Abstract:
BACKGROUND:The relationship between pervasive developmental disorder (PDD) and obsessive-compulsive disorder (OCD) has not been extensively studied despite having some phenomenological features in common. Abnormal social and communication behaviors (pragmatic behaviors) are key components of PDD and are also part of the broader autism phenotype (BAP). In this study we sought to establish if there is any association between the presence of abnormal pragmatic behaviors and OCD and whether this association delineates a familial subtype of OCD. SAMPLING AND METHODS:As part of the Johns Hopkins OCD Family Study, 80 OCD case probands were recruited and matched with 73 control probands. Probands and their first-degree relatives were interviewed using the Schedule for Affective Disorders and Schizophrenia-Lifetime Anxiety and other diagnostic instruments. A Pragmatic Rating Scale (PRS) to assess pragmatic behaviors was completed by the examiner. RESULTS:The PRS was completed on 395 subjects, of which 3% (n = 11) achieved a score of greater than 6. The prevalence of high PRS scores was significantly greater amongst case probands and relatives (5%) compared to control probands and relatives (0.5%, p = 0.011). In case relatives the prevalence of OCD was significantly higher in those relatives who had a family member with a high PRS score (p < 0.001). CONCLUSIONS:The presence of social and communication difficulties in members of OCD case families appears to identify a familial subtype of OCD that may be related to PDD and/or BAP. This study was limited to using the PRS to identify pragmatic behaviors in subjects with OCD.
journal_name
Psychopathologyjournal_title
Psychopathologyauthors
Cullen B,Samuels J,Grados M,Landa R,Bienvenu OJ,Liang KY,Riddle M,Hoehn-Saric R,Nestadt Gdoi
10.1159/000120988subject
Has Abstractpub_date
2008-01-01 00:00:00pages
194-200issue
3eissn
0254-4962issn
1423-033Xpii
000120988journal_volume
41pub_type
杂志文章相关文献
PSYCHOPATHOLOGY文献大全abstract:BACKGROUND:Previous studies have shown that alexithymia is associated with gene polymorphisms that regulate the availability of serotonin (5-HT) in the brain. Since the 5-HT network is involved in interferon (IFN)-induced depression, this paper aimed to investigate the role of alexithymia and the functional gene varian...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000441682
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The diagnostic stability of the ICD-10 diagnosis of depressive disorder has not been investigated in clinical practice. SAMPLING AND METHODS:All patients who were diagnosed with depressive disorder at least once in a period from 1994 to 2002 in psychiatric out- or inpatient settings in Denmark were identifi...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000083968
更新日期:2005-01-01 00:00:00
abstract::The following case report describes a pregnant woman who was convinced that her pregnancy was non-existent despite being in an advanced stage of clinically obvious pregnancy. The nosologically unspecific syndrome of denial of pregnancy is discussed by reviewing the literature. Based on the existing literature it will ...
