Adherence of adolescents to multiple sclerosis disease-modifying therapy.

Abstract:

:In this mixed-methods study, utilization data for disease-modifying therapies were reviewed to determine the adherence rate among our pediatric multiple sclerosis cohort. Adolescents were interviewed to explore their experiences with multiple sclerosis and the impact of peer relationships on adherence to treatment. Seventeen adolescents (6 male, 11 female) started interferon beta or glatiramer acetate before age 18. The mean age at first drug start date was 15.8 years. Eight of the adolescents (47%) discontinued treatment after a median duration of 20 months. Many of the adolescents struggled to integrate the injections into their daily lives, with peers either facilitating or impeding this transition. In conclusion, adolescents in this cohort had difficulty adhering to disease-modifying therapies, and peers played an important role in mediating their adjustment to multiple sclerosis. Specific strategies are required to improve adolescents' adherence to treatment, including less intrusive options and enhancing peer support.

journal_name

Pediatr Neurol

journal_title

Pediatric neurology

authors

Thannhauser JE,Mah JK,Metz LM

doi

10.1016/j.pediatrneurol.2009.03.004

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

119-23

issue

2

eissn

0887-8994

issn

1873-5150

pii

S0887-8994(09)00141-6

journal_volume

41

pub_type

杂志文章
  • Prevalence of tics in schoolchildren in central Spain: a population-based study.

    abstract::Tic disorders constitute a neurodevelopmental disorder of childhood. This study sought to determine the prevalence of tic disorders in a school-based sample. A randomized sample of 1158 schoolchildren, based on clusters (classrooms) in the province of Burgos (Spain), was identified on a stratified sampling frame combi...

    journal_title:Pediatric neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.pediatrneurol.2011.03.003

    authors: Cubo E,Gabriel y Galán JM,Villaverde VA,Velasco SS,Benito VD,Macarrón JV,Guevara JC,Louis ED,Benito-León J

    更新日期:2011-08-01 00:00:00

  • Association between frequency of nocturnal epilepsy and language disturbance in children.

    abstract::In clinical practice, an association is commonly suggested between nocturnal epileptiform activity and language disorders in children. However, this association has not been studied systematically. This study explored the correlation between daily and nocturnal epileptiform discharges ratio, frequency of nocturnal epi...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/j.pediatrneurol.2010.10.014

    authors: Overvliet GM,Besseling RM,Vles JS,Hofman PA,van Hall MH,Backes WH,Aldenkamp AP

    更新日期:2011-05-01 00:00:00

  • Pediatric Hirayama disease.

    abstract::We report on a 16-year-old girl with muscular atrophy of a distal upper extremity (Hirayama disease). The disease progressed insidiously, and during our first examination, she exhibited weakness and wasting in the right hand, accompanied by cold paresis. No sensory disturbance was evident. A nerve conduction test reve...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/j.pediatrneurol.2010.03.015

    authors: Hosokawa T,Fujieda M,Wakiguchi H,Oosaki Y

    更新日期:2010-08-01 00:00:00

  • Clinical profile of oxcarbazepine-related angioneurotic edema: case report and review.

    abstract::Oxcarbazepine, a carbamazepine analog, was approved for use as an antiepileptic agent in the United States in 2000. A search of the United States Food and Drug Administration's Adverse Event Reporting System identified nine cases of oxcarbazepine-associated angioedema in pediatric patients aged 16 years and younger. W...

    journal_title:Pediatric neurology

    pub_type: 杂志文章,评审

    doi:10.1016/j.pediatrneurol.2007.03.010

    authors: Knudsen JF,Flowers CM,Kortepeter C,Awaad Y

    更新日期:2007-08-01 00:00:00

  • Mild encephalopathy with splenial lesion and parainfluenza virus infection.

    abstract::Mild encephalopathy with reversible splenial lesions has mainly been associated with influenza A and B virus infection. Patients present with neurologic symptoms 1 to 3 days after a prodromal illness and recover completely within a few days. Magnetic resonance imaging typically shows reversible lesions with reduced di...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/j.pediatrneurol.2012.11.007

    authors: Abenhaim Halpern L,Agyeman P,Steinlin M,El-Koussy M,Grunt S

    更新日期:2013-03-01 00:00:00

  • Phenotypic variability in a portuguese family with x-linked creatine transport deficiency.

