Abstract:
OBJECTIVE:To evaluate yttrium-90 (Y90) radioembolization outcomes across Child-Pugh scores in patients with advanced hepatocellular carcinoma (HCC). MATERIALS AND METHODS:From April 2005 to December 2018, 106 consecutive patients with BCLC Stage C HCC who underwent Y90 radioembolization were retrospectively analyzed. Exclusion criteria included additional malignancy (n = 7), death unrelated to liver disease (n = 2), metastases (n = 2), or lack of follow-up data (n = 4). Ninety-one patients were analyzed. Overall survival (OS) was calculated using the Kaplan-Meier method and compared between groups with the log-rank test. Cox regression modeling was used to evaluate the prognostic factors for survival. RESULTS:Mean age was 63 years and 85.7% were male. HCV infection was the most common etiology of liver disease (58.2%). Sixty-four (70.3%) patients were Child-Pugh A, 19 (20.9%) patients were B7, and eight (8.8%) patients were B8-9. Median OS after radioembolization was 20.2 [95% confidence interval (CI) 13.0-27.4], 6.0 (95% CI 4.4-7.6), and 5.5 (95% CI 2.5-8.5) months for Child-Pugh A, B7, and B8/9 groups, respectively (P < 0.001 for B7 vs. A; P = 0.537 for B7 vs. B8/9). The multivariable Cox regression analysis showed that Eastern Cooperative Oncology Group (ECOG) score (P < 0.001), Child-Pugh class (P = 0.005), tumor morphology pattern (P = 0.012), and Y90 delivery location (P = 0.020) were significant independent predictors of overall survival. CONCLUSIONS:Outcomes from Y90 for BCLC C HCC for Child-Pugh B7 patients were equivalent to B8/9 patients and significantly worse compared to Child-Pugh A patients. Although further research is warranted, these results suggest continued cautious patient selection for radioembolization in advanced HCC.
journal_name
Cardiovasc Intervent Radioljournal_title
Cardiovascular and interventional radiologyauthors
Zu Q,Schenning RC,Jahangiri Y,Tomozawa Y,Kolbeck KJ,Kaufman JA,Al-Hakim R,Naugler WE,Nabavizadeh N,Kardosh A,Billingsley KG,Mayo SC,Orloff SL,Enestvedt KK,Maynard E,Ahn J,Lhewa D,Farsad Kdoi
10.1007/s00270-020-02434-4subject
Has Abstractpub_date
2020-05-01 00:00:00pages
721-731issue
5eissn
0174-1551issn
1432-086Xpii
10.1007/s00270-020-02434-4journal_volume
43pub_type
杂志文章abstract:PURPOSE:To retrospectively evaluate the usefulness of virtual fluoroscopic preprocedural planning (VFPP) in the percutaneous transhepatic biliary drainage (PTBD) procedure. MATERIALS AND METHODS:Twenty-two patients who were treated by PTBD were included in this study. Twelve patients were treated using PTBD intraopera...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-017-1581-9
更新日期:2017-06-01 00:00:00
abstract::Subintimal angioplasty (SAP) is frequently performed for the treatment of critical limb ischemia (CLI) and has been recognized as an effective technique for these patients. Nevertheless, this approach is limited by the lack of controlled re-entry into the true lumen of the target vessel. We describe a novel device for...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-010-9859-1
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:To report the long-term outcomes of bovine ureter grafts as novel conduits for haemodialysis fistulas. MATERIALS AND METHODS:Thirty-five patients underwent placement of a total of 40 SynerGraft 100 (SG100; CryoLife Europa(®), Guildford, UK) bovine ureter grafts between April 2002 and February 2009. Prospective...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-011-0096-z
更新日期:2011-10-01 00:00:00
abstract::This study evaluated the safety, feasibility, and clinical utility of hyaluronic acid gel injection to separate the gastrointestinal tract from the tumor during liver radiofrequency ablation (RFA). Eleven patients with liver tumors measuring 0.9-3.5 cm (mean ± standard deviation, 2.1 ± 0.8 cm) that were adjacent to th...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-013-0546-x
更新日期:2013-08-01 00:00:00
abstract::A 38-year-old woman was treated for malignant stricture by the endoscopic placement of a biliary endoprosthesis. She developed a large retroperitoneal biloma secondary to acute duodenal perforation by the stent. We describe the successful percutaneous retrieval of the biliary stent through a retroperitoneal approach w...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF00204152
更新日期:1995-05-01 00:00:00
abstract:INTRODUCTION:Onyx and ethanol are well-known embolic and sclerotic agents that are frequently used in embolization. These agents present advantages and disadvantages regarding visibility, injection control and penetration depth. Mixing both products might yield a new product with different characteristics. The aim of t...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-016-1559-z
更新日期:2017-05-01 00:00:00
