Abstract:
:The purpose of this article is to present the early results of a multicentre trial using HepaSphere microspheres loaded with chemotherapeutic agents for transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma. From December 2005 to March 2007, 50 patients (36 male and 14 female, mean age 68.4 years) were treated by selective TACE using HepaSphere microspheres loaded with doxorubicin or epirubicin. The diameter of the treated lesions ranged from 20 to 100 mm (mean 42.5; maximum of 4 tumor nodules). Tumor response was evaluated by computed axial tomography according to the World Health Organization criteria as modified by the European Association for the Study of Liver Diseases. All of the procedures were technically successful, and there were no major complications. At 1-month follow-up, complete tumor response was observed in 24 of 50 (48%), partial response in 18 of 50 (36%), and stable disease in 8 of 50 (16%) patients, and there were no cases of disease progression. At 6-month follow-up (31 of 50 patients), complete tumor response was obtained in 16 of 31 (51.6%), partial response in 8 of 31 (25.8%), and progressive disease in 7 of 31 (22.6%) patients. Within the initial 9-month follow-up, TACE with HepaSphere was successfully repeated twice in 3 patients, whereas 3 patients underwent the procedure 3 times. Our initial multicentre experience demonstrates that TACE using HepaSphere is feasible, is well tolerated, has a low complication rate, and is associated with promising tumor response. When complete tumor response in not achieved, additional treatments can be performed without difficulties. Longer follow-up on larger series is mandatory to confirm these preliminary results.
journal_name
Cardiovasc Intervent Radioljournal_title
Cardiovascular and interventional radiologyauthors
Grosso M,Vignali C,Quaretti P,Nicolini A,Melchiorre F,Gallarato G,Bargellini I,Petruzzi P,Massa Saluzzo C,Crespi S,Sarti Idoi
10.1007/s00270-008-9409-2subject
Has Abstractpub_date
2008-11-01 00:00:00pages
1141-9issue
6eissn
0174-1551issn
1432-086Xjournal_volume
31pub_type
杂志文章,多中心研究abstract::This CIRSE Standards of Practice document provides best practices for the safe administration of procedural sedation and analgesia for interventional radiology procedures in adults. The document is aimed at health professionals involved in the provision of sedation and analgesia during interventional radiology procedu...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-020-02536-z
更新日期:2020-09-01 00:00:00
abstract::Acute vertebrobasilar occlusion (VBO) is associated with a high risk of stroke and death. Although local thrombolysis may achieve recanalization and improve outcome, mortality is still between 35% and 75%. However, without recanalization the chance of a good outcome is extremely poor, with mortality rates of 80-90%. E...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-008-9410-9
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:Evaluation of patient radiation exposure during uterine artery embolization (UAE) and literature review to identify techniques minimizing required dose. METHODS:A total of 224 of all included 286 (78 %) women underwent UAE according to a standard UAE-protocol (bilateral UAE from unilateral approach using a Rös...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-014-0962-6
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:To evaluate the accuracy and technical success of positioning a radiofrequency ablation (RFA) electrode in osteoid osteomas by use of a new real-time needle guidance technology combining cone-beam computed tomography (CT) and fluoroscopy. MATERIALS AND METHODS:Percutaneous RFA of osteoid osteomas was performed...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-010-9950-7
更新日期:2011-02-01 00:00:00
abstract::We report the case of a 74-year-old man with post-percutaneous-nephrostomy venous hemorrhage from an iatrogenic fistula between the renal pelvis and a large tributary of the renal vein. Conservative management failed to contain the hemorrhage. Hence the fistula was occluded by coil embolization through the renal vein....