    abstract::Cerebral creatine transporter deficiency, attributable to mutations in the SLC6A8 gene, causes X-linked mental retardation, language delay, epilepsy, and autistic features. In contrast with creatine synthesis defects, the vast majority of patients with SLC6A8 deficiency do not respond to treatment. We describe a Portu...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/j.pediatrneurol.2011.10.005

    authors: Garcia P,Rodrigues F,Valongo C,Salomons GS,Diogo L

    更新日期:2012-01-01 00:00:00

  • Infection: a stimulus for tic disorders.

    abstract::The object of this study was to investigate the potential association of infections, especially group A hemolytic streptococcal infection, with the abrupt onset/exacerbation of tics or obsessive-compulsive behaviors. A structured clinical interview was used to evaluate 80 consecutive children, 5-17 years of age, with ...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/s0887-8994(00)00131-4

    authors: Singer HS,Giuliano JD,Zimmerman AM,Walkup JT

    更新日期:2000-05-01 00:00:00

  • West syndrome following deep hypothermic infant cardiac surgery.

    abstract::Postoperative seizures are among the more common complications of cardiac surgery in children. These seizures have traditionally been considered benign, transient phenomena with little, if any, prognostic significance. We report 4 infants with early postoperative seizures following cardiac surgery who later developed ...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/0887-8994(94)90111-2

    authors: du Plessis AJ,Kramer U,Jonas RA,Wessel DL,Riviello JJ

    更新日期:1994-10-01 00:00:00

  • Suicide Screening in Sturge-Weber Syndrome: An Important Issue in Need of Further Study.

    abstract:BACKGROUND:Sturge-Weber syndrome is a neurocutaneous disorder associated with epilepsy, glaucoma, cognitive impairments, and a port-wine birthmark. Although individuals with Sturge-Weber syndrome are vulnerable to known risk factors for suicide, including chronic illness and physical differences (port-wine birthmark), ...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/j.pediatrneurol.2020.03.013

    authors: Sebold AJ,Ahmed AS,Ryan TC,Cohen BA,Jampel HD,Suskauer SJ,Zabel TA,Comi AM,Rybczynski S

    更新日期:2020-09-01 00:00:00

  • Phasic sleep components in infants with cyanosis during feeding.

    abstract::Although brainstem immaturity has been postulated as one of the pathogenesis underlying cyanosis during feeding (CDF), there has been no widely accepted physiologic parameter that reflects brainstem function. We recently proposed that the dissociation index (DI), one of the phasic sleep parameters, is a reliable and q...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/0887-8994(91)90085-y

    authors: Kohyama J,Watanabe S,Iwakawa Y

    更新日期:1991-05-01 00:00:00

  • Balamuthia amebic meningoencephalitis and mycotic aneurysms in an infant.

    abstract::Balamuthia amebic encephalitis is rarely reported in infants. To the best of our knowledge, amebic encephalitis complicated by a mycotic aneurysm was only described once. We report on an 8-month-child with laboratory-confirmed Balamuthia mandrillaris meningoencephalitis, complicated by a mycotic aneurysm of the middle...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/j.pediatrneurol.2011.05.003

    authors: Hill CP,Damodaran O,Walsh P,Jevon GP,Blyth CC

    更新日期:2011-07-01 00:00:00

  • Reduction of seizures with low-dose clonazepam in children with epilepsy.

    abstract::The acute effects of low-dose clonazepam on seizure frequency in children with epilepsy was evaluated. In an open study, 19 children with epilepsy (15 generalized and four partial) were examined during hospitalization with recordings of seizures by trained personnel. Seizures were counted during two 24-hour periods: b...

    journal_title:Pediatric neurology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0887-8994(02)00468-x

    authors: Dahlin MG,Amark PE,Nergårdh AR

    更新日期:2003-01-01 00:00:00

  • Prognostic value of VEPs in young children with acute onset of cortical blindness.

    abstract::Visual evoked potentials (VEPs) were recorded in 32 children (ages 4 months to 5 years) who were clinically diagnosed as being cortically blind. None of the children had visual or neurologic abnormalities prior to the precipitating insult which included surgery (N = 15), trauma (N = 3), infectious disease (N = 5), hyp...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/0887-8994(91)90006-7

    authors: Taylor MJ,McCulloch DL

    更新日期:1991-03-01 00:00:00

  • Acute cerebellar swelling in varicella encephalitis.

    abstract::A 4-year-old male developed encephalitis 2 weeks after the onset of varicella. During his evaluation neuroradiologic procedures documented cerebellar edema and demyelination. Cerebrospinal fluid titers confirmed varicella encephalitis. To our knowledge, this patient is the first reported with focal cerebellar edema, a...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/0887-8994(88)90054-9

    authors: Hurst DL,Mehta S

    更新日期:1988-03-01 00:00:00

  • Clinical manifestations of neurofibromatosis-1 in Chinese children.

