The effect of unsaturated fatty acids on sodium nitroprusside stimulation of guanylate cyclase in the human astrocytoma clone, D384, and the human neuroblastoma clone, NB1-G.

abstract：:The antimalarial artemisinin derivatives artesunate (ART), arteether (ARE), and artemether (ARM) reveal remarkable antineoplastic activity. In the present investigation, we identified mRNA expression profiles associated with the response of tumor cells to ART, ARE, and ARM. We performed correlation and hierarchical cl...

journal_title：Biochemical pharmacology

authors： Efferth T,Olbrich A,Bauer R

更新日期：2002-08-15 00:00:00

abstract：:Infliximab (IFX), a chimeric monoclonal antibody against tumor necrosis factor-α (TNF-α), is widely used to treat autoimmune diseases and chronic diseases associated with inflammation. TNF-α was reported to inhibit klotho, reactivate β-catenin and cause tubular cell injury in vitro. Whether the inhibition of TNF-α can...

journal_title：Biochemical pharmacology

authors： Younis NN,Mohamed HE,Shaheen MA,Abdelghafour AM,Hammad SK

更新日期：2021-01-19 00:00:00

abstract：:The effect of oxidant stress produced by redox cycling of substituted 1,4-naphthoquinones on the activity of platelet (Na(+)-K+)ATPase and the active transport of serotonin (5-HT) was studied. 2-Methyl-1,4-naphthoquinone (menadione) produced a concentration-dependent (0-100 microM) and time-dependent (2-20 min) stimul...

journal_title：Biochemical pharmacology

authors： Bosin TR,Schaltenbrand SL

更新日期：1991-03-15 00:00:00

abstract：:The oxidative metabolism of FK506 by liver microsomes and purified cytochrome P450 (P450) enzymes from rats, dogs and humans was studied. The major metabolite formed by liver microsomes from all species was 13-demethylated FK506, named M-I. In adult rats, liver microsomal metabolic activity toward FK506 was higher in ...

journal_title：Biochemical pharmacology

authors： Shiraga T,Matsuda H,Nagase K,Iwasaki K,Noda K,Yamazaki H,Shimada T,Funae Y

更新日期：1994-02-11 00:00:00

abstract：:Augmented endothelium-dependent contractions (EDC) contributes to endothelial dysfunction and vascular disease progression. An early signal in EDC is cytosolic [Ca2+]i rise in endothelial cells, which stimulates the production of contractile prostanoids, leading to vascular contraction. In this study, the molecular id...

journal_title：Biochemical pharmacology

authors： Liang C,Zhang Y,Zhuo D,Lo CY,Yu L,Lau CW,Kwan YW,Tse G,Huang Y,Yao X

更新日期：2019-01-01 00:00:00

abstract：:Clinical use of fibrate hypolipidaemic agents has been associated with an increased incidence of hepatobiliary dysfunction including increased bile lithogenicity, gallstone formation, and cholestasis. The hepatic transport of bile acids plays an important role in bile formation and flow, and interference with the hepa...

journal_title：Biochemical pharmacology

authors： Sabordo L,Sallustio BC

更新日期：1997-07-01 00:00:00

abstract：:The aim of this study was to document the in vivo transport of everolimus (inhibitor of mTOR) by P-glycoprotein (P-gp), and to investigate the influence of lapatinib (inhibitor of P-gp) on everolimus disposition. Pharmacokinetics of everolimus (0.25mg/kg) has been investigated after oral administration in mdr1a-/1b- m...

journal_title：Biochemical pharmacology

authors： Chu C,Abbara C,Noël-Hudson MS,Thomas-Bourgneuf L,Gonin P,Farinotti R,Bonhomme-Faivre L

更新日期：2009-05-15 00:00:00

abstract：:Anandamide and 2-arachidonoylglycerol (2-AG) are two endogenous ligands for the cannabinoid receptors, and their cannabimimetic activities are lost when they are hydrolyzed enzymatically. Cytosol and particulate fractions of porcine brain exhibited a high 2-AG hydrolyzing activity of 100 nmol/min/mg protein. Most of t...

journal_title：Biochemical pharmacology

authors： Goparaju SK,Ueda N,Taniguchi K,Yamamoto S

更新日期：1999-02-15 00:00:00

abstract：:Porcine cerebral microvessels were isolated by differential sieving and centrifugation and were characterized by microscopic examination and marker enzyme enrichment (gamma-glutamyltransferase; EC 2.3.2.2). Purified microvessels contained a membrane-bound enzyme immunologically indistinguishable from renal aminopeptid...

journal_title：Biochemical pharmacology

authors： Bausback HH,Churchill L,Ward PE

更新日期：1988-01-15 00:00:00

abstract：:The extraction and partial purification of endogenous "monoamine oxidase (MAO) inhibitor-like" material from the monkey brain are described. The endogenous material (F-1 and F-2) obtained after Bio-Gel P-2 gel filtration and silica column chromatography inhibited MAO in the monkey brain mitochondria toward 5-hydroxytr...

