Abstract：
PURPOSE:To evaluate ocular penetration of topically applied linezolid, a new antibiotic agent targeted against gram-positive organisms. SETTING:Laboratory of Pharmacology, University Hospital of Strasbourg, Strasbourg, France. METHODS:New Zealand White rabbits were divided into 3 equal groups. One drop of 50 microL (2 mg/mL) linezolid was administrated in Group 1. In Group 2, eyes were dosed in accordance with a keratitis protocol (1 drop of 2 mg/mL every 15 minutes for 1 hour). Aqueous humor was sampled 6 times from immediately after to 3 hours after drop delivery. In Group 3, a keratitis protocol was implemented before the animals were humanely killed. Conjunctiva, cornea, vitreous, and blood samples were collected 1 hour and 2 hours after the last drop. Linezolid concentrations were measured by high-performance liquid chromatography. RESULTS:Each group comprised 8 rabbits. In Group 1 and Group 2, the peak linezolid concentration in the aqueous humor (mean 0.87 mg/L +/- 0.16 [SD] and 2.17 +/- 0.4 mg/L, respectively) was 45 minutes after the last drop delivery. In Group 3, the concentrations 1 hour and 2 hours after the last drop were higher than 3 microg/g in the conjunctiva samples and higher than 4 microg/g in the cornea samples. The linezolid concentration in the vitreous and serum was negligible. CONCLUSIONS:Linezolid levels in the aqueous humor, conjunctiva, and cornea exceeded the minimum inhibitory concentration of most gram-positive organisms that cause bacterial keratitis and endophthalmitis. Linezolid could be a valuable alternative in cases of increased resistance to vancomycin.
journal_name
J Cataract Refract Surgjournal_title
Journal of cataract and refractive surgeryauthors
Saleh M,Jehl F,Dory A,Lefevre S,Prevost G,Gaucher D,Sauer A,Speeg-Schatz C,Bourcier Tdoi
10.1016/j.jcrs.2009.09.036subject
Has Abstractpub_date
2010-03-01 00:00:00pages
488-92issue
3eissn
0886-3350issn
1873-4502pii
S0886-3350(09)01132-8journal_volume
36pub_type
杂志文章abstract：:We describe a technique for creating a continuous curvilinear capsulorhexis (CCC) using an endoscope. Three 2.0 mm limbal incisions 120 degrees apart were made in 4 cadaver eyes. The anterior capsule was stained with trypan blue 0.1% (Vision Blue). Under endoscopic visualization, a CCC was attempted in each of the 4 g...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2003.09.051
更新日期：2004-05-01 00:00:00
abstract：:Small incision cataract surgery has several advantages over conventional surgery, including faster postoperative visual rehabilitation. We evaluated 100 consecutive cases of no-stitch, small incision surgery with a square sclerocorneal tunnel and a flexible intraocular lens. Permanent self-sealing of the wound seemed ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(13)80234-9
更新日期：1994-09-01 00:00:00
abstract：:We discuss a case of bipseudophakia with secondary dislocation of a posterior chamber intraocular lens (IOL) into the anterior chamber that was managed by explantation of the anterior and posterior chamber IOLs and implantation of an iris claw IOL. ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(02)01991-0
更新日期：2003-07-01 00:00:00
abstract：PURPOSE:To compare the relative degrees of adherence of a clinical strain of Pseudomonas aeruginosa to the optic material of four intraocular lenses (IOLs). SETTING:Center for Applied and Environmental Microbiology, Georgia State University, Atlanta, Georgia, USA. METHODS:Intraocular lens optics made of poly(methyl m...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(98)80085-0
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:To evaluate the long-term evolution of refractive error changes in eyes of children who have primary intraocular lens (IOL) implantation to allow more accurate prediction of what IOL power should be implanted at a given age. SETTING:Department of Ophthalmology, Indiana University School of Medicine, Indianapol...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(01)01156-7
更新日期：2002-05-01 00:00:00
abstract：:We describe a technique for making an optimal flange in intraocular lenses (IOLs) used for flanged intrascleral IOL fixation. The flange shape varies in poly(methyl methacrylate) (PMMA) haptics of different IOLs of different manufacturers. We identified the distance between the forceps grip of the haptic and the end o...