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-009-9767-4
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:To evaluate yttrium-90 (Y90) radioembolization outcomes across Child-Pugh scores in patients with advanced hepatocellular carcinoma (HCC). MATERIALS AND METHODS:From April 2005 to December 2018, 106 consecutive patients with BCLC Stage C HCC who underwent Y90 radioembolization were retrospectively analyzed. ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-020-02434-4
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to establish an animal model of implanted inferior vena cava tumor thrombus (IVCTT) and to evaluate the effect of linear iodine-125 seeds strand in treating implanted IVCTT. METHODS:Tumor cell line VX2 was inoculated subcutaneously into New Zealand rabbit to develop the parent t...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-013-0628-9
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVES:CT-guided ethanol-mediated renal sympathetic denervation in treatment of therapy-resistant hypertension was performed to assess patient safety and collect preliminary data on treatment efficacy. MATERIALS AND METHODS:Eleven patients with therapy-resistant hypertension (blood pressure of >160 mmHg despite th...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-015-1261-6
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:To assess the efficacy of temporary vena cava filters in patients undergoing ultrahigh-dose streptokinase thrombolysis for iliocaval thrombosis and to determine therapy success and filter and therapy complications. METHODS:Forty-five patients were studied regarding extension and characteristics of thrombosis, ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002700010068
更新日期:2000-07-01 00:00:00
abstract:PURPOSE:To evaluate the patency and clinical efficacy of percutaneous intraductal microwave ablation (PIMWA) and uncovered self-expandable metallic stents (USEMs) in inoperable malignant extrahepatic biliary obstruction. MATERIALS AND METHODS:The procedures to be performed on patients with malignant inoperable extrahe...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-020-02684-2
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:The aim of this study is to evaluate the feasibility of percutaneous lung tumor biopsy under cone beam-computed tomography (CBCT) with PET-CT imaging fusion. MATERIALS AND METHODS:Eleven patients (four women and seven men) underwent C-arm CBCT lung biopsy with PET-CT fusion imaging. A preprocedural PET-CT scan...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-019-02270-1
更新日期:2019-11-01 00:00:00
abstract::The purpose of this study was to evaluate the fibroid morphology in a cohort of women achieving pregnancy following treatment with uterine artery embolization (UAE) for symptomatic uterine fibroids. A retrospective review of magnetic resonance imaging (MRI) of the uterus was performed to assess pre-embolization fibroi...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-007-9118-2
更新日期:2007-09-01 00:00:00
abstract::Placement of a balloon-expandable metallic stent (Strecker-Stent) for biliary drainage has been attempted in 30 patients. The stent was successfully implanted in 22 patients; in the remaining 8 patients, dilatation of the biliary stricture prior to stent placement was inadequate and delivery of the Strecker-Stent was,...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02734118
更新日期:1992-11-01 00:00:00
abstract::Magnetic resonance angiography (MRA) places high demands on instrumentation capabilities. Magnetic gradient strength capabilities, main magnetic field strength and homogeneity, and eddy current compensation all play a role in determining the quality of the flow studies. In addition, radiofrequency coil design and use ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02733895
更新日期:1992-01-01 00:00:00
abstract::We report the percutaneous injection of tissue adhesive (Tisseal, Immuno, Vienna, Austria) to ablate a 12-cm internal iliac aneurysm. The complex history of this lesion included previous surgery for a ruptured aortic aneurysm, attempted repair of the internal iliac aneurysm, and several embolization procedures. These ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002700010088
更新日期:2000-09-01 00:00:00
abstract::In this article, we study in vitro evaluation of needle artefacts and image quality for musculoskeletal laser-interventions in an open high-field magnetic resonance imaging (MRI) scanner at 1.0T with vertical field orientation. Five commercially available MRI-compatible puncture needles were assessed based on artefact...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-009-9676-6
更新日期:2010-04-01 00:00:00
abstract::Retrievable inferior vena cava filters are being increasingly used for the prevention of life-threatening pulmonary emboli in patients who have temporary contraindications to anticoagulation therapy. We report two cases of failure to remove these devices. ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-005-0145-6
更新日期:2006-01-01 00:00:00
abstract::Ultrafast computed tomographic (CT) scanning provides cross-sectional millisecond tomography, similar in many ways to cineangiography. The technique, which combines digital imaging and high resolution without the need for cardiac catheterization, is rapidly being validated. Fifty millisecond scans at rates of 34/secon...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章,评审
