The effect of thrombospondin-1 on breast cancer metastasis.

abstract：:Kinase suppressor of Ras 1 (KSR1) has been implicated in tumorigenesis in multiple cancers, including skin, pancreatic and lung carcinomas. However, our recent study revealed a role of KSR1 as a tumour suppressor in breast cancer, the expression of which is potentially correlated with chemotherapy response. Here, we a...

journal_title：Breast cancer research and treatment

authors： Zhang H,Angelopoulos N,Xu Y,Grothey A,Nunes J,Stebbing J,Giamas G

更新日期：2015-06-01 00:00:00

abstract：:Clinical practice guidelines recommend yearly surveillance mammography for breast cancer survivors, yet many women do not receive this service. The objective of this study was to evaluate factors related to long-term surveillance mammography adherence among breast cancer survivors. We conducted a retrospective cohort ...

journal_title：Breast cancer research and treatment

authors： Wirtz HS,Boudreau DM,Gralow JR,Barlow WE,Gray S,Bowles EJ,Buist DS

更新日期：2014-02-01 00:00:00

abstract：PURPOSE:The malignant upgrade rate of flat epithelial atypia (FEA) diagnosed on core needle biopsy varies between 0 and 30%. Excision versus observation with radiological follow-up for these lesions remains controversial. We hypothesize that the local rate of FEA is low and that close radiological surveillance is a rea...

journal_title：Breast cancer research and treatment

authors： DiPasquale A,Silverman S,Farag E,Peiris L

更新日期：2020-01-01 00:00:00

abstract：:Angiogenesis is important for the growth and spread of malignant tumors, and anti-angiogenesis treatment is currently being evaluated for breast cancer and other tumors. Although microvessel density is the most commonly used tissue-based marker of tumor associated angiogenesis, it has significant limitations and has n...

journal_title：Breast cancer research and treatment

authors： Arnes JB,Stefansson IM,Straume O,Baak JP,Lønning PE,Foulkes WD,Akslen LA

更新日期：2012-06-01 00:00:00

abstract：:Uncontrolled proliferation is one of the hallmarks of breast cancer. We have previously identified the human Ecd protein (human ortholog of Drosophila Ecdysoneless, hereafter called Ecd) as a novel promoter of mammalian cell cycle progression, a function related to its ability to remove the repressive effects of Rb-fa...

journal_title：Breast cancer research and treatment

authors： Zhao X,Mirza S,Alshareeda A,Zhang Y,Gurumurthy CB,Bele A,Kim JH,Mohibi S,Goswami M,Lele SM,West W,Qiu F,Ellis IO,Rakha EA,Green AR,Band H,Band V

更新日期：2012-07-01 00:00:00

abstract：:The purpose of the study was to evaluate the use of metabolic phenotype, described by high-resolution magic angle spinning magnetic resonance spectroscopy (HR MAS MRS), as a tool for prediction of histological grade, hormone status, and axillary lymphatic spread in breast cancer patients. Biopsies from breast cancer (...

journal_title：Breast cancer research and treatment

authors： Bathen TF,Jensen LR,Sitter B,Fjösne HE,Halgunset J,Axelson DE,Gribbestad IS,Lundgren S

更新日期：2007-08-01 00:00:00

abstract：:We characterized the structure and the function of insulin receptors isolated from 10 human breast cancer specimens. We observed that the insulin receptor content, as determined by a specific radioimmunoassay, was four fold increased in human breast cancer tissue when compared to normal breast tissues. In both cancer ...

journal_title：Breast cancer research and treatment

authors： Frittitta L,Vigneri R,Papa V,Goldfine ID,Grasso G,Trischitta V

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Insomnia is a common issue among patients with breast cancer with a potentially devastating impact on quality of life. It can be caused or exacerbated by multiple disease and treatment-related factors. Despite the prevalence and impact of insomnia, it is rarely addressed systematically in the oncology clinic. W...

journal_title：Breast cancer research and treatment

authors： Kwak A,Jacobs J,Haggett D,Jimenez R,Peppercorn J

更新日期：2020-06-01 00:00:00

abstract：:The Rho family of GTPases has been intensively studied for their roles in signal transduction processes leading to cytoskeletal-dependent responses, including cell migration and phagocytosis. In addition, they are important regulators of cell cycle progression and affect the expression of a number of genes, including ...

journal_title：Breast cancer research and treatment

authors： Ridley AJ

更新日期：2004-03-01 00:00:00

abstract：:The concept of cancer cells being hierarchically organized and arising from their own progenitor stem cells will have important implications on cancer therapy. If this hypothesis were to be true then the paucity of estrogen receptors in stem cells as well as their inherent drug resistance mechanisms pose a challenge t...