journal_title：Journal of cataract and refractive surgery
pub_type： 评论,杂志文章
doi：10.1016/j.jcrs.2018.07.042
更新日期：2018-11-01 00:00:00
abstract：:We describe a technique for femtosecond laser-assisted bag-in-the-lens (BIL) intraocular lens (IOL) implantation. Anterior capsulotomy and lens division into small pieces are performed by the laser. A fluid-filled interface makes it possible to re-dock the laser to the eye for posterior capsulotomy after the eye has b...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2013.07.014
更新日期：2013-09-01 00:00:00
abstract：:Horizontal chopping is effective for endocapsular nucleofractis. We describe pop and chop, a variant of chopping that enables an easy first crack and initial segment removal. It involves partial extracapsular prolapse of the nucleus prior to the initial chop. It is particularly useful when hydrodissection results in p...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(03)00339-0
更新日期：2003-11-01 00:00:00
abstract：PURPOSE:Previous studies have reported conflicting results on the influence of seasons on post-cataract surgery endophthalmitis incidences. This study aimed to investigate the seasonality associated with the incidence of postoperative endophthalmitis, and to evaluate its association with climate variables in South Kore...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2019.07.022
更新日期：2019-12-01 00:00:00
abstract：PURPOSE:To determine whether the addition of a bioadhesive drug-delivery system to topical azithromycin induces intraocular inflammation and damage when introduced intraocularly by different approaches and in varying doses. SETTING:John A. Moran Eye Center, Salt Lake City, Utah, USA. DESIGN:Experimental study. METHO...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2011.06.038
更新日期：2012-01-01 00:00:00
abstract：PURPOSE:To assess the capability of new software to decrease the proportion of eyes that have insufficient signal-to-noise ratio (SNR) in optical biometry. SETTING:Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom. DESIGN:Evaluation of diagnostic test or technology. METHODS:In a prospective study,...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2010.07.023
更新日期：2011-01-01 00:00:00
abstract：UNLABELLED:An 84-year-old woman had routine laser-assisted cataract surgery with anterior laser capsulotomy and lens fragmentation. During hydropolishing of the posterior capsule, an unexpected posterior capsule rupture occurred without vitreous loss. The haptics of the intraocular lens (IOL) were implanted in the cili...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2015.06.016
更新日期：2015-07-01 00:00:00
abstract：PURPOSE:To evaluate 1-year outcomes of corneal collagen crosslinking (CXL) for treatment of keratoconus and corneal ectasia. SETTING:Cornea and refractive surgery subspecialty practice. DESIGN:Prospective randomized controlled clinical trial. METHODS:Collagen crosslinking was performed in eyes with keratoconus or ec...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jcrs.2010.07.030
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:To determine whether sutureless small incision cataract surgery reduces induced astigmatism over the long term. SETTING:University Eye Hospital, Vienna, Austria. METHODS:In a prospective study, we investigated surgically induced astigmatism in 63 cases of no-stitch, small incision cataract surgery with a 4.0 ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(97)80180-0
更新日期：1997-04-01 00:00:00
abstract：:In eyes with low scleral rigidity, penetrating keratoplasty (PKP) is a high-risk procedure because forward movement of the lens-iris diaphragm can result in prolapse of intraocular contents, expulsive choroidal hemorrhage, and damage to the crystalline lens. We developed a method for safer PKP in eyes with low scleral...
journal_title：Journal of cataract and refractive surgery
pub_type： 临床试验,杂志文章
doi：10.1016/s0886-3350(99)00071-1
更新日期：1999-07-01 00:00:00
abstract：PURPOSE:To determine the astigmatic effect of a supero-oblique clear corneal phacoemulsification cataract incision. SETTING:A university-based general ophthalmology practice. METHODS:All eyes having supero-oblique phacoemulsification cataract surgery using the right hand of a single surgeon between April 17, 1997, an...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(99)00074-7
更新日期：1999-07-01 00:00:00
abstract：PURPOSE:To compare corneal astigmatism measurements obtained using a new optical biometer (AL-Scan) and a standard biometer based on partial coherence interferometry (IOLMaster 500) for toric intraocular lens (IOL) selection. SETTING:Siriraj Hospital, Mahidol University, Bangkok, Thailand. DESIGN:Prospective comparat...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2014.06.029
更新日期：2015-02-01 00:00:00
abstract：:Three children were born with partial corneal opacity and anterior segment anomalies but no cataract (Peter's anomaly type 1). In each affected eye, the corneal scar was off center and encroached on the visual axis. Glaucoma (if present) was controlled medically or surgically, after which an optical iridectomy was per...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(98)80272-1
更新日期：1998-05-01 00:00:00
abstract：:To evaluate the biocompatibility of various materials including a poly(2-hydroxyethyl methacrylate [HEMA])/(6-hydroxyhexyl methacrylate [HOHEXMA]) hydrophilic hydrogel intraocular lens (IOL) (Hydroview, Bausch & Lomb). Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan. Ten opacified anterior ca...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(02)01988-0
更新日期：2003-06-01 00:00:00
abstract：PURPOSE:To assess the predictability, efficacy, stability and safety of implantation of an Artisan (Ophtec BV, the Netherlands) iris-fixated phakic intraocular lens (IF-pIOL) for the correction of hyperopia with a follow-up of up to 15 years. SETTING:Leiden University Medical Center, The Netherlands METHODS:: Patients...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000532
更新日期：2020-11-27 00:00:00
abstract：PURPOSE:To evaluate visual and refractive outcome of microincision cataract surgery (MICS) with implantation of an Acri. Smart 48S intraocular lens (IOL) (Acri.Tech) through a sub-1.9 mm incision. SETTING:Vissum/Instituto Oftalmologico de Alicante and Ophthalmology Department, Miguel Hernandez University, Alicante, Sp...
