmology, Universidad Nacional de Colombia, Bogota, Colombia. METHODS:Corneal strips (12.0 mm x 2.3 mm) were harvested from porcine eyes and treated by incubation with genipin at concentrations of 1.00%, 0.25%, and 0.10%. Parallel corneal strips from the same eye were used as untreated controls. After treatment at 20 degrees C for 40 minutes, tensile strain measurements were performed in a biomaterial tester. Porcine button corneas were treated with genipin 0.25% for 15 minutes and then digested by bacterial collagenase. Treated and untreated corneas were evaluated by light microscopy. RESULTS:Young modulus and stiffness in treated corneas increased in a concentration-dependent manner. Genipin increased resistance to corneal collagenase 5-fold in comparison with the controls. A decrease in the interlamellar space in treated corneas was also observed. CONCLUSIONS:Corneal collagen crosslinking induced with genipin produced a significant increase in biomechanical strength and resistance to bacterial collagenase. This crosslinker could be useful in treating corneal ectasia and corneal infectious and noninfectious diseases involving corneal melting.
journal_name
J Cataract Refract Surgjournal_title
Journal of cataract and refractive surgeryauthors
Avila MY,Navia JLdoi
10.1016/j.jcrs.2009.11.003subject
Has Abstractpub_date
2010-04-01 00:00:00pages
659-64issue
4eissn
0886-3350issn
1873-4502pii
S0886-3350(10)00073-8journal_volume
36pub_type
杂志文章abstract：:We present the results of a survey carried out by independent researchers to determine the subjective success rate of a series of excimer laser photorefractive keratectomy procedures to correct myopia. Thirty patients, selected at random from a group of 300, had received treatment to both eyes with a minimum of six mo...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(13)80766-3
更新日期：1994-03-01 00:00:00
abstract：PURPOSE:To evaluate a commercially available neural network program for calculation of photorefractive keratectomy treatment nomograms. SETTING:University referral refractive surgery clinic. METHODS:PRK/LASIK Brain, a commercial neural network computer program, was trained using the demographics, preoperative clinica...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(98)80043-6
更新日期：1998-07-01 00:00:00
abstract：PURPOSE:To evaluate the agreement of ocular measurements obtained with a new optical biometer (AL-Scan) and a previously validated optical biometer (Lenstar). SETTING:Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. DESIGN:Prospective observational cross-sectional study. METHODS:For a comprehens...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2015.05.042
更新日期：2016-01-01 00:00:00
abstract：PURPOSE:To compare anterior chamber depth (ACD) measurements with a new optical device with those taken with a standard ultrasound (US) device in emmetropic phakic and pseudophakic eyes. SETTING:Department of Ophthalmology, Medical Health and Science Center, University of Debrecen, Debrecen, Hungary. METHODS:Forty-tw...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2006.02.057
更新日期：2006-08-01 00:00:00
abstract：PURPOSE:To assess the practical feasibility and signal quality of axial length measurements by partial coherence laser interferometry in silicone oil-filled eyes with previous complicated vitreoretinal surgery. SETTINGS:Department of Ophthalmology, University Cologne, Cologne, Germany. METHODS:Using a Zeiss IOLMaster...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2004.09.049
更新日期：2005-05-01 00:00:00
abstract：PURPOSE:To compare posterior capsule opacification (PCO) after phacoemulsification and implantation of heparin-surface-modified (HSM) poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) in the capsular bag in patients with diabetes mellitus with that in a control group. SETTING:St. Erik's Eye Hospital, Stockhol...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(99)80132-1
更新日期：1999-02-01 00:00:00
abstract：PURPOSE:To evaluate corneal endothelium morphology and function after phacoemulsification using different viscoelastics. SETTING:Eye Clinic, University of Trieste, Italy. METHODS:This prospective, randomized study included results of preoperative and postoperative (7, 30, and 90 days) examinations of 66 patients sche...
