HLA sharing and spontaneous abortion in humans.

Abstract:

:Twenty-one Caucasian couples with two or more idiopathic fetal losses and with either no live-born children or with only one live-born child were typed for HLA-A, B, and DR antigens, and mixed lymphocyte responses of the maternal lymphocytes to stimulation by paternal lymphocytes were studied. The mixed lymphocyte response results showed that women who experienced habitual fetal loss had normal immune responses, thereby lending less credence to the idea that a defective immunologic response is involved in problem pregnancies. The data were pooled and analyzed with those of similar reports, and there was a strong indication that aborting couples shared a greater portion of the chromosome that contains the major histocompatibility complex (MHC) than would be expected in random matings.

journal_name

Am J Obstet Gynecol

authors

Thomas ML,Harger JH,Wagener DK,Rabin BS,Gill TJ 3rd

doi

10.1016/0002-9378(85)90379-5

subject

Has Abstract

pub_date

1985-04-15 00:00:00

pages

1053-8

issue

8

eissn

0002-9378

issn

1097-6868

pii

0002-9378(85)90379-5

journal_volume

151

pub_type

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