journal_title：Journal of cataract and refractive surgery
pub_type： 临床试验,杂志文章
doi：10.1016/j.jcrs.2005.01.030
更新日期：2005-08-01 00:00:00
abstract：PURPOSE:To determine whether radial transsection of the inner lamina of the phaco tunnel (T-cut) allows intraocular pressure (IOP) control in cases of co-existing cataract and glaucoma and to evaluate the results of this glaucoma triple procedure. SETTING:Department of Ophthalmology, Hanusch Hospital, Vienna, Austria....
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(99)00454-x
更新日期：2000-05-01 00:00:00
abstract：PURPOSE:To demonstrate the outcome for patients after cataract extraction using the Catquest cataract questionnaire and discuss the models validity in assessing outcome. SETTING:Thirty-five Swedish departments of ophthalmology. METHODS:Patients having cataract extraction performed by surgeons from 35 Swedish departme...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,多中心研究
doi：10.1016/s0886-3350(98)80053-9
更新日期：1998-07-01 00:00:00
abstract：:A 25-year-old woman with moderate myopia presented for refractive surgery. Bilateral femtosecond laser-assisted small-incision lenticule extraction (SMILE) was scheduled and her right eye was completed smoothly. However, during the lenticule cutting of her left eye, a large inferior black area was noted. The operation...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000185
更新日期：2020-06-01 00:00:00
abstract：:Positive pressure during cataract surgery can adversely affect the clinical outcome if the surgeon is unprepared. A variety of surgical maneuvers are described, including dry insertion of the phacoemulsification needle, capsule protection with the second instrument, dry cortical aspiration in an ophthalmic viscosurgic...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2006.06.011
更新日期：2006-09-01 00:00:00
abstract：PURPOSE:To identify potential risk factors associated with post-cataract surgery bacterial endophthalmitis. SETTING:The John A. Moran Eye Center, Salt Lake City, Utah, USA. METHODS:This retrospective cohort study consisted of patients who had surgery for cataract(s) at this eye hospital. A 10% sampling of all patient...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2004.10.057
更新日期：2005-04-01 00:00:00
abstract：PURPOSE:To determine the in vitro bacterial adherence to intraocular lenses (IOLs) routinely used at 1 center. SETTING:University Hospital of Vienna, Vienna, Austria. METHODS:Four types of rigid IOLs (hydrophobic poly[methyl methacrylate] [PMMA] and hydrophilic heparin-surface-modified PMMA) and 5 types of foldable i...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(02)01741-8
更新日期：2003-02-01 00:00:00
abstract：PURPOSE:To evaluate the protective properties of combined sodium hyaluronate 2% and mannitol 0.5% (Visiol) on the corneal endothelium in the presence of oxidative stress induced by hydrogen peroxide (H(2)O(2)). SETTING:Instituto Oftalmológico de Alicante, Universidad Miguel Hernández, Alicante, Spain. METHODS:This wa...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2004.11.055
更新日期：2005-06-01 00:00:00
abstract：:We used ultrasound to measure axial length in 66 eyes before and three months after extracapsular cataract extraction with implantation of a posterior chamber lens. An ultrasound velocity of 2,718 m/s for poly(methyl methacrylate) was assumed. The intraindividually measured difference (postoperative--preoperative axia...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(89)80035-5
更新日期：1989-11-01 00:00:00
abstract：PURPOSE:To correlate cycloplegic subjective refraction with cycloplegic autorefractometry in eyes that have had laser in situ keratomileusis (LASIK). SETTING:Vlemma Eye Institute, Athens, Greece. METHODS:Subjective refraction and autorefractometry under cycloplegia were performed in 73 eyes of 46 patients 1, 6, and 1...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(02)01743-1
更新日期：2003-01-01 00:00:00
