Abstract:
STUDY DESIGN:A case-control evaluating seminal citrate in patients with spinal cord injury (SCI). OBJECTIVE:Several studies have shown neurological prostatic dysfunction in patients with SCI, as confirmed by low levels of seminal prostate-specific antigen (PSA), which is used as a parameter of gland activity. However, seminal citrate, produced almost exclusively by the prostate, could also be used as a marker of prostate function. Thus, the objective of this study was to determine whether SCI causes any changes in seminal citrate concentration and to compare the results obtained for patients and healthy men (controls). SETTING:The study was carried out in Brazil. METHODS:We studied 30 men with SCI aged on average 37.77+/-10.04 years and 30 controls aged on average 38.03+/-10.06 years. Blood and semen samples were collected after 3 days of abstinence from ejaculation. Fifteen minutes after collection, semen was stored in liquid nitrogen and the samples were submitted to (1)H nuclear magnetic resonance ((1)H NMR). Serum was stored at a controlled temperature of -70 to -79 degrees C and later used for the determination of testosterone, prolactin and total PSA using an AxSYM instrument and Abbott reagents. RESULTS:The median concentration of seminal citrate was significantly lower in patients than in controls (521.65 versus 858.30 mg per 100 ml, P<0.001). CONCLUSIONS:Patients with SCI have a significant reduction of seminal citrate as a consequence of neurological dysfunction of the prostate.
journal_name
Spinal Cordjournal_title
Spinal cordauthors
Alexandrino AP,Rodrigues MA,Matsuo T,Schuquel IT,Costa WF,Santilli JCdoi
10.1038/sc.2009.62subject
Has Abstractpub_date
2009-12-01 00:00:00pages
878-81issue
12eissn
1362-4393issn
1476-5624pii
sc200962journal_volume
47pub_type
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