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Effects of glimepiride and glibenclamide on insulin and glucagon secretion by the perfused rat pancreas.

Abstract：

:Glimepiride and glibenclamide act apparently in a closely comparable manner upon both insulin and glucagon release. Except for the decreased efficiency of D-glucose in suppressing glucagon release after a prior exposure of the pancreas to the hypoglycemic sulfonylureas, no evidence was obtained to suggest that a positive glucagonotropic action of the latter drugs would counteract their hypoglycemic action, as mainly attributable to stimulation of insulin release.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Ledercq-Meyer V,Akkan AG,Marchand J,Malaisse WJ

doi

10.1016/0006-2952(91)90435-8

subject

Has Abstract

pub_date

1991-09-27 00:00:00

pages

1634-7

issue

8

eissn

0006-2952

issn

1873-2968

pii

0006-2952(91)90435-8

journal_volume

42

pub_type

杂志文章

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