Breast-feeding after breast cancer: if you wish, madam.

abstract：:Over the last several years, evidence has accumulated to support the idea that rare Ha-ras polymorphisms are associated with inherited susceptibility to certain human cancers. A recent epidemiologic study conducted at our institution found a significant association specifically with breast cancer, although the mechani...

journal_title：Breast cancer research and treatment

authors： Conway K,Edmiston S,Fried DB,Hulka BS,Garrett PA,Liu ET

更新日期：1995-07-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of erlotinib in advanced breast cancer. Experimental design Multicenter, phase II study of erlotinib (150 mg orally daily). Cohort 1: progression after anthracyclines, taxanes, and capecitabine (n = 47). Cohort 2: progression after >1 chemotherapy for advanced-stage disease (...

journal_title：Breast cancer research and treatment

authors： Dickler MN,Cobleigh MA,Miller KD,Klein PM,Winer EP

更新日期：2009-05-01 00:00:00

abstract：:Molecular profiles of asynchronous breast cancer metastases are of clinical relevance to individual patients' treatment, whereas the role of profiles in synchronous lymph node metastases is not defined. The present study aimed to assess individual biomarkers and molecular subtypes according to the St Gallen classifica...

journal_title：Breast cancer research and treatment

authors： Falck AK,Bendahl PO,Chebil G,Olsson H,Fernö M,Rydén L

更新日期：2013-07-01 00:00:00

abstract：:This review will focus on the role of sphingosine and its phosphorylated derivative sphingosine-1-phosphate (SPP) in cell growth regulation and signal transduction. We will show that many of the effects attributed to sphingosine in quiescent Swiss 3T3 fibroblasts are mediated via its conversion to SPP. We propose that...

journal_title：Breast cancer research and treatment

authors： Spiegel S,Olivera A,Zhang H,Thompson EW,Su Y,Berger A

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Given its high recurrence risk, guidelines recommend systemic therapy for most patients with early-stage triple-negative breast cancer (TNBC). While some clinicopathologic factors and tumor-infiltrating lymphocytes (TILs) are known to be prognostic in patients receiving chemotherapy, their prognostic implica...

journal_title：Breast cancer research and treatment

authors： Leon-Ferre RA,Polley MY,Liu H,Gilbert JA,Cafourek V,Hillman DW,Elkhanany A,Akinhanmi M,Lilyquist J,Thomas A,Negron V,Boughey JC,Liu MC,Ingle JN,Kalari KR,Couch FJ,Visscher DW,Goetz MP

更新日期：2018-01-01 00:00:00

abstract：:Numerous allelic variants identified in the familial breast cancer and DNA repair genes BRCA1 and BRCA2 are of unknown impact on protein function or clinical relevance, referred to as unclassified variants (UCV). Lymphocytes from pathogenic BRCA1/2 mutation carriers exhibit an increased level of chromosomal damage aft...

journal_title：Breast cancer research and treatment

authors： Becker AA,Graeser MK,Landwehr C,Hilger T,Baus W,Wappenschmidt B,Meindl A,Weber RG,Schmutzler RK

更新日期：2012-08-01 00:00:00

abstract：:Tumor formation can result from a decrease in cell death, as well as an increase in cell proliferation. In spite of the high incidence of mammary gland tumors (MGTs) in female dogs, the understanding of its etiology is still poor. Consistent with several proto-oncogenes (such as Wnt) for the mammary gland, sFRP2 is ex...

journal_title：Breast cancer research and treatment

authors： Lee JL,Chang CJ,Chueh LL,Lin CT

更新日期：2006-11-01 00:00:00

abstract：:The expression of amphiregulin (AR), heregulin (HRG), and cripto-1 (CR-1) mRNA transcripts was assessed in 60 human primary breast carcinoma. AR and HRG transcripts were expressed respectively in 58% and 25% of the carcinomas as measured by Northern blot analysis. CR-1 mRNA was found in 77% of the carcinomas using Rev...

journal_title：Breast cancer research and treatment

authors： Normanno N,Kim N,Wen D,Smith K,Harris AL,Plowman G,Colletta G,Ciardiello F,Salomon DS

更新日期：1995-09-01 00:00:00

abstract：:Several independent randomized controlled trials are initiated to investigate whether sentinel lymph node biopsy can be safely omitted in clinically node negative breast cancer patients with negative axillary ultrasound findings, who are treated with breast conserving therapy. A consequence of omitting sentinel lymph ...

journal_title：Breast cancer research and treatment

authors： van Roozendaal LM,Schipper RJ,Van de Vijver KK,Haekens CM,Lobbes MB,Tjan-Heijnen VC,de Boer M,Smidt ML

更新日期：2014-02-01 00:00:00

abstract：:The tumor-stroma ratio has previously been shown to be prognostic for patients with invasive breast cancer. We present a validation study to assess the prognostic significance in lymph node-negative, premenopausal patients from the perioperative chemotherapy trial (POP trial, 10854) conducted by the European Organizat...

