The normal fetus of an acardiac twin pregnancy: perinatal management based on echocardiographic and sonographic evaluation.


:Experience with three prenatally diagnosed pregnancies complicated by an acardiac twin reveals that ultrasonography and echocardiography are helpful in detecting early signs of in-utero congestive heart failure in the normal twin. The use of Doppler blood flow analysis to determine direction of blood flow, post-mortem placental and fetal angiography, and umbilical cord blood gas determination provided proof that retrograde arterial perfusion occurs in the acardiac fetus. In a fourth pregnancy, an experimental approach to occlude the acardiac twin's umbilical cord was attempted, but was unsuccessful.


Prenat Diagn


Prenatal diagnosis


Donnenfeld AE,van de Woestijne J,Craparo F,Smith CS,Ludomirsky A,Weiner S




Has Abstract


1991-04-01 00:00:00












  • Pathologic correlation of sonographic echogenic foci in the fetal heart.

    abstract::The goal of the current paper is to present, on the basis of six investigated fetal hearts, the pathological substrate of prenatally, sonographically diagnosed echogenic intramyocardial foci. The right ventricle, left ventricle, interventricular septum and papillary muscles of both ventricles of six hearts of the fetu...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Tennstedt C,Chaoui R,Vogel M,Göldner B,Dietel M

    更新日期:2000-04-01 00:00:00

  • Fetal karyotype from cystic hygroma fluid.

    abstract::In cystic hygroma (CH) fetuses, hydrops fetalis and anamnios make it difficult or impossible to obtain amniotic fluid or cord blood for cytogenetic analysis. We report six cases of CH in which cytogenetic analysis was simply and successfully performed using nuchal fluid cells. The karyotypes were 47,XY, + 18,46,XY,46,...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Ville Y,Borghi E,Pons JC,Lelorc'h M

    更新日期:1992-02-01 00:00:00

  • Cost-effectiveness of cytogenetic evaluation of products of conception by chorionic villus sampling in recurrent miscarriage.

    abstract:OBJECTIVE:To compare the cost-effectiveness of performing chorionic villus sampling (CVS) of products of conception (POC) in the evaluation of recurrent miscarriage versus standard evidence-based work-up (EBW) of the couple. MATERIAL AND METHODS:A decision-analytic model was performed in couples with a third miscarria...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Petracchi F,Paez C,Igarzabal L

    更新日期:2017-03-01 00:00:00

  • Cost-effective screening methods for various single gene defects in single cells using high magnesium and total ionic strength and restriction enzymes.

    abstract::A reliable cost-effective protocol for the diagnosis of various defective genes in single blastomeres from preimplantation embryos has been established. Single cells were lysed in alkali buffer followed by neutralization and addition of a solution containing a high concentration of sulfhydryl reducing agents and MgCl(...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Tsai YH

    更新日期:2000-12-01 00:00:00

  • Prenatal diagnosis of HNF1B-associated renal cysts: Is there a need to differentiate intragenic variants from 17q12 microdeletion syndrome?

    abstract:OBJECTIVE:17q12 microdeletions containing HNF1B and intragenic variants within this gene are associated with variable developmental, endocrine, and renal anomalies, often already noted prenatally as hyperechogenic/cystic kidneys. Here, we describe prenatal and postnatal phenotypes of seven individuals with HNF1B aberra...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Vasileiou G,Hoyer J,Thiel CT,Schaefer J,Zapke M,Krumbiegel M,Kraus C,Zweier M,Uebe S,Ekici AB,Schneider M,Wiesener M,Rauch A,Faschingbauer F,Reis A,Zweier C,Popp B

    更新日期:2019-11-01 00:00:00

  • Down syndrome serum screening also identifies an increased risk for multicystic dysplastic kidney, two-vessel cord, and hydrocele.

    abstract:OBJECTIVE:The FASTER trial compared first and second trimester screening methods for aneuploidy. We examined relationships between maternal serum markers and common congenital anomalies in the pediatric outcome data set of 36 837 subjects. METHODS:We used nested case-control studies, with cases defined by the most com...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章,多中心研究


    authors: Hoffman JD,Bianchi DW,Sullivan LM,Mackinnon BL,Collins J,Malone FD,Porter TF,Nyberg DA,Comstock CH,Bukowski R,Berkowitz RL,Gross SJ,Dugoff L,Craigo SD,Timor-Tritsch IE,Carr SR,Wolfe HM,D'Alton ME

    更新日期:2008-12-01 00:00:00

  • First-trimester maternal serum ADAM12-s and PAPP-A levels are altered in pregnancies conceived after assisted reproduction techniques (ART).