journal_title：Biochemical pharmacology

authors： Egashira T,Obata T,Nagai T,Kimba Y,Takano R,Yamanaka Y

更新日期：1989-02-15 00:00:00

abstract：:A method for the isolation of an intact, non-covalent complex formed by the interaction of aldose reductase, NADP(H) nucleotide, and inhibitor has been developed to aid in the discovery and development of novel aldose reductase inhibitors. In the complexes isolated, both the carboxylic acid-containing inhibitor tolres...

journal_title：Biochemical pharmacology

authors： Sugiyama K,Chen Z,Lee YS,Kador PF

更新日期：2000-02-15 00:00:00

abstract：:Glimepiride and glibenclamide act apparently in a closely comparable manner upon both insulin and glucagon release. Except for the decreased efficiency of D-glucose in suppressing glucagon release after a prior exposure of the pancreas to the hypoglycemic sulfonylureas, no evidence was obtained to suggest that a posit...

journal_title：Biochemical pharmacology

authors： Ledercq-Meyer V,Akkan AG,Marchand J,Malaisse WJ

更新日期：1991-09-27 00:00:00

abstract：:Surfaces of higher eukaryotes such as plants, invertebrates, and vertebrates, including humans, are normally covered with microorganisms but usually are not infected by them. The reason, apart from physical barriers, is the production of gene-encoded antimicrobial peptides by epithelial cells. Many novel antimicrobial...

journal_title：Biochemical pharmacology

authors： Schröder JM

更新日期：1999-01-15 00:00:00

abstract：:The inactive anthracycline analog 4-demethoxy-7,9-di-epi-daunorubicin was covalently coupled to polyglutaraldehyde microspheres. The polymer-bound analog acquired significant cytostatic activity as evaluated with doxorubicin resistant and sensitive murine L1210 leukemia cells. A suggested multiple membrane interaction...

journal_title：Biochemical pharmacology

authors： Rogers KE,Tökés ZA

更新日期：1984-02-15 00:00:00

abstract：:Cannabis and cannabinoids are known to affect female reproduction. However, the role of the endocannabinoid system in mouse uterine contractility in the dioestrus and oestrus phases has not been previously investigated. The present study aimed at filling this gap. Endocannabinoid (anandamide and 2-arachidonoylglycerol...

journal_title：Biochemical pharmacology

authors： Pagano E,Orlando P,Finizio S,Rossi A,Buono L,Iannotti FA,Piscitelli F,Izzo AA,Di Marzo V,Borrelli F

更新日期：2017-01-15 00:00:00

abstract：:Targeted drug therapy or "smart" drug delivery, potentially combined with simultaneous imaging modalities to monitor the delivery of drugs to specific tissues, is arguably the "holy grail" of pharmacology. Therapeutic approaches that exploit nanoparticles to deliver drugs selectively to cancer cells are currently cons...

journal_title：Biochemical pharmacology

authors： Garcia-Bennett A,Nees M,Fadeel B

更新日期：2011-04-15 00:00:00

abstract：:Homocysteine has been shown to increase glutathione levels in C3H/10T1/2 Cl 8 cells. The present paper confirms that this increase was specific for non-dividing cells. Several other thiols and disulfides, including cysteamine, mercaptoethanol and dithioerythritol, also increased glutathione, but the specificity for qu...

journal_title：Biochemical pharmacology

authors： Djurhuus R,Svardal AM,Ueland PM

更新日期：1990-02-01 00:00:00

abstract：:The effects of streptozotocin (STZ)-induced diabetes on acetaminophen metabolism and hepatotoxicity in male Sprague-Dawley (SD) and Long Evans Hooded (LEH) rats were compared. In agreement with earlier studies, normal SD rats were more resistant to acetaminophen-induced hepatic necrosis than normal LEH rats. In contra...

journal_title：Biochemical pharmacology

authors： Price VF,Jollow DJ

更新日期：1986-02-15 00:00:00

abstract：:Cephaloridine and cephaloglycin are the two most nephrotoxic cephalosporins released for human use. Cephaloridine has been shown to produce both oxidative and mitochondrial respiratory injury in renal cortex in patterns of dose (or concentration) and time that are consistent with pathogenicity. Cephaloglycin also prod...

journal_title：Biochemical pharmacology

authors： Tune BM,Fravert D,Hsu CY

更新日期：1989-03-01 00:00:00

abstract：:Tannic acid (TA) is a naturally occurring phenol, which has been found to display an antipromotion effect on mouse skin carcinogenesis. In order to explore the molecular mechanism, we have examined the process of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced protein kinase C (PKC) activation, including phorbol es...