journal_title:Psychopathology
pub_type: 杂志文章,评审
doi:10.1159/000096685
更新日期:2007-01-01 00:00:00
abstract::Anxiety disorders are common in patients with depressive disorders. This preliminary study investigated some clinical correlates of comorbidity between dysthymic disorder (DD) and generalized anxiety disorder (GAD) in a clinically referred sample of children and adolescents. After psychiatric evaluation, including a d...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000049318
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:The DSM criteria for a delusion indicate that it should not include any beliefs held by a person's 'culture or subculture'. The internet has many examples of people reporting 'mind control experiences' (MCEs) on self-published web pages, many of which suggest a community based around such beliefs and experie...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000090598
更新日期:2006-01-01 00:00:00
abstract::The diagnosis of reactive psychosis is more commonly used in Denmark and Norway, where 50 and 40%, respectively, of first-admitted patients with functional psychoses will be diagnosed as having a reactive psychosis. The predictive validity of the concept is discussed. The concept has to be better operationalized and l...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000284481
更新日期:1987-01-01 00:00:00
abstract::77 patients with delusional psychoses, regardless of their nosological attribution (except severe organicity), and their first-degree relatives were diagnosed with the Research Diagnostic Criteria (RDC) and the Vienna Research Criteria (VRC). The diagnostic procedure was performed blindly in the relatives. Both criter...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000284469
更新日期:1986-01-01 00:00:00
abstract::Color preferences of 61 patients with major depressive disorder were compared to 69 controls. A multidimensional scaling analysis revealed a difference in overall color arrangements between groups. The possible significance of this is discussed. ...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000284510
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Up to 60% of bipolar disorder (BD) patients develop alcohol use disorders (AUD) at some point in their lives. The causes of this highly prevalent comorbidity are unknown. High trait impulsivity characterizes both isolated BD and AUD and may be a link to explain the association between BD and AUD. In this stu...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000336730
更新日期:2013-01-01 00:00:00
abstract::In the Bonn Schizophrenia Study (Huber et al., Monogr. Gesamtgebiete Psychiat., vol. 21, Springer, Berlin 1979) 113 cases fulfilled the criteria for four types of schizo-affective and/or cycloid psychoses. Each of these subgroups had a significantly more favorable long-term prognosis than that of the Bonn sample as a ...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000284429
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:In this study, we conducted a broad investigation of neuropsychological functioning in schizophrenia patients with first-rank (passivity) symptoms (FRS) using standardized cognitive tests. We focused on 3 neuropsychological domains, partly informed by 3 broad hypotheses concerning the pathogenesis of FRS. We...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000187634
更新日期:2009-01-01 00:00:00
abstract::The phylogenetic and ontogenetic developments of social cognition have been a major research focus of evolutionary and developmental psychology. Theory of mind or so-called Machiavellian intelligence, that is the capacity to infer mental states of other individuals and to manipulate them in order to maximise social su...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000049286
更新日期:2001-03-01 00:00:00
abstract::Transsexualism is a challenging entity posing diagnostical, etiological, ethical and moral questions with no general consensus of opinion and a controversial management policy. The present article tries to deal with these questions by drawing a parallel with another psychiatric syndrome in which there is also a distur...
journal_title:Psychopathology
pub_type: 杂志文章,评审
doi:10.1159/000284965
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Although difficulties in emotion regulation (ER) are considered a core feature of borderline personality disorder (BPD), the specific strategies that individuals with BPD most commonly use, their diagnostic specificity, and their associations with harmful behaviors have not been firmly established. SAMPLING...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000487008
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:We prospectively investigated a sample of 42 patients with acute and transient psychotic disorder (ATPD) as defined by the 10th revision of the International Classification of Diseases (ICD-10; F23) to determine the clinical and demographic features of this entity and its relationship to cycloid psychoses. M...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000049329
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Psychoanalytical theories coincide in understanding depersonalization (DP) as a disorder of narcissistic self-regulation. DP is described as an ego defense against overwhelming shame resulting in a splitting of an observing ego detached from the experiencing self. In contrast to a behavioral-cognitive theory...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000093523
更新日期:2006-01-01 00:00:00
abstract::Seventy-four patients who met DSM-III-R criteria for obsessive compulsive disorder (OCD) were studied in a prospective follow-up study in order to investigate course and prognosis of OCD with or without comorbid depressive symptomatology. Subjects were examined three times: at admission (baseline), 6 months later (fol...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000029124
更新日期:2000-03-01 00:00:00
abstract::A patient may experience hallucinations in more than one modality simultaneously or at different times and they may or may not appear to emanate from a single source. Current nomenclature is imprecise, often has particular diagnostic implications and fails to distinguish between these different phenomena. This has res...