abstract::We implanted stents in three patients who had traumatic abdominal aortic dissections, complicated by right limb ischemia in one case. The circulating false channel extended to the left iliac artery in one case and to both iliac arteries in the last case. Diagnosis and radiological follow-up included ultrasound, comput...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002709900197
更新日期:1997-11-01 00:00:00
abstract::Although current techniques for percutaneous biliary stone extraction are highly successful, many patients require manipulation of the calculi before such extraction is possible. This article describes several adjunctive techniques for biliary stone retrieval that have proven to be effective. These include the modific...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02578013
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:Covered, self-expandable metallic stents (SEMS) have been enthusiastically adopted for the treatment of esophagotracheal fistula, but problems with stent migration have yet to be resolved. To overcome this problem, we have developed a new hanging-type esophageal stent designed to prevent migration, and we condu...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-011-0240-9
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:To evaluate the protective effect of using thermo-sensitive basement membrane extract (Matrigel) for hydrodissection to minimize thermal injury to nearby structures and to evaluate its heat sink effect on the ablation zone in radiofrequency ablation (RFA) of the liver. MATERIALS AND METHODS:First, the viscosit...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-017-1617-1
更新日期:2017-07-01 00:00:00
abstract::A renal pseudotumor caused by a small portion of normal spleen receiving blood supply from a renal capsular artery is described. CT with nonselective enhancement and liver/spleen scan may fail to delineate this previously unreported finding. CT angiography, however, can establish the diagnosis. The consideration of th...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02578632
更新日期:1990-10-01 00:00:00
abstract:PURPOSE:To investigate the influence that measurement of balloon volume as a controlled variable in addition to balloon pressure has on the outcome of balloon angioplasty in an experimental model. METHODS:One hundred and three segments of explanted normal porcine carotid arteries were obtained. Five were used as contr...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-007-9193-4
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To describe our experiences with treatment of visceral artery pseudoaneurysms (VAPA) by transcatheter coil embolization using an isolation technique and to propose indications for treating VAPA with this method. MATERIALS AND METHODS:We treated 37 patients with VAPA endovascularly: There were 15 pancreaticoduo...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-010-9973-0
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:In vertebrobasilar occlusion, rapid recanalization is the only substantial means to improve the prognosis. We introduced a standard operating procedure (SOP) for interventional therapy to analyze the effects on interdisciplinary time management. METHODS:Intrahospital time periods between hospital admission a...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-011-0222-y
更新日期:2012-06-01 00:00:00
abstract::Stent-assisted coil embolization is a well-described technique for the treatment of wide-necked intracranial aneurysms. We describe a modification of this technique used successfully to occlude a wide-necked internal iliac artery aneurysm. ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-009-9675-7
更新日期:2010-10-01 00:00:00
abstract::The aim of this study was to assess if percutaneous vertebroplasty (PVP) could relieve back pain, reduce drug consumption, and improve the mobility of patients with metastases and vertebral compression fractures. From August 2002 to July 2004, 283 patients (216 females; mean age: 73.8 +/- 9.9 years) underwent PVP on 7...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-006-0146-0
更新日期:2007-05-01 00:00:00
abstract::The damage threshold during aortic valvuloplasty was determined in 12 normal swine subjected to inflation of oversized dual balloons. Catheters with combined balloon diameters of 1.2-2.0 times the aortic annulus were selected. Following completion of the procedure, the animals were sacrificed and examined for patholog...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02577363
更新日期:1990-04-01 00:00:00
abstract:PURPOSE:To assess the feasibility of radiological stage-1 ALPPS, associating liver partition and portal vein ligation for staged hepatectomy, by combining portal vein embolization (PVE) with percutaneous intrahepatic split by ablation (PISA). MATERIALS AND METHODS:Three patients (mean age 65.0 ± 7.3 years) underwent P...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-018-1882-7
更新日期:2018-05-01 00:00:00