    abstract::The complications of 50 Chinese children with neurofibromatosis-1 were found to be different from other ethnic groups. There was a predominance of scoliosis, speech problems, and blood malignancies, but brain tumors were rare. The majority had good prognosis. Clinical manifestations depend on the age of ascertainment ...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/0887-8994(94)90006-x

    authors: Wong VC

    更新日期:1994-11-01 00:00:00

  • Duane retraction syndrome associated with Chiari I malformation.

    abstract::A 13-year-old girl who had Duane retraction syndrome associated with Chiari I malformation is reported. Neuro-ophthalmologic examination revealed severe limitation of abduction of the left eye, as well as narrowing of the palpebral fissure and retraction of the globe on adduction. Electro-oculography of the affected e...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/0887-8994(93)90075-n

    authors: Yamanouchi H,Iwasaki Y,Sugai K,Mukuno K

    更新日期:1993-07-01 00:00:00

  • Kawasaki disease with predominant central nervous system involvement.

    abstract::A 4-year-old female was hospitalized with clinical and electroencephalographic evidence of acute encephalopathy. Five days later the classic signs of Kawasaki disease appeared. The neurologic outcome in this female was poor despite early treatment with immunoglobulin. Like many other vasculitidies, Kawasaki disease ca...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/s0887-8994(01)00290-9

    authors: Tabarki B,Mahdhaoui A,Selmi H,Yacoub M,Essoussi AS

    更新日期:2001-09-01 00:00:00

  • Primary malignant melanoma of meninges: atypical presentation of subacute meningitis.

    abstract::Primary malignant melanoma of the meninges is described in a 5-year-old boy who presented with a 3-month history suggestive of subacute meningitis. Clinically the diagnosis of tuberculous meningitis was made and antituberculous treatment was begun. Despite this treatment, the patient's condition continued to deteriora...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/0887-8994(94)00155-u

    authors: Nicolaides P,Newton RW,Kelsey A

    更新日期:1995-02-01 00:00:00

  • A young infant with musicogenic epilepsy.

    abstract::Musicogenic epilepsy is a relatively rare form of epilepsy. In its pure form, it is characterized by epileptic seizures that are provoked exclusively by listening to music. The usual type of seizure is partial complex or generalized tonic-clonic. Precipitating factors are quite specific, such as listening to only one ...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/s0887-8994(03)00011-0

    authors: Lin KL,Wang HS,Kao PF

    更新日期:2003-05-01 00:00:00

  • Evaluation of Responsiveness to Reduced-Dose Rituximab in Corticotropin/Intravenous Immunoglobulin/Rituximab Combination Immunotherapy for Opsoclonus-Myoclonus Syndrome.

    abstract:BACKGROUND:Rituximab (anti-CD20) has been used as B-cell-targeted intervention to treat opsoclonus-myoclonus syndrome. Due to isolated reports of chronic hypogammaglobulinemia and B lymphopenia following rituximab in several disorders, and rapid B-cell depletion after a few doses, we reduced the dosage 20% in our clini...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/j.pediatrneurol.2018.05.003

    authors: Pranzatelli MR,Tate ED,McGee NR,MacArthur CA

    更新日期:2018-08-01 00:00:00

  • Factors associated with behavioral and cognitive abnormalities in children receiving topiramate.

    abstract::The objective of this study was to examine the factors associated with the occurrence of behavioral and cognitive abnormalities in children treated with topiramate. A retrospective chart review of patients up to 18 years of age who had been treated with topiramate at a tertiary epilepsy center was performed. Behaviora...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/s0887-8994(99)00151-4

    authors: Gerber PE,Hamiwka L,Connolly MB,Farrell K

    更新日期:2000-03-01 00:00:00

  • Sensibility of the Hand in Children With Conservatively or Surgically Treated Upper Neonatal Brachial Plexus Lesion.

    abstract:BACKGROUND:The aim of this study was to assess the sensibility of the hand in children with a neonatal brachial plexus palsy (NBPP) involving the C5 and C6, and to correlate results with dexterity. METHODS:Fifty children with NBPP (30 after nerve surgery, mean age 9.8 years) and 25 healthy controls (mean age 9.6 years...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/j.pediatrneurol.2018.04.006

    authors: Buitenhuis SM,Pondaag W,Wolterbeek R,Malessy MJA

    更新日期:2018-09-01 00:00:00

  • Oxcarbazepine in children with nocturnal frontal-lobe epilepsy.