journal_title：Journal of cataract and refractive surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0886-3350(97)80190-3
更新日期：1997-04-01 00:00:00
abstract：PURPOSE:To describe the demographic data, evaluate the long-term refractive and anatomical outcomes, and report the incidence of complications of anterior iris (prepupillary) and posterior iris (retropupillary) fixation of the Artisan aphakia iris-claw intraocular lens (IOL). SETTING:Complejo Hospitalario Universitari...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2018.05.010
更新日期：2018-07-01 00:00:00
abstract：PURPOSE:To evaluate the relationship between the thinnest point in corneal thickness and the refractive state, keratometry, age, sex, and the ocular side. SETTING:Eye clinics in Germany and Austria and the Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. DESIGN:Cross-section...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2011.06.033
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:To examine whether clinically significant differences exist in corneal elevation data from a sampling of countries worldwide. SETTING:International multicenter. DESIGN:Evaluation of diagnostic test or technology. METHODS:One randomly selected eye of normal adults from 8 countries spanning 6 continents was ex...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jcrs.2011.04.030
更新日期：2011-10-01 00:00:00
abstract：:A randomized prospective trial compared keratometric and visual outcomes for 196 patients receiving 3.2 mm, 5.0 mm, or 6.0 mm incisions for cataract removal and intraocular lens implantation. There were no statistically significant differences among the groups preoperatively or at one to two days or three to six month...
journal_title：Journal of cataract and refractive surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0886-3350(13)80402-6
更新日期：1993-01-01 00:00:00
abstract：PURPOSE:To assess the repeatability and agreement of corneal power, corneal astigmatism, axis location, and astigmatic vector component measurements using an autokeratometer and a corneal topographer in healthy subjects. SETTING:Department of Ophthalmology, Kitasato University, Kanagawa, Japan. DESIGN:Evaluation of d...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2011.11.026
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:To evaluate the results and complications of hyperopic laser in situ keratomileusis (LASIK) with a low-energy femtosecond laser and non-custom tissue-saving ablation profile. SETTING:Private practice, Siena, Italy. DESIGN:Case series. METHODS:Hyperopic eyes with a spherical equivalent (SE) between +1.0 and +...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2013.11.031
更新日期：2014-07-01 00:00:00
abstract：PURPOSE:To prospectively evaluate the usefulness of a subconjunctival steroid injection given at the completion of cataract surgery in patients with diabetes mellitus. SETTING:University of Tokyo School of Medicine, Tokyo, Kaiya Eye Clinic, Hamamatsu, and Jyosai Hospital, Tokyo, Japan. METHODS:One hundred four eyes o...
journal_title：Journal of cataract and refractive surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0886-3350(01)00783-0
更新日期：2001-09-01 00:00:00
abstract：:Long-term stability of intrastromal corneal ring segments is important in maintaining patients' corrected distance visual acuity and avoiding injury to the local tissues. We report a case of traumatic shattering of intrastromal segments due to blunt trauma, with successful removal of the fragments. ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2010.03.022
更新日期：2010-06-01 00:00:00
abstract：:A transition from trabeculectomy to nonpenetrating trabecular surgery (NPTS) is proposed under the name of sclerotrabeculectomy. The technique, which is aimed at facilitating the transition to NPTS, is a modification of both penetrating and nonpenetrating techniques. Sclerotrabeculectomy uses a more superficial sclero...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(02)01363-9
更新日期：2002-12-01 00:00:00
abstract：:This paper describes a surgical training system for teaching and practicing the necessary skills to perform phacoemulsification, endocapsular phacoemulsification, and small incision intraocular lens insertion techniques. The surgical system includes head, bilateral globes, removable corneas, and replaceable synthetic ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(88)80100-7
更新日期：1988-03-01 00:00:00
abstract：:A patient with bilateral Salzmann's nodular degeneration developed a myopic shift of 9 diopters in the right eye and 5 diopters in the left eye after removal of his nodules. This previously unreported complication of removal of peripheral corneal pathology is discussed in light of our current understanding of keratore...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(13)80658-x
更新日期：1994-11-01 00:00:00