journal_title：Breast cancer research and treatment

authors： Dekker TJ,van de Velde CJ,van Pelt GW,Kroep JR,Julien JP,Smit VT,Tollenaar RA,Mesker WE

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:Mitochondrial unfolding protein are abundant in breast cancer cells, but the mechanism by which breast cancer cells resist apoptosis is still not fully elucidated. In this study, we explored the role of mitochondrial unfolded protein response (mtUPR)-related proteins in four types of breast cancer tissues. MET...

journal_title：Breast cancer research and treatment

authors： Chen FM,Huang LJ,Ou-Yang F,Kan JY,Kao LC,Hou MF

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine the effects of an 8-week high-intensity interval training (HIIT) intervention on vascular endothelial function, measured as brachial artery flow-mediated dilation (baFMD), and vascular wall thickness measured by carotid intima media thickness (cIMT) in breast cancer pa...

journal_title：Breast cancer research and treatment

authors： Lee K,Kang I,Mack WJ,Mortimer J,Sattler F,Salem G,Lu J,Dieli-Conwright CM

更新日期：2019-09-01 00:00:00

abstract：:Nicotine, a main addictive compound in tobacco smoke, has been linked to promotion and progression of lung, head and neck, pancreatic, and breast cancers, but the detailed mechanisms of cancer progression remain elusive. Here, we show that nicotine induces the expression of galectin-3 (an anti-apoptotic β-galactoside-...

journal_title：Breast cancer research and treatment

authors： Guha P,Bandyopadhyaya G,Polumuri SK,Chumsri S,Gade P,Kalvakolanu DV,Ahmed H

更新日期：2014-05-01 00:00:00

abstract：:After more than 100 reported randomized trials of systemic adjuvant therapy in breast cancer, it is clear that this therapy will prolong the time to recurrence and the survival time significantly, at least in some patient subsets. But there is less than complete agreement as to which subsets, which therapies, how much...

journal_title：Breast cancer research and treatment

authors： Henderson IC

更新日期：1989-10-01 00:00:00

abstract：:The relationship between IGF genotypes and phenotypes in breast tumors and their associations with breast cancer risk remain to be elucidated. Such information is especially scarce in Chinese women. To evaluate IGF-I and IGFBP-3 genotypes in relation to their phenotypes in local breast tissues and in association with ...

journal_title：Breast cancer research and treatment

authors： Qian B,Zheng H,Yu H,Chen K

更新日期：2011-11-01 00:00:00

abstract：:Steroid receptor coactivators are important in regulating the function of the receptors in endocrine organ development and in cancers, including breast. Androgen receptor (AR) coactivator ARA70, was first identified as a gene fused to the ret oncogene and later characterized as an AR coactivator. We previously reporte...

journal_title：Breast cancer research and treatment

authors： Wu X,Chen F,Sahin A,Albarracin C,Pei Z,Zou X,Singh B,Xu R,Daniels G,Li Y,Wei J,Blake M,Schneider RJ,Cowin P,Lee P

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:Discordance between HER2 expression in tumor tissue (tHER2) and HER2 status on circulating tumor cells (cHER2) has been reported. It remains largely underexplored whether patients with tHER2-/cHER2+ can benefit from anti-HER2 targeted therapies. METHODS:cHER2 status was determined in 105 advanced-stage patient...

journal_title：Breast cancer research and treatment

authors： Wang C,Mu Z,Ye Z,Zhang Z,Abu-Khalaf MM,Silver DP,Palazzo JP,Jagannathan G,Fellin FM,Bhattacharya S,Jaslow RJ,Tsangaris TN,Berger A,Neupane M,Cescon TP,Lopez A,Yao K,Chong W,Lu B,Myers RE,Hou L,Wei Q,Li B,Cri

更新日期：2020-06-01 00:00:00

abstract：:To investigate the expression levels of CXCL10 and CXCR3 in tumors from breast cancer patients randomized to adjuvant tamoxifen treatment or no endocrine treatment, in order to further study the connection to prognosis and prediction of tamoxifen treatment outcome. Immunohistochemistry on tissue microarrays from 912 b...

journal_title：Breast cancer research and treatment

authors： Hilborn E,Sivik T,Fornander T,Stål O,Nordenskjöld B,Jansson A

更新日期：2014-05-01 00:00:00

abstract：:Conflicting opinions exist concerning clinical and pathological presentation, as well as evolution and prognosis, of breast cancer in young women. The roles of associated pregnancy and lactation on these parameters is also unclear. These two conditions are studied in the present work through the comparison of two brea...

journal_title：Breast cancer research and treatment

authors： Tabbane F,el May A,Hachiche M,Bahi J,Jaziri M,Cammoun M,Mourali N

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:Platelets are essential components of hemostasis and also play an important role in the tumor microenvironment. The purposes of our research were to examine the role of thrombocytosis in inflammatory breast cancer (IBC) and to know which cytokine drives thrombocytosis. METHODS:We reviewed the medical records o...

