Abstract:
INTRODUCTION:Some studies have made use of the antioxidative capabilities of high doses of vitamins C and E with the aim of neutralizing the noxious effects of free radicals following spinal cord lesion. OBJECTIVES:To evaluate the effects of vitamins C and E, separately and together, on the functional performance of rats that were subjected to standardized spinal cord contusion. MATERIALS AND METHODS:Forty male Wistar rats were used, divided into four groups of 10 animals each. Group 3 received vitamin C 100 mg kg(-1) day(-1) intraperitoneally; Group 2 received vitamin E 100 mg kg(-1) day(-1) orally; Group 1 received vitamins C and E, at the same dosages; and Group 4 was the control. The vitamin therapy was administered for 1 month and then the animals were killed. A direct contusional injury was caused and functional evaluation was performed using the Basso, Beattie and Bresnahan rating scale. The rats were evaluated on the second postoperative day and weekly thereafter, until the end of the experiment. RESULTS:The results were evaluated by means of the one-tailed, non-paired and non-parametric Mann-Whitney test, comparing the groups two by two. No significant difference in functional performance was observed between the groups. CONCLUSION:The use of vitamins C and E in these rats did not improve their neurological performance. However, histopathological examination showed that the inflammatory response was less intense following administration of the combination of vitamins C and E.
journal_name
Spinal Cordjournal_title
Spinal cordauthors
Cristante AF,Barros Filho TE,Oliveira RP,Marcon RM,Rocha ID,Hanania FR,Daci Kdoi
10.1038/sc.2008.155subject
Has Abstractpub_date
2009-06-01 00:00:00pages
458-63issue
6eissn
1362-4393issn
1476-5624pii
sc2008155journal_volume
47pub_type
杂志文章相关文献
SPINAL CORD文献大全abstract::Hyposmolar hyponatremia (serum sodium < 130 mmol/l) is a common phenomenon in the spinal cord injury (SCI) patient population and in most cases, it is of relatively little consequence. However, rapid correction or over correction of hyponatremia (a change in serum sodium > 25 mmol/l within 48 h) has been linked to Cen...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3100371
更新日期:1997-05-01 00:00:00
abstract:STUDY DESIGN:Case-control study. OBJECTIVES:To investigate the level of autonomic nervous system dysfunction in patients with spinal cord injury and to determine its effect on the basal metabolic rate and oxygen consumption during daily living activities. SETTING:Turkish Armed Forces Rehabilitation Center, Ankara, Tu...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2016.111
更新日期:2017-03-01 00:00:00
abstract:STUDY DESIGN:Systematic review and meta-analysis. OBJECTIVE:To determine the risk factors predictive of dysphagia after a spinal cord injury (SCI). SETTING:None. METHODS:A comprehensive literature search was performed in five scientific databases for English articles that identified risk factors for dysphagia after ...
journal_title:Spinal cord
pub_type: 杂志文章,meta分析
doi:10.1038/s41393-018-0170-3
更新日期:2018-12-01 00:00:00
abstract:STUDY DESIGN:Prospective multidimensional study by means of: (1) clinical assessment, (2) parental-administered questionnaire for general health (CHQ-PF50), and (3) standardised disability measurements. OBJECTIVES:To assess the health-related quality of life (QoL) and disability in children with spina bifida (SB) and ...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101707
更新日期:2005-04-01 00:00:00
abstract:STUDY DESIGN:Three independent experiments in a rat model of contusive spinal cord (SC) injury were performed. Two studied the alterations induced by SC injury on some immunological aspects of the T-cell response. The third one evaluated the motor recovery of rats with low-thoracic injuries. OBJECTIVE:To examine the e...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101972
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:The objective of this study is to investigate the changes of urothelial junction proteins, apoptosis and suburothelial inflammation after detrusor injection of botulinum toxin A (BoNT-A) in patients with spinal cord injury (SCI) and neurogenic detrusor overactivity (NDO). METHODS:A total of 26 patients with ...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2015.241
更新日期:2016-10-01 00:00:00
abstract::The case histories of two patients who had had a spinal cord injury (SCI) were selected by the senior author and sent to four experts in the field of SCI. Based on the 1992 American Spinal Injury Association (ASIA) and International Medical Society of Paraplegia (IMSOP) standards, the four participants plus the senior...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3100449
更新日期:1997-05-01 00:00:00
abstract:STUDY DESIGN:Cross-sectional observational study. OBJECTIVES:To examine variables associated with the development of pressure ulcers in subjects with spinal cord injury (SCI). SETTING:SCI patients under coverage of the State Welfare Organization of Iran. METHODS:Mobile rehabilitation teams gathered data from 20 of t...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2012.75
更新日期:2012-12-01 00:00:00
abstract:STUDY DESIGN:A retrospective hospital-based study. OBJECTIVES:To describe the epidemiologic features of traumatic spinal cord injury (TSCI) in Anhui Province. SETTING:Two hospitals within Anhui Province, China. METHODS:We retrospectively reviewed the hospital records on all patients with TSCI, admitted between 1 Jan...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2012.92
更新日期:2013-01-01 00:00:00
abstract:STUDY DESIGN:Quasi-experimental translational study with pre- and post-measures. OBJECTIVES:To determine the effects of the Spinal Cord Injury and Physical Activity in the Community (SCIPA Com) intervention on leisure-time physical activity (LTPA) and associated outcomes among participants with spinal cord injury (SCI...
