Abstract：
:Prion diseases, also known as the transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative disorders that affect humans and animals. These diseases are intimately associated with conformational conversion of the cellular prion protein, PrP(C), into an oligomeric beta-sheet-rich form, PrP(Sc). A growing number of observations support the once heretical hypothesis that transmission of TSE diseases does not require nucleic acids and that PrP(Sc) alone can act as an infectious agent. The view that misfolded proteins can be infectious is also supported by recent findings regarding prion phenomena in yeast and other fungi. One of the most intriguing facets of prions is their ability to form different strains, leading to distinct phenotypes of TSE diseases. Within the context of the "protein-only" model, prion strains are believed to be encoded in distinct conformations of misfolded prion protein aggregates. In this review, we describe recent advances in biochemical aspects of prion research, with a special focus on the mechanism of conversion of prion protein to the pathogenic form(s), the emerging structural knowledge of fungal and mammalian prions, and our rapidly growing understanding of the molecular basis of prion strains and their relation to barriers of interspecies transmissibility.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Cobb NJ,Surewicz WKdoi
10.1021/bi900108vsubject
Has Abstractpub_date
2009-03-31 00:00:00pages
2574-85issue
12eissn
0006-2960issn
1520-4995journal_volume
48pub_type
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