journal_title：Breast cancer research and treatment

authors： Resetkova E,Reis-Filho JS,Jain RK,Mehta R,Thorat MA,Nakshatri H,Badve S

更新日期：2010-08-01 00:00:00

abstract：:A class distribution of plasma cells associated with the stroma in twenty-eight cases of medullary carcinoma of the breast was investigated by an unlabeled immunoperoxidase method. The stroma of the medullary carcinomas tested was found to contain predominantly IgG plasma cells except in two cases. Stroma of the other...

journal_title：Breast cancer research and treatment

authors： Ito T,Saga S,Nagayoshi S,Imai M,Aoyama A,Yokoi T,Hoshino M

更新日期：1986-01-01 00:00:00

abstract：:The sentinel lymph node (SLN) is the only focus of axillary metastasis in a significant proportion of patients. In this single institutional study, clinicopathologic characteristics were investigated to determine the factors predicting the status of a SLN biopsy and the metastatic involvement of non-SLNs. Data were re...

journal_title：Breast cancer research and treatment

authors： Ozmen V,Karanlik H,Cabioglu N,Igci A,Kecer M,Asoglu O,Tuzlali S,Mudun A

更新日期：2006-01-01 00:00:00

abstract：:Inflammatory breast cancer (IBC) is a rare and aggressive disease. Previous studies have shown that among patients with stage III breast cancer, IBC is associated with a worse prognosis than noninflammatory breast cancer (non-IBC). Whether this difference holds true among patients with stage IV breast cancer has not b...

journal_title：Breast cancer research and treatment

authors： Fouad TM,Kogawa T,Liu DD,Shen Y,Masuda H,El-Zein R,Woodward WA,Chavez-MacGregor M,Alvarez RH,Arun B,Lucci A,Krishnamurthy S,Babiera G,Buchholz TA,Valero V,Ueno NT

更新日期：2015-07-01 00:00:00

abstract：:The early spread of tumor cells in primary breast cancer patients may occur either through lymphatic or hematogenous dissemination. Lymph node (LN) status and presence of disseminated tumor cells (DTC) in bone marrow (BM) are independent predictors of poor outcome. It is unknown which factors determine one or the othe...

journal_title：Breast cancer research and treatment

authors： Hartkopf AD,Banys M,Krawczyk N,Staebler A,Becker S,Hoffmann J,Hahn M,Wallwiener M,Fehm T

更新日期：2012-01-01 00:00:00

abstract：:The polypeptide hormone prolactin (Prl), acting through its cell surface receptors, promotes growth and differentiation in normal and malignant breast cells. We demonstrate herein that two Prl-responsive cell lines, NOG-8 normal mouse mammary epithelial and T47D human breast cancer cells, respond to Prl by rapid and t...

journal_title：Breast cancer research and treatment

authors： Das R,Vonderhaar BK

更新日期：1996-01-01 00:00:00

abstract：:Women who have been treated for breast cancer are typically followed up with regular mammography and palpation, with the aim of detecting recurrences and contralateral breast cancer (CBC). This study aims to investigate if the diagnostic work-up of breast cancer patients has improved over the last 25 years and resulte...

journal_title：Breast cancer research and treatment

authors： Sandberg ME,Hartman M,Edgren G,Eloranta S,Ploner A,Hall P,Czene K

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:To determine if response to endocrine therapy of breast cancer can be predicted by either a metabolic "flare reaction" detected by positron emission tomography (PET) with 2-[(18)F]-fluoro-2-deoxyglucose (FDG), induced by an estradiol challenge, or by estrogen-receptor (ER) status, determined by PET with the est...

journal_title：Breast cancer research and treatment

authors： Dehdashti F,Mortimer JE,Trinkaus K,Naughton MJ,Ellis M,Katzenellenbogen JA,Welch MJ,Siegel BA

更新日期：2009-02-01 00:00:00

abstract：:Identification and characterization of tumor subtypes using gene expression profiles of triple negative breast cancer patients. Microarray data of four breast cancer studies were pooled and evaluated. Molecular subtype classification was performed using random forest and a novel algorithm for feature extraction via co...

journal_title：Breast cancer research and treatment

authors： Koch M,Hanl M,Wiese M

更新日期：2012-08-01 00:00:00

abstract：:Wide fluctuations in results obtained by different laboratories for the content of estrogen receptors from a single source of tissue powder were reported by several investigators at the 1979 NCI Consensus Committee Meeting for Steroid Receptors in Breast Cancer and were further supported by data collected by our labor...

journal_title：Breast cancer research and treatment

authors： Raam S,Gelman R,Faulkner J,White GM,Cohen JL

更新日期：1982-01-01 00:00:00

abstract：:The DNA repair pathway is known to play a role in the etiology of breast cancer. A number of studies have demonstrated that common germline variants in genes involved in the DNA repair pathway influence breast cancer risk. To assess whether alterations in DNA repair genes contribute to breast cancer, we genotyped 12 s...