abstract:PURPOSE:Evaluate therapeutic results of transcatheter segmental hepatic artery chemo-oily-embolization (segmental TAE) against advanced hepatocellular carcinomas (HCC) accompanied by portal tumor thrombus (PTT). METHODS:Segmental TAE was performed in nine patients with hepatic cirrhosis and advanced HCCs accompanied b...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF00239415
更新日期:1995-07-01 00:00:00
abstract::Purpose To evaluate the technical feasibility and safety of percutaneous cryoablation (CA) for the treatment of single/oligometastatic lymph-node (LN) relapse in different anatomic regions. MATERIALS AND METHODS:This is a retrospective study of all patients who underwent percutaneous CA of LN metastases (May 2014-Apr...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-019-02341-3
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:To compare the feasibility, safety, and efficacy with small and large irinotecan drug-eluting beads (DEBIRI) for treating hepatic colorectal metastases. METHODS:Using our prospectively maintained, multi-center, intra-arterial therapy registry, we identified 196 patients treated with a combination of large bead...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00270-014-1011-1
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:To evaluate the accuracy and technical success of positioning a radiofrequency ablation (RFA) electrode in osteoid osteomas by use of a new real-time needle guidance technology combining cone-beam computed tomography (CT) and fluoroscopy. MATERIALS AND METHODS:Percutaneous RFA of osteoid osteomas was performed...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-010-9950-7
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Complications of portal hypertension, such as variceal hemorrhage and ascites, are associated with significant increases in both mortality and complications during pregnancy. Transjugular intrahepatic portosystemic shunt (TIPS) is a well-established procedure for treating portal hypertension, but th...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-015-1053-z
更新日期:2015-10-01 00:00:00
abstract::Performing an interventional procedure imposes a commitment on interventional radiologists to conduct the initial patient assessment, determine the best course of therapy, and provide long-term care after the procedure is completed. After patient referral, contact with the referring physician and multidisciplinary tea...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章,评审
doi:10.1007/s00270-015-1228-7
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:To report the first experience using the chimney technique in combination with the latest-generation low-profile stent-graft to seal abdominal aortic aneurysms having a very short neck (proximal sealing zone) and difficult access due to very small iliac vessels. MATERIALS AND METHODS:Use of an ultra low-profil...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-013-0748-2
更新日期:2014-04-01 00:00:00
abstract::We report on a 72-year-old female with an unusual intracranial bleeding complication after an extracranial carotid artery stenting procedure performed for a tight left ICA stenosis associated with contralateral carotid occlusion. Two hours after the procedure, the initial signs of intracranial bleeding appeared that l...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-004-0155-9
更新日期:2005-07-01 00:00:00
abstract:PURPOSE:Mechanical thrombectomy (MT) is the first-line treatment in acute stroke patients presenting with large vessel occlusion (LVO). The efficacy of intravenous thrombolysis (IVT) prior to MT is being contested. The objective of this study was to evaluate the efficacy of MT without IVT in patients with no contraindi...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-020-02727-8
更新日期:2020-12-22 00:00:00
abstract:BACKGROUND:Most epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) patients treated with tyrosine kinase inhibitors (TKIs) experience oligoprogressive disease. Local ablation for isolated resistant sites continued with the original EGFR-TKI showed good efficacy in these patients. We condu...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00270-018-02153-x
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND AND AIMS:Until now, no study has focused exclusively on low-flow retrobulbar intraconal venous malformations (RIVMs) which may require treatment due to cosmetic defect, pain, and visual dysfunction. The treatment for RIVMs which surround the optic nerve remains challenging. This case series aimed to evaluate...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-017-1822-y
更新日期:2018-03-01 00:00:00
abstract::A 71-year-old man developed pyloric stenosis caused by gastric cancer. Vomiting and nausea resolved after the insertion of an uncovered Ultraflex stent (length 10 cm, inner diameter 18-23 mm) through a 7-cm-long stenosis, and the patient was able to eat a soft diet. After 6 weeks, stent occlusion occurred due to tumor...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002700010078
更新日期:2000-07-01 00:00:00