    abstract:OBJECTIVE:The objective of this article is to estimate whether the maternal serum levels of A disintegrin and metalloprotease domain 12 (ADAM12-s), pregnancy-associated plasma protein-A (PAPP-A), and free beta human chorionic gonadotrophin (fβ-hCG) are altered in assisted reproduction techniques (ART) pregnancies. MET...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Sahraravand M,Laitinen P,Järvelä I,Ryynänen M

    更新日期:2016-02-01 00:00:00

  • Prenatal diagnosis and obstetrical management of multicystic dysplastic kidney disease.

    abstract::Multicystic dysplastic kidney disease (MDKD) is one of the most common congenital renal anomalies. We report 16 consecutive cases of MDKD recognized in the antenatal period by sonography. Diagnosis is usually easy as MDKD has in the vast majority of cases a striking ultrasound appearance including enlargement of the k...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Rizzo N,Gabrielli S,Pilu G,Perolo A,Cacciari A,Domini R,Bovicelli L

    更新日期:1987-02-01 00:00:00

  • Cytogenetic analysis of 2928 CVS samples and 1075 amniocenteses from randomized studies.

    abstract::We report cytogenetic results from a randomized Danish chorionic villus sampling (CVS) and amniocentesis (AC) study including 2928 placental and 1075 amniotic fluid specimens processed in the same laboratory. The results are presented in groups comparing CVS with amniocentesis and transabdominal (TA) CVS with transcer...

    journal_title:Prenatal diagnosis

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Smidt-Jensen S,Lind AM,Permin M,Zachary JM,Lundsteen C,Philip J

    更新日期:1993-08-01 00:00:00

  • Psychological impact of the detection of soft markers on routine ultrasound scanning: a pilot study investigating the modifying role of information.

    abstract:OBJECTIVES:To determine the impact on maternal anxiety of detecting a soft marker, and the association between anxiety and the information given during the scan. METHODS:Routine 20-week fetal anomaly scans were audiotaped in the obstetric ultrasound unit of a London teaching hospital, across a four month study period....

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Watson MS,Hall S,Langford K,Marteau TM

    更新日期:2002-07-01 00:00:00

  • First-trimester prenatal diagnosis of cystic fibrosis using the polymerase chain reaction: report of eight cases.

    abstract::Eight pregnancies at risk for cystic fibrosis have been monitored by first-trimester prenatal diagnosis with DNA amplification analysis. The polymerase chain reaction (PCR) was used in all cases to amplify the region detected by KM19. In two cases, the region detected by CS.7, another DNA probe tightly linked to the C...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Gasparini P,Novelli G,Savoia A,Dallapiccola B,Pignatti PF

    更新日期:1989-05-01 00:00:00

  • Aneuploidy and cystic hygroma detectable by ultrasound.

    abstract::During one year, five second trimester fetuses with cystic hygromata and varying degrees of oedema presented to the authors from hospitals in the West of Scotland. Two fetuses had 45X karyotypes, one each had 47XY + 21 and 47XX + 18 karyotypes, and the fifth had a normal 46XY karyotype. Fetal oedema detectable by ultr...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Redford DH,McNay MB,Ferguson-Smith ME,Jamieson ME

    更新日期:1984-09-01 00:00:00

  • Cervical teratoma: prenatal diagnosis and long-term follow-up.

    abstract::Cervical teratomas are rare tumours which are the result of abnormal prenatal development. They are usually detected at birth, but can occasionally remain silent until adulthood. Obstruction of the airway is the major challenge in the neonatal period. Prenatal diagnosis allows for early consultation with paediatric su...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Kerner B,Flaum E,Mathews H,Carlson DE,Pepkowitz SH,Hixon H,Graham JM Jr

    更新日期:1998-01-01 00:00:00

  • Detection of aneuploidy from single fetal nucleated red blood cells using whole genome sequencing.

    abstract:OBJECTIVE:The objective of the study was to detect aneuploidy in single fetal nucleated red blood cells (FNRBCs) from placental villi using whole genome amplification (WGA) and next generation sequencing. METHODS:Three single FNRBCs per sample were manually picked from villi collected from ten women undergoing electiv...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Hua R,Barrett AN,Tan TZ,Huang Z,Mahyuddin AP,Ponnusamy S,Sandhu JS,Ho SS,Chan JK,Chong S,Quan S,Choolani M

    更新日期:2015-07-01 00:00:00

  • Fetal hypertension: an insight into the pathogenesis of the twin-twin transfusion syndrome.