doi:10.1007/BF02577345
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:We present our experience with embolization of incompetent pelvic veins (IPV) in women with recurrence of varicose veins (VV) in lower limbs, as well as symptoms of pelvic congestion syndrome (PCS), after first surgery. In addition, we evaluated the effects of embolization in decreasing the symptoms of VV befor...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-012-0389-x
更新日期:2013-02-01 00:00:00
abstract::Balloon-occluded retrograde transvenous obliteration (BRTO) of gastric varices is an image-guided transcatheter procedure used to treat gastric varices with sclerosants rather than decompression of the portal venous system. The history of its development, relevant portal venous, and systemic venous anatomic considerat...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章,评审
doi:10.1007/s00270-013-0715-y
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:To perform a systemic review to determine the effect of anticoagulation on the rates of venous thromboembolism (pulmonary embolus, deep venous thrombosis, inferior vena cava (IVC) filter thrombosis) following placement of an IVC filter. METHODS:A comprehensive computerized literature search was performed to id...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章,评审
doi:10.1007/s00270-007-9244-x
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:To assess the accuracy of intraarterial measurement of transstenotic pressure gradients for the detection of hemodynamically suboptimal iliac angioplasty. METHODS:In 14 patients, referred for diagnostic angiography, mean pressure gradients in the aorta and iliac artery were obtained twice, using a double-senso...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002709900187
更新日期:1997-11-01 00:00:00
abstract::A peripheral pulmonary artery aneurysm appeared as a solitary, smooth and discrete coin lesion in the lung. The aneurysm was surgically resected. Various etiologies possibly responsible for this entity are discussed. The complications of transthoracic needle aspiration biopsy are reviewed, with emphasis on the hazards...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02625112
更新日期:1984-01-01 00:00:00
abstract::Chronic mesenteric ischemia (CMI) is a rare disorder that is commonly caused by progressive atherosclerotic stenosis or occlusion of one or more mesenteric arteries. Endovascular treatment for symptomatic CMI represents a viable option, especially in high-operative risk patients. We report a case of acute symptomatic ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-012-0469-y
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:System-related complications in surgically implanted catheter-port systems (CPS) for intraarterial (i.a.) chemotherapy are well known. In most cases of complications, the treatment must be interrupted and the catheter-port system must be repaired surgically. We describe microinvasive interventional radiological...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002700001714
更新日期:2001-01-01 00:00:00
abstract::From March 1990 to May 1991, arterial stents were placed in seven patients because of a tight stenosis (five patients) or a total chronic occlusion (two patients) located in the infrarenal aorta. In one case, the aortic occlusion extended to both common iliac arteries. After balloon dilatation, aortic stents were succ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02602961
更新日期:1993-07-01 00:00:00
abstract:PURPOSE:To describe our experiences with treatment of visceral artery pseudoaneurysms (VAPA) by transcatheter coil embolization using an isolation technique and to propose indications for treating VAPA with this method. MATERIALS AND METHODS:We treated 37 patients with VAPA endovascularly: There were 15 pancreaticoduo...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-010-9973-0
更新日期:2010-12-01 00:00:00
abstract:AIMS:In this article we present our experience with radiofrequency ablation (RFA) in the treatment of 105 renal tumors. MATERIALS AND METHODS:RFA was performed on 105 renal tumors in 97 patients, with a mean tumor size of 32 mm (11-68 mm). The mean patient age was 71.7 years (range, 36-89 years). The ablations were ca...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-007-9090-x
更新日期:2007-09-01 00:00:00
abstract::We present a rare case of a central venous catheter-malposition-induced life-threatening cardiac tamponade as a result of computed tomography (CT) with contrast enhancement in an infant with a ventricular septal defect and pulmonary atresia after a modified Blalock-Taussig shunt. The diagnosis was confirmed by chest r...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-004-0340-x
更新日期:2005-11-01 00:00:00
abstract::CT-guided needle biopsy is a common procedure for obtaining a tissue diagnosis and consequently correctly managing patients. This procedure has many potential complications, ranging from simple pneumothorax or self-limiting hemoptysis to life-threatening pulmonary hemorrhage and air embolism. Though the latter is a ra...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-004-0118-1
更新日期:2005-01-01 00:00:00