journal_title:Psychopathology
pub_type: 杂志文章,评审
doi:10.1159/000284883
更新日期:1994-01-01 00:00:00
abstract::It is widely accepted that depressives focus on negative memories, and forget or repress positive memories (showing a mood-congruent affective tendency). Normals have an opposite positive bias in memory ('Pollyanna tendency'). Research evidence for depressives' negative bias in memory comes mainly from studies of retr...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000284974
更新日期:1996-01-01 00:00:00
abstract::Consecutively referred out-patients (n = 102) with non-psychotic functional psychiatric disorders were examined. Nine syndrome scores (panic attack, phobic anxiety, generalized anxiety, obsessive-compulsive, dissociative, conversion, somatoform, depersonalization, and depressive) showed patterns corresponding to ICD-1...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000285047
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:Basic symptoms are early subtle changes in thinking, feeling and perception that are subjectively experienced and precede the onset of a psychotic illness. In adult samples, high basic symptom scores are regarded as specific risk factors for the development of schizophrenia. The aim of this study was to explo...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000105530
更新日期:2007-01-01 00:00:00
abstract::Although obsessive-compulsive disorder (OCD) is regarded as a unitary nosological entity, it encompasses a rich variety of heterogeneous mental and behavioural phenomena. The identification of clinical subtypes within this broad concept has been a focus of attention in recent years. In the present study, we administer...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000079509
更新日期:2004-07-01 00:00:00
abstract::The present study involves a retrospective chart review of all patients who visited the Emergency Mental Health Service during the period of July 1, 1985 to June, 30, 1986 (total visits = 2,772). It compares those 'suicidal' patients seen only once during the index year with those seen multiple times (comparison of fi...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000284650
更新日期:1990-01-01 00:00:00
abstract::The present report studies the differences between schizophrenic responders and nonresponders within the different symptomatologic groups of the Scale for the Assessment of Negative Symptoms (SANS) and the Scale for the Assessment of Positive Symptoms (SAPS). The relationship between the different electrodermal activi...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000284799
更新日期:1993-01-01 00:00:00
abstract::A postmortem inquiry of 105 legal documents concerning suicide deaths obtained from the Office of the District Attorney covering the province of Achaia was studied for the 15-year period 1970-1984. The suicides were classified into two groups; group A consisting of 63 suicides (with a history of psychiatric illness) a...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000284699
更新日期:1991-01-01 00:00:00
abstract::Musical expression of the instrumental playing of 61 mentally ill patients and 29 controls recorded several times was assessed by means of a short polarity profile. The performances were reversibly impaired in correlation with the psychopathology. Musical expression followed a systematic variation according to nosolog...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000284415
更新日期:1985-01-01 00:00:00
abstract::Medical records of 1,911 alcoholics admitted to the Alcohol Inpatient Service at the University of New Mexico in Albuquerque (USA) were examined to find the frequencies among there variables: hallucination (H), nausea/vomiting (N/V), and elevated liver enzymes (L). The variable L is thought to be independent of neurot...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000284407
更新日期:1985-01-01 00:00:00
abstract::The coexistence of the delusions of infestation and of body smell is reported. In the analysis of a schizophrenic patient, the authors suppose a connection between object loss and the formation of secondary symptoms. Delusions of infestation and/or body smell can be an indication for a careful psychological analysis i...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000284836
更新日期:1993-01-01 00:00:00
abstract::Several C-3-substituted beta-carbolines (e.g., the ethyl ester of beta-carboline-3-carboxylic acid) have high affinities for benzodiazepine receptors and can antagonize the principal pharmacologic actions of the benzodiazepines. The observation that some of these compounds also possess 'intrinsic' actions, best descri...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000284131
更新日期:1984-01-01 00:00:00
abstract::A clinical follow-up lasting from 1 to 6 years on 25 outpatients affected by endogenous psychoses and manifesting ego disorders demonstrates the presence of both activity and passivity experiences in schizophrenias and affective psychoses. No differential diagnosis between the two nosographical groups can be based on ...
journal_title:Psychopathology
pub_type: 杂志文章
doi:10.1159/000284817
更新日期:1993-01-01 00:00:00