journal_title：Breast cancer research and treatment

authors： Harano K,Kogawa T,Wu J,Yuan Y,Cohen EN,Lim B,Reuben JM,Ueno NT

更新日期：2017-12-01 00:00:00

abstract：:Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate with demonstrated anti-proliferative and anti-cancer activity in mammary cells. We hypothesized that IP6 modulates cell cycle proteins by action on cytoplasmic signaling molecules. The effects of both pharmacological (2 mM) and physi...

journal_title：Breast cancer research and treatment

authors： Vucenik I,Ramakrishna G,Tantivejkul K,Anderson LM,Ramljak D

更新日期：2005-05-01 00:00:00

abstract：:The use of exogenous sex-steroids for hormonal contraception is important to the way of life of many modern women. The widespread use of hormonal contraceptives represents a unique opportunity to have a substantial positive impact on women's health. The observation that users of oral combination type contraceptives ha...

journal_title：Breast cancer research and treatment

authors： Spicer DV,Pike MC

更新日期：1993-11-01 00:00:00

abstract：:Integrins are cell surface receptors, which mediate cell-to-cell and cell-to-extracellular matrix adhesion. Some of them, e.g. alpha(V)beta(3), alpha(IIb)beta(3) and alpha(2)beta(1), have been suggested as key players for cancer development and tumor metastasis. Two polymorphisms in the gene for the alpha(2) component...

journal_title：Breast cancer research and treatment

authors： Langsenlehner U,Renner W,Yazdani-Biuki B,Eder T,Wascher TC,Paulweber B,Clar H,Hofmann G,Samonigg H,Krippl P

更新日期：2006-05-01 00:00:00

abstract：:It is unclear which patients with breast cancer benefit from anthracycline-based neoadjuvant chemotherapy and whether taxanes increase survival. Hsp70 and serpinB3 inhibit a lysosomal cell death pathway induced in anthracycline and taxane treated cells, which may be critical for breast cancer cell survival. Thus we ev...

journal_title：Breast cancer research and treatment

authors： Collie-Duguid ES,Sweeney K,Stewart KN,Miller ID,Smyth E,Heys SD

更新日期：2012-04-01 00:00:00

abstract：:Mammography and ultrasound are often used concurrently for patients with palpable breast masses. While mammography has a false-negative rate of approximately 15 %, the addition of breast ultrasound decreases this rate among patients with palpable breast masses. There are no recent outcome data regarding the use of com...

journal_title：Breast cancer research and treatment

authors： Chan CH,Coopey SB,Freer PE,Hughes KS

更新日期：2015-10-01 00:00:00

abstract：:Resistance to endocrine therapy is a major clinical challenge in current treatment of estrogen receptor-positive breast cancer. The molecular mechanisms underlying resistance are yet not fully clarified. In this study, we investigated whether NFκB signaling is causally involved in antiestrogen resistant cell growth an...

journal_title：Breast cancer research and treatment

authors： Yde CW,Emdal KB,Guerra B,Lykkesfeldt AE

更新日期：2012-08-01 00:00:00

abstract：:Digital breast tomosynthesis (DBT) is emerging as the new standard of care for breast cancer screening based on improved cancer detection coupled with reductions in recall compared to screening with digital mammography (DM) alone. However, many prior studies lack follow-up data to assess false negatives examinations. ...

journal_title：Breast cancer research and treatment

authors： Conant EF,Beaber EF,Sprague BL,Herschorn SD,Weaver DL,Onega T,Tosteson AN,McCarthy AM,Poplack SP,Haas JS,Armstrong K,Schnall MD,Barlow WE

更新日期：2016-02-01 00:00:00

abstract：:There are divergent opinions regarding the optimum surgical management of the axilla in patients with invasive breast cancer. Guidelines mandate axillary lymph node dissection (ALND) in the setting of positive sentinel lymph nodes. However, recent studies have questioned the true benefits of this procedure. Therefore,...

journal_title：Breast cancer research and treatment

authors： Joyce DP,Manning A,Carter M,Hill AD,Kell MR,Barry M

更新日期：2015-09-01 00:00:00

abstract：:The sentinel lymph node (SLN) is the only focus of axillary metastasis in a significant proportion of patients. In this single institutional study, clinicopathologic characteristics were investigated to determine the factors predicting the status of a SLN biopsy and the metastatic involvement of non-SLNs. Data were re...

journal_title：Breast cancer research and treatment

authors： Ozmen V,Karanlik H,Cabioglu N,Igci A,Kecer M,Asoglu O,Tuzlali S,Mudun A

更新日期：2006-01-01 00:00:00

abstract：:The biology of breast cancer in Japan appears to be changing in that, while post-menopausal Japanese patients have a better prognosis than comparable British women, no differences in recurrence or survival rates can now be found in pre-menopausal patients. ...

journal_title：Breast cancer research and treatment

authors： Allen DS,Bulbrook RD,Chaudary MA,Hayward JL,Yoshida M,Miura S,Murai JT

更新日期：1991-05-01 00:00:00