abstract：PURPOSE:To present a complex surgical technique used for the management of luxated crystalline lenses and evaluate treatment results. SETTING:Department of Ophthalmology, Medical University of Lodz, Lodz, Poland. METHODS:This prospective study involved 29 consecutive patients (30 eyes) with the mean age of 60.3 years...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2005.04.039
更新日期：2005-11-01 00:00:00
abstract：PURPOSE:To describe the use of a motorized milling drill to perform nonpenetrating glaucoma surgery and to assess its safety. SETTING:Instituto Oftalmológico de Alicante, Miguel Hernandez University, School of Medicine, Alicante, Spain. METHODS:This prospective noncomparative study included 16 eyes (13 patients) diag...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2003.11.052
更新日期：2004-07-01 00:00:00
abstract：:Twenty-eight epikeratophakia procedures have been performed at the University of Minnesota since December 1985. This report describes several technique modifications and compares the refractive and visual outcome of these cases with the national results. There have been 17 aphakic cases (13 adult and four pediatric), ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(89)80091-4
更新日期：1989-05-01 00:00:00
abstract：UNLABELLED:Laser in situ keratomileusis (LASIK) articles published between 2008 and 2015 that contain clinical outcomes data were reviewed and graded for quality, impression, and potential bias. All 97 relevant articles (representing 67 893 eyes) provided a positive or neutral impression of LASIK. Industry bias was not...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,评审
doi：10.1016/j.jcrs.2016.07.012
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:To understand, demonstrate, and further research the mechanisms of accommodation and presbyopia. SETTING:Private practice, Little Silver, New Jersey, USA. DESIGN:Experimental study. METHODS:The CAMA 2.0 computer-animated model of accommodation and presbyopia was produced in collaboration with an experienced ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2014.07.028
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:To assess the accuracy of intraocular lens (IOL) power calculation formulas in Chinese eyes with axial lengths (ALs) longer than 26.0 mm. SETTING:Department of Cataract Surgery, Shanxi Eye Hospital, China. DESIGN:Prospective case series. METHODS:This study evaluated (1) two new formulas (Barrett Universal II...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2019.01.018
更新日期：2019-06-01 00:00:00
abstract：UNLABELLED:An 83-year-old man presented with a 1-year history of blurry vision in his left eye. Bilateral cataract surgery and ciliary sulcus posterior chamber intraocular lens (IOL) implantation had been performed 11 years earlier. The corrected distance visual acuity (CDVA) was 20/60 in the left eye. Slitlamp examina...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,评审
doi：10.1016/j.jcrs.2015.09.013
更新日期：2015-10-01 00:00:00
abstract：:A 77-year-old woman had uneventful phacoemulsification. Postoperative examination revealed that chloramphenicol ointment instilled in the conjunctival fornix had entered the anterior chamber and smeared the intraocular lens (IOL). Immediate surgical removal of the ointment with IOL exchange was performed. The eye sett...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(02)01503-1
更新日期：2003-03-01 00:00:00
abstract：PURPOSE:To determine whether frozen cultured sheets of human allogeneic epidermal keratinocytes (CEAK) improved wound repair after experimental corneal ablation by photorefractive keratectomy (PRK). SETTING:Hospital "Luis Sanchez Bulnes" de la Asociación para Evitar la Ceguera en Mexico, I.A.P, and Department of Cell ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(01)01349-9
更新日期：2002-09-01 00:00:00
abstract：PURPOSE:To assess the refractive accuracy of different formulas for intraocular lens (IOL) power calculation in eyes with keratoconus. SETTING:IRCCS Fondazione Bietti, Rome, Italy. DESIGN:Multicenter retrospective interventional study. METHODS:A consecutive series of eyes with keratoconus that had cataract surgery w...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jcrs.2018.11.029
更新日期：2019-05-01 00:00:00
abstract：PURPOSE:To assess the clinical results of transepithelial collagen crosslinking (CXL) in patients 26 years and younger with progressive keratoconus suitable for epithelium-off (epi-off) CXL. SETTING:Department of Ophthalmology, Siena University Hospital, Siena, Italy. DESIGN:Prospective case series. METHODS:The stud...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2013.03.026
更新日期：2013-08-01 00:00:00
abstract：:The first 45 cases of extracapsular cataract extraction, with posterior chamber intraocular lens implantation performed by ophthalmology residents at an urban county hospital were evaluated. These cases, which were performed from March 1983 to June 1984, involved a patient population that was primarily black and Hispa...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(86)80054-2
更新日期：1986-01-01 00:00:00