journal_title:Spinal cord
pub_type: 杂志文章,多中心研究
doi:10.1038/sc.2015.235
更新日期:2016-10-01 00:00:00
abstract:STUDY DESIGN:Retrospective study of 432 patients admitted to our institution with a spinal injury over a 5-year period. OBJECTIVES:To present epidemiological data relating to this spinal population, reporting specifically on delayed admission and length of hospitalisation. SETTING:Royal National Orthopaedic Hospital,...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101734
更新日期:2005-07-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Spinal cord
pub_type: 已发布勘误
doi:10.1038/s41393-020-00534-z
更新日期:2020-10-01 00:00:00
abstract::To survey the situation of traumatic spinal cord injuries (SCI) in Jordan and for a future nationwide epidemiological survey, a retrospective study was conducted at the Royal Jordanian Rehabilitation Centre (RJRC) King Hussein Medical Centre (KHMC) Amman-Jordan, where all traumatic cases within this centre in addition...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3100402
更新日期:1997-04-01 00:00:00
abstract::Forty-five patients with incomplete cervical spinal cord injuries were examined as to the mechanism of injury, neurological deficits in the initial stage and differences in treatment. Nineteen (42.2%) were treated non-surgically and 26 (57.8%) surgically. Their injuries could be divided into seven types of cervical sp...
journal_title:Spinal cord
pub_type: 临床试验,杂志文章
doi:10.1038/sc.1996.111
更新日期:1996-10-01 00:00:00
abstract:STUDY DESIGN:This is a narrative review of the literature. OBJECTIVES:This review aims to be useful in identifying therapeutic targets. It focuses on the molecular and biochemical neuroplasticity changes that occur in the somatosensory system, including ascending and descending pathways, during the development of neur...
journal_title:Spinal cord
pub_type: 杂志文章,评审
doi:10.1038/sc.2015.225
更新日期:2016-05-01 00:00:00
abstract:STUDY DESIGN:Case report. OBJECTIVE:To report a rare thoracic intervertebral disc herniation followed by acutely progressing paraplegia. SETTING:Spinal Injuries Center, Fukuoka, Japan. METHOD:A 37-year-old man presented with sudden severe backache and acutely progressing motor impairments of both lower extremities a...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101781
更新日期:2005-12-01 00:00:00
abstract:STUDY DESIGN:A prospective study. OBJECTIVES:To investigate the risk factors predicting upper urinary tract (UUT) deterioration in patients with spinal cord injury (SCI). SETTING:Beijing, China. METHODS:We reviewed the medical records and UUT imaging studies of 112 patients, with a mean follow-up of 2 years. Variabl...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2014.63
更新日期:2014-06-01 00:00:00
abstract:STUDY DESIGN:Prospective, single centre study. OBJECTIVES:Previous studies have suggested a relationship between stress reaction and elevated levels of prolactine. The aim of the present study was to investigate if there was a relationship between s-prolactine and menstrual cycle status following spinal cord injury (S...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3102095
更新日期:2008-03-01 00:00:00
abstract::The importance of urinary tract infection (UTI) in patients with spinal cord injury cannot be understated. Many patients with significant bacteriuria are considered to be colonised rather than infected, and treatment should be reserved for those with clinical symptoms or other signs of infection. Published research on...