journal_title：Biochemical pharmacology

authors： Kuo ML,Wu WS,Lee KC,Lin JK

更新日期：1993-10-19 00:00:00

abstract：:The effect of methotrexate (MTX) on 6-mercaptopurine (6-MP) metabolism was studied in four human leukemic cell lines in vitro. CCRF-CEM, WI-L2, TBJ, and HL-60 all expressed thiopurine methyltransferase (TPMT) activity. The cells were grown in horse serum-supplemented RPMI 1640 medium to which was added 4 microM of 6-M...

journal_title：Biochemical pharmacology

authors： Giverhaug T,Loennechen T,Aarbakke J

更新日期：1998-05-15 00:00:00

abstract：:The effect of 5 consecutive daily i.p. doses of CPZ (5 mg/kg), PZ (10 mg/kg) and PMZ (10 mg/kg) on the activity of kynurenine hydrolase and kynurenine aminotransferase in mouse liver was studied. All three phenothiazines effected an increase in the activity of kynurenine hydrolase per unit weight of liver with CPZ sho...

journal_title：Biochemical pharmacology

authors： Mostafa MH,El-Sewedy SM,El-Bassiouni EA,Abdel-Tawab GA

更新日期：1982-07-01 00:00:00

abstract：:Acetaminophen (AP) is a widely-used analgesic agent that has been linked to human liver and kidney disease with prolonged or high-dose usage. In rodents, the target organs that are affected include liver, kidney, and the olfactory mucosa. AP toxicity requires cytochrome P450(CYP)-mediated metabolic activation, and the...

journal_title：Biochemical pharmacology

authors： Genter MB,Liang HC,Gu J,Ding X,Negishi M,McKinnon RA,Nebert DW

更新日期：1998-06-01 00:00:00

abstract：:The localization of the low-affinity adenosine binding protein adenotin-1 with respect to distribution in rat organs and subcellular compartments was investigated. Adenotin-1 was characterized by 5'-N-ethylcarboxamido[2,8-3H]adenosine ([3H]NECA) binding and Western blotting. Cytosolic as well as membrane fractions of ...

journal_title：Biochemical pharmacology

authors： Lorenzen A,Engelhardt J,Kerst B,Schwabe U

更新日期：1998-02-15 00:00:00

abstract：:Cocaine has been shown to be hepatotoxic in mice, rats and humans. N-Oxidative metabolism of cocaine is required for this effect, and it has been proposed that binding of cocaine reactive metabolites formed via this pathway might be responsible for cytotoxicity. To explore this hypothesis, cocaine-protein adducts in l...

journal_title：Biochemical pharmacology

authors： Ndikum-Moffor FM,Roberts SM

更新日期：2003-07-01 00:00:00

abstract：:Sublines of K562 human leukemia cells were selected for resistance (30- to 80-fold) to etoposide by continuous exposure to 0.5 microM VP-16. Two etoposide-resistant cell lines, K/VP.5 and K/VP.5-1, showed a 5-fold reduction in levels of topoisomerase II alpha protein compared with K562 cells. Northern analysis indicat...

journal_title：Biochemical pharmacology

authors： Ritke MK,Yalowich JC

更新日期：1993-12-03 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the most prevalent lethal complications of diabetes that leads to end stage renal disease. Although several clinical approaches exist to attenuate DN, there is not curative treatment to date. DN is complicated, as it involves several simultaneous molecular pathways. Some natural and...

journal_title：Biochemical pharmacology

authors： Dewanjee S,Bhattacharjee N

更新日期：2018-09-01 00:00:00

abstract：:Runt-related transcription factor 1 (RUNX1), one subunit of core-binding factors in hematopoiesis and leukemia, was highly expressed in ovarian cancer (OC), but the role of RUNX1 in OC is largely unknown. Since we found that high expression of RUNX1 is correlated with poor survival in patients with OC through bioinfor...

journal_title：Biochemical pharmacology

authors： Xiao L,Peng Z,Zhu A,Xue R,Lu R,Mi J,Xi S,Chen W,Jiang S

更新日期：2020-10-01 00:00:00

abstract：:Cyclophilin (163 amino acids; 17,737 daltons) is a ubiquitous cytosolic protein that specifically binds the potent immunosuppressive drug cyclosporin A (CsA). To characterize the structural details of this interaction, extensive use has been made of two-dimensional (2D) NMR methods. For studies on CsA, these methods a...

journal_title：Biochemical pharmacology

authors： Hsu VL,Heald SL,Harding MW,Handschumacher RE,Armitage IM

更新日期：1990-07-01 00:00:00

abstract：:This study evaluated the effects of synthetic benzylamide compound I (2,6-dimethoxy-N-phenylbenzamide) on the ultraviolet B (UV B)-induced hyperpigmentation of the skin. UV B-induced hyperpigmentation was elicited on brownish guinea pig skin according to the method reported by Hideya et al. [Arch Dermatol Res 290 (199...

journal_title：Biochemical pharmacology

authors： Choi SY,Kim S,Hwang JS,Lee BG,Kim H,Kim SY

更新日期：2004-02-15 00:00:00