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In vivo and in vitro effects of magnesium sulfate in the cerebrovascular bed of the goat.

Abstract：

:The effects of magnesium sulfate in the cerebrovascular bed were studied both in vivo, by measuring cerebral blood flow in conscious nonpregnant goats, and in vitro, by recording isometric tension in isolated goat middle cerebral arteries. Injections of increasing doses (10 to 300 mg) of magnesium sulfate directly into the cerebral circulation elicited transient and dose-dependent increases in cerebral blood flow and decreases in cerebral vascular resistance. Similar results were obtained when increasing doses (0.3 to 3 gm/15 min) of magnesium sulfate were infused intravenously, although the vasodilatations reached a stable plateau that remained when the infusions finished. Cumulative addition of magnesium sulfate (10(-5) to 3 x 10(-2) mol/L) did not change the isometric tension of isolated arterial segments at resting tone, but relaxed in a concentration-dependent manner the arterial segments preconstricted with 10(-5) mol/L prostaglandin F2 alpha. These results demonstrate that magnesium sulfate acts as a dilator in the cerebral circulation by acting directly on the cerebral arteries. This could explain, at least in part, its beneficial effects on preeclampsia-eclampsia.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Perales AJ,Torregrosa G,Salom JB,Miranda FJ,Alabadí JA,Monleón J,Alborch E

doi

10.1016/0002-9378(91)90401-c

subject

Has Abstract

pub_date

1991-11-01 00:00:00

pages

1534-8

issue

5 Pt 1

eissn

0002-9378

issn

1097-6868

pii

0002-9378(91)90401-C

journal_volume

165

pub_type

杂志文章

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