    abstract:OBJECTIVES:To investigate if systemic hypertension occurs in fetuses with twin-to-twin transfusion syndrome (TTTS). METHODS:We conducted an observational cohort study in a tertiary care centre in 23 pregnant women with TTTS. Polyhydramnios stuck twin sequence occurred at a median gestational age of 22 weeks (range 15-...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Mahieu-Caputo D,Salomon LJ,Le Bidois J,Fermont L,Brunhes A,Jouvet P,Dumez Y,Dommergues M

    更新日期:2003-08-01 00:00:00

  • Prenatal diagnosis of Fanconi anemia (Group C) subsequent to abnormal sonographic findings.

    abstract::Manifestations of Fanconi Anemia Complementation Group C (FA-C) include multiple major congenital malformations, hypoplastic radius, absent thumb, growth retardation, elfin-like facial features, microphthalmia, microcephaly, cafe-au-lait spots, early onset of hematologic disease and poor survival (Auerbach, 1997). We ...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Merrill A,Rosenblum-Vos L,Driscoll DA,Daley K,Treat K

    更新日期:2005-01-01 00:00:00

  • Development and targeted application of a rapid QF-PCR test for sex chromosome imbalance.

    abstract:OBJECTIVES:A QF-PCR test has been developed to diagnose sex chromosome imbalances in prenatal samples and has been applied to a diagnostic service. METHODS:The test uses a PCR multiplex with eight primer pairs: six X-chromosome polymorphic markers, including two markers from Xp (a region not included in previously pub...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Donaghue C,Roberts A,Mann K,Ogilvie CM

    更新日期:2003-03-01 00:00:00

  • Prenatal sonographic diagnosis of autosomal recessive polycystic kidney disease (ARPKD) during the early second trimester.

    abstract::Autosomal recessive polycystic kidney disease (ARPKD) is a rare hereditary disease with a high neonatal mortality. Currently, prenatal diagnosis is possible only during the second half of pregnancy, when bilaterally enlarged, echogenic kidneys are visible by ultrasound. We describe a case in which a diagnosis of ARPKD...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Wisser J,Hebisch G,Froster U,Zerres K,Stallmach T,Leumann E,Schinzel A,Huch A

    更新日期:1995-09-01 00:00:00

  • Ethical and counseling challenges in prenatal exome sequencing.

    abstract:OBJECTIVE:Ethical and counseling challenges are expected with the introduction of prenatal whole exome sequencing. In this study, we describe specific challenges identified through the UNC-Chapel Hill Prenatal Exome Sequencing Study. METHODS:Participants were a subset of women participating in the fetal exome study, w...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Harris S,Gilmore K,Hardisty E,Lyerly AD,Vora NL

    更新日期:2018-11-01 00:00:00

  • Uterine and umbilical artery Doppler at 28 weeks for predicting adverse pregnancy outcomes in women with abnormal uterine artery Doppler findings in the early second trimester.

    abstract:OBJECTIVE:The objective of this study was to determine the contribution of uterine (UtA) and umbilical arteries (UA) Doppler examination at 28 weeks to predict adverse pregnancy outcomes in women who had increased resistance in UtA in the early second trimester. METHODS:Women with UtA mean pulsatility index (PI) above...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Ventura W,De Paco Matallana C,Prieto-Sanchez MT,Macizo MI,Pertegal M,Nieto A,Delgado JL

    更新日期:2015-03-01 00:00:00

  • Microarray analysis in fetuses with duodenal obstruction: It is not just trisomy 21.

    abstract:OBJECTIVE:To explore the copy number variants (CNVs) in case of fetal duodenal obstruction (DO) and assess the associated prenatal findings and postnatal outcomes. MATERIALS AND METHODS:This retrospective study reviewed 51 fetuses with DO and the findings of chromosomal microarray analysis (CMA) used as a first-tier t...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Zhang W,Lei T,Fu F,Deng Q,Li R,Wang D,Yang X,Li D,Liao C

    更新日期:2020-09-30 00:00:00

  • Transplacental treatment of fetal tachycardia: A systematic review and meta-analysis.

    abstract:OBJECTIVE:Multiple transplacental medications can be used to treat fetal tachycardia. We sought to perform a systematic review and meta-analysis to determine whether digoxin, flecainide, or sotalol was the most efficacious therapy for converting fetal tachycardia to sinus rhythm. METHOD:We performed a systematic revie...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章,meta分析,评审


    authors: Hill GD,Kovach JR,Saudek DE,Singh AK,Wehrheim K,Frommelt MA

    更新日期:2017-11-01 00:00:00

  • Prenatal diagnosis of respiratory chain deficiency by direct mutation screening.

