Abstract：
:Using a series of reporter constructs in which a CAT coding sequence is constitutively transcribed under the influence of the SV40 late promoter but followed by varying portions of the 3'-untranslanted region of TNF, we have shown that the UA-rich element, present in the distal third of the 3'-unstranslated region of TNF, is absolutely required for translational activation of TNF synthesis. Replacement of the UA-rich element by an unrelated sequence of similar length completely abolishes the response. However, the context within which the UA-rich element is presented also appears to be essential, since replacement of flanking portions of 3'-untranslated sequence also blocks the response to LPS. These findings suggest that the primary role of the UA-rich element may consist in its ability to mediate translational activation in response to specific inducing signals.
journal_name
Eur Cytokine Netwjournal_title
European cytokine networkauthors
Han J,Beutler Bsubject
Has Abstractpub_date
1990-05-01 00:00:00pages
71-5issue
2eissn
1148-5493issn
1952-4005journal_volume
1pub_type
杂志文章abstract：:IL-1beta is suspected to be involved in the diarrhea that always accompanies inflammatory bowel disease. This work was aimed at studying the in vivo effect of IL-1beta on the net absorption of fluid, Na(+) and Cl(-) from the rat colon, and at delineating its mechanism of action. Rats were injected i.p. with IL-1beta (...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
abstract：:Oncostatin M (OSM) is known to inhibit the growth of melanocytes and early-stage melanomas, but this ability is lost with melanoma progression. The biological effects of OSM involve the activation of Janus kinases (Jak) and signal transducer and activator of transcription (STAT) factors. Since SOCS (suppressor of cyto...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：:Interleukin-10 (IL-10) is a pleiotropic cytokine, which has both regulatory and stimulatory effects on different immune cell types. Different studies have reported the importance of IL-10 and Transforming growth factor-beta (TGF-β) in the regulation of B cell class switching the production of immunoglobulin A (IgA); h...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2019.0434
更新日期：2019-09-01 00:00:00
abstract：INTRODUCTION:In vitro studies have shown that oxidized, low density lipoprotein (ox-LDL) stimulates macrophages to release interleukin-6 (IL-6) and interleukin-1β (IL-1β). In this study, we aimed to investigate the correlation between ox-LDL and IL-6 and IL-1β levels in the peripheral circulation of patients with type ...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2011.0282
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:High levels of inflammatory cytokines lead to lung damage in premature newborns. We investigated whether single nucleotide polymorphisms (SNP) of innate immunity cytokine genes influence the length of oxygen supplementation. METHODS:We genotyped 123 very low birth weight (VLBW) infants for the tumour necros...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVE:To investigate the relationship between the response to influenza vaccination and the ability to produce proinflamatory cytokines in elderly subjects. METHODS:Whole blood samples from 25 elderly subjects collected before influenza vaccination were stimulated with the influenza vaccine in order to evaluate th...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2016.0378
更新日期：2016-09-01 00:00:00
abstract：:In this in vitro study, the influence of serum-concentration, heat inactivation of the serum and the origin of the serum on the responsiveness of cultured human umbilical vein endothelial cells (HUVEC) to immunological challenges was investigated. Addition of human serum during stimulation with 1 microgram/ml bacteria...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:The effects of IL-3, GM-CSF and IL-5 on the expression of CD23 (Fc epsilon RII), CD25 (IL-2R/p55) and CD4 on an eosinophilic cell line (EoL-3) were investigated by flow cytometry. A separate incubation with IL-3, GM-CSF or IL-5 alone, did not induce the expression of CD23, CD25, or CD4. However, a sequential incubatio...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Multiple studies have shown that the cytokine leukemia inhibitory factor (LIF) is protective of the myocardium in the acute stress of ischemia-reperfusion. All three major intracellular signaling pathways that are activated by LIF in cardiac myocytes have been linked to actions that protect against oxidative stress an...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：10.1684/ecn.2013.0335
更新日期：2013-03-01 00:00:00
abstract：:Monocyte chemotactic protein-3 (MCP-3) is a C-C chemokine which interacts with the CCR1, CCR2 (MCP-1) and CCR3 receptors and has a distinct spectrum of action. The present study was designed to investigate whether human endothelial cells (EC) and, by way of comparison, monocytes express MCP-3 and its regulation by pro...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：:A network of pro-inflammatory cytokines is a central feature in the pathophysiology of cutaneous inflammatory diseases. Thus, the delineation of precise roles for particular cytokines and the development of cytokine-directed therapeutics have become areas of intense investigation. While anti-TNF therapeutics have prov...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：
更新日期：2005-06-01 00:00:00
abstract：:Leishmania parasites persist in their vertebrate host after the treatment-induced clinical cure and in the asymptomatic infection. They confer resistance to reinfection but represent a risk of occurrence of acute leishmaniosis in immunosuppressed conditions. We examined the effects of prolonged dexamethasone administr...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:We investigated the serum concentration of the tumour necrosis factor (TNF) family ligands (TNF-alpha and TNF-beta) and their soluble receptors (sTNF-R p55 and sTNF-R p75) in 66 patients with rheumatoid arthritis (RA) and 14 healthy subjects as a control group, using an enzyme-linked immunosorbent assay (ELISA). We ex...