    abstract::Nocturnal frontal-lobe epilepsy is characterized by paroxysmal arousals, motor seizures with dystonic or hyperkinetic features, and episodic nocturnal wanderings. Carbamazepine is effective for seizure control in some of these patients, but seizures may be refractory to multiple antiepileptic drugs. We report on eight...

    journal_title:Pediatric neurology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.pediatrneurol.2007.06.013

    authors: Raju GP,Sarco DP,Poduri A,Riviello JJ,Bergin AM,Takeoka M

    更新日期:2007-11-01 00:00:00

  • Acquired microcephaly in blepharophimosis-ptosis-epicanthus inversus syndrome because of an interstitial 3q22.3q23 deletion.

    abstract:BACKGROUND:Blepharophimosis-ptosis-epicanthus inversus syndrome is an autosomal dominant condition because of mutations or deletions of the FOXL2 gene. Microcephaly is not associated with FOXL2 mutations but has been reported in individuals with chromosome 3q deletions, which include the FOXL2 gene and other contiguous...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/j.pediatrneurol.2014.01.055

    authors: Dean SJ,Holden KR,Dwivedi A,Dupont BR,Lyons MJ

    更新日期:2014-06-01 00:00:00

  • Onset of generalized seizures after intrathecal interferon therapy of SSPE.

    abstract::An 11-year-old male was admitted with inability to walk and speech abnormality. He was diagnosed with subacute sclerosing panencephalitis on the basis of clinical and laboratory findings. Therapy with inosiplex (100 mg/kg/day orally) plus intrathecal interferon-alpha (3 million units/dose twice per week) and ribavirin...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/s0887-8994(03)00040-7

    authors: Caksen H,Odabaş D,Anlar O,Ataş B,Tuncer O

    更新日期:2003-07-01 00:00:00

  • Cortical atrophy and cognitive performance in infantile nephropathic cystinosis.

    abstract::A group of children and adolescents with infantile nephropathic cystinosis underwent cognitive testing and were examined for cortical atrophy using magnetic resonance imaging or computed tomography. Ten of 11 patients demonstrated cortical atrophy. A consistent pattern of lower cognitive performance was found in patie...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/0887-8994(90)90004-k

    authors: Nichols SL,Press GA,Schneider JA,Trauner DA

    更新日期:1990-11-01 00:00:00

  • Premonitory Symptoms in Episodic and Chronic Migraine From a Pediatric Headache Clinic.

    abstract:OBJECTIVE:We evaluated the frequency of six commonly reported adult migraine premonitory symptoms in children and adolescents with episodic and chronic migraine and elicited psychological or behavioral comorbidities that may be associated with these symptoms. BACKGROUND:Premonitory symptoms are commonly reported in th...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/j.pediatrneurol.2019.03.023

    authors: Jacobs H,Pakalnis A

    更新日期:2019-08-01 00:00:00

  • Uncoupling of EEG-clinical neonatal seizures after antiepileptic drug use.

    abstract::A prospective study of the efficacy of seizure cessation by phenobarbital versus phenytoin administration utilized both clinical and electroencephalographic expressions of seizure behaviors. The phenomenon of uncoupling was defined as the persistence of electrographic seizures despite the suppression of >or=50% clinic...

    journal_title:Pediatric neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0887-8994(02)00621-5

    authors: Scher MS,Alvin J,Gaus L,Minnigh B,Painter MJ

    更新日期:2003-04-01 00:00:00

  • Vertigo is an underestimated symptom of ocular disorders: dizzy children do not always need MRI.

    abstract::Vertigo, instability, dizziness, or equilibrium disorders are not usually considered as consequences of ophthalmologic problems. We present data indicating that ocular disorders can be responsible for these symptoms in children. In a population of 523 pediatric patients with vertigo or disequilibrium and referred for ...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/s0887-8994(00)00140-5

    authors: Anoh-Tanon MJ,Bremond-Gignac D,Wiener-Vacher SR

    更新日期:2000-07-01 00:00:00

  • Visual field plasticity in a female with right occipital cortical dysplasia.

    abstract::Brain plasticity refers to its ability to recover after damage. Visual field plasticity is not well recognized. We report a 12-year-old female who first presented with recurrent seizures and was subsequently found to have a large, right occipital cortical dysplasia on magnetic resonance imaging. Her visual field by Go...

    journal_title:Pediatric neurology

    pub_type: 杂志文章

    doi:10.1016/s0887-8994(00)00171-5

    authors: Kong CK,Wong LY,Yuen MK

    更新日期:2000-09-01 00:00:00