journal_title：Breast cancer research and treatment

authors： Loizidou MA,Michael T,Neuhausen SL,Newbold RF,Marcou Y,Kakouri E,Daniel M,Papadopoulos P,Malas S,Hadjisavvas A,Kyriacou K

更新日期：2009-06-01 00:00:00

abstract：:The widespread use of mammography has resulted in the detection of an increasing number of small invasive breast cancers, i.e. those that are 1cm and smaller. Patients with these small cancers generally have a low incidence of axillary lymph node metastases, and this has led some to question the routine use of axillar...

journal_title：Breast cancer research and treatment

authors： Chen YY,Schnitt SJ

更新日期：1998-01-01 00:00:00

abstract：:To determine whether capecitabine schedule adaptation improves the tolerability of capecitabine-paclitaxel combination therapy for metastatic breast cancer (MBC), patients with anthracycline-pretreated HER2-negative MBC were randomized to either arm A (21-day cycles: capecitabine 1,000 mg/m(2) twice daily, days 1-14; ...

journal_title：Breast cancer research and treatment

authors： Lortholary A,Hardy-Bessard AC,Bachelot T,de Rauglaudre G,Alexandre J,Bourgeois H,Jaubert D,Paraiso D,Largillier R

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:To evaluate a simplified method of pre-test information and germline BRCA1/2 mutation testing. METHODS:In a prospective, single-arm study, comprehensive BRCA1/2 testing was offered to unselected patients with newly diagnosed breast cancer at three hospitals in south Sweden (BRCAsearch, ClinicalTrials.gov Ident...

journal_title：Breast cancer research and treatment

authors： Nilsson MP,Törngren T,Henriksson K,Kristoffersson U,Kvist A,Silfverberg B,Borg Å,Loman N

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:The national guidelines recommend more intensive screening for breast cancer for women with a family history of breast or ovarian cancer. Using the data from the 2000 National Health Interview Survey (NHIS), we examined factors related to the underuse of mammogram in this population. METHOD:The study subject...

journal_title：Breast cancer research and treatment

authors： Wu H,Zhu K,Jatoi I,Shah M,Shriver CD,Potter J

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:Nearly half of the 3.5 million female breast cancer survivors in the US are aged 65 years or older at diagnosis, yet little is known about associations of obesity and physical activity with breast cancer-specific mortality (BCSM) among older survivors. METHODS:Between 1992 and 2013, 5254 women in the Cancer Pr...

journal_title：Breast cancer research and treatment

authors： Maliniak ML,Patel AV,McCullough ML,Campbell PT,Leach CR,Gapstur SM,Gaudet MM

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Clearance of large molecules from the interstitial space is an important function of lymphatics and is affected by local pathologic changes. OBJECTIVE:To determine if the clearance rate of interstitially injected albumin is correlated to tumour characteristics and outcome in women with invasive breast cance...

journal_title：Breast cancer research and treatment

authors： Sterns EE,SenGupta S,Zee B

更新日期：1997-01-01 00:00:00

abstract：:The mitochondrial DNA (mtDNA) 4977-bp deletion (DeltamtDNA(4977) mutation) is one of the most frequently observed mtDNA mutations in human tissues and may play a role in carcinogenesis. Only a few studies have evaluated DeltamtDNA(4977) mutation in breast cancer tissue, and the findings have been inconsistent, which m...

journal_title：Breast cancer research and treatment

authors： Ye C,Shu XO,Wen W,Pierce L,Courtney R,Gao YT,Zheng W,Cai Q

更新日期：2008-04-01 00:00:00

abstract：:CH50, a recombinant CBD-HepII polypeptide of human fibronectin, was shown to suppress tumor metastasis in murine hepatocarcinoma and melanoma models. However, the effect of CH50 on human cancer cells is still not clear. Here we evaluated the efficiency of CH50 delivered by recombinant adeno-associated virus (rAAV) vec...

journal_title：Breast cancer research and treatment

authors： He ZH,Lei Z,Zhen Y,Gong W,Huang B,Yuan Y,Zhang GM,Wang XJ,Feng ZH

更新日期：2014-01-01 00:00:00

abstract：:Breast cancer is the most common malignant tumor-affecting women during the child bearing period. With the rising trend in delaying pregnancy later in life, the issue of subsequent pregnancy and lactation following breast cancer diagnosis has been more frequently encountered. In this context, data is scarce particular...

journal_title：Breast cancer research and treatment

authors： Azim HA Jr,Bellettini G,Gelber S,Peccatori FA

更新日期：2009-03-01 00:00:00

abstract：:We examined the factors associated with screening mammography adherence behaviors and influencing factors on women's attitudes toward mammography in non-adherent women. Design-based logistic regression models were developed to characterize the influencing factors, including socio-demographic, health related, behaviora...

journal_title：Breast cancer research and treatment

authors： Madadi M,Zhang S,Yeary KH,Henderson LM

更新日期：2014-02-01 00:00:00