journal_title：European cytokine network
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：UNLABELLED:It is well known that alcoholics are prone to severe infections and that the immune system is impaired by chronic ethanol abuse. The aim of this study is to compare serum inflammatory mediators in response to sepsis in chronic alcoholic with sepsis, non-alcoholics with sepsis and non-infected alcoholics. ME...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2011.0272_1
更新日期：2011-03-01 00:00:00
abstract：:Interferon-gamma (IFN-gamma) is a lymphokine produced by activated T lymphocytes and NK cells, that plays an important role in host defense mechanisms by exerting pleiotropic activities on a wide range of cell types. Cellular responses to IFN-gamma are mediated by its heterodimeric cell surface receptor (IFN-gammaR), ...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:Lymph nodes (LNs) are among the first sites of tumor metastasis. The expression of chemokines and chemokine receptors in LNs are involved in cancer prognosis and are considered to be good predictors of tumor progression. The main aim of this study was to assess the expression of important, tumor-promoting ch...
journal_title：European cytokine network
pub_type： 杂志文章
doi：10.1684/ecn.2012.0310
更新日期：2012-07-01 00:00:00
abstract：:Recent studies have shown that the T cell-derived cytokine, interleukin-17 (IL-17), stimulates hematopoiesis, specifically granulopoiesis inducing expansion of committed and immature progenitors in bone marrow. Our previous results pointed to its role in erythropoiesis too, demonstrating significant stimulation of BFU...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
abstract：:A panel of monoclonal antibodies against the soluble IL-6 receptor was used to search for linear epitopes by a Pepscan analysis. Two such epitopes were found and the corresponding peptides were synthesized chemically. The peptides were active to inhibit the IL-6 dependent growth of human multiple myeloma cell line and...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：:Toll-like receptor (TLR)-4 is an important pattern recognition receptor for Candida albicans, playing a role in innate host defense. We investigated whether there is an association between the TLR4 Asp299Gly or TLR4 Thr399Ile polymorphism, and the occurrence of Candida bloodstream infection. We performed a case-contro...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：:Carbocysteine lysine salt monohydrate (SCMC-Lys) is a well-known mucoactive drug whose therapeutic efficacy is commonly related to the ability of SCMC-Lys to replace fucomucins by sialomucins. The aim of this study was to determine if SCMC-Lys could exert an anti-oxidant action by scavenging reactive oxygen intermedia...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:We have recently shown that IL-10 represents an efficient stimulus for suppressor of cytokine signalling (SOCS)-3 mRNA expression in human neutrophils and PBMC. Herein, we identify cAMP-elevating agents such as prostaglandin E2 (PGE2), PGE1, forskolin, dibutyryl cAMP (dbcAMP) and cholera toxin as a novel class of agon...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:We analysed the specific effects of IL-1beta immunoneutralization on the expression of IL-6 in different pure cultures of neurones and glia after both experimental subliminal hypoxia and recovery. Whereas the IL-1beta-deprivation signal induced a decrease in IL-6 expression and release of normoxic neurones, it provoke...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2003-04-01 00:00:00
abstract：:Pathogenic mechanisms of brain microvascular injury were studied in an experimental model of cerebral malaria (CM). The lesion, leading to perivascular microhemorrhages, is due to cytokine overproduction, and is associated with the sequestration of macrophages and parasitized erythrocytes in cerebral venules. In this ...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：:Interleukin-6 (IL-6) is a pleiotropic cytokine which regulates the immune response, the acute-phase response, hematopoiesis and body energy balance. Genetic polymorphism at -174 position of IL-6 promoter has been recently reported to be linked with insulin resistance, however, with conflicting results. The C allele at...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2004-04-01 00:00:00
abstract：:Since the initial discovery of endothelial progenitor cells (EPC), and their promise in increasing angiogenesis and vasculogenesis, a myriad of papers have highlighted their potential application in experimental and clinical neovascularization and in tissue engineering. However, promising reports are contrasted by oth...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：10.1684/ecn.2009.0174
更新日期：2009-12-01 00:00:00
abstract：:In the central nervous system, cytokine-primed microglia play a pivotal role in host defence against parasite infections. In this study, the effect of recombinant (r) prolactin (rPRL) and rIFN-gamma on A. castellanii infection in murine microglia was examined. Priming of microglia with rPRL and rIFN-gamma synergistica...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2002-10-01 00:00:00
abstract：:Apoptosis is a major mechanism for reducing acute inflammation by elimination of unwanted cellular responses causing tissue damage and monocytes (Mo) and macrophages (Mo) play an important role in these processes. Therefore, in the following we summarize how these cells may contribute to regulation of apoptosis of oth...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：
更新日期：1998-12-01 00:00:00
abstract：:We investigated the serum concentration of the interleukin-10 (IL-10), along with cytokines of interleukin-6 (IL-6) family (IL-6, IL-11 and oncostatin M - OSM), as well as soluble receptor for IL-6 (sIL-6R), in 121 patients with multiple myeloma (MM) and 28 healthy subjects. We studied the interactions between IL-10 a...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:Members of the Toll-like receptor family are essential components of the innate immune system. Herein we report the molecular cloning and characterization of three novel human Toll-like receptors (hTLRs) designated hTLR7, hTLR8, and hTLR9. Human TLR7-9, like the previously described members hTLR1-6 contain an ectodoma...
journal_title：European cytokine network
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:Thrombopoietin (TPO), the primary physiological regulator of platelet production, was initially thought to be a lineage-specific factor acting predominantly on megakaryocytopoiesis. Detailed studies establish that this cytokine mediates biological effects on a broad spectrum of hematopoietic progenitor cells, includin...
journal_title：European cytokine network
pub_type： 杂志文章,评审
doi：
更新日期：1998-09-01 00:00:00
