Season of birth and multiple sclerosis in Sweden.

Abstract:

OBJECTIVE:To estimate the risk of multiple sclerosis (MS) by month of birth in Sweden. MATERIALS AND METHODS:Cases (n = 9361) were obtained from the Swedish MS Registry. All births in Sweden 1900-2007 served as controls (n = 12,116,853). The risk of MS was analyzed for each month of birth separately compared with birth during the other 11 months. RESULTS:More (11%) cases with MS than expected were born in June. Fewer (8% and 10%) cases with MS than expected were born in December and January (non-significant after correction for multiple analyses). More (5%) cases with MS than expected were born in February-July as compared with August-January. CONCLUSIONS:This study supports previous results suggesting an association between the risk of MS and the season of birth. Decreased exposure to sun in the winter leading to low vitamin D levels during pregnancy is a possible explanation that needs further research.

journal_name

Acta Neurol Scand

authors

Salzer J,Svenningsson A,Sundström P

doi

10.1111/j.1600-0404.2009.01181.x

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

20-3

issue

1

eissn

0001-6314

issn

1600-0404

pii

ANE1181

journal_volume

121

pub_type

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