journal_title:Spinal cord
pub_type: 杂志文章,评审
doi:10.1038/sj.sc.3100382
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVES:Noxious stimuli activate small to medium-sized dorsal root ganglion (DRG) neurons. Intense noxious stimuli result in the release of substance P (SP) from the central terminals of these neurons. It binds to the neurokinin type 1 receptor (NK1r) and sensitises the dorsal horn neurons. SP is also released from ...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2015.206
更新日期:2016-03-01 00:00:00
abstract::An extremely rare case of extradural spinal cysticercosis in an adult male is presented. The patient had evidence of extradural granulation tissue with associated destruction of C4 and C5 pedicles and laminae, causing tetraparesis. Histopathological examination revealed evidence of a degenerated cysticercal cyst with ...
journal_title:Spinal cord
pub_type: 杂志文章,评审
doi:10.1038/sj.sc.3100524
更新日期:1998-04-01 00:00:00
abstract:STUDY DESIGN:A biomechanical unitary classification of spinal injuries is proposed. OBJECTIVE:To present an evaluation of spinal injuries based on the essential traumatic spinal mechanisms: axial deformation, torsion, translation and combined mechanisms in connection with the concept of the stabilizing axial spinal pi...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101468
更新日期:2003-07-01 00:00:00
abstract:STUDY DESIGN:A systematic review of all sexual health outcome measures reporting psychometric properties for a spinal cord injury (SCI) population. OBJECTIVES:To evaluate the psychometric evidence for sexual health outcome measures used in a SCI population in order to (1) determine the clinical relevance of current to...
journal_title:Spinal cord
pub_type: 杂志文章,评审
doi:10.1038/sj.sc.3102136
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND CONTEXT:Spondyloarthropathy has been described radiographically in patients following paralysis from spinal cord trauma. Onset of these findings after cauda equina syndrome have not been reported previously. Furthermore, the magnetic resonance documentation of its early evolution has not been recorded. PURP...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2014.190
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:To report the simultaneous occurrence of generalised spinal cord atrophy, Chiari-I malformation, and syringomyelia. SETTING:Vienna, Austria. CASE DESCRIPTION:An 83-year old woman presented with predominantly lower limb and distal tetraparesis, diffuse wasting, spasticity of both lower limbs, contractures, ...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101138
更新日期:2001-03-01 00:00:00
abstract:STUDY DESIGN:The functional outcome of the diaphragm after acute spinal cord injury was reviewed over a 16 year period for 107 patients who had required assisted ventilation in the acute phase. OBJECTIVES:To quantify the incidence of recovery of diaphragm function which occurred beyond the period of acute oedema; to p...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3100775
更新日期:1999-02-01 00:00:00
abstract:STUDY DESIGN:Retrospective cohort study. OBJECTIVES:The old-version JOA score for cervical myelopathy (CM) is an evaluation system performed by medical providers that focuses only on neurological function. The purpose of this study was to evaluate patient-reported outcomes using the Japanese Orthopaedic Association Ce...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/s41393-019-0258-4
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:Hypertension (HTN) is an important risk factor for cardiovascular disease, a major cause of morbidity and mortality among people with spinal cord injury and disorders (SCI/D). Our study examined prevalence, associated factors, and pharmacological treatment of HTN in Veterans with SCI/D compared with a matche...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2012.122
更新日期:2013-02-01 00:00:00
abstract:STUDY DESIGN:This study was designed to investigate the effects of oxidant and antioxidant treatment, as well as regular exercise, on neurotrophin levels in the spinal cord of rats. OBJECTIVES:Reactive oxygen species (ROS) play a role in neurodegenerative diseases, but ROS at moderate levels could stimulate biochemica...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2008.125
更新日期:2009-06-01 00:00:00
abstract:STUDY DESIGN:In some young adults non-shunted myelomeningocele (MMC) patients without symptoms or with unspecific clinical findings, moderate or severe stabilised ventriculomegaly are observed in control CT scans. Physicians are then faced with the so-called 'Arrested Hydrocephalus' (AH) syndrome. The present study is ...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101032
更新日期:2000-08-01 00:00:00