Abstract：
BACKGROUND:Mobility and balance in Huntington's disease (HD) are currently assessed in the clinic with three items from the unified Huntington's disease rating scale (UHDRS): walk, tandem and pull tests. These tests may not be optimal because they are scored on an ordinal scale and do not test anticipatory balance. We tested the validity and responsiveness of three clinical tests of mobility and balance. METHODS:Three clinical tests (FRT, timed up and go (TUG), Berg balance scale (BBS)) were validated with seven quantitative gait measures and two indicators of functional limitation (HD-ADL and total functional capacity) in 30 subjects with HD. These tests were also assessed for responsiveness to disease severity. RESULTS:FRT and BBS were correlated with five quantitative gait measures, and TUG with eight (all p<0.05). All tests were correlated with indicators of functional limitation (p<0.05) and were responsive to disease severity. CONCLUSIONS:FRT, TUG and BBS are valid, responsive and easy to administer clinical tests that should be routinely included with the UHDRS in therapeutic trials for subjects with HD.
journal_name
Gait Posturejournal_title
Gait & postureauthors
Rao AK,Muratori L,Louis ED,Moskowitz CB,Marder KSdoi
10.1016/j.gaitpost.2008.11.002subject
Has Abstractpub_date
2009-04-01 00:00:00pages
433-6issue
3eissn
0966-6362issn
1879-2219pii
S0966-6362(08)00363-9journal_volume
29pub_type
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