    abstract::Respiratory chain deficiency (RCD) is responsible for a clinically heterogeneous group of early-onset untreatable disorders. Enzymological prenatal diagnosis (PD) can only be offered to a fraction of families. Moreover, due to the two-fold genetic origin of the respiratory chain (nuclear and mitochondrial DNA) and owi...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Amiel J,Gigarel N,Benacki A,Benit P,Valnot I,Parfait B,Von Kleist-Retzow JC,Raclin V,Hadj-Rabia S,Dumez Y,Rustin P,Bonnefont JP,Munnich A,Rötig A

    更新日期:2001-07-01 00:00:00

  • Maternal serum CA 125 for aneuploidy detection in early pregnancy.

    abstract::Maternal serum CA 125 levels were determined at 9-11 menstrual weeks for 26 cases of trisomy 13 (n = 4), trisomy 18 (n = 7), trisomy 21 (n = 15), and appropriate controls. There were no statistically significant differences between groups. ...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Norton ME,Golbus MS

    更新日期:1992-09-01 00:00:00

  • Patient choice and clinical outcomes following positive noninvasive prenatal screening for aneuploidy with cell-free DNA (cfDNA).

    abstract:OBJECTIVE:Evaluate patient choices and outcomes following positive cfDNA. METHOD:Retrospective cohort study of women with positive cfDNA through two academic centers between March 2012 and December 2014. Patients were screened based on ACOG indications. Medical records reviewed for counseling, ultrasound findings, dia...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Dobson LJ,Reiff ES,Little SE,Wilkins-Haug L,Bromley B

    更新日期:2016-05-01 00:00:00

  • International perspectives on the implementation of reproductive carrier screening.

    abstract::Reproductive carrier screening started in some countries in the 1970s for hemoglobinopathies and Tay-Sachs disease. Cystic fibrosis carrier screening became possible in the late 1980s and with technical advances, screening of an ever increasing number of genes has become possible. The goal of carrier screening is to i...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章,评审


    authors: Delatycki MB,Alkuraya F,Archibald A,Castellani C,Cornel M,Grody WW,Henneman L,Ioannides AS,Kirk E,Laing N,Lucassen A,Massie J,Schuurmans J,Thong MK,van Langen I,Zlotogora J

    更新日期:2020-02-01 00:00:00

  • Application of proteomics for the identification of differentially expressed protein markers for Down syndrome in maternal plasma.

    abstract:BACKGROUND:Despite the large impact of ultrasonographic and biochemical markers on prenatal screening, the ability to accurately diagnose Down syndrome (DS) is still limited and better diagnostic testing is needed. METHODS:Plasma from 8 women carrying a DS foetus and 12 with non-DS foetuses matched for gestational age...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Kolialexi A,Tsangaris GT,Papantoniou N,Anagnostopoulos AK,Vougas K,Bagiokos V,Antsaklis A,Mavrou A

    更新日期:2008-08-01 00:00:00

  • Identification of fetal nucleated red cells in co-cultures from fetal and adult peripheral blood: differential effects of serum on fetal and adult erythropoiesis.

    abstract::Seeking to optimize a novel method of isolating rare fetal erythroid cells in cultures from maternal blood, we have explored the effects of serum supplement on fetal and adult erythropoiesis. We used flow cytometry and sorting after labelling with antibodies to fetal haemoglobin (HbF) and adult haemoglobin (HbA). In a...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Bohmer RM,Zhen D,Bianchi DW

    更新日期:1999-07-01 00:00:00

  • Serum lipid, apolipoprotein and lipoparticle levels in the human fetus.

    abstract::Blood collected from 62 fetuses aged 20-38 weeks of gestation was studied. The values of ten lipid parameters were determined: cholesterol (TC), triglycerides (TGs), apolipoprotein A1 (apo A1), apolipoprotein B (apo B), apolipoprotein E (apo E), total apolipoprotein CIII (apo CIII), apolipoprotein CIII present in part...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Legras B,Durou MR,Ruelland A,Gallou G,Jezequel C,Cloarec L

    更新日期:1995-03-01 00:00:00

  • Heat stable and urea resistant alkaline phosphatase in maternal neutrophils from normal and Down syndrome pregnancies.

    abstract::Activity levels of total and placental alkaline phosphatase (AP) were determined in maternal serum and neutrophils of normal and Down syndrome pregnancies. The placental iso-enzyme (PAP) was identified by its relative stability to urea and heat. Significant increase in the activity of all iso-enzymes across gestationa...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章


    authors: Peleg L,Ries L,Getslev V,Lusky A,Chaki R,Lipitz S,Barkai G

    更新日期:1999-03-01 00:00:00