The common hyperlipoproteinemias: an understanding of disease mechanisms and their control.

Abstract:

:Our review focuses on low density lipoprotein (LD lipoprotein) and very low density lipoprotein (VLD lipoprotein) in their roles as transporters of cholesterol and triglyceride and as factors contributing to premature arteriovascular disease. We describe the clinical manifestations of the common, primary hyperlipoproteinemias--that is, hyper-beta-lipoproteinemia, combined hyperlipoproteinemia, hyper-pre-beta-lipoproteinemia, and sporadic hyperlipoproteinemia--and discuss the variations in lipoprotein structure and metabolism that occur in these diseases. Based on an understanding of the physiologic control of lipoprotein metabolism, it is possible for the physician to alter the concentrations of LD lipoprotein and VLD lipoprotein by selecting a course of therapy appropriate to the specific disease. We describe the effects of obesity, diet, insulin, ethanol, estrogens, and the drugs clofibrate, nicotinic acid, and cholestyramine.

journal_name

Ann Intern Med

authors

Fisher WR,Truitt DH

doi

10.7326/0003-4819-85-4-497

subject

Has Abstract

pub_date

1976-10-01 00:00:00

pages

497-508

issue

4

eissn

0003-4819

issn

1539-3704

journal_volume

85

pub_type

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